DCPIB, a potent volume-regulated anion channel antagonist, Attenuates microglia-mediated inflammatory response and neuronal injury following focal cerebral ischemia

Brain Research

Volumn 1542, Issue , 2014, Pages 176-185

  Han, Qingdong ^a   Liu, Shengwen ^a   Li, Zhengwei ^a   Hu, Feng ^a   Zhang, Qiang ^a   Zhou, Min ^b   Chen, Jingcao ^a   Lei, Ting ^a   Zhang, Huaqiu ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

Cerebral ischemia; Microglia; Neuroinflammation; Volume regulation anion channels (VRACs)

Indexed keywords

4 (2 BUTYL 6,7 DICHLORO 2 CYCLOPENTYL INDAN 1 ON 5 YL)OXOBUTYRIC ACID; BUTYRIC ACID; GLUCOSE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OXYGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN ISCHEMIA; CELL ACTIVATION; CELL MIGRATION; CONTROLLED STUDY; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

ANIMALIA; RATTUS;

4-(2-BUTYL-6, 7-DICHLORO-2-CYCLOPENTYL-INDAN-1-ON-5-YL) OXOBUTYRIC ACID; CEREBRAL ISCHEMIA; DCPIB; ELISA; ENZYME-LINKED IMMUNOSORBENT ASSAY; IF; IL-1Β; IMMUNOFLUORESCENCE; INTERLUKIN-1Β; LIPOPOLYSACCHARIDES; LPS; MAPK; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASE; NEUROINFLAMMATION; OGD; OXYGEN-GLUCOSE DEPRIVATION; REGULATORY VOLUME DECREASE; REVERSIBLE MIDDLE CEREBRAL ARTERY OCCLUSION; RMCAO; RVD; TNF-Α; TUMOR NECROSIS FACTOR Α; VOLUME-REGULATED ANION CHANNEL; VOLUME-REGULATION ANION CHANNELS (VRACS); VRAC;

ANIMALS; ANIMALS, NEWBORN; ANOXIA; ANTIGENS, CD11B; BRAIN INJURIES; CELLS, CULTURED; COCULTURE TECHNIQUES; CYCLOPENTANES; CYTOKINES; DISEASE MODELS, ANIMAL; GLUCOSE; HIPPOCAMPUS; INDANS; INFARCTION, MIDDLE CEREBRAL ARTERY; KI-67 ANTIGEN; MICE; MICROGLIA; NEURONS; RATS; TIME FACTORS;

EID: 84890804684     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.10.026     Document Type: Article

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