메뉴 건너뛰기




Volumn 35, Issue 37, 2016, Pages 4829-4835

Targeting the RB-E2F pathway in breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE RB E2F; UNCLASSIFIED DRUG; AROMATASE INHIBITOR; CDK6 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; PALBOCICLIB; PIPERAZINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE; RB1 PROTEIN, HUMAN; RETINOBLASTOMA BINDING PROTEIN; TRANSCRIPTION FACTOR E2F; UBIQUITIN PROTEIN LIGASE;

EID: 84959218324     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2016.32     Document Type: Review
Times cited : (171)

References (66)
  • 1
    • 84880481139 scopus 로고    scopus 로고
    • CDK4: A key player in the cell cycle, development, cancer
    • Baker SJ, Reddy EP. CDK4: a key player in the cell cycle, development, cancer. Genes Cancer 2012; 3: 658-669.
    • (2012) Genes Cancer , vol.3 , pp. 658-669
    • Baker, S.J.1    Reddy, E.P.2
  • 2
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle CDKs and cancer: A changing paradigm
    • Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 2009; 9: 153-166.
    • (2009) Nat Rev Cancer , vol.9 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 3
    • 70350518233 scopus 로고    scopus 로고
    • Emerging roles of E2Fs in cancer: An exit from cell cycle control
    • Chen HZ, Tsai SY, Leone G. Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer 2009; 9: 785-797.
    • (2009) Nat Rev Cancer , vol.9 , pp. 785-797
    • Chen, H.Z.1    Tsai, S.Y.2    Leone, G.3
  • 4
    • 72449177341 scopus 로고    scopus 로고
    • E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells
    • Chong JL, Wenzel PL, Saenz-Robles MT, Nair V, Ferrey A, Hagan JP et al. E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature 2009; 462: 930-934.
    • (2009) Nature , vol.462 , pp. 930-934
    • Chong, J.L.1    Wenzel, P.L.2    Saenz-Robles, M.T.3    Nair, V.4    Ferrey, A.5    Hagan, J.P.6
  • 6
    • 84881131933 scopus 로고    scopus 로고
    • The DREAM complex: Master coordinator of cell cycle-dependent gene expression
    • Sadasivam S, DeCaprio JA. The DREAM complex: master coordinator of cell cycle-dependent gene expression. Nat Rev Cancer 2013; 13: 585-595.
    • (2013) Nat Rev Cancer , vol.13 , pp. 585-595
    • Sadasivam, S.1    DeCaprio, J.A.2
  • 8
    • 0036653392 scopus 로고    scopus 로고
    • E2F transcriptional repressor complexes are critical downstream targets of p19 (ARF)/p53-induced proliferative arrest
    • Rowland BD, Denissov SG, Douma S, Stunnenberg HG, Bernards R, Peeper DS. E2F transcriptional repressor complexes are critical downstream targets of p19 (ARF)/p53-induced proliferative arrest. Cancer Cell 2002; 2: 55-65.
    • (2002) Cancer Cell , vol.2 , pp. 55-65
    • Rowland, B.D.1    Denissov, S.G.2    Douma, S.3    Stunnenberg, H.G.4    Bernards, R.5    Peeper, D.S.6
  • 10
    • 33646528191 scopus 로고    scopus 로고
    • Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation
    • Berthet C, Klarmann KD, Hilton MB, Suh HC, Keller JR, Kiyokawa H et al. Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev Cell 2006; 10: 563-573.
    • (2006) Dev Cell , vol.10 , pp. 563-573
    • Berthet, C.1    Klarmann, K.D.2    Hilton, M.B.3    Suh, H.C.4    Keller, J.R.5    Kiyokawa, H.6
  • 11
    • 4444247138 scopus 로고    scopus 로고
    • Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
    • Malumbres M, Sotillo R, Santamaria D, Galan J, Cerezo A, Ortega S et al. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 2004; 118: 493-504.
    • (2004) Cell , vol.118 , pp. 493-504
    • Malumbres, M.1    Sotillo, R.2    Santamaria, D.3    Galan, J.4    Cerezo, A.5    Ortega, S.6
  • 12
    • 0041854279 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice
    • Ortega S, Prieto I, Odajima J, Martin A, Dubus P, Sotillo R et al. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat Genet 2003; 35: 25-31.
    • (2003) Nat Genet , vol.35 , pp. 25-31
    • Ortega, S.1    Prieto, I.2    Odajima, J.3    Martin, A.4    Dubus, P.5    Sotillo, R.6
  • 14
  • 15
    • 33745714239 scopus 로고    scopus 로고
    • Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells
    • Yoon SO, Shin S, Mercurio AM. Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells. Cancer Res 2006; 66: 6288-6295.
    • (2006) Cancer Res , vol.66 , pp. 6288-6295
    • Yoon, S.O.1    Shin, S.2    Mercurio, A.M.3
  • 16
    • 84863702188 scopus 로고    scopus 로고
    • The retinoblastoma tumor suppressor and stem cell biology
    • Sage J. The retinoblastoma tumor suppressor and stem cell biology. Genes Dev 2012; 26: 1409-1420.
    • (2012) Genes Dev , vol.26 , pp. 1409-1420
    • Sage, J.1
  • 17
    • 84858016877 scopus 로고    scopus 로고
    • Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer
    • Arima Y, Hayashi H, Sasaki M, Hosonaga M, Goto TM, Chiyoda T et al. Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer. J Biol Chem 2012; 287: 7896-7906.
    • (2012) J Biol Chem , vol.287 , pp. 7896-7906
    • Arima, Y.1    Hayashi, H.2    Sasaki, M.3    Hosonaga, M.4    Goto, T.M.5    Chiyoda, T.6
  • 18
    • 84862907531 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease
    • Johnson JL, Pillai S, Pernazza D, Sebti SM, Lawrence NJ, Chellappan SP. Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease. Cancer Res 2012; 72: 516-526.
    • (2012) Cancer Res , vol.72 , pp. 516-526
    • Johnson, J.L.1    Pillai, S.2    Pernazza, D.3    Sebti, S.M.4    Lawrence, N.J.5    Chellappan, S.P.6
  • 19
    • 84935867705 scopus 로고    scopus 로고
    • Beta-arrestin-1 mediates nicotine-induced metastasis through E2F1 target genes that modulate epithelial-mesenchymal transition
    • Pillai S, Trevino J, Rawal B, Singh S, Kovacs M, Li X et al. Beta-arrestin-1 mediates nicotine-induced metastasis through E2F1 target genes that modulate epithelial-mesenchymal transition. Cancer Res 2015; 75: 1009-1020.
    • (2015) Cancer Res , vol.75 , pp. 1009-1020
    • Pillai, S.1    Trevino, J.2    Rawal, B.3    Singh, S.4    Kovacs, M.5    Li, X.6
  • 20
    • 84905037705 scopus 로고    scopus 로고
    • The retinoblastoma tumor suppressor pathway modulates the invasiveness of ErbB2-positive breast cancer
    • Witkiewicz AK, Cox DW, Rivadeneira D, Ertel AE, Fortina P, Schwartz GF et al. The retinoblastoma tumor suppressor pathway modulates the invasiveness of ErbB2-positive breast cancer. Oncogene 2014; 33: 3980-3991.
    • (2014) Oncogene , vol.33 , pp. 3980-3991
    • Witkiewicz, A.K.1    Cox, D.W.2    Rivadeneira, D.3    Ertel, A.E.4    Fortina, P.5    Schwartz, G.F.6
  • 24
    • 79952221879 scopus 로고    scopus 로고
    • Prediction and genetic demonstration of a role for activator E2Fs in Myc-induced tumors
    • Fujiwara K, Yuwanita I, Hollern DP,rechek ER. Prediction and genetic demonstration of a role for activator E2Fs in Myc-induced tumors. Cancer Res 2011; 71: 1924-1932.
    • (2011) Cancer Res , vol.71 , pp. 1924-1932
    • Fujiwara, K.1    Yuwanita, I.2    Hollern, D.P.3    Rechek, E.R.4
  • 27
    • 70349467638 scopus 로고    scopus 로고
    • Lessons in signaling and tumorigenesis from polyomavirus middle T antigen
    • Table of contents
    • Fluck MM, Schaffhausen BS. Lessons in signaling and tumorigenesis from polyomavirus middle T antigen. Microbiol Mol Biol Rev 2009; 73: 542-563; Table of contents.
    • (2009) Microbiol Mol Biol Rev , vol.73 , pp. 542-563
    • Fluck, M.M.1    Schaffhausen, B.S.2
  • 28
    • 84925582075 scopus 로고    scopus 로고
    • The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer
    • Hollern DP, Honeysett J, Cardiff RD,rechek ER. The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer. Mol Cell Biol 2014; 34: 3229-3243.
    • (2014) Mol Cell Biol , vol.34 , pp. 3229-3243
    • Hollern, D.P.1    Honeysett, J.2    Cardiff, R.D.3    Rechek, E.R.4
  • 29
    • 84964314758 scopus 로고    scopus 로고
    • Selective roles of E2Fs for ErbB2-and Myc-mediated mammary tumorigenesis
    • Wu L, de Bruin A, Wang H, Simmons T, Cleghorn W, Goldenberg LE et al. Selective roles of E2Fs for ErbB2-and Myc-mediated mammary tumorigenesis. Oncogene 2015; 34: 119-128.
    • (2015) Oncogene , vol.34 , pp. 119-128
    • Wu, L.1    De Bruin, A.2    Wang, H.3    Simmons, T.4    Cleghorn, W.5    Goldenberg, L.E.6
  • 30
    • 84890470353 scopus 로고    scopus 로고
    • HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors
    • Andrechek ER. HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors. Oncogene 2015; 34: 217-225.
    • (2015) Oncogene , vol.34 , pp. 217-225
    • Andrechek, E.R.1
  • 32
    • 78951482208 scopus 로고    scopus 로고
    • Deconstructing the molecular portraits of breast cancer
    • Prat A, Perou CM. Deconstructing the molecular portraits of breast cancer. Mol Oncol 2011; 5: 5-23.
    • (2011) Mol Oncol , vol.5 , pp. 5-23
    • Prat, A.1    Perou, C.M.2
  • 33
    • 84945566252 scopus 로고    scopus 로고
    • Epithelial-mesenchymal plasticity: A central regulator of cancer progression
    • Ye X, Weinberg RA. Epithelial-mesenchymal plasticity: a central regulator of cancer progression. Trends Cell Biol 2015; 25: 675-686.
    • (2015) Trends Cell Biol , vol.25 , pp. 675-686
    • Ye, X.1    Weinberg, R.A.2
  • 34
    • 31144459985 scopus 로고    scopus 로고
    • Oncogenic pathway signatures in human cancers as a guide to targeted therapies
    • Bild AH, Yao G, Chang JT, Wang Q, Potti A, Chasse D et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 2006; 439: 353-357.
    • (2006) Nature , vol.439 , pp. 353-357
    • Bild, A.H.1    Yao, G.2    Chang, J.T.3    Wang, Q.4    Potti, A.5    Chasse, D.6
  • 38
    • 0035949684 scopus 로고    scopus 로고
    • Predicting the clinical status of human breast cancer by using gene expression profiles
    • West M, Blanchette C, Dressman H, Huang E, Ishida S, Spang R et al. Predicting the clinical status of human breast cancer by using gene expression profiles. Proc Natl Acad Sci USA 2001; 98: 11462-11467.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11462-11467
    • West, M.1    Blanchette, C.2    Dressman, H.3    Huang, E.4    Ishida, S.5    Spang, R.6
  • 39
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008; 40: 499-507.
    • (2008) Nat Genet , vol.40 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3    Ge, R.4    Bell, G.W.5    Regev, A.6
  • 40
    • 54849425774 scopus 로고    scopus 로고
    • Integrative bioinformatics analysis of transcriptional regulatory programs in breast cancer cells
    • Niida A, Smith AD, Imoto S, Tsutsumi S, Aburatani H, Zhang MQ et al. Integrative bioinformatics analysis of transcriptional regulatory programs in breast cancer cells. BMC Bioinform 2008; 9: 404.
    • (2008) BMC Bioinform , vol.9 , pp. 404
    • Niida, A.1    Smith, A.D.2    Imoto, S.3    Tsutsumi, S.4    Aburatani, H.5    Zhang, M.Q.6
  • 42
    • 78650584621 scopus 로고    scopus 로고
    • Biological functions of the genes in the mammaprint breast cancer profile reflect the hallmarks of cancer
    • Tian S, Roepman P, Van't Veer LJ, Bernards R, de Snoo F, Glas AM. Biological functions of the genes in the mammaprint breast cancer profile reflect the hallmarks of cancer. Biomarker Insights 2010; 5: 129-138.
    • (2010) Biomarker Insights , vol.5 , pp. 129-138
    • Tian, S.1    Roepman, P.2    Van'T Veer, L.J.3    Bernards, R.4    De Snoo, F.5    Glas, A.M.6
  • 43
    • 79960338041 scopus 로고    scopus 로고
    • An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors
    • Huang L, Zhao S, Frasor JM, Dai Y. An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors. PloS One 2011; 6: e22274.
    • (2011) PloS One , vol.6 , pp. e22274
    • Huang, L.1    Zhao, S.2    Frasor, J.M.3    Dai, Y.4
  • 44
    • 41549114264 scopus 로고    scopus 로고
    • A gene expression signature that can predict the recurrence of tamoxifen-treated primary breast cancer
    • Chanrion M, Negre V, Fontaine H, Salvetat N, Bibeau F, Mac Grogan G et al. A gene expression signature that can predict the recurrence of tamoxifen-treated primary breast cancer. Clin Cancer Res 2008; 14: 1744-1752.
    • (2008) Clin Cancer Res , vol.14 , pp. 1744-1752
    • Chanrion, M.1    Negre, V.2    Fontaine, H.3    Salvetat, N.4    Bibeau, F.5    Mac Grogan, G.6
  • 45
    • 33847277446 scopus 로고    scopus 로고
    • The use of gene-expression profiling to better understand the clinical heterogeneity of estrogen receptor positive breast cancers and tamoxifen response
    • Loi S, Piccart M, Sotiriou C. The use of gene-expression profiling to better understand the clinical heterogeneity of estrogen receptor positive breast cancers and tamoxifen response. Crit Rev Oncol Hematol 2007; 61: 187-194.
    • (2007) Crit Rev Oncol Hematol , vol.61 , pp. 187-194
    • Loi, S.1    Piccart, M.2    Sotiriou, C.3
  • 46
    • 44949121510 scopus 로고    scopus 로고
    • Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen
    • Loi S, Haibe-Kains B, Desmedt C, Wirapati P, Lallemand F, Tutt AM et al. Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen. BMC Genomics 2008; 9: 239.
    • (2008) BMC Genomics , vol.9 , pp. 239
    • Loi, S.1    Haibe-Kains, B.2    Desmedt, C.3    Wirapati, P.4    Lallemand, F.5    Tutt, A.M.6
  • 47
    • 84890377527 scopus 로고    scopus 로고
    • Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties
    • Lin X, Li J, Yin G, Zhao Q, Elias D, Lykkesfeldt AE et al. Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties. Breast Cancer Res 2013; 15: R119.
    • (2013) Breast Cancer Res , vol.15 , pp. R119
    • Lin, X.1    Li, J.2    Yin, G.3    Zhao, Q.4    Elias, D.5    Lykkesfeldt, A.E.6
  • 48
    • 84880901715 scopus 로고    scopus 로고
    • REACTIN: Regulatory activity inference of transcription factors underlying human diseases with application to breast cancer
    • Zhu M, Liu CC, Cheng C. REACTIN: regulatory activity inference of transcription factors underlying human diseases with application to breast cancer. BMC Genomics 2013; 14: 504.
    • (2013) BMC Genomics , vol.14 , pp. 504
    • Zhu, M.1    Liu, C.C.2    Cheng, C.3
  • 49
    • 84924276447 scopus 로고    scopus 로고
    • E2F4 regulatory program predicts patient survival prognosis in breast cancer
    • Khaleel SS,rews EH, Ung M, DiRenzo J, Cheng C. E2F4 regulatory program predicts patient survival prognosis in breast cancer. Breast Cancer Res 2014; 16: 486.
    • (2014) Breast Cancer Res , vol.16 , pp. 486
    • Khaleel, S.S.1    Rews, E.H.2    Ung, M.3    DiRenzo, J.4    Cheng, C.5
  • 50
    • 3242657301 scopus 로고    scopus 로고
    • Expression of E2F-4 in invasive breast carcinomas is associated with poor prognosis
    • Rakha EA, Pinder SE, Paish EC, Robertson JF, Ellis IO. Expression of E2F-4 in invasive breast carcinomas is associated with poor prognosis. J Pathol 2004; 203: 754-761.
    • (2004) J Pathol , vol.203 , pp. 754-761
    • Rakha, E.A.1    Pinder, S.E.2    Paish, E.C.3    Robertson, J.F.4    Ellis, I.O.5
  • 51
    • 60949083872 scopus 로고    scopus 로고
    • Gene expression meta-analysis identifies metastatic pathways and transcription factors in breast cancer
    • Thomassen M, Tan Q, Kruse TA. Gene expression meta-analysis identifies metastatic pathways and transcription factors in breast cancer. BMC Cancer 2008; 8: 394.
    • (2008) BMC Cancer , vol.8 , pp. 394
    • Thomassen, M.1    Tan, Q.2    Kruse, T.A.3
  • 52
    • 78649904427 scopus 로고    scopus 로고
    • Small molecule regulators of Rb-E2F pathway as modulators of transcription
    • Singh S, Johnson J, Chellappan S. Small molecule regulators of Rb-E2F pathway as modulators of transcription. Biochim Biophys Acta 2010; 1799: 788-794.
    • (2010) Biochim Biophys Acta , vol.1799 , pp. 788-794
    • Singh, S.1    Johnson, J.2    Chellappan, S.3
  • 53
    • 84878252263 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor therapy for hematologic malignancies
    • Bose P, Simmons GL, Grant S. Cyclin-dependent kinase inhibitor therapy for hematologic malignancies. Exp Opin Investig Drugs 2013; 22: 723-738.
    • (2013) Exp Opin Investig Drugs , vol.22 , pp. 723-738
    • Bose, P.1    Simmons, G.L.2    Grant, S.3
  • 54
    • 33749503799 scopus 로고    scopus 로고
    • Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells
    • Cai D, Latham Jr VM, Zhang X, Shapiro GI. Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells. Cancer Res 2006; 66: 9270-9280.
    • (2006) Cancer Res , vol.66 , pp. 9270-9280
    • Cai, D.1    Latham, Jr.V.M.2    Zhang, X.3    Shapiro, G.I.4
  • 57
    • 84922369296 scopus 로고    scopus 로고
    • The cyclindependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): A randomised phase 2 study
    • Finn RS, Crown JP, Lang I, Boer K, Bondarenko IM, Kulyk SO et al. The cyclindependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study. Lancet Oncol 2015; 16: 25-35.
    • (2015) Lancet Oncol , vol.16 , pp. 25-35
    • Finn, R.S.1    Crown, J.P.2    Lang, I.3    Boer, K.4    Bondarenko, I.M.5    Kulyk, S.O.6
  • 58
    • 9444228344 scopus 로고    scopus 로고
    • Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts
    • Fry DW, Harvey PJ, Keller PR, Elliott WL, Meade M, Trachet E et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther 2004; 3: 1427-1438.
    • (2004) Mol Cancer Ther , vol.3 , pp. 1427-1438
    • Fry, D.W.1    Harvey, P.J.2    Keller, P.R.3    Elliott, W.L.4    Meade, M.5    Trachet, E.6
  • 60
    • 76049104235 scopus 로고    scopus 로고
    • PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro
    • Finn RS, Dering J, Conklin D, Kalous O, Cohen DJ, Desai AJ et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res 2009; 11: R77
    • (2009) Breast Cancer Res , vol.11 , pp. R77
    • Finn, R.S.1    Dering, J.2    Conklin, D.3    Kalous, O.4    Cohen, D.J.5    Desai, A.J.6
  • 61
    • 0033613085 scopus 로고    scopus 로고
    • Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element
    • Sabbah M, Courilleau D, Mester J, Redeuilh G. Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element. Proc Natl Acad Sci USA 1999; 96: 11217-11222.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11217-11222
    • Sabbah, M.1    Courilleau, D.2    Mester, J.3    Redeuilh, G.4
  • 62
    • 84903843882 scopus 로고    scopus 로고
    • Molecular pathways: CDK4 inhibitors for cancer therapy
    • Dickson MA. Molecular pathways: CDK4 inhibitors for cancer therapy. Clin Cancer Res 2014; 20: 3379-3383.
    • (2014) Clin Cancer Res , vol.20 , pp. 3379-3383
    • Dickson, M.A.1
  • 63
    • 84904259645 scopus 로고    scopus 로고
    • CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors
    • Vora SR, Juric D, Kim N, Mino-Kenudson M, Huynh T, Costa C et al. CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors. Cancer Cell 2014; 26: 136-149.
    • (2014) Cancer Cell , vol.26 , pp. 136-149
    • Vora, S.R.1    Juric, D.2    Kim, N.3    Mino-Kenudson, M.4    Huynh, T.5    Costa, C.6
  • 64
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005; 434: 917-921.
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3    Tutt, A.N.4    Johnson, D.A.5    Richardson, T.B.6
  • 65
    • 84863230465 scopus 로고    scopus 로고
    • Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
    • Prahallad A, Sun C, Huang S, Di Nicolantonio F, Salazar R, Zecchin D et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 2012; 483: 100-103.
    • (2012) Nature , vol.483 , pp. 100-103
    • Prahallad, A.1    Sun, C.2    Huang, S.3    Di Nicolantonio, F.4    Salazar, R.5    Zecchin, D.6
  • 66
    • 79955166265 scopus 로고    scopus 로고
    • GISTIC2 0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
    • Mermel CH, Schumacher SE, Hill B, Meyerson ML, Beroukhim R, Getz G. GISTIC2. 0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol 2011; 12: R41.
    • (2011) Genome Biol , vol.12 , pp. R41
    • Mermel, C.H.1    Schumacher, S.E.2    Hill, B.3    Meyerson, M.L.4    Beroukhim, R.5    Getz, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.