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Volumn 6, Issue 35, 2015, Pages 38210-38224

Increased metastasis with loss of E2F2 in Myc-driven tumors

Author keywords

E2F transcription factors; Gene expression; Metastasis; MMTV Myc; PTPRD

Indexed keywords

MYC PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSCRIPTION FACTOR E2F2; E2F2 PROTEIN, HUMAN; E2F2 PROTEIN, MOUSE; PTPRD PROTEIN, HUMAN; PTPRD PROTEIN, MOUSE; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE;

EID: 84947798673     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5690     Document Type: Article
Times cited : (27)

References (65)
  • 2
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A. 2001; 98:10869-74.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10869-10874
    • Sorlie, T.1    Perou, C.M.2    Tibshirani, R.3    Aas, T.4    Geisler, S.5    Johnsen, H.6
  • 5
    • 34548863946 scopus 로고    scopus 로고
    • Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    • Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z, et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol. 2007; 8:R76.
    • (2007) Genome Biol , vol.8
    • Herschkowitz, J.I.1    Simin, K.2    Weigman, V.J.3    Mikaelian, I.4    Usary, J.5    Hu, Z.6
  • 6
    • 84887398348 scopus 로고    scopus 로고
    • Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts
    • Pfefferle AD, Herschkowitz JI, Usary J, Harrell JC, Spike BT, Adams JR, et al. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol. 2013; 14:R125.
    • (2013) Genome Biol , vol.14
    • Pfefferle, A.D.1    Herschkowitz, J.I.2    Usary, J.3    Harrell, J.C.4    Spike, B.T.5    Adams, J.R.6
  • 7
    • 84901982281 scopus 로고    scopus 로고
    • A genomic analysis of mouse models of breast cancer reveals molecular features of mouse models and relationships to human breast cancer
    • Hollern DP, Andrechek E. A genomic analysis of mouse models of breast cancer reveals molecular features of mouse models and relationships to human breast cancer. Breast Cancer Res. 2014; 16:R59.
    • (2014) Breast Cancer Res , vol.16
    • Hollern, D.P.1    Andrechek, E.2
  • 11
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: from dissemination to organ-specific colonization
    • Nguyen DX, Bos PD, Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer. 2009; 9:274-84.
    • (2009) Nat Rev Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massague, J.3
  • 12
    • 0026587657 scopus 로고
    • Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease
    • Guy CT, Cardiff RD, Muller WJ. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol. 1992; 12:954-61.
    • (1992) Mol Cell Biol , vol.12 , pp. 954-961
    • Guy, C.T.1    Cardiff, R.D.2    Muller, W.J.3
  • 13
    • 84925582075 scopus 로고    scopus 로고
    • The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer
    • Hollern DP, Honeysett J, Cardiff RD, Andrechek ER. The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer. Mol Cell Biol. 2014; 34:3229-43.
    • (2014) Mol Cell Biol , vol.34 , pp. 3229-3243
    • Hollern, D.P.1    Honeysett, J.2    Cardiff, R.D.3    Andrechek, E.R.4
  • 14
    • 0021720781 scopus 로고
    • Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/Myc fusion genes
    • Stewart TA, Pattengale PK, Leder P. Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/Myc fusion genes. Cell. 1984; 38:627-37.
    • (1984) Cell , vol.38 , pp. 627-637
    • Stewart, T.A.1    Pattengale, P.K.2    Leder, P.3
  • 15
    • 0031056820 scopus 로고    scopus 로고
    • Differential regulation of cell cycle characteristics and apoptosis in MMTV-Myc and MMTV-ras mouse mammary tumors
    • Hundley JE, Koester SK, Troyer DA, Hilsenbeck SG, Barrington RE, Windle JJ. Differential regulation of cell cycle characteristics and apoptosis in MMTV-Myc and MMTV-ras mouse mammary tumors. Cancer Res. 1997; 57:600-3.
    • (1997) Cancer Res , vol.57 , pp. 600-603
    • Hundley, J.E.1    Koester, S.K.2    Troyer, D.A.3    Hilsenbeck, S.G.4    Barrington, R.E.5    Windle, J.J.6
  • 17
    • 51649085736 scopus 로고    scopus 로고
    • Identification of VEGF-regulated genes associated with increased lung metastatic potential: functional involvement of tenascin-C in tumor growth and lung metastasis
    • Calvo A, Catena R, Noble MS, Carbott D, Gil-Bazo I, Gonzalez-Moreno O, et al. Identification of VEGF-regulated genes associated with increased lung metastatic potential: functional involvement of tenascin-C in tumor growth and lung metastasis. Oncogene. 2008; 27:5373-84.
    • (2008) Oncogene , vol.27 , pp. 5373-5384
    • Calvo, A.1    Catena, R.2    Noble, M.S.3    Carbott, D.4    Gil-Bazo, I.5    Gonzalez-Moreno, O.6
  • 19
    • 0035063183 scopus 로고    scopus 로고
    • The Rb/E2F pathway and cancer
    • Nevins JR. The Rb/E2F pathway and cancer. Hum Mol Genet. 2001; 10:699-703.
    • (2001) Hum Mol Genet , vol.10 , pp. 699-703
    • Nevins, J.R.1
  • 21
    • 70350518233 scopus 로고    scopus 로고
    • Emerging roles of E2Fs in cancer: an exit from cell cycle control
    • Chen HZ, Tsai SY, Leone G. Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer. 2009; 9:785-97.
    • (2009) Nat Rev Cancer , vol.9 , pp. 785-797
    • Chen, H.Z.1    Tsai, S.Y.2    Leone, G.3
  • 22
    • 84890330004 scopus 로고    scopus 로고
    • E2F1 promotes angiogenesis through the VEGF-C/VEGFR-3 axis in a feedback loop for cooperative induction of PDGF-B
    • Engelmann D, Mayoli-Nussle D, Mayrhofer C, Furst K, Alla V, Stoll A, et al. E2F1 promotes angiogenesis through the VEGF-C/VEGFR-3 axis in a feedback loop for cooperative induction of PDGF-B. J Mol Cell Biol. 2013; 5:391-403.
    • (2013) J Mol Cell Biol , vol.5 , pp. 391-403
    • Engelmann, D.1    Mayoli-Nussle, D.2    Mayrhofer, C.3    Furst, K.4    Alla, V.5    Stoll, A.6
  • 24
    • 0035166496 scopus 로고    scopus 로고
    • Expression of E2F-1 and E2F-4 is reduced in primary and metastatic breast carcinomas
    • Ho GH, Calvano JE, Bisogna M, Van Zee KJ. Expression of E2F-1 and E2F-4 is reduced in primary and metastatic breast carcinomas. Breast Cancer Res Treat. 2001; 69:115-22.
    • (2001) Breast Cancer Res Treat , vol.69 , pp. 115-122
    • Ho, G.H.1    Calvano, J.E.2    Bisogna, M.3    Van Zee, K.J.4
  • 25
    • 0345003786 scopus 로고    scopus 로고
    • Deletion mapping of chromosomal region 1p32-pter in primary breast cancer
    • Bieche I, Khodja A, Lidereau R. Deletion mapping of chromosomal region 1p32-pter in primary breast cancer. Genes Chromosomes Cancer. 1999; 24:255-63.
    • (1999) Genes Chromosomes Cancer , vol.24 , pp. 255-263
    • Bieche, I.1    Khodja, A.2    Lidereau, R.3
  • 26
    • 70349496099 scopus 로고    scopus 로고
    • Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potential
    • Andrechek ER, Cardiff RD, Chang JT, Gatza ML, Acharya CR, Potti A, et al. Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potential. Proc Natl Acad Sci U S A. 2009; 106:16387-92.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 16387-16392
    • Andrechek, E.R.1    Cardiff, R.D.2    Chang, J.T.3    Gatza, M.L.4    Acharya, C.R.5    Potti, A.6
  • 27
    • 84890470353 scopus 로고    scopus 로고
    • HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors
    • Andrechek ER. HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors. Oncogene. 2015; 34:217-25.
    • (2015) Oncogene , vol.34 , pp. 217-225
    • Andrechek, E.R.1
  • 28
    • 79952221879 scopus 로고    scopus 로고
    • Prediction and Genetic Demonstration of a Role for Activator E2Fs in Myc-Induced Tumors
    • Fujiwara K, Yuwanita I, Hollern DP, Andrechek ER. Prediction and Genetic Demonstration of a Role for Activator E2Fs in Myc-Induced Tumors. Cancer Res. 2011; 71:1924-32.
    • (2011) Cancer Res , vol.71 , pp. 1924-1932
    • Fujiwara, K.1    Yuwanita, I.2    Hollern, D.P.3    Andrechek, E.R.4
  • 29
    • 84964314758 scopus 로고    scopus 로고
    • Selective roles of E2Fs for ErbB2-and Myc-mediated mammary tumorigenesis
    • Wu L, de Bruin A, Wang H, Simmons T, Cleghorn W, Goldenberg LE, et al. Selective roles of E2Fs for ErbB2-and Myc-mediated mammary tumorigenesis. Oncogene. 2015; 34:119-28.
    • (2015) Oncogene , vol.34 , pp. 119-128
    • Wu, L.1    de Bruin, A.2    Wang, H.3    Simmons, T.4    Cleghorn, W.5    Goldenberg, L.E.6
  • 30
    • 84862907531 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease
    • Johnson JL, Pillai S, Pernazza D, Sebti SM, Lawrence NJ, Chellappan SP. Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease. Cancer Res. 2012; 72:516-26.
    • (2012) Cancer Res , vol.72 , pp. 516-526
    • Johnson, J.L.1    Pillai, S.2    Pernazza, D.3    Sebti, S.M.4    Lawrence, N.J.5    Chellappan, S.P.6
  • 31
    • 84907942931 scopus 로고    scopus 로고
    • Association of RHAMM with E2F1 promotes tumour cell extravasation by transcriptional up-regulation of fibronectin
    • Meier C, Spitschak A, Abshagen K, Gupta S, Mor JM, Wolkenhauer O, et al. Association of RHAMM with E2F1 promotes tumour cell extravasation by transcriptional up-regulation of fibronectin. J Pathol. 2014; 234:351-64.
    • (2014) J Pathol , vol.234 , pp. 351-364
    • Meier, C.1    Spitschak, A.2    Abshagen, K.3    Gupta, S.4    Mor, J.M.5    Wolkenhauer, O.6
  • 32
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Oct 4
    • Network TCGA. Comprehensive molecular portraits of human breast tumours. Nature. 2012; Oct 4;490:61-70.
    • (2012) Nature , vol.490 , pp. 61-70
  • 33
    • 67249088143 scopus 로고    scopus 로고
    • The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers
    • Veeriah S, Brennan C, Meng S, Singh B, Fagin JA, Solit DB, et al. The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proc Natl Acad Sci U S A. 2009; 106:9435-40.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9435-9440
    • Veeriah, S.1    Brennan, C.2    Meng, S.3    Singh, B.4    Fagin, J.A.5    Solit, D.B.6
  • 34
    • 84901854064 scopus 로고    scopus 로고
    • Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis
    • Ortiz B, Fabius AW, Wu WH, Pedraza A, Brennan CW, Schultz N, et al. Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis. Proc Natl Acad Sci U S A. 2014; 111:8149-54.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 8149-8154
    • Ortiz, B.1    Fabius, A.W.2    Wu, W.H.3    Pedraza, A.4    Brennan, C.W.5    Schultz, N.6
  • 35
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009; 119:1420-8.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 37
    • 84857781883 scopus 로고    scopus 로고
    • MYC gene amplification is often acquired in lethal distant breast cancer metastases of unamplified primary tumors
    • Singhi AD, Cimino-Mathews A, Jenkins RB, Lan F, Fink SR, Nassar H, et al. MYC gene amplification is often acquired in lethal distant breast cancer metastases of unamplified primary tumors. Mod Pathol. 2012; 25:378-87.
    • (2012) Mod Pathol , vol.25 , pp. 378-387
    • Singhi, A.D.1    Cimino-Mathews, A.2    Jenkins, R.B.3    Lan, F.4    Fink, S.R.5    Nassar, H.6
  • 38
    • 33846283395 scopus 로고    scopus 로고
    • Compensation and specificity of function within the E2F family
    • Kong LJ, Chang JT, Bild AH, Nevins JR. Compensation and specificity of function within the E2F family. Oncogene. 2007; 26:321-7.
    • (2007) Oncogene , vol.26 , pp. 321-327
    • Kong, L.J.1    Chang, J.T.2    Bild, A.H.3    Nevins, J.R.4
  • 43
    • 44449094545 scopus 로고    scopus 로고
    • Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis
    • Chan TA, Glockner S, Yi JM, Chen W, Van Neste L, Cope L, et al. Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis. PLoS medicine. 2008; 5:e114.
    • (2008) PLoS medicine , vol.5
    • Chan, T.A.1    Glockner, S.2    Yi, J.M.3    Chen, W.4    Van Neste, L.5    Cope, L.6
  • 44
    • 0033521595 scopus 로고    scopus 로고
    • STAT3 is required for the gp130-mediated full activation of the c-Myc gene
    • Kiuchi N, Nakajima K, Ichiba M, Fukada T, Narimatsu M, Mizuno K, et al. STAT3 is required for the gp130-mediated full activation of the c-Myc gene. J Exp Med. 1999; 189:63-73.
    • (1999) J Exp Med , vol.189 , pp. 63-73
    • Kiuchi, N.1    Nakajima, K.2    Ichiba, M.3    Fukada, T.4    Narimatsu, M.5    Mizuno, K.6
  • 45
    • 16844368861 scopus 로고    scopus 로고
    • Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice
    • Ling X, Arlinghaus RB. Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice. Cancer Res. 2005; 65:2532-6.
    • (2005) Cancer Res , vol.65 , pp. 2532-2536
    • Ling, X.1    Arlinghaus, R.B.2
  • 46
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: novel molecular targets for cancer drug discovery
    • Turkson J, Jove R. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene. 2000; 19:6613-26.
    • (2000) Oncogene , vol.19 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 48
    • 0037023755 scopus 로고    scopus 로고
    • Signaling networks that link cell proliferation and cell fate
    • Sears RC, Nevins JR. Signaling networks that link cell proliferation and cell fate. J Biol Chem. 2002; 277:11617-20.
    • (2002) J Biol Chem , vol.277 , pp. 11617-11620
    • Sears, R.C.1    Nevins, J.R.2
  • 49
    • 0030995824 scopus 로고    scopus 로고
    • Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F
    • Leone G, DeGregori J, Sears R, Jakoi L, Nevins JR. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature. 1997; 387:422-6.
    • (1997) Nature , vol.387 , pp. 422-426
    • Leone, G.1    DeGregori, J.2    Sears, R.3    Jakoi, L.4    Nevins, J.R.5
  • 50
    • 84861592850 scopus 로고    scopus 로고
    • MYC suppresses cancer metastasis by direct transcriptional silencing of alphav and beta3 integrin subunits
    • Liu H, Radisky DC, Yang D, Xu R, Radisky ES, Bissell MJ, et al. MYC suppresses cancer metastasis by direct transcriptional silencing of alphav and beta3 integrin subunits. Nat Cell Biol. 2012; 14:567-74.
    • (2012) Nat Cell Biol , vol.14 , pp. 567-574
    • Liu, H.1    Radisky, D.C.2    Yang, D.3    Xu, R.4    Radisky, E.S.5    Bissell, M.J.6
  • 51
    • 18244409134 scopus 로고    scopus 로고
    • Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity
    • Murga M, Fernandez-Capetillo O, Field SJ, Moreno B, Borlado LR, Fujiwara Y, et al. Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. Immunity. 2001; 15:959-70.
    • (2001) Immunity , vol.15 , pp. 959-970
    • Murga, M.1    Fernandez-Capetillo, O.2    Field, S.J.3    Moreno, B.4    Borlado, L.R.5    Fujiwara, Y.6
  • 53
    • 62549125109 scopus 로고    scopus 로고
    • High-Dimensional Sparse Factor Modeling: Applications in Gene Expression Genomics
    • Carvalho CM, Chang J, Lucas JE, Nevins JR, Wang Q, West M. High-Dimensional Sparse Factor Modeling: Applications in Gene Expression Genomics. J Am Stat Assoc. 2008; 103:1438-56.
    • (2008) J Am Stat Assoc , vol.103 , pp. 1438-1456
    • Carvalho, C.M.1    Chang, J.2    Lucas, J.E.3    Nevins, J.R.4    Wang, Q.5    West, M.6
  • 55
    • 31144459985 scopus 로고    scopus 로고
    • Oncogenic pathway signatures in human cancers as a guide to targeted therapies
    • Bild AH, Yao G, Chang JT, Wang Q, Potti A, Chasse D, et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature. 2006; 439:353-7.
    • (2006) Nature , vol.439 , pp. 353-357
    • Bild, A.H.1    Yao, G.2    Chang, J.T.3    Wang, Q.4    Potti, A.5    Chasse, D.6
  • 57
    • 79151483638 scopus 로고    scopus 로고
    • An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
    • Gyorffy B, Lanczky A, Eklund AC, Denkert C, Budczies J, Li Q, et al. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res Treat. 2010; 123:725-31.
    • (2010) Breast Cancer Res Treat , vol.123 , pp. 725-731
    • Gyorffy, B.1    Lanczky, A.2    Eklund, A.C.3    Denkert, C.4    Budczies, J.5    Li, Q.6
  • 58
    • 84893181929 scopus 로고    scopus 로고
    • Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer
    • Gyorffy B, Surowiak P, Budczies J, Lanczky A. Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer. PLoS One. 2013; 8:e82241.
    • (2013) PLoS One , vol.8
    • Gyorffy, B.1    Surowiak, P.2    Budczies, J.3    Lanczky, A.4
  • 59
    • 77951940923 scopus 로고    scopus 로고
    • Gene selection in microarray survival studies under possibly non-proportional hazards
    • Dunkler D, Schemper M, Heinze G. Gene selection in microarray survival studies under possibly non-proportional hazards. Bioinformatics. 2010; 26:784-90.
    • (2010) Bioinformatics , vol.26 , pp. 784-790
    • Dunkler, D.1    Schemper, M.2    Heinze, G.3
  • 60
    • 33751384465 scopus 로고    scopus 로고
    • GATHER: a systems approach to interpreting genomic signatures
    • Chang JT, Nevins JR. GATHER: a systems approach to interpreting genomic signatures. Bioinformatics. 2006; 22:2926-33.
    • (2006) Bioinformatics , vol.22 , pp. 2926-2933
    • Chang, J.T.1    Nevins, J.R.2
  • 61
    • 33846067980 scopus 로고    scopus 로고
    • SwissRegulon: a database of genome-wide annotations of regulatory sites
    • Pachkov M, Erb I, Molina N, van Nimwegen E. SwissRegulon: a database of genome-wide annotations of regulatory sites. Nucleic Acids Res. 2007; 35:D127-31.
    • (2007) Nucleic Acids Res , vol.35 , pp. D127-D131
    • Pachkov, M.1    Erb, I.2    Molina, N.3    van Nimwegen, E.4
  • 63
    • 84875740314 scopus 로고    scopus 로고
    • Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
    • Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Science signaling. 2013; 6:pl1.
    • (2013) Science signaling , vol.6 , pp. pl1
    • Gao, J.1    Aksoy, B.A.2    Dogrusoz, U.3    Dresdner, G.4    Gross, B.5    Sumer, S.O.6
  • 64
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
    • Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer discovery. 2012; 2:401-4.
    • (2012) Cancer discovery , vol.2 , pp. 401-404
    • Cerami, E.1    Gao, J.2    Dogrusoz, U.3    Gross, B.E.4    Sumer, S.O.5    Aksoy, B.A.6
  • 65
    • 77955469972 scopus 로고    scopus 로고
    • MLK3 is critical for breast cancer cell migration and promotes a malignant phenotype in mammary epithelial cells
    • Chen J, Miller EM, Gallo KA. MLK3 is critical for breast cancer cell migration and promotes a malignant phenotype in mammary epithelial cells. Oncogene. 2010; 29:4399-411.
    • (2010) Oncogene , vol.29 , pp. 4399-4411
    • Chen, J.1    Miller, E.M.2    Gallo, K.A.3


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