메뉴 건너뛰기




Volumn 51, Issue 3, 2013, Pages 1021-1029

Chemokine CCL2 induces apoptosis in cortex following traumatic brain injury

Author keywords

Apoptosis; CCL2; Chemokine; Traumatic brain injury

Indexed keywords

CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NEURON SPECIFIC NUCLEAR PROTEIN; RS 504393; UNCLASSIFIED DRUG;

EID: 84885960817     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-013-0091-8     Document Type: Article
Times cited : (52)

References (36)
  • 1
    • 67649479358 scopus 로고    scopus 로고
    • Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis
    • 19580914 10.1016/j.neubiorev.2009.03.011 1:CAS:528:DC%2BD1MXotFOhsrs%3D
    • Bales JW, Wagner AK, Kline AE, Dixon CE (2009) Persistent cognitive dysfunction after traumatic brain injury: a dopamine hypothesis. Neurosci Biobehav Rev 33(7):981-1003
    • (2009) Neurosci Biobehav Rev , vol.33 , Issue.7 , pp. 981-1003
    • Bales, J.W.1    Wagner, A.K.2    Kline, A.E.3    Dixon, C.E.4
  • 2
    • 26644458316 scopus 로고    scopus 로고
    • Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: Functional effect of MCP-1/CCL2 on calcium mobilization in primary cultured neurons
    • 16196033 10.1002/cne.20729 1:CAS:528:DC%2BD2MXht1SqsrrN
    • Banisadr G, Gosselin RD, Mechighel P, Rostène W, Kitabgi P, Mélik Parsadaniantz S (2005) Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: functional effect of MCP-1/CCL2 on calcium mobilization in primary cultured neurons. J Comp Neurol 492(2):178-192
    • (2005) J Comp Neurol , vol.492 , Issue.2 , pp. 178-192
    • Banisadr, G.1    Gosselin, R.D.2    Mechighel, P.3    Rostène, W.4    Kitabgi, P.5    Mélik Parsadaniantz, S.6
  • 3
    • 0030584891 scopus 로고    scopus 로고
    • Localization of monocyte chemoattractant peptide-1 expression in the central nervous system in experimental autoimmune encephalomyelitis and trauma in the rat
    • 8609424 1:CAS:528:DyaK28Xit1eiu7w%3D
    • Berman JW, Guida MP, Warren J, Amat J, Brosnan CF (1996) Localization of monocyte chemoattractant peptide-1 expression in the central nervous system in experimental autoimmune encephalomyelitis and trauma in the rat. J Immunol 156(8):3017-3023
    • (1996) J Immunol , vol.156 , Issue.8 , pp. 3017-3023
    • Berman, J.W.1    Guida, M.P.2    Warren, J.3    Amat, J.4    Brosnan, C.F.5
  • 4
    • 0034674939 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor administration after traumatic brain injury in the rat does not protect against behavioral or histological deficits
    • 11029540 10.1016/S0306-4522(00)00214-1 1:CAS:528:DC%2BD3cXls1Cltrc%3D
    • Blaha GR, Raghupathi R, Saatman KE, McIntosh TK (2000) Brain-derived neurotrophic factor administration after traumatic brain injury in the rat does not protect against behavioral or histological deficits. Neuroscience 99(3):483-493
    • (2000) Neuroscience , vol.99 , Issue.3 , pp. 483-493
    • Blaha, G.R.1    Raghupathi, R.2    Saatman, K.E.3    McIntosh, T.K.4
  • 5
    • 0035368670 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 expressed in neurons and astrocytes during focal ischemia in mice
    • 11384610 10.1016/S0006-8993(01)02328-9 1:CAS:528:DC%2BD3MXjvV2qs78%3D
    • Che X, Ye W, Panga L, Wu DC, Yang GY (2001) Monocyte chemoattractant protein-1 expressed in neurons and astrocytes during focal ischemia in mice. Brain Res 902(2):171-177
    • (2001) Brain Res , vol.902 , Issue.2 , pp. 171-177
    • Che, X.1    Ye, W.2    Panga, L.3    Wu, D.C.4    Yang, G.Y.5
  • 6
    • 79959969839 scopus 로고    scopus 로고
    • Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice
    • 21623956 10.1111/j.1460-9568.2011.07723.x
    • Clausen F, Hånell A, Israelsson C, Hedin J, Ebendal T, Mir AK, Gram H, Marklund N (2011) Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice. Eur J Neurosci 34(1):110-123
    • (2011) Eur J Neurosci , vol.34 , Issue.1 , pp. 110-123
    • Clausen, F.1    Hånell, A.2    Israelsson, C.3    Hedin, J.4    Ebendal, T.5    Mir, A.K.6    Gram, H.7    Marklund, N.8
  • 8
    • 0019421846 scopus 로고
    • Responses to cortical injury: I. Methodology and local effects of contusions in the rat
    • 7225844 10.1016/0006-8993(81)90067-6 1:CAS:528:DyaL3MXhslahtbc%3D
    • Feeney DM, Boyeson MG, Linn RT, Murray HM, Dail WG (1981) Responses to cortical injury: I. Methodology and local effects of contusions in the rat. Brain Res 211(1):67-77
    • (1981) Brain Res , vol.211 , Issue.1 , pp. 67-77
    • Feeney, D.M.1    Boyeson, M.G.2    Linn, R.T.3    Murray, H.M.4    Dail, W.G.5
  • 9
    • 4043167143 scopus 로고    scopus 로고
    • Motor and cognitive function evaluation following experimental traumatic brain injury
    • 15341032 10.1016/j.neubiorev.2004.06.002
    • Fujimoto ST, Longhi L, Saatman KE, Conte V, Stocchetti N, McIntosh TK (2004) Motor and cognitive function evaluation following experimental traumatic brain injury. Neurosci Biobehav Rev 28(4):365-378
    • (2004) Neurosci Biobehav Rev , vol.28 , Issue.4 , pp. 365-378
    • Fujimoto, S.T.1    Longhi, L.2    Saatman, K.E.3    Conte, V.4    Stocchetti, N.5    McIntosh, T.K.6
  • 10
    • 0033797853 scopus 로고    scopus 로고
    • Acute excitotoxic injury induces expression of monocyte chemoattractant protein-1 and its receptor, CCR2, in neonatal rat brain
    • 10993690 10.1006/exnr.2000.7466 1:CAS:528:DC%2BD3cXmsFemt7k%3D
    • Galasso JM, Miller MJ, Cowell RM, Harrison JK, Warren JS, Silverstein FS (2000) Acute excitotoxic injury induces expression of monocyte chemoattractant protein-1 and its receptor, CCR2, in neonatal rat brain. Exp Neurol 165(2):295-305
    • (2000) Exp Neurol , vol.165 , Issue.2 , pp. 295-305
    • Galasso, J.M.1    Miller, M.J.2    Cowell, R.M.3    Harrison, J.K.4    Warren, J.S.5    Silverstein, F.S.6
  • 11
    • 84855958227 scopus 로고    scopus 로고
    • Mesenchymal stem cell therapy modulates the inflammatory response in experimental traumatic brain injury
    • doi: 10.1155/2011/564089
    • Galindo LT, Filippo TR, Semedo P, Ariza CB, Moreira CM, Camara NO, Porcionatto MA (2011) Mesenchymal stem cell therapy modulates the inflammatory response in experimental traumatic brain injury. Neurol Res Int. doi: 10.1155/2011/564089
    • (2011) Neurol Res Int
    • Galindo, L.T.1    Filippo, T.R.2    Semedo, P.3    Ariza, C.B.4    Moreira, C.M.5    Camara, N.O.6    Ma, P.7
  • 12
    • 74149093963 scopus 로고    scopus 로고
    • Astrocyte- and endothelial-targeted CCL2 conditional knockout mice: Critical tools for studying the pathogenesis of neuroinflammation
    • 19340610 10.1007/s12031-009-9197-4 1:CAS:528:DC%2BD1MXhtFaksbrM
    • Ge S, Murugesan N, Pachter JS (2009) Astrocyte- and endothelial-targeted CCL2 conditional knockout mice: critical tools for studying the pathogenesis of neuroinflammation. J Mol Neurosci 39(1-2):269-283
    • (2009) J Mol Neurosci , vol.39 , Issue.1-2 , pp. 269-283
    • Ge, S.1    Murugesan, N.2    Pachter, J.S.3
  • 13
    • 0029931236 scopus 로고    scopus 로고
    • Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain
    • 8666808 1:CAS:528:DyaK28XjtFCnu7c%3D
    • Glabinski AR, Balasingam V, Tani M, Kunkel SL, Strieter RM, Yong VW, Ransohoff RM (1996) Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain. J Immunol 156(11):4363-4368
    • (1996) J Immunol , vol.156 , Issue.11 , pp. 4363-4368
    • Glabinski, A.R.1    Balasingam, V.2    Tani, M.3    Kunkel, S.L.4    Strieter, R.M.5    Yong, V.W.6    Ransohoff, R.M.7
  • 14
    • 84866300984 scopus 로고    scopus 로고
    • IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: Implications for functional recovery
    • 22992283 10.1186/1750-1326-7-47 1:CAS:528:DC%2BC38XhvVSiurvO
    • Lian H, Shim DJ, Gaddam SS, Rodriguez-Rivera J, Bitner BR, Pautler RG, Robertson CS, Zheng H (2012) IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery. Mol Neurodegener 7:47
    • (2012) Mol Neurodegener , vol.7 , pp. 47
    • Lian, H.1    Shim, D.J.2    Gaddam, S.S.3    Rodriguez-Rivera, J.4    Bitner, B.R.5    Pautler, R.G.6    Robertson, C.S.7    Zheng, H.8
  • 15
    • 48449095239 scopus 로고    scopus 로고
    • Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury
    • 18590543 10.1186/1742-2094-5-28
    • Lloyd E, Somera-Molina K, Van Eldik LJ, Watterson DM, Wainwright MS (2008) Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury. J Neuroinflammation 5:28
    • (2008) J Neuroinflammation , vol.5 , pp. 28
    • Lloyd, E.1    Somera-Molina, K.2    Van Eldik, L.J.3    Watterson, D.M.4    Wainwright, M.S.5
  • 16
    • 0037300319 scopus 로고    scopus 로고
    • The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE)
    • 12495638 10.1016/S1044-5323(02)00125-2 1:CAS:528:DC%2BD38XpsFyhtrs%3D
    • Mahad DJ, Ransohoff RM (2003) The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Semin Immunol 15(1):23-32
    • (2003) Semin Immunol , vol.15 , Issue.1 , pp. 23-32
    • Mahad, D.J.1    Ransohoff, R.M.2
  • 17
    • 0033192741 scopus 로고    scopus 로고
    • Traumatic brain injury
    • 10433652 1:STN:280:DyaK1Mzmt1KnsA%3D%3D
    • McNair ND (1999) Traumatic brain injury. Nurs Clin North Am 34(3):637-659
    • (1999) Nurs Clin North Am , vol.34 , Issue.3 , pp. 637-659
    • McNair, N.D.1
  • 18
    • 0037198975 scopus 로고    scopus 로고
    • Ablation of the chemokine monocyte chemoattractant protein-1 delays retrograde neuronal degeneration, attenuates microglial activation, and alters expression of cell death molecules
    • 12106688 10.1016/S0169-328X(02)00158-4 1:CAS:528:DC%2BD38XltFSis7c%3D
    • Muessel MJ, Klein RM, Wilson AM, Berman NE (2002) Ablation of the chemokine monocyte chemoattractant protein-1 delays retrograde neuronal degeneration, attenuates microglial activation, and alters expression of cell death molecules. Brain Res Mol Brain Res 103(1-2):12-27
    • (2002) Brain Res Mol Brain Res , vol.103 , Issue.1-2 , pp. 12-27
    • Muessel, M.J.1    Klein, R.M.2    Wilson, A.M.3    Berman, N.E.4
  • 19
    • 64849090434 scopus 로고    scopus 로고
    • The temporal expression, cellular localization, and inhibition of the chemokines MIP-2 and MCP-1 after traumatic brain injury in the rat
    • 19210118 10.1089/neu.2008.0686
    • Rhodes JK, Sharkey J, Andrews PJ (2009) The temporal expression, cellular localization, and inhibition of the chemokines MIP-2 and MCP-1 after traumatic brain injury in the rat. J Neurotrauma 26(4):507-525
    • (2009) J Neurotrauma , vol.26 , Issue.4 , pp. 507-525
    • Rhodes, J.K.1    Sharkey, J.2    Andrews, P.J.3
  • 20
    • 78650928745 scopus 로고    scopus 로고
    • Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury
    • 20965168 10.1016/j.expneurol.2010.10.003 1:CAS:528:DC%2BC3MXjsFSitw%3D%3D
    • Sauerbeck A, Gao J, Readnower R, Liu M, Pauly JR, Bing G, Sullivan PG (2011) Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury. Exp Neurol 227(1):128-135
    • (2011) Exp Neurol , vol.227 , Issue.1 , pp. 128-135
    • Sauerbeck, A.1    Gao, J.2    Readnower, R.3    Liu, M.4    Pauly, J.R.5    Bing, G.6    Sullivan, P.G.7
  • 21
    • 77950520442 scopus 로고    scopus 로고
    • Role of CCL2 (MCP-1) in traumatic brain injury (TBI): Evidence from severe TBI patients and CCL2-/- mice
    • 20029451 10.1038/jcbfm.2009.262
    • Semple BD, Bye N, Rancan M, Ziebell JM, Morganti-Kossmann MC (2010a) Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice. J Cereb Blood Flow Metab 30(4):769-782
    • (2010) J Cereb Blood Flow Metab , vol.30 , Issue.4 , pp. 769-782
    • Semple, B.D.1    Bye, N.2    Rancan, M.3    Ziebell, J.M.4    Morganti-Kossmann, M.C.5
  • 22
    • 77957798179 scopus 로고    scopus 로고
    • CCL2 modulates cytokine production in cultured mouse astrocytes
    • 20942978 10.1186/1742-2094-7-67
    • Semple BD, Frugier T, Morganti-Kossmann MC (2010b) CCL2 modulates cytokine production in cultured mouse astrocytes. J Neuroinflammation 7:67
    • (2010) J Neuroinflammation , vol.7 , pp. 67
    • Semple, B.D.1    Frugier, T.2    Morganti-Kossmann, M.C.3
  • 23
    • 77954862661 scopus 로고    scopus 로고
    • Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury
    • 20551947 10.1038/nrneurol.2010.74 1:CAS:528:DC%2BC3cXovFKgt7g%3D
    • Shlosberg D, Benifla M, Kaufer D, Friedman A (2010) Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury. Nat Rev Neurol 6(7):393-403
    • (2010) Nat Rev Neurol , vol.6 , Issue.7 , pp. 393-403
    • Shlosberg, D.1    Benifla, M.2    Kaufer, D.3    Friedman, A.4
  • 24
    • 78650173528 scopus 로고    scopus 로고
    • Genetic and histologic evidence implicates role of inflammation in traumatic brain injury-induced apoptosis in the rat cerebral cortex following moderate fluid percussion injury
    • 20950674 10.1016/j.neuroscience.2010.10.018 1:CAS:528:DC%2BC3cXhsVGntbbM
    • Shojo H, Kaneko Y, Mabuchi T, Kibayashi K, Adachi N, Borlongan CV (2010) Genetic and histologic evidence implicates role of inflammation in traumatic brain injury-induced apoptosis in the rat cerebral cortex following moderate fluid percussion injury. Neuroscience 171(4):1273-1282
    • (2010) Neuroscience , vol.171 , Issue.4 , pp. 1273-1282
    • Shojo, H.1    Kaneko, Y.2    Mabuchi, T.3    Kibayashi, K.4    Adachi, N.5    Borlongan, C.V.6
  • 25
    • 0031020222 scopus 로고    scopus 로고
    • Improvement of cognitive deficits and decreased cholinergic neuronal cell loss and apoptotic cell death following neurotrophin infusion after experimental traumatic brain injury
    • 9046309 10.3171/jns.1997.86.3.0511 1:CAS:528:DyaK2sXitVSks7Y%3D
    • Sinson G, Perri BR, Trojanowski JQ, Flamm ES, McIntosh TK (1997) Improvement of cognitive deficits and decreased cholinergic neuronal cell loss and apoptotic cell death following neurotrophin infusion after experimental traumatic brain injury. J Neurosurg 86(3):511-518
    • (1997) J Neurosurg , vol.86 , Issue.3 , pp. 511-518
    • Sinson, G.1    Perri, B.R.2    Trojanowski, J.Q.3    Flamm, E.S.4    McIntosh, T.K.5
  • 26
    • 0028330343 scopus 로고
    • Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3. Similarities and differences with MCP-1
    • 8144937 1:CAS:528:DyaK2cXis1Oru7k%3D
    • Sozzani S, Zhou D, Locati M, Rieppi M, Proost P, Magazin M, Vita N, van Damme J, Mantovani A (1994) Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3. Similarities and differences with MCP-1. J Immunol 152(7):3615-3622
    • (1994) J Immunol , vol.152 , Issue.7 , pp. 3615-3622
    • Sozzani, S.1    Zhou, D.2    Locati, M.3    Rieppi, M.4    Proost, P.5    Magazin, M.6    Vita, N.7    Van Damme, J.8    Mantovani, A.9
  • 27
    • 84871960061 scopus 로고    scopus 로고
    • Formaldehyde impairs learning and memory involving the disturbance of hydrogen sulfide generation in the hippocampus of rats
    • 23108488 10.1007/s12031-012-9912-4 1:CAS:528:DC%2BC3sXmvVCi
    • Tang XQ, Zhuang YY, Zhang P, Fang HR, Zhou CF, Gu HF, Zhang H, Wang CY (2013) Formaldehyde impairs learning and memory involving the disturbance of hydrogen sulfide generation in the hippocampus of rats. J Mol Neurosci 49(1):140-149
    • (2013) J Mol Neurosci , vol.49 , Issue.1 , pp. 140-149
    • Tang, X.Q.1    Zhuang, Y.Y.2    Zhang, P.3    Fang, H.R.4    Zhou, C.F.5    Gu, H.F.6    Zhang, H.7    Wang, C.Y.8
  • 28
    • 84859709927 scopus 로고    scopus 로고
    • Combination of vascular endothelial and fibroblast growth factor 2 for induction of neurogenesis and angiogenesis after traumatic brain injury
    • 22246995 10.1007/s12031-012-9706-8 1:CAS:528:DC%2BC38Xlt1yjt7s%3D
    • Thau-Zuchman O, Shohami E, Alexandrovich AG, Leker RR (2012) Combination of vascular endothelial and fibroblast growth factor 2 for induction of neurogenesis and angiogenesis after traumatic brain injury. J Mol Neurosci 47(1):166-172
    • (2012) J Mol Neurosci , vol.47 , Issue.1 , pp. 166-172
    • Thau-Zuchman, O.1    Shohami, E.2    Alexandrovich, A.G.3    Leker, R.R.4
  • 29
    • 0029872031 scopus 로고    scopus 로고
    • Expression of adhesion molecules and monocyte chemoattractant protein-1 (MCP-1) in the spinal cord lesions in HTLV-I-associated myelopathy
    • 8928610 10.1007/s004010050435 1:CAS:528:DyaK28XisF2jsbw%3D
    • Umehara F, Izumo S, Takeya M, Takahashi K, Sato E, Osame M (1996) Expression of adhesion molecules and monocyte chemoattractant protein-1 (MCP-1) in the spinal cord lesions in HTLV-I-associated myelopathy. Acta Neuropathol 91(4):343-350
    • (1996) Acta Neuropathol , vol.91 , Issue.4 , pp. 343-350
    • Umehara, F.1    Izumo, S.2    Takeya, M.3    Takahashi, K.4    Sato, E.5    Osame, M.6
  • 30
  • 31
    • 0036232894 scopus 로고    scopus 로고
    • Leucocyte chemotaxis: Examination of mitogen-activated protein kinase and phosphoinositide 3-kinase activation by monocyte chemoattractant proteins-1, -2, -3 and -4
    • 10.1046/j.1365-2249.2002.01764.x
    • Wain JH, Kirby JA, Ali S (2009) Leucocyte chemotaxis: examination of mitogen-activated protein kinase and phosphoinositide 3-kinase activation by monocyte chemoattractant proteins-1, -2, -3 and -4. Clin Exp Immunol 127(3):436-444
    • (2009) Clin Exp Immunol , vol.127 , Issue.3 , pp. 436-444
    • Wain, J.H.1    Kirby, J.A.2    Ali, S.3
  • 32
    • 80054722837 scopus 로고    scopus 로고
    • Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats
    • 21732763 10.1089/neu.2011.1939
    • Wang GH, Jiang ZL, Li YC, Li X, Shi H, Gao YQ, Vosler PS, Chen J (2011) Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats. J Neurotrauma 28(10):2123-2134
    • (2011) J Neurotrauma , vol.28 , Issue.10 , pp. 2123-2134
    • Wang, G.H.1    Jiang, Z.L.2    Li, Y.C.3    Li, X.4    Shi, H.5    Gao, Y.Q.6    Vosler, P.S.7    Chen, J.8
  • 33
    • 12344275932 scopus 로고    scopus 로고
    • Calcium homeostasis following traumatic neuronal injury
    • 16185191 10.2174/1567202043480134
    • Weber JT (2004) Calcium homeostasis following traumatic neuronal injury. Curr Neurovasc Res 1(2):151-171
    • (2004) Curr Neurovasc Res , vol.1 , Issue.2 , pp. 151-171
    • Weber, J.T.1
  • 34
    • 34447527791 scopus 로고    scopus 로고
    • Pathophysiology of traumatic brain injury
    • 17573392 10.1093/bja/aem131 1:CAS:528:DC%2BD2sXovFWktLc%3D
    • Werner C, Engelhard K (2007) Pathophysiology of traumatic brain injury. Br J Anaesth 99(1):4-9
    • (2007) Br J Anaesth , vol.99 , Issue.1 , pp. 4-9
    • Werner, C.1    Engelhard, K.2
  • 35
    • 79952465356 scopus 로고    scopus 로고
    • Neurorestorative treatments for traumatic brain injury
    • 21122475
    • Xiong Y, Mahmood A, Chopp M (2010) Neurorestorative treatments for traumatic brain injury. Discov Med 10(54):434-442
    • (2010) Discov Med , vol.10 , Issue.54 , pp. 434-442
    • Xiong, Y.1    Mahmood, A.2    Chopp, M.3
  • 36
    • 84862487337 scopus 로고    scopus 로고
    • Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain
    • 22721162 10.1186/1742-2094-9-136 1:CAS:528:DC%2BC38XhtVyku7fO
    • Zhang ZJ, Dong YL, Lu Y, Cao S, Zhao ZQ, Gao YJ (2012) Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain. J Neuroinflammation 9:136
    • (2012) J Neuroinflammation , vol.9 , pp. 136
    • Zhang, Z.J.1    Dong, Y.L.2    Lu, Y.3    Cao, S.4    Zhao, Z.Q.5    Gao, Y.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.