-
1
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
-
Terry, R.D. et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 30, 572-580 (1991).
-
(1991)
Ann. Neurol.
, vol.30
, pp. 572-580
-
-
Terry, R.D.1
-
2
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
Selkoe, D.J. Alzheimer's disease is a synaptic failure. Science 298, 789-791 (2002).
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
3
-
-
78049477126
-
Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease
-
Jack, C.R. Jr. et al. Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease. Brain 133, 3336-3348 (2010).
-
(2010)
Brain
, vol.133
, pp. 3336-3348
-
-
Jack, C.R.1
-
4
-
-
80052501210
-
Resolving controversies on the path to Alzheimer's therapeutics
-
Selkoe, D.J. Resolving controversies on the path to Alzheimer's therapeutics. Nat. Med. 17, 1060-1065 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 1060-1065
-
-
Selkoe, D.J.1
-
5
-
-
67249087641
-
Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake
-
Li, S. et al. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron 62, 788-801 (2009).
-
(2009)
Neuron
, vol.62
, pp. 788-801
-
-
Li, S.1
-
6
-
-
33845411954
-
AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss
-
Hsieh, H. et al. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron 52, 831-843 (2006).
-
(2006)
Neuron
, vol.52
, pp. 831-843
-
-
Hsieh, H.1
-
7
-
-
33947314641
-
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
-
Shankar, G.M. et al. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J. Neurosci. 27, 2866-2875 (2007).
-
(2007)
J. Neurosci.
, vol.27
, pp. 2866-2875
-
-
Shankar, G.M.1
-
8
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar, G.M. et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat. Med. 14, 837-842 (2008).
-
(2008)
Nat. Med.
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
-
9
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh, D.M. et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539 (2002).
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
-
10
-
-
0030942145
-
Beta-Amyloid produces a delayed NMDA receptor-dependent reduction in synaptic transmission in rat hippocampus
-
Cullen, W.K., Wu, J., Anwyl, R. & Rowan, M.J. beta-Amyloid produces a delayed NMDA receptor-dependent reduction in synaptic transmission in rat hippocampus. Neuroreport 8, 87-92 (1996).
-
(1996)
Neuroreport
, vol.8
, pp. 87-92
-
-
Cullen, W.K.1
Wu, J.2
Anwyl, R.3
Rowan, M.J.4
-
11
-
-
11544279355
-
Diffusible, nonfbrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
-
Lambert, M.P. et al. Diffusible, nonfbrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. USA 95, 6448-6453 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
-
12
-
-
0037762556
-
Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons
-
Man, H.Y. et al. Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons. Neuron 38, 611-624 (2003).
-
(2003)
Neuron
, vol.38
, pp. 611-624
-
-
Man, H.Y.1
-
13
-
-
33847113902
-
LTP inhibits LTD in the hippocampus via regulation of GSK3beta
-
Peineau, S. et al. LTP inhibits LTD in the hippocampus via regulation of GSK3beta. Neuron 53, 703-717 (2007).
-
(2007)
Neuron
, vol.53
, pp. 703-717
-
-
Peineau, S.1
-
14
-
-
73949117548
-
PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane
-
Arendt, K.L. et al. PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane. Nat. Neurosci. 13, 36-44 (2010).
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 36-44
-
-
Arendt, K.L.1
-
15
-
-
77955850746
-
PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression
-
Jurado, S. et al. PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression. EMBO J. 29, 2827-2840 (2010).
-
(2010)
EMBO J.
, vol.29
, pp. 2827-2840
-
-
Jurado, S.1
-
16
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
Holcomb, L. et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med. 4, 97-100 (1998).
-
(1998)
Nat. Med.
, vol.4
, pp. 97-100
-
-
Holcomb, L.1
-
17
-
-
33947496373
-
A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN)
-
Rosivatz, E. et al. A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem. Biol. 1, 780-790 (2006).
-
(2006)
ACS Chem. Biol.
, vol.1
, pp. 780-790
-
-
Rosivatz, E.1
-
18
-
-
77956698237
-
Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research
-
Jan, A., Hartley, D.M. & Lashuel, H.A. Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research. Nat. Protoc. 5, 1186-1209 (2010).
-
(2010)
Nat. Protoc.
, vol.5
, pp. 1186-1209
-
-
Jan, A.1
Hartley, D.M.2
Lashuel, H.A.3
-
19
-
-
44549087765
-
Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior
-
Selkoe, D.J. Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav. Brain Res. 192, 106-113 (2008).
-
(2008)
Behav. Brain Res.
, vol.192
, pp. 106-113
-
-
Selkoe, D.J.1
-
20
-
-
34547165139
-
Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP
-
Welsby, P.J., Rowan, M.J. & Anwyl, R. Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP. Neuropharmacology 53, 188-195 (2007).
-
(2007)
Neuropharmacology
, vol.53
, pp. 188-195
-
-
Welsby, P.J.1
Rowan, M.J.2
Anwyl, R.3
-
21
-
-
2942626182
-
Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo
-
Klyubin, I. et al. Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo. Eur. J. Neurosci. 19, 2839-2846 (2004).
-
(2004)
Eur. J. Neurosci.
, vol.19
, pp. 2839-2846
-
-
Klyubin, I.1
-
22
-
-
1842610852
-
Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5
-
Wang, Q., Walsh, D.M., Rowan, M.J., Selkoe, D.J. & Anwyl, R. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. J. Neurosci. 24, 3370-3378 (2004).
-
(2004)
J. Neurosci.
, vol.24
, pp. 3370-3378
-
-
Wang, Q.1
Walsh, D.M.2
Rowan, M.J.3
Selkoe, D.J.4
Anwyl, R.5
-
23
-
-
0036354603
-
Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus
-
Chen, Q.S., Wei, W.Z., Shimahara, T. & Xie, C.W. Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus. Neurobiol. Learn. Mem. 77, 354-371 (2002).
-
(2002)
Neurobiol. Learn. Mem.
, vol.77
, pp. 354-371
-
-
Chen, Q.S.1
Wei, W.Z.2
Shimahara, T.3
Xie, C.W.4
-
24
-
-
84858037735
-
Pten positively regulates brown adipose function, energy expenditure, and longevity
-
Ortega-Molina, A. et al. Pten positively regulates brown adipose function, energy expenditure, and longevity. Cell Metab. 15, 382-394 (2012).
-
(2012)
Cell Metab.
, vol.15
, pp. 382-394
-
-
Ortega-Molina, A.1
-
25
-
-
32344434991
-
Analysis of Rab protein function in neurotransmitter receptor traffcking at hippocampal synapses
-
Gerges, N.Z., Brown, T.C., Correia, S.S. & Esteban, J.A. Analysis of Rab protein function in neurotransmitter receptor traffcking at hippocampal synapses. Methods Enzymol. 403, 153-166 (2005).
-
(2005)
Methods Enzymol.
, vol.403
, pp. 153-166
-
-
Gerges, N.Z.1
Brown, T.C.2
Correia, S.S.3
Esteban, J.A.4
-
26
-
-
0344672942
-
APP processing and synaptic function
-
Kamenetz, F. et al. APP processing and synaptic function. Neuron 37, 925-937 (2003).
-
(2003)
Neuron
, vol.37
, pp. 925-937
-
-
Kamenetz, F.1
-
27
-
-
0028924248
-
Generation of amyloid beta protein from its precursor is sequence specifc
-
Citron, M., Teplow, D.B. & Selkoe, D.J. Generation of amyloid beta protein from its precursor is sequence specifc. Neuron 14, 661-670 (1995).
-
(1995)
Neuron
, vol.14
, pp. 661-670
-
-
Citron, M.1
Teplow, D.B.2
Selkoe, D.J.3
-
28
-
-
33645520634
-
Early-onset behavioral and synaptic defcits in a mouse model of Alzheimer's disease
-
Jacobsen, J.S. et al. Early-onset behavioral and synaptic defcits in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 103, 5161-5166 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 5161-5166
-
-
Jacobsen, J.S.1
-
29
-
-
59749104724
-
Widespread changes in dendritic spines in a model of Alzheimer's disease
-
Knafo, S. et al. Widespread changes in dendritic spines in a model of Alzheimer's disease. Cereb. Cortex 19, 586-592 (2009).
-
(2009)
Cereb. Cortex
, vol.19
, pp. 586-592
-
-
Knafo, S.1
-
30
-
-
75549092259
-
Amyloid beta from axons and dendrites reduces local spine number and plasticity
-
Wei, W. et al. Amyloid beta from axons and dendrites reduces local spine number and plasticity. Nat. Neurosci. 13, 190-196 (2010).
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 190-196
-
-
Wei, W.1
-
31
-
-
23444448170
-
Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
-
Spires, T.L. et al. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J. Neurosci. 25, 7278-7287 (2005).
-
(2005)
J. Neurosci.
, vol.25
, pp. 7278-7287
-
-
Spires, T.L.1
-
32
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate
-
Maehama, T. & Dixon, J.E. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate. J. Biol. Chem. 273, 13375-13378 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
33
-
-
33646346138
-
Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins
-
He, J. et al. Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. J. Biol. Chem. 281, 2820-2827 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 2820-2827
-
-
He, J.1
-
34
-
-
0034647496
-
Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase
-
Wu, Y. et al. Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. J. Biol. Chem. 275, 21477-21485 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 21477-21485
-
-
Wu, Y.1
-
35
-
-
0034636038
-
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
-
Wu, X. et al. Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. Proc. Natl. Acad. Sci. USA 97, 4233-4238 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 4233-4238
-
-
Wu, X.1
-
36
-
-
17744386543
-
Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling
-
von Stein, W., Ramrath, A., Grimm, A., Müller-Borg, M. & Wodarz, A. Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling. Development 132, 1675-1686 (2005).
-
(2005)
Development
, vol.132
, pp. 1675-1686
-
-
Von Stein, W.1
Ramrath, A.2
Grimm, A.3
Müller-Borg, M.4
Wodarz, A.5
-
37
-
-
78650970378
-
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model
-
Cissé, M. et al. Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Nature 469, 47-52 (2011).
-
(2011)
Nature
, vol.469
, pp. 47-52
-
-
Cissé, M.1
-
38
-
-
79955484857
-
A(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β
-
Jo, J. et al. A(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β. Nat. Neurosci. 14, 545-547 (2011).
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 545-547
-
-
Jo, J.1
-
39
-
-
78651483724
-
PKC ε activation prevents synaptic loss Aβ elevation and cognitive defcits in Alzheimer's disease transgenic mice
-
Hongpaisan, J., Sun, M.K. & Alkon, D.L. PKC ε activation prevents synaptic loss, Aβ elevation, and cognitive defcits in Alzheimer's disease transgenic mice. J. Neurosci. 31, 630-643 (2011).
-
(2011)
J. Neurosci.
, vol.31
, pp. 630-643
-
-
Hongpaisan, J.1
Sun, M.K.2
Alkon, D.L.3
-
40
-
-
77958465822
-
Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease
-
Ma, T. et al. Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease. PLoS One 5, e12845 (2010).
-
(2010)
PLoS One
, vol.5
, pp. e12845
-
-
Ma, T.1
-
41
-
-
78149253527
-
NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
-
Kwak, Y.D. et al. NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration. Mol. Neurodegener. 5, 49 (2010).
-
(2010)
Mol. Neurodegener.
, vol.5
, pp. 49
-
-
Kwak, Y.D.1
-
42
-
-
84859718265
-
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
-
Talbot, K. et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J. Clin. Invest. 122, 1316-1338 (2012).
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 1316-1338
-
-
Talbot, K.1
-
43
-
-
33845619414
-
Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules
-
Zhang, X. et al. Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules. FASEB J. 20, 1272-1274 (2006).
-
(2006)
FASEB J.
, vol.20
, pp. 1272-1274
-
-
Zhang, X.1
-
44
-
-
16244391770
-
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
-
Griffn, R.J. et al. Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J. Neurochem. 93, 105-117 (2005).
-
(2005)
J. Neurochem.
, vol.93
, pp. 105-117
-
-
Griffn, R.J.1
-
45
-
-
0038100358
-
Role of protein kinase B in Alzheimer's neurofbrillary pathology
-
Pei, J.J. et al. Role of protein kinase B in Alzheimer's neurofbrillary pathology. Acta Neuropathol. 105, 381-392 (2003).
-
(2003)
Acta Neuropathol.
, vol.105
, pp. 381-392
-
-
Pei, J.J.1
-
46
-
-
70349672704
-
Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease
-
Freude, S. et al. Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. FASEB J. 23, 3315-3324 (2009).
-
(2009)
FASEB J.
, vol.23
, pp. 3315-3324
-
-
Freude, S.1
-
47
-
-
71449108913
-
Reduced IGF-1 signaling delays age-associated proteotoxicity in mice
-
Cohen, E. et al. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell 139, 1157-1169 (2009).
-
(2009)
Cell
, vol.139
, pp. 1157-1169
-
-
Cohen, E.1
-
48
-
-
84897907030
-
How does brain insulin resistance develop in Alzheimer's disease?
-
De Felice, F.G., Lourenco, M.V. & Ferreira, S.T. How does brain insulin resistance develop in Alzheimer's disease? Alzheimers Dement. 10 (suppl. 1) S26-S32 (2014).
-
(2014)
Alzheimers Dement.
, vol.10
, pp. S26-S32
-
-
De Felice, F.G.1
Lourenco, M.V.2
Ferreira, S.T.3
-
49
-
-
0033536055
-
Recombinant Semliki Forest virus and Sindbis virus effciently infect neurons in hippocampal slice cultures
-
Ehrengruber, M.U. et al. Recombinant Semliki Forest virus and Sindbis virus effciently infect neurons in hippocampal slice cultures. Proc. Natl. Acad. Sci. USA 96, 7041-7046 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 7041-7046
-
-
Ehrengruber, M.U.1
-
50
-
-
0035146778
-
Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues
-
Torres, J. et al. Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues. Eur. J. Cancer 37, 114-121 (2001).
-
(2001)
Eur. J. Cancer
, vol.37
, pp. 114-121
-
-
Torres, J.1
-
51
-
-
23844473290
-
Binding of PTEN to specifc PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases
-
Valiente, M. et al. Binding of PTEN to specifc PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. J. Biol. Chem. 280, 28936-28943 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 28936-28943
-
-
Valiente, M.1
-
52
-
-
38849117770
-
Fast conventional Fmoc solid-phase peptide synthesis with HCTU
-
Hood, C.A. et al. Fast conventional Fmoc solid-phase peptide synthesis with HCTU. J. Pept. Sci. 14, 97-101 (2008).
-
(2008)
J. Pept. Sci.
, vol.14
, pp. 97-101
-
-
Hood, C.A.1
|