Enhancement of LPS-induced microglial inflammation response via TLR4 under high glucose conditions

Cellular Physiology and Biochemistry

Volumn 35, Issue 4, 2015, Pages 1571-1581

  Zhang, Xiang ^a   Dong, Hongquan ^a   Zhang, Susu ^a   Lu, Shunmei ^a   Sun, Jie ^a   Qian, Yanning ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

High glucose; JAK2 STAT3; Microglia; TLR4

Indexed keywords

CYTOKINE; GLUCOSE; INTERLEUKIN 6; JANUS KINASE 2; LIPOPOLYSACCHARIDE; STAT3 PROTEIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL CULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DIABETES MELLITUS; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; IN VITRO STUDY; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NEWBORN; NONHUMAN; PATHOPHYSIOLOGY; POSTOPERATIVE COGNITIVE DYSFUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CYTOLOGY; DRUG EFFECTS; INFLAMMATION; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; GLUCOSE; INFLAMMATION; INTERLEUKIN-6; JANUS KINASE 2; LIPOPOLYSACCHARIDES; MICROGLIA; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84925433011     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000373972     Document Type: Article

References (34)

1. Popovich PG: Immunological regulation of neuronal degeneration and regeneration in the injured spinal cord. Prog Brain Res 2000;128:43-58.
2. Csuka E, Hans VH, Ammann E, Trentz O, Kossmann T, Morganti-Kossmann MC: Cell activation and inflammatory response following traumatic axonal injury in the rat. Neuroreport 2000;11:2587-2590.
3. Heppner FL, Greter M, Marino D, Falsig J, Raivich G, Hovelmeyer N, Waisman A, Rulicke T, Prinz M, Priller J, Becher B, Aguzzi A: Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med 2005;11:146-152.
4. Gao H, Liu B, Zhang W, Hong J: Novel anti-inflammatory therapy for Parkinson's disease. Trends Pharmacol Sci 2003;24:395-401.
5. Block ML, Hong J: Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism. Prog Neurobiol 2005;76:77-98.
6. Herrera AJ, Tomas-Camardiel M, Venero JL, Cano J, Machado A: Inflammatory process as a determinant factor for the degeneration of substantia nigra dopaminergic neurons. J Neural Transm 2005;112:111-119.
7. Lien E, Means TK, Heine H, Yoshimura A, Kusumoto S, Fukase K, Fenton MJ, Oikawa M, Qureshi N, Monks B, Finberg RW, Ingalls RR, Golenbock DT: Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J Clin Invest 2000;105:497-504.
8. Cheong MH, Lee SR, Yoo HS, Jeong JW, Kim GY, Kim WJ, Jung IC, Choi YH: Anti-inflammatory effects of Polygala tenuifolia root through inhibition of NF-kappaB activation in lipopolysaccharide-induced BV2 microglial cells. J Ethnopharmacol 2011;137:1402-1408.
9. Kettenmann H, Hanisch UK, Noda M, Verkhratsky A: Physiology of microglia. Physiol Rev 2011;91:461-553.
10. Medi C, Evered L, Silbert B, Teh A, Halloran K, Morton J, Kistler P, Kalman J: Subtle post-procedural cognitive dysfunction after atrial fibrillation ablation. J Am Coll Cardiol 2013;62:531-539.
11. Cui QT, Fu QL, Han PL, Zhang J: [Risk factors of cognitive impairment after off-pump coronary artery bypass grafting]. Zhonghua Xin Xue Guan Bing Za Zhi 2012;40:104-107.
12. Mu DL, Wang DX, Li LH, Shan GJ, Su Y, Yu QJ, Shi CX: [Postoperative delirium is associated with cognitive dysfunction one week after coronary artery bypass grafting surgery]. Beijing Da Xue Xue Bao 2011;43:242-249.
13. Liu YH, Wang DX, Li LH, Wu XM, Shan GJ, Su Y, Li J, Yu QJ, Shi CX, Huang YN, Sun W: The effects of cardiopulmonary bypass on the number of cerebral microemboli and the incidence of cognitive dysfunction after coronary artery bypass graft surgery. Anesth Analg 2009;109:1013-1022.
14. Garcia-Bueno B, Caso JR, Leza JC: Stress as a neuroinflammatory condition in brain: Damaging and protective mechanisms. Neurosci Biobehav Rev 2008;32:1136-1151.
15. Dong H, Zhang X, Dai X, Lu S, Gui B, Jin W, Zhang S, Zhang S, Qian Y: Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway. J Neuroinflammation 2014;11:140.
16. Lee JJ, Kim DH, Kim DG, Lee HJ, Min W, Rhee MH, Cho JY, Watarai M, Kim S: Toll-like receptor 4-linked Janus kinase 2 signaling contributes to internalization of Brucella abortus by macrophages. Infect Immun 2013;81:2448-2458.
17. Lund S, Porzgen P, Mortensen AL, Hasseldam H, Bozyczko-Coyne D, Morath S, Hartung T, Bianchi M, Ghezzi P, Bsibsi M, Dijkstra S, Leist M: Inhibition of microglial inflammation by the MLK inhibitor CEP-1347. J Neurochem 2005;92:1439-1451.
18. Park BS, Lee JO: Recognition of lipopolysaccharide pattern by TLR4 complexes. Exp Mol Med 2013;45:e66.
19. Pasare C, Medzhitov R: Toll-like receptors: Linking innate and adaptive immunity. Microbes Infect 2004;6:1382-1387.
20. Akira S, Takeda K: Toll-like receptor signalling. Nat Rev Immunol 2004;4:499-511.
21. Doyle SL, O'Neill LA: Toll-like receptors: From the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity. Biochem Pharmacol 2006;72:1102-1113.
22. Jeong JW, Lee HH, Han MH, Kim GY, Kim WJ, Choi YH: Anti-inflammatory effects of genistein via suppression of the toll-like receptor 4-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglia. Chem Biol Interact 2014;212:30-39.
23. Kim HY, Park EJ, Joe EH, Jou I: Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia. J Immunol 2003;171:6072-6079.
24. Kim OS, Park EJ, Joe EH, Jou I: JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells. J Biol Chem 2002;277:40594-40601.
25. Yang X, He G, Hao Y, Chen C, Li M, Wang Y, Zhang G, Yu Z: The role of the JAK2-STAT3 pathway in pro-inflammatory responses of EMF-stimulated N9 microglial cells. J Neuroinflammation 2010;7:54.
26. Huang C, Ma R, Sun S, Wei G, Fang Y, Liu R, Li G: JAK2-STAT3 signaling pathway mediates thrombin-induced proinflammatory actions of microglia in vitro. J Neuroimmunol 2008;204:118-125.
27. Schram MT, Chaturvedi N, Schalkwijk C, Giorgino F, Ebeling P, Fuller JH, Stehouwer CD: Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes: The EURODIAB Prospective Complications Study. Diabetes Care 2003;26:2165-2173.
28. Devaraj S, Glaser N, Griffen S, Wang-Polagruto J, Miguelino E, Jialal I: Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes. Diabetes 2006;55:774-779.
29. Jain SK, Kannan K, Lim G, Matthews-Greer J, McVie R, Bocchini JJ: Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes. Diabetes Care 2003;26:2139-2143.
30. Shanmugam N, Reddy MA, Guha M, Natarajan R: High glucose-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells. Diabetes 2003;52:1256-1264.
31. Igarashi M, Wakasaki H, Takahara N, Ishii H, Jiang ZY, Yamauchi T, Kuboki K, Meier M, Rhodes CJ, King GL: Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest 1999;103:185-195.
32. Ceolotto G, Gallo A, Miola M, Sartori M, Trevisan R, Del PS, Semplicini A, Avogaro A: Protein kinase C activity is acutely regulated by plasma glucose concentration in human monocytes in vivo. Diabetes 1999;48:1316-1322.
33. Pereira TDOS, Da Costa GNF, Santiago ARS, Ambrósio AF, Dos Santos PFM: High glucose enhances intracellular Ca2+ responses triggered by purinergic stimulation in retinal neurons and microglia. Brain Res 2010;1316:129-138.
34. Dasu MR, Devaraj S, Zhao L, Hwang DH, Jialal I: High glucose induces Toll-Like receptor expression in human monocytes: Mechanism of activation. Diabetes 2008;57:3090-3098.