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Volumn 4, Issue , 2016, Pages 129-154

Porcine reproductive and respiratory syndrome virus (PRRSV): Pathogenesis and interaction with the immune system

Author keywords

Fetal infection; Genetic control; Host immunity; Porcine reproductive and respiratory syndrome; PRRSV; Vaccine responses

Indexed keywords

VIRUS VACCINE;

EID: 84959058063     PISSN: 21658102     EISSN: 21658110     Source Type: Journal    
DOI: 10.1146/annurev-animal-022114-111025     Document Type: Review
Times cited : (502)

References (156)
  • 1
    • 84874844948 scopus 로고    scopus 로고
    • Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on United States pork producers
    • Holtkamp DJ, Kliebenstein JB, Neumann EJ, Zimmerman J, Rotto HF, et al. 2013. Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on United States pork producers. J. Swine Health Prod. 21:72-84
    • (2013) J. Swine Health Prod. , vol.21 , pp. 72-84
    • Holtkamp, D.J.1    Kliebenstein, J.B.2    Neumann, E.J.3    Zimmerman, J.4    Rotto, H.F.5
  • 2
    • 84884170985 scopus 로고    scopus 로고
    • Arterivirus molecular biology and pathogenesis
    • Snijder EJ, Kikkert M, Fang Y. 2013. Arterivirus molecular biology and pathogenesis. J. Gen. Virol. 94:2141-63
    • (2013) J. Gen. Virol. , vol.94 , pp. 2141-2163
    • Snijder, E.J.1    Kikkert, M.2    Fang, Y.3
  • 3
    • 78649326444 scopus 로고    scopus 로고
    • The structural biology of PRRSV
    • Dokland T. 2010. The structural biology of PRRSV. Virus Res. 154:86-97
    • (2010) Virus Res. , vol.154 , pp. 86-97
    • Dokland, T.1
  • 4
    • 78649322018 scopus 로고    scopus 로고
    • The PRRSV replicase: Exploring the multifunctionality of an intriguing set of nonstructural proteins
    • Fang Y, Snijder EJ. 2010. The PRRSV replicase: exploring the multifunctionality of an intriguing set of nonstructural proteins. Virus Res. 154:61-76
    • (2010) Virus Res. , vol.154 , pp. 61-76
    • Fang, Y.1    Snijder, E.J.2
  • 5
    • 84867904673 scopus 로고    scopus 로고
    • Efficient2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein
    • Fang Y, Treffers EE, Li Y, Tas A, Sun Z, et al. 2012. Efficient2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein. PNAS 109:E2920-28
    • (2012) PNAS , vol.109 , pp. E2920-E2928
    • Fang, Y.1    Treffers, E.E.2    Li, Y.3    Tas, A.4    Sun, Z.5
  • 6
    • 84901687955 scopus 로고    scopus 로고
    • Transactivation of programmed ribosomal frameshifting by a viral protein
    • Li Y, Treffers EE, Napthine S, Tas A, Zhu L, et al. 2014. Transactivation of programmed ribosomal frameshifting by a viral protein. PNAS 111:E2172-81
    • (2014) PNAS , vol.111 , pp. E2172-E2181
    • Li, Y.1    Treffers, E.E.2    Napthine, S.3    Tas, A.4    Zhu, L.5
  • 7
    • 0031443350 scopus 로고    scopus 로고
    • Effects of origin and state of differentiation and activation of monocytes/macrophages on their susceptibility to porcine reproductive and respiratory syndrome virus (PRRSV)
    • Duan X, Nauwynck HJ, Pensaert MB. 1997. Effects of origin and state of differentiation and activation of monocytes/macrophages on their susceptibility to porcine reproductive and respiratory syndrome virus (PRRSV). Arch. Virol. 142:2483-97
    • (1997) Arch. Virol. , vol.142 , pp. 2483-2497
    • Duan, X.1    Nauwynck, H.J.2    Pensaert, M.B.3
  • 8
    • 33845973334 scopus 로고    scopus 로고
    • Differential type i interferon activation and susceptibility of dendritic cell populations to porcine arterivirus
    • Loving CL, Brockmeier SL, Sacco RE. 2007. Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus. Immunology 120:217-29
    • (2007) Immunology , vol.120 , pp. 217-229
    • Loving, C.L.1    Brockmeier, S.L.2    Sacco, R.E.3
  • 9
    • 0027130980 scopus 로고
    • Enhanced replication of porcine reproductive and respiratory syndrome (PRRS) virus in a homogeneous subpopulation of MA-104 cell line
    • Kim HS, Kwang J, Yoon IJ, Joo HS, Frey ML. 1993. Enhanced replication of porcine reproductive and respiratory syndrome (PRRS) virus in a homogeneous subpopulation of MA-104 cell line. Arch. Virol. 133:477-83
    • (1993) Arch. Virol. , vol.133 , pp. 477-483
    • Kim, H.S.1    Kwang, J.2    Yoon, I.J.3    Joo, H.S.4    Frey, M.L.5
  • 10
    • 0032969255 scopus 로고    scopus 로고
    • Entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages via receptor-mediated endocytosis
    • Nauwynck HJ, Duan X, Favoreel HW, Van Oostveldt P, Pensaert MB. 1999. Entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages via receptor-mediated endocytosis. J. Gen. Virol. 80:297-305
    • (1999) J. Gen. Virol. , vol.80 , pp. 297-305
    • Nauwynck, H.J.1    Duan, X.2    Favoreel, H.W.3    Van Oostveldt, P.4    Pensaert, M.B.5
  • 11
    • 78649319822 scopus 로고    scopus 로고
    • A brief review of CD163 and its role in PRRSV infection
    • Welch SK, Calvert JG. 2010. A brief review of CD163 and its role in PRRSV infection. Virus Res. 154:98-103
    • (2010) Virus Res. , vol.154 , pp. 98-103
    • Welch, S.K.1    Calvert, J.G.2
  • 12
    • 77649201036 scopus 로고    scopus 로고
    • TheM/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner
    • Van BreedamW,Van Gorp H, Zhang JQ, Crocker PR, Delputte PL,NauwynckHJ. 2010. TheM/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner. PLOS Pathog. 6:e1000730
    • (2010) PLOS Pathog. , vol.6 , pp. e1000730
    • Van Breedam, W.1    Van Gorp, H.2    Zhang, J.Q.3    Crocker, P.R.4    Delputte, P.L.5    Nauwynck, H.J.6
  • 13
    • 84883276947 scopus 로고    scopus 로고
    • An intact sialoadhesin (Sn/SIGLEC1/CD169) is not required for attachment/internalization of the porcine reproductive and respiratory syndrome virus
    • Prather RS, Rowland RR, Ewen C, Trible B, Kerrigan M, et al. 2013. An intact sialoadhesin (Sn/SIGLEC1/CD169) is not required for attachment/internalization of the porcine reproductive and respiratory syndrome virus. J. Virol. 87:9538-46
    • (2013) J. Virol. , vol.87 , pp. 9538-9546
    • Prather, R.S.1    Rowland, R.R.2    Ewen, C.3    Trible, B.4    Kerrigan, M.5
  • 14
    • 34447281283 scopus 로고    scopus 로고
    • CD163 expression confers susceptibility to porcine reproductive and respiratory syndrome viruses
    • Calvert JG, Slade DE, Shields SL, Jolie R, Mannan RM, et al. 2007. CD163 expression confers susceptibility to porcine reproductive and respiratory syndrome viruses. J. Virol. 81:7371-79
    • (2007) J. Virol. , vol.81 , pp. 7371-7379
    • Calvert, J.G.1    Slade, D.E.2    Shields, S.L.3    Jolie, R.4    Mannan, R.M.5
  • 15
    • 75449111993 scopus 로고    scopus 로고
    • Theminor envelope glycoproteins GP2a and GP4 of porcine reproductive and respiratory syndrome virus interact with the receptor CD163
    • Das PB, Dinh PX, Ansari IH, de Lima M, Osorio FA, Pattnaik AK. 2010. Theminor envelope glycoproteins GP2a and GP4 of porcine reproductive and respiratory syndrome virus interact with the receptor CD163. J. Virol. 84:1731-40
    • (2010) J. Virol. , vol.84 , pp. 1731-1740
    • Das, P.B.1    Dinh, P.X.2    Ansari, I.H.3    De Lima, M.4    Osorio, F.A.5    Pattnaik, A.K.6
  • 16
    • 84861325267 scopus 로고    scopus 로고
    • Arterivirusminor envelope proteins are a major determinant of viral tropism in cell culture
    • Tian D, Wei Z, Zevenhoven-Dobbe JC, Liu R, Tong G, et al. 2012. Arterivirusminor envelope proteins are a major determinant of viral tropism in cell culture. J. Virol. 86:3701-12
    • (2012) J. Virol. , vol.86 , pp. 3701-3712
    • Tian, D.1    Wei, Z.2    Zevenhoven-Dobbe, J.C.3    Liu, R.4    Tong, G.5
  • 18
    • 0033761397 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus: Description of persistence in individual pigs upon experimental infection
    • Allende R, Laegreid WW, Kutish GF, Galeota JA, Wills RW, Osorio FA. 2000. Porcine reproductive and respiratory syndrome virus: description of persistence in individual pigs upon experimental infection. J. Virol. 74:10834-37
    • (2000) J. Virol. , vol.74 , pp. 10834-10837
    • Allende, R.1    Laegreid, W.W.2    Kutish, G.F.3    Galeota, J.A.4    Wills, R.W.5    Osorio, F.A.6
  • 19
    • 1542502616 scopus 로고    scopus 로고
    • Lymphoid tissue tropism of porcine reproductive and respiratory syndrome virus replication during persistent infection of pigs originally exposed to virus in utero
    • Rowland RRR, Lawson S, Rossow K, Benfield DA. 2003. Lymphoid tissue tropism of porcine reproductive and respiratory syndrome virus replication during persistent infection of pigs originally exposed to virus in utero. Vet. Microbiol. 96:219-35
    • (2003) Vet. Microbiol. , vol.96 , pp. 219-235
    • Rowland, R.R.R.1    Lawson, S.2    Rossow, K.3    Benfield, D.A.4
  • 20
    • 50549088104 scopus 로고    scopus 로고
    • Comparative antiviral and proviral factors in semen and vaccines for preventing viral dissemination from the male reproductive tract and semen
    • Christopher-Hennings J, Nelson EA, Althouse GC, Lunney J. 2008. Comparative antiviral and proviral factors in semen and vaccines for preventing viral dissemination from the male reproductive tract and semen. Anim. Health Res. Rev. 9:59-69
    • (2008) Anim. Health Res. Rev. , vol.9 , pp. 59-69
    • Christopher-Hennings, J.1    Nelson, E.A.2    Althouse, G.C.3    Lunney, J.4
  • 21
    • 0037232194 scopus 로고    scopus 로고
    • Duration of infection and proportion of pigs persistently infected with porcine reproductive and respiratory syndrome virus
    • Wills RW, Doster AR, Galeota JA, Sur JH, Osorio FA. 2003. Duration of infection and proportion of pigs persistently infected with porcine reproductive and respiratory syndrome virus. J. Clin. Microbiol. 41:58-62
    • (2003) J. Clin. Microbiol. , vol.41 , pp. 58-62
    • Wills, R.W.1    Doster, A.R.2    Galeota, J.A.3    Sur, J.H.4    Osorio, F.A.5
  • 23
    • 0026198762 scopus 로고
    • Mystery swine disease in the Netherlands: The isolation of Lelystad virus
    • Wensvoort G, Terpstra C, Pol JM, ter Laak EA, Bloemraad M, et al. 1991. Mystery swine disease in The Netherlands: the isolation of Lelystad virus. Vet. Q. 13:121-30
    • (1991) Vet. Q. , vol.13 , pp. 121-130
    • Wensvoort, G.1    Terpstra, C.2    Pol, J.M.3    Ter Laak, E.A.4    Bloemraad, M.5
  • 24
    • 0033008414 scopus 로고    scopus 로고
    • North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions
    • Allende R, Lewis TL, Lu Z, Rock DL, Kutish GF, et al. 1999. North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions. J. Gen. Virol. 80:307-15
    • (1999) J. Gen. Virol. , vol.80 , pp. 307-315
    • Allende, R.1    Lewis, T.L.2    Lu, Z.3    Rock, D.L.4    Kutish, G.F.5
  • 25
    • 0032889516 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus comparison: Divergent evolution on two continents
    • Nelsen CJ, Murtaugh MP, Faaberg KS. 1999. Porcine reproductive and respiratory syndrome virus comparison: divergent evolution on two continents. J. Virol. 73:270-80
    • (1999) J. Virol. , vol.73 , pp. 270-280
    • Nelsen, C.J.1    Murtaugh, M.P.2    Faaberg, K.S.3
  • 26
    • 0043127469 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus: Origin hypothesis
    • Plagemann PG. 2003. Porcine reproductive and respiratory syndrome virus: origin hypothesis. Emerg. Infect. Dis. 9:903-8
    • (2003) Emerg. Infect. Dis. , vol.9 , pp. 903-908
    • Plagemann, P.G.1
  • 27
    • 0032238986 scopus 로고    scopus 로고
    • Clinical consequences of exposing pregnant gilts to strains of porcine reproductive and respiratory syndrome (PRRS) virus isolated from field cases of "atypical" PRRS
    • Mengeling WL, Lager KM, Vorwald AC. 1998. Clinical consequences of exposing pregnant gilts to strains of porcine reproductive and respiratory syndrome (PRRS) virus isolated from field cases of "atypical" PRRS. Am. J. Vet. Res. 59:1540-44
    • (1998) Am. J. Vet. Res. , vol.59 , pp. 1540-1544
    • Mengeling, W.L.1    Lager, K.M.2    Vorwald, A.C.3
  • 28
    • 33750417154 scopus 로고    scopus 로고
    • Complete genome analysis of RFLP 184 isolates of porcine reproductive and respiratory syndrome virus
    • Han J, Wang Y, Faaberg KS. 2006. Complete genome analysis of RFLP 184 isolates of porcine reproductive and respiratory syndrome virus. Virus Res. 122:175-82
    • (2006) Virus Res. , vol.122 , pp. 175-182
    • Han, J.1    Wang, Y.2    Faaberg, K.S.3
  • 29
    • 34547618481 scopus 로고    scopus 로고
    • Emergence of fatal PRRSV variants: Unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark
    • Tian K, Yu X, Zhao T, Feng Y, Cao Z, et al. 2007. Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLOS ONE 2:e526
    • (2007) PLOS ONE , vol.2 , pp. e526
    • Tian, K.1    Yu, X.2    Zhao, T.3    Feng, Y.4    Cao, Z.5
  • 30
    • 77955487727 scopus 로고    scopus 로고
    • Pathogenesis and antigenic characterization of a new East European subtype 3 porcine reproductive and respiratory syndrome virus isolate
    • Karniychuk UU, GeldhofM, VanheeM, Van Doorsselaere J, Saveleva TA,NauwynckHJ. 2010. Pathogenesis and antigenic characterization of a new East European subtype 3 porcine reproductive and respiratory syndrome virus isolate. BMC Vet. Res. 6:30
    • (2010) BMC Vet. Res. , vol.6 , pp. 30
    • Karniychuk, U.U.1    Geldho, F.M.2    Vanhee, M.3    Van Doorsselaere, J.4    Saveleva, T.A.5    Nauwynck, H.J.6
  • 31
    • 84923996475 scopus 로고    scopus 로고
    • Engineering the PRRS virus genome: Updates and perspectives
    • Han M, Yoo D. 2014. Engineering the PRRS virus genome: updates and perspectives. Vet. Microbiol. 174:279-95
    • (2014) Vet. Microbiol. , vol.174 , pp. 279-295
    • Han, M.1    Yoo, D.2
  • 32
    • 3843100894 scopus 로고    scopus 로고
    • Porcine respiratory disease complex
    • ed. KA Brogden, JM Guthmiller. Washington, DC: ASM Press
    • Brockmeier SL, Halbur PG, Thacker EL. 2002. Porcine respiratory disease complex. In Polymicrobial Diseases, ed. KA Brogden, JM Guthmiller, pp. 231-58. Washington, DC: ASM Press
    • (2002) Polymicrobial Diseases , pp. 231-258
    • Brockmeier, S.L.1    Halbur, P.G.2    Thacker, E.L.3
  • 33
    • 0033058350 scopus 로고    scopus 로고
    • Mycoplasma hyopneumoniae potentiation of porcine reproductive and respiratory syndrome virus-induced pneumonia
    • Thacker EL, Halbur PG, Ross RF, Thanawongnuwech R, Thacker BJ. 1999. Mycoplasma hyopneumoniae potentiation of porcine reproductive and respiratory syndrome virus-induced pneumonia. J. Clin. Microbiol. 37:620-27
    • (1999) J. Clin. Microbiol. , vol.37 , pp. 620-627
    • Thacker, E.L.1    Halbur, P.G.2    Ross, R.F.3    Thanawongnuwech, R.4    Thacker, B.J.5
  • 34
    • 0034242452 scopus 로고    scopus 로고
    • Effects of intranasal inoculation of porcine reproductive and respiratory syndrome virus, Bordetella bronchiseptica, or a combination of both organisms in pigs
    • Brockmeier SL, Palmer MV, Bolin SR. 2000. Effects of intranasal inoculation of porcine reproductive and respiratory syndrome virus, Bordetella bronchiseptica, or a combination of both organisms in pigs. Am. J. Vet. Res. 61:892-99
    • (2000) Am. J. Vet. Res. , vol.61 , pp. 892-899
    • Brockmeier, S.L.1    Palmer, M.V.2    Bolin, S.R.3
  • 36
    • 0029873804 scopus 로고    scopus 로고
    • Dual infections of feeder pigs with porcine reproductive and respiratory syndrome virus followed by porcine respiratory coronavirus or swine influenza virus: A clinical and virological study
    • Van Reeth K, Nauwynck H, PensaertM. 1996. Dual infections of feeder pigs with porcine reproductive and respiratory syndrome virus followed by porcine respiratory coronavirus or swine influenza virus: a clinical and virological study. Vet. Microbiol. 48:325-35
    • (1996) Vet. Microbiol. , vol.48 , pp. 325-335
    • Van Reeth, K.1    Nauwynck, H.2    Pensaert, M.3
  • 37
    • 0030872042 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus (PRRSv) interaction with Haemophilus parasuis
    • Solano GI, Segalés J, Collins JE, Molitor TW, Pijoan C. 1997. Porcine reproductive and respiratory syndrome virus (PRRSv) interaction with Haemophilus parasuis. Vet. Microbiol. 55:247-57
    • (1997) Vet. Microbiol. , vol.55 , pp. 247-257
    • Solano, G.I.1    Segalés, J.2    Collins, J.E.3    Molitor, T.W.4    Pijoan, C.5
  • 38
    • 0028471099 scopus 로고
    • A modified serum neutralization test for the detection of antibody to porcine reproductive and respiratory syndrome virus in swine sera
    • Yoon IJ, Joo HS, Goyal SM, Molitor TW. 1994. A modified serum neutralization test for the detection of antibody to porcine reproductive and respiratory syndrome virus in swine sera. J. Vet. Diagn. Investig. 6:289-92
    • (1994) J. Vet. Diagn. Investig. , vol.6 , pp. 289-292
    • Yoon, I.J.1    Joo, H.S.2    Goyal, S.M.3    Molitor, T.W.4
  • 40
    • 34147191519 scopus 로고    scopus 로고
    • Protection against porcine reproductive and respiratory syndrome virus (PRRSV) infection through passive transfer of PRRSVneutralizing antibodies is dose dependent
    • Lopez OJ, Oliveira MF, Garcia EA, Kwon BJ, Doster A, Osorio FA. 2007. Protection against porcine reproductive and respiratory syndrome virus (PRRSV) infection through passive transfer of PRRSVneutralizing antibodies is dose dependent. Clin. Vaccine Immunol. 14:269-75
    • (2007) Clin. Vaccine Immunol. , vol.14 , pp. 269-275
    • Lopez, O.J.1    Oliveira, M.F.2    Garcia, E.A.3    Kwon, B.J.4    Doster, A.5    Osorio, F.A.6
  • 41
    • 7044220260 scopus 로고    scopus 로고
    • Role of neutralizing antibodies in PRRSV protective immunity
    • Lopez OJ, Osorio FA. 2004. Role of neutralizing antibodies in PRRSV protective immunity. Vet. Immunol. Immunopathol. 102:155-63
    • (2004) Vet. Immunol. Immunopathol. , vol.102 , pp. 155-163
    • Lopez, O.J.1    Osorio, F.A.2
  • 42
    • 33748684385 scopus 로고    scopus 로고
    • Serologic marker candidates identified among B-cell linear epitopes ofNsp2 and structural proteins of aNorth American strain of porcine reproductive and respiratory syndrome virus
    • de Lima M, Pattnaik AK, Flores EF, Osorio FA. 2006. Serologic marker candidates identified among B-cell linear epitopes ofNsp2 and structural proteins of aNorth American strain of porcine reproductive and respiratory syndrome virus. Virology 353:410-21
    • (2006) Virology , vol.353 , pp. 410-421
    • De Lima, M.1    Pattnaik, A.K.2    Flores, E.F.3    Osorio, F.A.4
  • 43
    • 0035104619 scopus 로고    scopus 로고
    • Epitope mapping porcine reproductive and respiratory syndrome virus by phage display: The nsp2 fragment of the replicase polyprotein contains a cluster of B-cell epitopes
    • Oleksiewicz MB, Botner A, Toft P, Normann P, Storgaard T. 2001. Epitope mapping porcine reproductive and respiratory syndrome virus by phage display: The nsp2 fragment of the replicase polyprotein contains a cluster of B-cell epitopes. J. Virol. 75:3277-90
    • (2001) J. Virol. , vol.75 , pp. 3277-3290
    • Oleksiewicz, M.B.1    Botner, A.2    Toft, P.3    Normann, P.4    Storgaard, T.5
  • 44
    • 0036434193 scopus 로고    scopus 로고
    • Passive transfer of virus-specific antibodies confers protection against reproductive failure induced by a virulent strain of porcine reproductive and respiratory syndrome virus and establishes sterilizing immunity
    • Osorio FA, Galeota JA, Nelson E, Brodersen B, Doster A, et al. 2002. Passive transfer of virus-specific antibodies confers protection against reproductive failure induced by a virulent strain of porcine reproductive and respiratory syndrome virus and establishes sterilizing immunity. Virology 302:9-20
    • (2002) Virology , vol.302 , pp. 9-20
    • Osorio, F.A.1    Galeota, J.A.2    Nelson, E.3    Brodersen, B.4    Doster, A.5
  • 45
    • 33645776979 scopus 로고    scopus 로고
    • Influence of N-linked glycosylation of porcine reproductive and respiratory syndrome virus GP5 on virus infectivity, antigenicity, and ability to induce neutralizing antibodies
    • Ansari IH, Kwon B, Osorio FA, Pattnaik AK. 2006. Influence of N-linked glycosylation of porcine reproductive and respiratory syndrome virus GP5 on virus infectivity, antigenicity, and ability to induce neutralizing antibodies. J. Virol. 80:3994-4004
    • (2006) J. Virol. , vol.80 , pp. 3994-4004
    • Ansari, I.H.1    Kwon, B.2    Osorio, F.A.3    Pattnaik, A.K.4
  • 46
    • 0036223761 scopus 로고    scopus 로고
    • Identification of neutralizing and nonneutralizing epitopes in the porcine reproductive and respiratory syndrome virus GP5 ectodomain
    • OstrowskiM,Galeota JA, JarAM,PlattKB, OsorioFA, Lopez OJ. 2002. Identification of neutralizing and nonneutralizing epitopes in the porcine reproductive and respiratory syndrome virus GP5 ectodomain. J. Virol. 76:4241-50
    • (2002) J. Virol. , vol.76 , pp. 4241-4250
    • Ostrowski, M.1    Galeota, J.A.2    Jar, A.M.3    Platt, K.B.4    Osorio, F.A.5    Lopez, O.J.6
  • 47
    • 7044251779 scopus 로고    scopus 로고
    • Monoclonal antibody analysis of porcine reproductive and respiratory syndrome virus epitopes associated with antibody-dependent enhancement and neutralization of virus infection
    • Cancel-Tirado SM,Evans RB, Yoon KJ. 2004. Monoclonal antibody analysis of porcine reproductive and respiratory syndrome virus epitopes associated with antibody-dependent enhancement and neutralization of virus infection. Vet. Immunol. Immunopathol. 102:249-62
    • (2004) Vet. Immunol. Immunopathol. , vol.102 , pp. 249-262
    • Cancel-Tirado, S.M.1    Evans, R.B.2    Yoon, K.J.3
  • 48
    • 84856257847 scopus 로고    scopus 로고
    • Interaction between innate immunity and porcine reproductive and respiratory syndrome virus
    • Sang Y, Rowland RR, Blecha F. 2011. Interaction between innate immunity and porcine reproductive and respiratory syndrome virus. Anim. Health Res. Rev. 12:149-67
    • (2011) Anim. Health Res. Rev. , vol.12 , pp. 149-167
    • Sang, Y.1    Rowland, R.R.2    Blecha, F.3
  • 49
    • 84905743866 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome (PRRS): An immune dysregulatory pandemic
    • Butler JE, LagerKM, GoldeW, FaabergKS, SinkoraM, et al. 2014. Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic. Immunol. Res. 59:81-108
    • (2014) Immunol. Res. , vol.59 , pp. 81-108
    • Butler, J.E.1    Lager, K.M.2    Golde, W.3    Faaberg, K.S.4    Sinkora, M.5
  • 50
    • 79956096989 scopus 로고    scopus 로고
    • Immune evasion of porcine reproductive and respiratory syndrome virus through glycan shielding involves both glycoprotein 5 as well as glycoprotein 3
    • Vu HL, Kwon B, Yoon KJ, Laegreid WW, Pattnaik AK, Osorio FA. 2011. Immune evasion of porcine reproductive and respiratory syndrome virus through glycan shielding involves both glycoprotein 5 as well as glycoprotein 3. J. Virol. 85:5555-64
    • (2011) J. Virol. , vol.85 , pp. 5555-5564
    • Vu, H.L.1    Kwon, B.2    Yoon, K.J.3    Laegreid, W.W.4    Pattnaik, A.K.5    Osorio, F.A.6
  • 51
    • 84868094739 scopus 로고    scopus 로고
    • DNA shuffling of the GP3 genes of porcine reproductive and respiratory syndrome virus (PRRSV) produces a chimeric virus with an improved cross-neutralizing ability against a heterologous PRRSV strain
    • Zhou L, Ni YY, Pineyro P, Sanford BJ, Cossaboom CM, et al. 2012. DNA shuffling of the GP3 genes of porcine reproductive and respiratory syndrome virus (PRRSV) produces a chimeric virus with an improved cross-neutralizing ability against a heterologous PRRSV strain. Virology 434:96-109
    • (2012) Virology , vol.434 , pp. 96-109
    • Zhou, L.1    Ni, Y.Y.2    Pineyro, P.3    Sanford, B.J.4    Cossaboom, C.M.5
  • 52
    • 84930816565 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies against the rapidly evolving porcine reproductive and respiratory syndrome virus
    • Robinson SR, Li J, Nelson EA, Murtaugh MP. 2015. Broadly neutralizing antibodies against the rapidly evolving porcine reproductive and respiratory syndrome virus. Virus Res. 203:56-65
    • (2015) Virus Res. , vol.203 , pp. 56-65
    • Robinson, S.R.1    Li, J.2    Nelson, E.A.3    Murtaugh, M.P.4
  • 53
    • 84901604609 scopus 로고    scopus 로고
    • Protective humoral immune response induced by an inactivated porcine reproductive and respiratory syndrome virus expressing the hypoglycosylated glycoprotein 5
    • Lee JA, Kwon B, Osorio FA, Pattnaik AK, Lee NH, et al. 2014. Protective humoral immune response induced by an inactivated porcine reproductive and respiratory syndrome virus expressing the hypoglycosylated glycoprotein 5. Vaccine 32:3617-22
    • (2014) Vaccine , vol.32 , pp. 3617-3622
    • Lee, J.A.1    Kwon, B.2    Osorio, F.A.3    Pattnaik, A.K.4    Lee, N.H.5
  • 54
    • 84929598311 scopus 로고    scopus 로고
    • A single amino acid deletion in the matrix protein of porcine reproductive and respiratory syndrome virus confers resistance to a polyclonal swine antibody with broadly neutralizing activity
    • Trible BR, Popescu LN, Monday N, Calvert JG, Rowland RR. 2015. A single amino acid deletion in the matrix protein of porcine reproductive and respiratory syndrome virus confers resistance to a polyclonal swine antibody with broadly neutralizing activity. J. Virol. 89:6515-20
    • (2015) J. Virol. , vol.89 , pp. 6515-6520
    • Trible, B.R.1    Popescu, L.N.2    Monday, N.3    Calvert, J.G.4    Rowland, R.R.5
  • 55
    • 51349087106 scopus 로고    scopus 로고
    • Innate immune response to viral infection
    • Koyama S, Ishii KJ, Coban C, Akira S. 2008. Innate immune response to viral infection. Cytokine 43:336-41
    • (2008) Cytokine , vol.43 , pp. 336-341
    • Koyama, S.1    Ishii, K.J.2    Coban, C.3    Akira, S.4
  • 57
    • 0033175579 scopus 로고    scopus 로고
    • Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: Correlations with pathogenicity
    • Van Reeth K, Labarque G, Nauwynck H, Pensaert M. 1999. Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: correlations with pathogenicity. Res. Vet. Sci. 67:47-52
    • (1999) Res. Vet. Sci. , vol.67 , pp. 47-52
    • Van Reeth, K.1    Labarque, G.2    Nauwynck, H.3    Pensaert, M.4
  • 58
    • 0031903841 scopus 로고    scopus 로고
    • Interferon-response to swine arterivirus (PoAV), the porcine reproductive and respiratory syndrome virus
    • Albina E, Carrat C, Charley B. 1998. Interferon-response to swine arterivirus (PoAV), the porcine reproductive and respiratory syndrome virus. J. Interf. Cytokine Res. 18:485-90
    • (1998) J. Interf. Cytokine Res. , vol.18 , pp. 485-490
    • Albina, E.1    Carrat, C.2    Charley, B.3
  • 59
    • 77957727737 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus-induced immunosuppression exacerbates the inflammatory response to porcine respiratory coronavirus in pigs
    • Renukaradhya GJ, Alekseev K, Jung K, Fang Y, Saif LJ. 2010. Porcine reproductive and respiratory syndrome virus-induced immunosuppression exacerbates the inflammatory response to porcine respiratory coronavirus in pigs. Viral. Immunol. 23:457-66
    • (2010) Viral. Immunol. , vol.23 , pp. 457-466
    • Renukaradhya, G.J.1    Alekseev, K.2    Jung, K.3    Fang, Y.4    Saif, L.J.5
  • 60
    • 72449151699 scopus 로고    scopus 로고
    • Age-dependent resistance to Porcine reproductive and respiratory syndrome virus replication in swine
    • Klinge KL, Vaughn EM, Roof MB, Bautista EM, Murtaugh MP. 2009. Age-dependent resistance to Porcine reproductive and respiratory syndrome virus replication in swine. Virol. J. 6:177
    • (2009) Virol. J. , vol.6 , pp. 177
    • Klinge, K.L.1    Vaughn, E.M.2    Roof, M.B.3    Bautista, E.M.4    Murtaugh, M.P.5
  • 62
    • 0036452972 scopus 로고    scopus 로고
    • Immunological responses of swine to porcine reproductive and respiratory syndrome virus infection
    • Murtaugh MP, Xiao Z, Zuckermann F. 2002. Immunological responses of swine to porcine reproductive and respiratory syndrome virus infection. Viral Immunol. 15:533-47
    • (2002) Viral Immunol. , vol.15 , pp. 533-547
    • Murtaugh, M.P.1    Xiao, Z.2    Zuckermann, F.3
  • 63
    • 79955651326 scopus 로고    scopus 로고
    • Cross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvant
    • Dwivedi V,Manickam C, Patterson R, Dodson K, Murtaugh M, et al. 2011. Cross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvant. Vaccine 29:4058-66
    • (2011) Vaccine , vol.29 , pp. 4058-4066
    • Dwivedi, V.1    Manickam, C.2    Patterson, R.3    Dodson, K.4    Murtaugh, M.5
  • 64
    • 84856944382 scopus 로고    scopus 로고
    • Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs during early stage of infection under farm conditions
    • DwivediV,Manickam C, Binjawadagi B, LinharesD,MurtaughMP, Renukaradhya GJ. 2012. Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs during early stage of infection under farm conditions. Virol. J. 9:45
    • (2012) Virol. J. , vol.9 , pp. 45
    • Dwivedi, V.1    Manickam, C.2    Binjawadagi, B.3    Linhares, D.4    Murtaugh, M.P.5    Renukaradhya, G.J.6
  • 65
    • 79955652343 scopus 로고    scopus 로고
    • Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs
    • Dwivedi V, Manickam C, Patterson R, Dodson K, Weeman M, Renukaradhya GJ. 2011. Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs. Vaccine 29:4067-76
    • (2011) Vaccine , vol.29 , pp. 4067-4076
    • Dwivedi, V.1    Manickam, C.2    Patterson, R.3    Dodson, K.4    Weeman, M.5    Renukaradhya, G.J.6
  • 66
    • 0037108345 scopus 로고    scopus 로고
    • Coordinated and distinct roles for IFN-, IL-12, and IL-15 regulation ofNKcell responses to viral infection
    • Nguyen KB, Salazar-Mather TP, Dalod MY, Van Deusen JB, Wei XQ, et al. 2002. Coordinated and distinct roles for IFN-, IL-12, and IL-15 regulation ofNKcell responses to viral infection. J. Immunol. 169:4279-87
    • (2002) J. Immunol. , vol.169 , pp. 4279-4287
    • Nguyen, K.B.1    Salazar-Mather, T.P.2    Dalod, M.Y.3    Van Deusen, J.B.4    Wei, X.Q.5
  • 68
    • 77953948394 scopus 로고    scopus 로고
    • Interleukin-8, interleukin-1 and interferon-levels are linked to PRRS virus clearance
    • Lunney JK, Fritz ER, Reecy JM, Kuhar D, Prucnal E, et al. 2010. Interleukin-8, interleukin-1 and interferon-levels are linked to PRRS virus clearance. Viral Immunol. 23:127-34
    • (2010) Viral Immunol. , vol.23 , pp. 127-134
    • Lunney, J.K.1    Fritz, E.R.2    Reecy, J.M.3    Kuhar, D.4    Prucnal, E.5
  • 69
    • 75849149994 scopus 로고    scopus 로고
    • Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: Nsp1 function as interferon antagonist
    • Chen Z, Lawson S, Sun Z, Zhou X, Guan X, et al. 2010. Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist. Virology 398:87-97
    • (2010) Virology , vol.398 , pp. 87-97
    • Chen, Z.1    Lawson, S.2    Sun, Z.3    Zhou, X.4    Guan, X.5
  • 70
    • 34748908493 scopus 로고    scopus 로고
    • IFN-treatment enhances porcine arterivirus infection of monocytes via upregulation of the porcine arterivirus receptor sialoadhesin
    • Delputte PL, Van Breedam W, Barbe F, Van Reeth K, Nauwynck HJ. 2007. IFN-treatment enhances porcine arterivirus infection of monocytes via upregulation of the porcine arterivirus receptor sialoadhesin. J. Interf. Cytokine Res. 27:757-66
    • (2007) J. Interf. Cytokine Res. , vol.27 , pp. 757-766
    • Delputte, P.L.1    Van Breedam, W.2    Barbe, F.3    Van Reeth, K.4    Nauwynck, H.J.5
  • 71
    • 57149100942 scopus 로고    scopus 로고
    • Species specialization in cytokine biology: Is interleukin-4 central to the TH1-TH2 paradigm in swine
    • Murtaugh MP, Johnson CR, Xiao Z, Scamurra RW, Zhou Y. 2009. Species specialization in cytokine biology: Is interleukin-4 central to the TH1-TH2 paradigm in swine Dev. Comp. Immunol. 33:344-52
    • (2009) Dev. Comp. Immunol. , vol.33 , pp. 344-352
    • Murtaugh, M.P.1    Johnson, C.R.2    Xiao, Z.3    Scamurra, R.W.4    Zhou, Y.5
  • 72
    • 0028130429 scopus 로고
    • Interleukin-4 suppresses inflammatory cytokine gene transcription in porcine macrophages
    • Zhou Y, Lin G, BaarschMJ, Scamurra RJ,MurtaughMP. 1994. Interleukin-4 suppresses inflammatory cytokine gene transcription in porcine macrophages. J. Leukoc. Biol. 56:507-13
    • (1994) J. Leukoc. Biol. , vol.56 , pp. 507-513
    • Zhou, Y.1    Lin, G.2    Baarsch, M.J.3    Scamurra, R.J.4    Murtaugh, M.P.5
  • 73
    • 84874572024 scopus 로고    scopus 로고
    • Comparative analysis of immune responses following experimental infection of pigs with European porcine reproductive and respiratory syndrome virus strains of differing virulence
    • Weesendorp E,Morgan S, Stockhofe-Zurwieden N, Popma-De Graaf DJ, Graham SP, Rebel JM. 2013. Comparative analysis of immune responses following experimental infection of pigs with European porcine reproductive and respiratory syndrome virus strains of differing virulence. Vet.Microbiol. 163:1-12
    • (2013) Vet. Microbiol. , vol.163 , pp. 1-12
    • Weesendorp, E.1    Morgan, S.2    Stockhofe-Zurwieden, N.3    Popma-De Graaf, D.J.4    Graham, S.P.5    Rebel, J.M.6
  • 74
    • 84909981478 scopus 로고    scopus 로고
    • Lung pathogenicity of European genotype 3 strain porcine reproductive and respiratory syndrome virus (PRRSV) differs from that of subtype 1 strains
    • Weesendorp E, Rebel JMJ, Popma-De Graaf DJ, Fijten HPD, Stockhofe-Zurwieden N. 2014. Lung pathogenicity of European genotype 3 strain porcine reproductive and respiratory syndrome virus (PRRSV) differs from that of subtype 1 strains. Vet. Microbiol. 174(1-2):127-38
    • (2014) Vet. Microbiol. , vol.174 , Issue.1-2 , pp. 127-138
    • Weesendorp, E.1    Rebel, J.M.J.2    Popma-De Graaf, D.J.3    Fijten, H.P.D.4    Stockhofe-Zurwieden, N.5
  • 75
    • 84926416488 scopus 로고    scopus 로고
    • A comparative study of the local cytokine response in the lungs of pigs experimentally infected with different PRRSV-1 strains: Upregulation of IL-1in highly pathogenic strain induced lesions
    • Amarilla SP,Gómez-Laguna J, Carrasco L, Rodrguez-G ómez IM, Caridad Y, et al. 2015. A comparative study of the local cytokine response in the lungs of pigs experimentally infected with different PRRSV-1 strains: upregulation of IL-1in highly pathogenic strain induced lesions. Vet. Immunol. Immunopathol. 164:137-47
    • (2015) Vet. Immunol. Immunopathol. , vol.164 , pp. 137-147
    • Amarilla, S.P.1    Gómez-Laguna, J.2    Carrasco, L.3    Rodrguez-Gómez, I.M.4    Caridad, Y.5
  • 76
    • 84873118449 scopus 로고    scopus 로고
    • Immunopathogenesis of porcine reproductive and respiratory syndrome in the respiratory tract of pigs
    • Gómez-Laguna J, Salguero FJ, Pallarés FJ, Carrasco L. 2013. Immunopathogenesis of porcine reproductive and respiratory syndrome in the respiratory tract of pigs. Vet. J. 195:148-55
    • (2013) Vet. J. , vol.195 , pp. 148-155
    • Gómez-Laguna, J.1    Salguero, F.J.2    Pallarés, F.J.3    Carrasco, L.4
  • 77
    • 2442690358 scopus 로고    scopus 로고
    • The level of virus-specific T-cell and macrophage recruitment in porcine reproductive and respiratory syndrome virus infection in pigs is independent of virus load
    • Xiao Z, Batista L, Dee S, Halbur P, Murtaugh MP. 2004. The level of virus-specific T-cell and macrophage recruitment in porcine reproductive and respiratory syndrome virus infection in pigs is independent of virus load. J. Virol. 78:5923-33
    • (2004) J. Virol. , vol.78 , pp. 5923-5933
    • Xiao, Z.1    Batista, L.2    Dee, S.3    Halbur, P.4    Murtaugh, M.P.5
  • 78
    • 84872765732 scopus 로고    scopus 로고
    • Lymphocyte activation as cytokine gene expression and secretion is related to the porcine reproductive and respiratory syndrome virus(PRRSV) isolate after in vitro homologous and heterologous recall of peripheral blood mononuclear cells (PBMC) from pigs vaccinated and exposed to natural infection
    • Ferrari L, Martelli P, Saleri R, De Angelis E, Cavalli V, et al. 2013. Lymphocyte activation as cytokine gene expression and secretion is related to the porcine reproductive and respiratory syndrome virus(PRRSV) isolate after in vitro homologous and heterologous recall of peripheral blood mononuclear cells (PBMC) from pigs vaccinated and exposed to natural infection. Vet. Immunol. Immunopathol. 151:193-206
    • (2013) Vet. Immunol. Immunopathol. , vol.151 , pp. 193-206
    • Ferrari, L.1    Martelli, P.2    Saleri, R.3    De Angelis, E.4    Cavalli, V.5
  • 80
    • 0036453622 scopus 로고    scopus 로고
    • CytokinemRNAprofiles in bronchoalveolar cells of piglets experimentally infected in utero with porcine reproductive and respiratory syndrome virus: Association of sustained expression of IFN-and IL-10 after viral clearance
    • Johnsen CK, Botner A, Kamstrup S,Lind P,Nielsen J. 2002. CytokinemRNAprofiles in bronchoalveolar cells of piglets experimentally infected in utero with porcine reproductive and respiratory syndrome virus: association of sustained expression of IFN-and IL-10 after viral clearance. Viral. Immunol. 15:549-56
    • (2002) Viral. Immunol. , vol.15 , pp. 549-556
    • Johnsen, C.K.1    Botner, A.2    Kamstrup, S.3    Lind, P.4    Nielsen, J.5
  • 81
    • 21444433341 scopus 로고    scopus 로고
    • Immune responses of pigs after experimental infection with a European strain of Porcine reproductive and respiratory syndrome virus
    • Dáz I, Darwich L, Pappaterra G, Pujols J,Mateu E. 2005. Immune responses of pigs after experimental infection with a European strain of Porcine reproductive and respiratory syndrome virus. J. Gen. Virol. 86:1943-51
    • (2005) J. Gen. Virol. , vol.86 , pp. 1943-1951
    • Dáz, I.1    Darwich, L.2    Pappaterra, G.3    Pujols, J.4    Mateu, E.5
  • 82
    • 0037316360 scopus 로고    scopus 로고
    • Upregulation of IL-10 gene expression in porcine peripheral blood mononuclear cells by porcine reproductive and respiratory syndrome virus
    • Suradhat S, Thanawongnuwech R, Poovorawan Y. 2003. Upregulation of IL-10 gene expression in porcine peripheral blood mononuclear cells by porcine reproductive and respiratory syndrome virus. J. Gen. Virol. 84:453-59
    • (2003) J. Gen. Virol. , vol.84 , pp. 453-459
    • Suradhat, S.1    Thanawongnuwech, R.2    Poovorawan, Y.3
  • 83
    • 84861155857 scopus 로고    scopus 로고
    • Role of porcine reproductive and respiratory syndrome virus nucleocapsid protein in induction of interleukin-10 and regulatory T-lymphocytes (Treg)
    • Wongyanin P, Buranapraditkul S, Yoo D, Thanawongnuwech R, Roth JA, Suradhat S. 2012. Role of porcine reproductive and respiratory syndrome virus nucleocapsid protein in induction of interleukin-10 and regulatory T-lymphocytes (Treg). J. Gen. Virol. 93:1236-46
    • (2012) J. Gen. Virol. , vol.93 , pp. 1236-1246
    • Wongyanin, P.1    Buranapraditkul, S.2    Yoo, D.3    Thanawongnuwech, R.4    Roth, J.A.5    Suradhat, S.6
  • 84
    • 84861553674 scopus 로고    scopus 로고
    • Regulatory T cells in arterivirus and coronavirus infections: Do they protect against disease or enhance it?
    • Cecere TE, Todd SM, LeRoith T. 2012. Regulatory T cells in arterivirus and coronavirus infections: Do they protect against disease or enhance it? Viruses 4:833-46
    • (2012) Viruses , vol.4 , pp. 833-846
    • Cecere, T.E.1    Todd, S.M.2    LeRoith, T.3
  • 86
    • 84861811537 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus induces CD4+CD8+CD25+Foxp3+ regulatory T cells (Tregs)
    • Silva-Campa E, Mata-Haro V, Mateu E, Hernández J. 2012. Porcine reproductive and respiratory syndrome virus induces CD4+CD8+CD25+Foxp3+ regulatory T cells (Tregs). Virology 430:73-80
    • (2012) Virology , vol.430 , pp. 73-80
    • Silva-Campa, E.1    Mata-Haro, V.2    Mateu, E.3    Hernández, J.4
  • 88
    • 84891525319 scopus 로고    scopus 로고
    • Comparative analysis of apoptotic changes in peripheral immune organs and lungs following experimental infection of piglets with highly pathogenic and classical porcine reproductive and respiratory syndrome virus
    • Wang G, He Y, Tu Y, Liu Y, Zhou EM, et al. 2014. Comparative analysis of apoptotic changes in peripheral immune organs and lungs following experimental infection of piglets with highly pathogenic and classical porcine reproductive and respiratory syndrome virus. Virol. J. 11:2
    • (2014) Virol. J. , vol.11 , pp. 2
    • Wang, G.1    He, Y.2    Tu, Y.3    Liu, Y.4    Zhou, E.M.5
  • 89
    • 78649332579 scopus 로고    scopus 로고
    • Genetic control of porcine reproductive and respiratory syndrome virus responses
    • Lunney JK, Chen H. 2010. Genetic control of porcine reproductive and respiratory syndrome virus responses. Virus Res. 154:161-69
    • (2010) Virus Res. , vol.154 , pp. 161-169
    • Lunney, J.K.1    Chen, H.2
  • 90
    • 84860235854 scopus 로고    scopus 로고
    • Interplay between interferon-mediated innate immunity and porcine reproductive and respiratory syndrome virus
    • SunY,Han M, Kim C, Calvert JG, YooD. 2012. Interplay between interferon-mediated innate immunity and porcine reproductive and respiratory syndrome virus. Viruses 4:424-46
    • (2012) Viruses , vol.4 , pp. 424-446
    • Sun, Y.1    Han, M.2    Kim, C.3    Calvert, J.G.4    Yoo, D.5
  • 91
    • 84925270998 scopus 로고    scopus 로고
    • Comparative analysis of cytokine transcript profiles within mediastinal lymph node compartments of pigs after infection with porcine reproductive and respiratory syndrome genotype 1 strains differing in pathogenicity
    • Garcá-Nicolás O, Rosales RS, Pallarés FJ, Risco D, Quereda JJ, et al. 2015. Comparative analysis of cytokine transcript profiles within mediastinal lymph node compartments of pigs after infection with porcine reproductive and respiratory syndrome genotype 1 strains differing in pathogenicity. Vet. Res. 46:34
    • (2015) Vet. Res. , vol.46 , pp. 34
    • Garcá-Nicolás, O.1    Rosales, R.S.2    Pallarés, F.J.3    Risco, D.4    Quereda, J.J.5
  • 92
    • 84896087000 scopus 로고    scopus 로고
    • Up-regulation of pro-inflammatory factors by HP-PRRSV infection in microglia: Implications for HP-PRRSV neuropathogenesis
    • Chen X, Quan R, Guo X, Gao L, Shi J, Feng WH. 2014. Up-regulation of pro-inflammatory factors by HP-PRRSV infection in microglia: implications for HP-PRRSV neuropathogenesis. Vet. Microbiol. 170:48-57
    • (2014) Vet. Microbiol. , vol.170 , pp. 48-57
    • Chen, X.1    Quan, R.2    Guo, X.3    Gao, L.4    Shi, J.5    Feng, W.H.6
  • 93
    • 84875685344 scopus 로고    scopus 로고
    • Pig immune response to general stimulus and to porcine reproductive and respiratory syndrome virus infection: A meta-analysis approach
    • Badaoui B, Tuggle CK, Hu Z, Reecy JM, Ait-Ali T, et al. 2013. Pig immune response to general stimulus and to porcine reproductive and respiratory syndrome virus infection: a meta-analysis approach. BMC Genom. 14:220
    • (2013) BMC Genom. , vol.14 , pp. 220
    • Badaoui, B.1    Tuggle, C.K.2    Hu, Z.3    Reecy, J.M.4    Ait-Ali, T.5
  • 94
    • 84873586638 scopus 로고    scopus 로고
    • MiR-125b reduces porcine reproductive and respiratory syndrome virus replication by negatively regulating the NF-B pathway
    • Cao L, Xu Z, Fang L, Zhong Y, Chen Q, et al. 2013. MiR-125b reduces porcine reproductive and respiratory syndrome virus replication by negatively regulating the NF-B pathway. PLOS ONE 8:e55838
    • (2013) PLOS ONE , vol.8 , pp. e55838
    • Cao, L.1    Xu, Z.2    Fang, L.3    Zhong, Y.4    Chen, Q.5
  • 95
    • 84880631380 scopus 로고    scopus 로고
    • MicroRNA 181 suppresses porcine reproductive and respiratory syndrome virus (PRRSV) infection by targeting PRRSV receptor CD163
    • Gao L, Guo XK, Wang L, Zhang Q, Li N, et al. 2013. MicroRNA 181 suppresses porcine reproductive and respiratory syndrome virus (PRRSV) infection by targeting PRRSV receptor CD163. J. Virol. 87:8808-12
    • (2013) J. Virol. , vol.87 , pp. 8808-8812
    • Gao, L.1    Guo, X.K.2    Wang, L.3    Zhang, Q.4    Li, N.5
  • 96
    • 84891637051 scopus 로고    scopus 로고
    • MicroRNA-23 inhibits PRRSV replication by directly targeting PRRSV RNA and possibly by upregulating type i interferons
    • Zhang Q, Guo XK, Gao L, Huang C, Li N, et al. 2014. MicroRNA-23 inhibits PRRSV replication by directly targeting PRRSV RNA and possibly by upregulating type I interferons. Virology 450-51:182-95
    • (2014) Virology 450 , vol.51 , pp. 182-195
    • Zhang, Q.1    Guo, X.K.2    Gao, L.3    Huang, C.4    Li, N.5
  • 97
    • 84925436561 scopus 로고    scopus 로고
    • MicroRNA miR-24-3p promotes porcine reproductive and respiratory syndrome virus replication through suppression of heme oxygenase-1 expression
    • Xiao S,WangX, Ni H, Li N, ZhangA, et al. 2015. MicroRNA miR-24-3p promotes porcine reproductive and respiratory syndrome virus replication through suppression of heme oxygenase-1 expression. J. Virol. 89:4494-503
    • (2015) J. Virol. , vol.89 , pp. 4494-4503
    • Xiao, S.1    Wang, X.2    Ni, H.3    Li, N.4    Zhang, A.5
  • 98
    • 84906939376 scopus 로고    scopus 로고
    • Integrated miRNA and mRNA transcriptomes of porcine alveolar macrophages (PAM cells) identifies strain-specific miRNA molecular signatures associated with H-PRRSV and N-PRRSV infection
    • Cong P, Xiao S, Chen Y, Wang L, Gao J, et al. 2014. Integrated miRNA and mRNA transcriptomes of porcine alveolar macrophages (PAM cells) identifies strain-specific miRNA molecular signatures associated with H-PRRSV and N-PRRSV infection. Mol. Biol. Rep. 41:5863-75
    • (2014) Mol. Biol. Rep. , vol.41 , pp. 5863-5875
    • Cong, P.1    Xiao, S.2    Chen, Y.3    Wang, L.4    Gao, J.5
  • 99
    • 84859738323 scopus 로고    scopus 로고
    • Identifying putative candidate genes and pathways involved in immune responses to porcine reproductive and respiratory syndrome virus (PRRSV) infection
    • Wysocki M, Chen H, Steibel JP, Kuhar D, Petry D, et al. 2012. Identifying putative candidate genes and pathways involved in immune responses to porcine reproductive and respiratory syndrome virus (PRRSV) infection. Anim. Genet. 43:328-32
    • (2012) Anim. Genet. , vol.43 , pp. 328-332
    • Wysocki, M.1    Chen, H.2    Steibel, J.P.3    Kuhar, D.4    Petry, D.5
  • 100
    • 84936772332 scopus 로고    scopus 로고
    • Whole blood microarray analysis of pigs showing extreme phenotypes after a porcine reproductive and respiratory syndrome virus infection
    • Schroyen M, Steibel JP, Koltes JE, Choi I, Eisley C, et al. 2015. Whole blood microarray analysis of pigs showing extreme phenotypes after a porcine reproductive and respiratory syndrome virus infection. BMC Genom. 16:516
    • (2015) BMC Genom. , vol.16 , pp. 516
    • Schroyen, M.1    Steibel, J.P.2    Koltes, J.E.3    Choi, I.4    Eisley, C.5
  • 103
    • 32944456975 scopus 로고    scopus 로고
    • In vitro susceptibility of macrophages to porcine reproductive and respiratory syndrome virus varies between genetically diverse lines of pigs
    • Vincent AL, Thacker BJ, Halbur PG, Rothschild MF, Thacker EL. 2005. In vitro susceptibility of macrophages to porcine reproductive and respiratory syndrome virus varies between genetically diverse lines of pigs. Viral Immunol. 18:506-12
    • (2005) Viral Immunol. , vol.18 , pp. 506-512
    • Vincent, A.L.1    Thacker, B.J.2    Halbur, P.G.3    Rothschild, M.F.4    Thacker, E.L.5
  • 105
    • 84858249024 scopus 로고    scopus 로고
    • Probing genetic control of swine responses to PRRSV infection: Current progress of the PRRS Host Genetics Consortium
    • Lunney JK, Steibel JP, Reecy JM, Fritz E, Rothschild M, et al. 2011. Probing genetic control of swine responses to PRRSV infection: current progress of the PRRS Host Genetics Consortium. BMC Proc. 5(Suppl. 4):S30
    • (2011) BMC Proc. , vol.5 , pp. S30
    • Lunney, J.K.1    Steibel, J.P.2    Reecy, J.M.3    Fritz, E.4    Rothschild, M.5
  • 106
    • 84876071883 scopus 로고    scopus 로고
    • Control of porcine reproductive and respiratory syndrome (PRRS) through genetic improvements in disease resistance and tolerance
    • Rowland RR, Lunney J, Dekkers J. 2012. Control of porcine reproductive and respiratory syndrome (PRRS) through genetic improvements in disease resistance and tolerance. Front. Genet. 3:260
    • (2012) Front. Genet. , vol.3 , pp. 260
    • Rowland, R.R.1    Lunney, J.2    Dekkers, J.3
  • 107
    • 84861895050 scopus 로고    scopus 로고
    • Evidence for a major QTL associated with host response to porcine reproductive and respiratory syndrome virus challenge
    • Boddicker N, Waide EH, Rowland RR, Lunney JK, Garrick DJ, et al. 2012. Evidence for a major QTL associated with host response to porcine reproductive and respiratory syndrome virus challenge. J. Anim. Sci. 90:1733-46
    • (2012) J. Anim. Sci. , vol.90 , pp. 1733-1746
    • Boddicker, N.1    Waide, E.H.2    Rowland, R.R.3    Lunney, J.K.4    Garrick, D.J.5
  • 108
    • 84892436815 scopus 로고    scopus 로고
    • Validation and further characterization of a major quantitative trait locus associated with host response to experimental infection with porcine reproductive and respiratory syndrome virus
    • Boddicker NJ, Garrick DJ, Rowland RR, Lunney JK, Reecy JM, Dekkers JC. 2014. Validation and further characterization of a major quantitative trait locus associated with host response to experimental infection with porcine reproductive and respiratory syndrome virus. Anim. Genet. 45:48-58
    • (2014) Anim. Genet. , vol.45 , pp. 48-58
    • Boddicker, N.J.1    Garrick, D.J.2    Rowland, R.R.3    Lunney, J.K.4    Reecy, J.M.5    Dekkers, J.C.6
  • 109
    • 84897983659 scopus 로고    scopus 로고
    • Genome-wide association and genomic prediction for host response to porcine reproductive and respiratory syndrome virus infection
    • Boddicker NJ, Bjorkquist A, Rowland RR, Lunney JK, Reecy JM, Dekkers JC. 2014. Genome-wide association and genomic prediction for host response to porcine reproductive and respiratory syndrome virus infection. Genet. Sel. Evol. 46:18
    • (2014) Genet. Sel. Evol. , vol.46 , pp. 18
    • Boddicker, N.J.1    Bjorkquist, A.2    Rowland, R.R.3    Lunney, J.K.4    Reecy, J.M.5    Dekkers, J.C.6
  • 110
    • 85019170930 scopus 로고    scopus 로고
    • Identification of a putative quantitative trait nucleotide in guanylate binding protein 5 for host response to PRRS virus infection
    • Koltes JE, Fritz-Waters E, Eisley CJ, Choi I, Bao H, et al. 2015. Identification of a putative quantitative trait nucleotide in guanylate binding protein 5 for host response to PRRS virus infection. BMC Genom. 16:412
    • (2015) BMC Genom. , vol.16 , pp. 412
    • Koltes, J.E.1    Fritz-Waters, E.2    Eisley, C.J.3    Choi, I.4    Bao, H.5
  • 111
    • 57149105712 scopus 로고    scopus 로고
    • Molecular genetics of the swine major histocompatibility complex, the SLA complex
    • Lunney JK, Ho C-S, Wysocki M, Smith DM. 2009. Molecular genetics of the swine major histocompatibility complex, the SLA complex. Dev. Comp. Immunol. 33:362-74
    • (2009) Dev. Comp. Immunol. , vol.33 , pp. 362-374
    • Lunney, J.K.1    Ho, C.-S.2    Wysocki, M.3    Smith, D.M.4
  • 113
    • 0030162005 scopus 로고    scopus 로고
    • Exposure of gilts in early gestation to porcine reproductive and respiratory syndrome virus
    • Prieto C, Sánchez R, Martń-Rillo S, Suárez P, Simarro I, et al. 1996. Exposure of gilts in early gestation to porcine reproductive and respiratory syndrome virus. Vet. Rec. 138:536-39
    • (1996) Vet. Rec. , vol.138 , pp. 536-539
    • Prieto, C.1    Sánchez, R.2    Martń-Rillo, S.3    Suárez, P.4    Simarro, I.5
  • 114
    • 18344405133 scopus 로고    scopus 로고
    • Transplacental infection following exposure of gilts to porcine reproductive and respiratory syndrome virus at the onset of gestation
    • Prieto C, Suárez P, Simarro I, Garcá C, Fernández A, Castro JM. 1997. Transplacental infection following exposure of gilts to porcine reproductive and respiratory syndrome virus at the onset of gestation. Vet. Microbiol. 57:301-11
    • (1997) Vet. Microbiol. , vol.57 , pp. 301-311
    • Prieto, C.1    Suárez, P.2    Simarro, I.3    Garcá, C.4    Fernández, A.5    Castro, J.M.6
  • 115
  • 116
    • 0032520620 scopus 로고    scopus 로고
    • Experimental inoculation of swine at various stages of gestation with a Danish isolate of porcine reproductive and respiratory syndrome virus (PRRSV)
    • Kranker S,Nielsen J, Bille-Hansen V, Botner A. 1998. Experimental inoculation of swine at various stages of gestation with a Danish isolate of porcine reproductive and respiratory syndrome virus (PRRSV). Vet. Microbiol. 61:21-31
    • (1998) Vet. Microbiol. , vol.61 , pp. 21-31
    • Kranker, S.1    Nielsen, J.2    Bille-Hansen, V.3    Botner, A.4
  • 117
    • 84930799080 scopus 로고    scopus 로고
    • Pathogenicity of three type 2 porcine reproductive and respiratory syndrome virus strains in experimentally inoculated pregnant gilts
    • Ladinig A, Detmer SE, Clarke K, Ashley C, Rowland RR, et al. 2015. Pathogenicity of three type 2 porcine reproductive and respiratory syndrome virus strains in experimentally inoculated pregnant gilts. Virus Res. 203:24-35
    • (2015) Virus Res. , vol.203 , pp. 24-35
    • Ladinig, A.1    Detmer, S.E.2    Clarke, K.3    Ashley, C.4    Rowland, R.R.5
  • 118
    • 0030098954 scopus 로고    scopus 로고
    • Pathogenesis of plaque variants of porcine reproductive and respiratory syndrome virus in pregnant sows
    • Park BK, Yoon IJ, JooHS. 1996. Pathogenesis of plaque variants of porcine reproductive and respiratory syndrome virus in pregnant sows. Am. J. Vet. Res. 57:320-23
    • (1996) Am. J. Vet. Res. , vol.57 , pp. 320-323
    • Park, B.K.1    Yoon, I.J.2    Joo, H.S.3
  • 119
    • 0028522501 scopus 로고
    • Temporal characterization of transplacental infection of porcine fetuses with porcine reproductive and respiratory syndrome virus
    • Mengeling WL, Lager KM, Vorwald AC. 1994. Temporal characterization of transplacental infection of porcine fetuses with porcine reproductive and respiratory syndrome virus. Am. J. Vet. Res. 55:1391-98
    • (1994) Am. J. Vet. Res. , vol.55 , pp. 1391-1398
    • Mengeling, W.L.1    Lager, K.M.2    Vorwald, A.C.3
  • 120
    • 0026195016 scopus 로고
    • Experimental reproduction of porcine epidemic abortion and respiratory syndrome (mystery swine disease) by infection with Lelystad virus: Koch's postulates fulfilled
    • Terpstra C, Wensvoort G, Pol JMA. 1991. Experimental reproduction of porcine epidemic abortion and respiratory syndrome (mystery swine disease) by infection with Lelystad virus: Koch's postulates fulfilled. Vet. Q. 13:131-36
    • (1991) Vet. Q. , vol.13 , pp. 131-136
    • Terpstra, C.1    Wensvoort, G.2    Pol, J.M.A.3
  • 121
    • 0034330602 scopus 로고    scopus 로고
    • Comparison of virus isolation, reverse transcription-polymerase chain reaction, immunohistochemistry, and in situ hybridization for the detection of porcine reproductive and respiratory syndrome virus from naturally aborted fetuses and stillborn piglets
    • Cheon DS, Chae C. 2000. Comparison of virus isolation, reverse transcription-polymerase chain reaction, immunohistochemistry, and in situ hybridization for the detection of porcine reproductive and respiratory syndrome virus from naturally aborted fetuses and stillborn piglets. J. Vet. Diagn. Investig. 12:582-87
    • (2000) J. Vet. Diagn. Investig. , vol.12 , pp. 582-587
    • Cheon, D.S.1    Chae, C.2
  • 122
    • 84938897145 scopus 로고    scopus 로고
    • Changes in leukocyte subsets of pregnant gilts experimentally infected with porcine reproductive and respiratory syndrome virus and relationships with viral load and fetal outcome
    • Ladinig A, GernerW, Saalm Üller A, Lunney JK, Ashley C, Harding JCS. 2014a. Changes in leukocyte subsets of pregnant gilts experimentally infected with porcine reproductive and respiratory syndrome virus and relationships with viral load and fetal outcome. Vet. Res. 45:128
    • (2014) Vet. Res. , vol.45 , pp. 128
    • Ladinig, A.1    Gerner, W.2    Saalm Üller, A.3    Lunney, J.K.4    Ashley, C.5    Harding, J.C.S.6
  • 123
    • 18544374561 scopus 로고    scopus 로고
    • Correlation of cell-mediated immunity against porcine reproductive and respiratory syndrome virus with protection against reproductive failure in sows during outbreaks of porcine reproductive and respiratory syndrome in commercial herds
    • Lowe JE, Husmann R, Firkins LD, Zuckermann FA, Goldberg TL, 2005. Correlation of cell-mediated immunity against porcine reproductive and respiratory syndrome virus with protection against reproductive failure in sows during outbreaks of porcine reproductive and respiratory syndrome in commercial herds. J. Am. Vet. Med. Assoc. 226:1707-11
    • (2005) J. Am. Vet. Med. Assoc. , vol.226 , pp. 1707-1711
    • Lowe, J.E.1    Husmann, R.2    Firkins, L.D.3    Zuckermann, F.A.4    Goldberg, T.L.5
  • 124
    • 84938897145 scopus 로고    scopus 로고
    • Cytokine profiles in pregnant gilts experimentally infected with porcine reproductive and respiratory syndrome virus and relationships with viral load and fetal outcome
    • Ladinig A, Lunney JK, Souza C, Ashley C, Plastow G, Harding J. 2014b. Cytokine profiles in pregnant gilts experimentally infected with porcine reproductive and respiratory syndrome virus and relationships with viral load and fetal outcome. Vet. Res. 45:113
    • (2014) Vet. Res. , vol.45 , pp. 113
    • Ladinig, A.1    Lunney, J.K.2    Souza, C.3    Ashley, C.4    Plastow, G.5    Harding, J.6
  • 125
    • 78649270060 scopus 로고    scopus 로고
    • The interaction between PRRSV and the late gestation pig fetus
    • Rowland RR. 2010. The interaction between PRRSV and the late gestation pig fetus. Virus Res. 154:114-22
    • (2010) Virus Res. , vol.154 , pp. 114-122
    • Rowland, R.R.1
  • 126
    • 84904963064 scopus 로고    scopus 로고
    • Genetic analysis of reproductive traits and antibody response in a PRRS outbreak herd
    • Serao NV, Matika O, Kemp RA, Harding JC, Bishop SC, et al. 2014. Genetic analysis of reproductive traits and antibody response in a PRRS outbreak herd. J. Anim. Sci. 92:2905-21
    • (2014) J. Anim. Sci. , vol.92 , pp. 2905-2921
    • Serao, N.V.1    Matika, O.2    Kemp, R.A.3    Harding, J.C.4    Bishop, S.C.5
  • 127
    • 84942246939 scopus 로고    scopus 로고
    • Maternal and fetal predictors of fetal viral load and death in third trimester, type 2 porcine reproductive and respiratory syndrome virus infected pregnant gilts
    • Ladinig A, Ashley C, Detmer SE, Wilkinson JM, Lunney JK, et al. 2015. Maternal and fetal predictors of fetal viral load and death in third trimester, type 2 porcine reproductive and respiratory syndrome virus infected pregnant gilts. Vet. Res. 46:107
    • (2015) Vet. Res. , vol.46 , pp. 107
    • Ladinig, A.1    Ashley, C.2    Detmer, S.E.3    Wilkinson, J.M.4    Lunney, J.K.5
  • 128
    • 84884996550 scopus 로고    scopus 로고
    • Pathogenesis and prevention of placental and transplacental porcine reproductive and respiratory syndrome virus infection
    • Karniychuk UU, Nauwynck HJ. 2013. Pathogenesis and prevention of placental and transplacental porcine reproductive and respiratory syndrome virus infection. Vet. Res. 44(1):95
    • (2013) Vet. Res. , vol.44 , Issue.1 , pp. 95
    • Karniychuk, U.U.1    Nauwynck, H.J.2
  • 129
    • 79959349023 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus (PRRSV) causes apoptosis during its replication in fetal implantation sites
    • Karniychuk UU, Saha D, Geldhof M, Vanhee M, Cornillie P, et al. 2011. Porcine reproductive and respiratory syndrome virus (PRRSV) causes apoptosis during its replication in fetal implantation sites. Microb. Pathol. 51:194-202
    • (2011) Microb. Pathol. , vol.51 , pp. 194-202
    • Karniychuk, U.U.1    Saha, D.2    Geldhof, M.3    Vanhee, M.4    Cornillie, P.5
  • 130
    • 84866164620 scopus 로고    scopus 로고
    • Impact of a novel inactivated PRRS virus vaccine on virus replication and virus-induced pathology in fetal implantation sites and fetuses upon challenge
    • Karniychuk UU, Saha D, Vanhee M, Geldhof M, Cornillie P, et al. 2012. Impact of a novel inactivated PRRS virus vaccine on virus replication and virus-induced pathology in fetal implantation sites and fetuses upon challenge. Theriogenology 78:1527-37
    • (2012) Theriogenology , vol.78 , pp. 1527-1537
    • Karniychuk, U.U.1    Saha, D.2    Vanhee, M.3    Geldhof, M.4    Cornillie, P.5
  • 131
    • 65649104079 scopus 로고    scopus 로고
    • Quantitative changes of sialoadhesin and CD163 positive macrophages in the implantation sites and organs of porcine embryos/fetuses during gestation
    • Karniychuk UU, Nauwynck HJ. 2009. Quantitative changes of sialoadhesin and CD163 positive macrophages in the implantation sites and organs of porcine embryos/fetuses during gestation. Placenta 30:497-500
    • (2009) Placenta , vol.30 , pp. 497-500
    • Karniychuk, U.U.1    Nauwynck, H.J.2
  • 132
    • 84881367695 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus infection is associated with an increased number of Sn-positive and CD8-positive cells in the maternal-fetal interface
    • Karniychuk UU, De Spiegelaere W, Nauwynck HJ. 2013. Porcine reproductive and respiratory syndrome virus infection is associated with an increased number of Sn-positive and CD8-positive cells in the maternal-fetal interface. Virus Res. 176:285-91
    • (2013) Virus Res. , vol.176 , pp. 285-291
    • Karniychuk, U.U.1    De Spiegelaere, W.2    Nauwynck, H.J.3
  • 133
    • 57749169521 scopus 로고    scopus 로고
    • Human uterine NK cells interact with uterinemacrophages viaNKG2D upon stimulation with PAMPs
    • Basu S, ErikssonM, Pioli PA, Conejo-Garcia J, Mselle TF, et al. 2009. Human uterine NK cells interact with uterinemacrophages viaNKG2D upon stimulation with PAMPs. Am. J. Reprod. Immunol. 61:52-61
    • (2009) Am. J. Reprod. Immunol. , vol.61 , pp. 52-61
    • Basu, S.1    Eriksson, M.2    Pioli, P.A.3    Conejo-Garcia, J.4    Mselle, T.F.5
  • 134
    • 33750695267 scopus 로고    scopus 로고
    • Uterine natural killer cells: A specialized differentiation regulated by ovarian hormones
    • Croy BA, van den Heuvel MJ, Borzychowski AM, Tayade C. 2006. Uterine natural killer cells: a specialized differentiation regulated by ovarian hormones. Immunol. Rev. 214:161-85
    • (2006) Immunol. Rev. , vol.214 , pp. 161-185
    • Croy, B.A.1    Van Den Heuvel, M.J.2    Borzychowski, A.M.3    Tayade, C.4
  • 135
    • 40949122447 scopus 로고    scopus 로고
    • Superficial implantation in pigs is associated with decreased numbers and redistribution of endometrial NK-cell populations
    • Dimova T, Mihaylova A, Spassova P, Georgieva R. 2008. Superficial implantation in pigs is associated with decreased numbers and redistribution of endometrial NK-cell populations. Am. J. Reprod. Immunol. 59:359-69
    • (2008) Am. J. Reprod. Immunol. , vol.59 , pp. 359-369
    • Dimova, T.1    Mihaylova, A.2    Spassova, P.3    Georgieva, R.4
  • 136
    • 0036199897 scopus 로고    scopus 로고
    • Evaluation of natural killer cell recruitment to embryonic attachment sites during early porcine pregnancy
    • Engelhardt H, Croy BA, King GJ, 2002. Evaluation of natural killer cell recruitment to embryonic attachment sites during early porcine pregnancy. Biol. Reprod. 66:1185-92
    • (2002) Biol. Reprod. , vol.66 , pp. 1185-1192
    • Engelhardt, H.1    Croy, B.A.2    King, G.J.3
  • 137
    • 0034942917 scopus 로고    scopus 로고
    • Distribution of porcine reproductive and respiratory syndrome virus in stillborn and liveborn piglets from experimentally infected sows
    • Cheon DS, Chae C. 2001. Distribution of porcine reproductive and respiratory syndrome virus in stillborn and liveborn piglets from experimentally infected sows. J. Comp. Pathol. 124:231-37
    • (2001) J. Comp. Pathol. , vol.124 , pp. 231-237
    • Cheon, D.S.1    Chae, C.2
  • 138
    • 84876809134 scopus 로고    scopus 로고
    • Pathogenesis of Korean type 1 (European genotype) porcine reproductive and respiratory syndrome virus in experimentally infected pregnant gilts
    • Han K, Seo HW,Oh Y, Kang I, Park C, et al. 2013. Pathogenesis of Korean type 1 (European genotype) porcine reproductive and respiratory syndrome virus in experimentally infected pregnant gilts. J. Comp. Pathol. 148:396-404
    • (2013) J. Comp. Pathol. , vol.148 , pp. 396-404
    • Han, K.1    Seo, H.W.2    Oh, Y.3    Kang, I.4    Park, C.5
  • 139
    • 0029680582 scopus 로고    scopus 로고
    • Fetal microscopic lesions in porcine reproductive and respiratory syndrome virus-induced abortion
    • Rossow KD, Laube KL, Goyal SM, Collins JE. 1996. Fetal microscopic lesions in porcine reproductive and respiratory syndrome virus-induced abortion. Vet. Pathol. 33:95-99
    • (1996) Vet. Pathol. , vol.33 , pp. 95-99
    • Rossow, K.D.1    Laube, K.L.2    Goyal, S.M.3    Collins, J.E.4
  • 140
    • 84883305596 scopus 로고    scopus 로고
    • Replication characteristics of porcine reproductive and respiratory syndrome virus (PRRSV) European subtype 1 (Lelystad) and subtype 3 (Lena) strains in nasal mucosa and cells of the monocytic lineage: Indications for the use of new receptors of PRRSV (Lena)
    • Frydas IS, Verbeeck M, Cao J, Nauwynck HJ. 2013. Replication characteristics of porcine reproductive and respiratory syndrome virus (PRRSV) European subtype 1 (Lelystad) and subtype 3 (Lena) strains in nasal mucosa and cells of the monocytic lineage: indications for the use of new receptors of PRRSV (Lena). Vet. Res. 44(1):73
    • (2013) Vet. Res. , vol.44 , Issue.1 , pp. 73
    • Frydas, I.S.1    Verbeeck, M.2    Cao, J.3    Nauwynck, H.J.4
  • 141
    • 33646596337 scopus 로고    scopus 로고
    • Development of the neonatal B and T cell repertoire in swine: Implications for comparative and veterinary immunology
    • Butler JE, Sinkora M, Wertz N, Holtmeier W, Lemke CD. 2006. Development of the neonatal B and T cell repertoire in swine: implications for comparative and veterinary immunology. Vet. Res. 37:417-41
    • (2006) Vet. Res. , vol.37 , pp. 417-441
    • Butler, J.E.1    Sinkora, M.2    Wertz, N.3    Holtmeier, W.4    Lemke, C.D.5
  • 142
    • 84905977561 scopus 로고    scopus 로고
    • Identification of apoptotic cells in the thymus of piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus
    • Li Y, Wang G, Liu Y, Tu Y, He Y, et al. 2014. Identification of apoptotic cells in the thymus of piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus. Virus Res. 189:29-33
    • (2014) Virus Res. , vol.189 , pp. 29-33
    • Li, Y.1    Wang, G.2    Liu, Y.3    Tu, Y.4    He, Y.5
  • 143
    • 0041408558 scopus 로고    scopus 로고
    • In utero infection with porcine reproductive and respiratory syndrome virus modulates leukocyte subpopulations in peripheral blood and bronchoalveolar fluid of surviving piglets
    • Nielsen J, Botner A, Tingstedt JE, Aasted B, Johnsen CK, et al. 2003. In utero infection with porcine reproductive and respiratory syndrome virus modulates leukocyte subpopulations in peripheral blood and bronchoalveolar fluid of surviving piglets. Vet. Immunol. Immunopathol. 93:135-51
    • (2003) Vet. Immunol. Immunopathol. , vol.93 , pp. 135-151
    • Nielsen, J.1    Botner, A.2    Tingstedt, J.E.3    Aasted, B.4    Johnsen, C.K.5
  • 144
    • 0036842514 scopus 로고    scopus 로고
    • Cytokine profiles in peripheral blood mononuclear cells and lymph node cells from piglets infected in utero with porcine reproductive and respiratory syndrome virus
    • Aasted B, Bach P, Nielsen J, Lind P. 2002. Cytokine profiles in peripheral blood mononuclear cells and lymph node cells from piglets infected in utero with porcine reproductive and respiratory syndrome virus. Clin. Diag. Lab. Immunol. 9:1229-34
    • (2002) Clin. Diag. Lab. Immunol. , vol.9 , pp. 1229-1234
    • Aasted, B.1    Bach, P.2    Nielsen, J.3    Lind, P.4
  • 145
    • 84899675449 scopus 로고    scopus 로고
    • Variation in fetal outcome, viral load and ORF5 sequence mutations in a large scale study of phenotypic responses to late gestation exposure to type 2 porcine reproductive and respiratory syndrome virus
    • Ladinig A, Wilkinson J, Ashley C, Detmer SE, Lunney JK, et al. 2014. Variation in fetal outcome, viral load and ORF5 sequence mutations in a large scale study of phenotypic responses to late gestation exposure to type 2 porcine reproductive and respiratory syndrome virus. PLOS ONE 9:e96104
    • (2014) PLOS ONE , vol.9 , pp. e96104
    • Ladinig, A.1    Wilkinson, J.2    Ashley, C.3    Detmer, S.E.4    Lunney, J.K.5
  • 146
    • 0030180092 scopus 로고    scopus 로고
    • Gross and microscopic lesions in porcine fetuses infected with porcine reproductive and respiratory syndrome virus
    • Lager KM, Halbur PG. 1996. Gross and microscopic lesions in porcine fetuses infected with porcine reproductive and respiratory syndrome virus. J. Vet. Diagn. Investig. 8:275-82
    • (1996) J. Vet. Diagn. Investig. , vol.8 , pp. 275-282
    • Lager, K.M.1    Halbur, P.G.2
  • 147
    • 0025797052 scopus 로고
    • Experimental in utero infection of pig foetuses with porcine parvovirus (PPV)
    • Nielsen J, Ronsholt L, Sorensen KJ. 1991. Experimental in utero infection of pig foetuses with porcine parvovirus (PPV). Vet. Microbiol. 28:1-11
    • (1991) Vet. Microbiol. , vol.28 , pp. 1-11
    • Nielsen, J.1    Ronsholt, L.2    Sorensen, K.J.3
  • 148
    • 1642534299 scopus 로고    scopus 로고
    • Viremia and effect of fetal infection with porcine viruses with special reference to porcine circovirus 2 infection
    • Pensaert MB, Sanchez RE Jr, Ladekjaer-Mikkelsen AS, Allan GM, Nauwynck HJ. 2004. Viremia and effect of fetal infection with porcine viruses with special reference to porcine circovirus 2 infection. Vet. Microbiol. 98:175-83
    • (2004) Vet. Microbiol. , vol.98 , pp. 175-183
    • Pensaert, M.B.1    Sanchez, R.E.2    Ladekjaer-Mikkelsen, A.S.3    Allan, G.M.4    Nauwynck, H.J.5
  • 149
    • 84937639949 scopus 로고    scopus 로고
    • Inactivated and subunit vaccines against porcine reproductive and respiratory syndrome: Current status and future direction
    • Renukaradhya GJ, Meng XJ, Calvert JG, Roof M, Lager KM. 2015. Inactivated and subunit vaccines against porcine reproductive and respiratory syndrome: Current status and future direction. Vaccine 33:3065-72
    • (2015) Vaccine , vol.33 , pp. 3065-3072
    • Renukaradhya, G.J.1    Meng, X.J.2    Calvert, J.G.3    Roof, M.4    Lager, K.M.5
  • 150
    • 84924589851 scopus 로고    scopus 로고
    • Carbopol improves the early cellular immune responses induced by the modified-life vaccine Ingelvac PRRS R- MLV
    • Mair KH, Koinig H, Gerner W, Höhne A, Bretthauer J, et al. 2015. Carbopol improves the early cellular immune responses induced by the modified-life vaccine Ingelvac PRRS R- MLV. Vet. Microbiol. 176:352-57
    • (2015) Vet. Microbiol. , vol.176 , pp. 352-357
    • Mair, K.H.1    Koinig, H.2    Gerner, W.3    Höhne, A.4    Bretthauer, J.5
  • 151
    • 84927919333 scopus 로고    scopus 로고
    • Production and evaluation of virus-like particles displaying immunogenic epitopes of porcine reproductive and respiratory syndrome virus (PRRSV)
    • Murthy AM, Ni Y,Meng X, Zhang C. 2015. Production and evaluation of virus-like particles displaying immunogenic epitopes of porcine reproductive and respiratory syndrome virus (PRRSV). Int. J. Mol. Sci. 16:8382-96
    • (2015) Int. J. Mol. Sci. , vol.16 , pp. 8382-8396
    • Murthy, A.M.1    Ni, Y.2    Meng, X.3    Zhang, C.4
  • 152
    • 84886768394 scopus 로고    scopus 로고
    • Enhancing neutralizing antibody production by an interferon-inducing porcine reproductive and respiratory syndrome virus strain
    • Wang R, Xiao Y, Opriessnig T, Ding Y, Yu Y, et al. 2013. Enhancing neutralizing antibody production by an interferon-inducing porcine reproductive and respiratory syndrome virus strain. Vaccine 31:5537-43
    • (2013) Vaccine , vol.31 , pp. 5537-5543
    • Wang, R.1    Xiao, Y.2    Opriessnig, T.3    Ding, Y.4    Yu, Y.5
  • 153
    • 84952637488 scopus 로고    scopus 로고
    • Live porcine reproductive and respiratory syndrome virus vaccines: Current status and future direction
    • Renukaradhya GJ, Meng XJ, Calvert JG, Roof M, Lager KM. 2015. Live porcine reproductive and respiratory syndrome virus vaccines: Current status and future direction. Vaccine 33:4069-80
    • (2015) Vaccine , vol.33 , pp. 4069-4080
    • Renukaradhya, G.J.1    Meng, X.J.2    Calvert, J.G.3    Roof, M.4    Lager, K.M.5
  • 154
    • 79956299886 scopus 로고    scopus 로고
    • Identification of immunodominant T-cell epitopes inmembrane protein of highly pathogenic porcine reproductive and respiratory syndrome virus
    • Wang YX, Zhou YJ, Li GX, Zhang SR, Jiang YF, et al. 2011. Identification of immunodominant T-cell epitopes inmembrane protein of highly pathogenic porcine reproductive and respiratory syndrome virus. Virus Res. 158:108-15
    • (2011) Virus Res. , vol.158 , pp. 108-115
    • Wang, Y.X.1    Zhou, Y.J.2    Li, G.X.3    Zhang, S.R.4    Jiang, Y.F.5
  • 155
    • 84873724515 scopus 로고    scopus 로고
    • Predicted peptides from non-structural proteins of porcine reproductive and respiratory syndrome virus are able to induce IFN-and IL-10
    • Burgara-Estrella A, Dáz I, Rodrguez-G ómez IM, Essler SE, Hernández J, Mateu E. 2013. Predicted peptides from non-structural proteins of porcine reproductive and respiratory syndrome virus are able to induce IFN-and IL-10. Viruses 5:663-77
    • (2013) Viruses , vol.5 , pp. 663-677
    • Burgara-Estrella, A.1    Dáz, I.2    Rodrguez-Gómez, I.M.3    Essler, S.E.4    Hernández, J.5    Mateu, E.6
  • 156
    • 84897673522 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus vaccines: Current status and strategies to a universal vaccine
    • Hu J, Zhang C. 2014. Porcine reproductive and respiratory syndrome virus vaccines: current status and strategies to a universal vaccine. Transbound. Emerg. Dis. 61:109-20
    • (2014) Transbound. Emerg. Dis. , vol.61 , pp. 109-120
    • Hu, J.1    Zhang, C.2


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