Live porcine reproductive and respiratory syndrome virus vaccines: Current status and future direction

Vaccine

Volumn 33, Issue 33, 2015, Pages 4069-4080

  Renukaradhya, Gourapura J ^a   Meng, Xiang Jin ^b   Calvert, Jay G ^c   Roof, Michael ^d   Lager, Kelly M ^e  

^a OHIO STATE UNIVERSITY   (United States)

^b VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^c ZOETIS   (United States)

^d BOEHRINGER INGELHEIM VETMEDICA INC   (United States)

^e NATIONAL ANIMAL DISEASE CENTER   (United States)

Author keywords

Cross protection, Vectors, Infectious cDNA clones; Immunity; Porcine reproductive and respiratory syndrome virus (PRRSV); PRRSV MLV

Indexed keywords

DIFFERENTIATING INFECTED FROM VACCINATED ANIMAL VACCINE; LIVE VACCINE; MARKER VACCINE; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS VACCINE; RNA VACCINE; UNCLASSIFIED DRUG; VIRUS VECTOR; VIRUS VACCINE;

ADAPTIVE IMMUNITY; CANINE ADENOVIRUS 2; CELLULAR IMMUNITY; CHIMERA; CODON; CROSS PROTECTION; CROSS REACTION; DNA SHUFFLING; DOWN REGULATION; DRUG EFFICACY; DRUG SAFETY; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HUMORAL IMMUNITY; IMMUNE EVASION; IMMUNOREGULATION; INNATE IMMUNITY; MOLECULAR CLONING; MYCOBACTERIUM BOVIS BCG; NONHUMAN; POINT MUTATION; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; PRIORITY JOURNAL; PSEUDORABIES VIRUS; REVERSE GENETICS; REVIEW; RNA IMMUNIZATION; TRANSMISSIBLE GASTROENTERITIS VIRUS; VIRUS ATTENUATION; VIRUS GENOME; VIRUS ISOLATION; VIRUS REPLICATION; VIRUS SHEDDING; VIRUS VIRULENCE; ANIMAL; DRUG DEVELOPMENT; GENETICS; HISTORY; IMMUNOLOGY; PIG; TRENDS;

ANIMALS; DRUG DISCOVERY; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SWINE; VACCINES, ATTENUATED; VIRAL VACCINES;

EID: 84952637488     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2015.06.092     Document Type: Review

References (138)

1. Terpstra C., Wensvoort G., Pol J.M. Experimental reproduction of porcine epidemic abortion and respiratory syndrome (mystery swine disease) by infection with Lelystad virus: Koch's postulates fulfilled. Vet Q 1991, 13:131-136.
2. Benfield D.A., Nelson E., Collins J.E., Harris L., Goyal S.M., Robison D., et al. Characterization of swine infertility and respiratory syndrome (SIRS) virus (isolate ATCC VR-2332). J Vet Diagn Invest 1992, 4:127-133.
3. Collins J.E., Benfield D.A., Christianson W.T., Harris L., Hennings J.C., Shaw D.P., et al. Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs. J Vet Diagn Invest 1992, 4:117-126.
4. Zimmerman J.J., Benfield D., Dee S., Murtaugh M., Stadejek T., Stevenson G.W., et al. Porcine reproductive and respiratory syndrome virus (porcine arterivirus). Diseases of swine 2012, Published by John Wiley & Sons, Inc., Ames, IA, USA. 10th ed.
5. Kim W.I., Lee D.S., Johnson W., Roof M., Cha S.H., Yoon K.J. Effect of genotypic and biotypic differences among PRRS viruses on the serologic assessment of pigs for virus infection. Vet Microbiol 2007, 123:1-14.
6. Mengeling W.L. The porcine reproductive and respiratory syndrome quandary Part II: Vaccines and vaccination strategy. J Swine Health Prod 2005, 15:2-6.
7. Mengeling W.L. The porcine reproductive and respiratory syndrome quandary. Part I: Fact versus speculation. J Swine Health Prod 2005, 13:91-95.
8. Welch S.K., Jolie R., Pearce D.S., Koertje W.D., Fuog E., Shields S.L., et al. Construction and evaluation of genetically engineered replication-defective porcine reproductive and respiratory syndrome virus vaccine candidates. Vet Immunol Immunopathol 2004, 102:277-290.
9. Calvert J.G., Slade D.E., Shields S.L., Jolie R., Mannan R.M., Ankenbauer R.G., et al. CD163 expression confers susceptibility to porcine reproductive and respiratory syndrome viruses. J Virol 2007, 81:7371-7379.
10. Wang X., Wei R., Li Q., Liu H., Huang B., Gao J., et al. PK-15 cells transfected with porcine CD163 by PiggyBac transposon system are susceptible to porcine reproductive and respiratory syndrome virus. J Virol Methods 2013, 193:383-390.
11. Provost C., Jia J.J., Music N., Levesque C., Lebel M.E., del Castillo J.R., et al. Identification of a new cell line permissive to porcine reproductive and respiratory syndrome virus infection and replication which is phenotypically distinct from MARC-145 cell line. Virol J 2012, 9:267.
12. Huang Y.W., Fang Y., Meng X.J. Identification and characterization of a porcine monocytic cell line supporting porcine reproductive and respiratory syndrome virus (PRRSV) replication and progeny virion production by using an improved DNA-launched PRRSV reverse genetics system. Virus Res 2009, 145:1-8.
13. Calzada-Nova G., Husmann R.J., Schnitzlein W.M., Zuckermann F.A. Effect of the host cell line on the vaccine efficacy of an attenuated porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol 2012, 148:116-125.
14. Park C., Seo H.W., Han K., Kang I., Chae C. Evaluation of the efficacy of a new modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine (Fostera PRRS) against heterologous PRRSV challenge. Vet Microbiol 2014, 172:432-442.
15. Li X., Galliher-Beckley A., Pappan L., Trible B., Kerrigan M., Beck A., et al. Comparison of host immune responses to homologous and heterologous type II porcine reproductive and respiratory syndrome virus (PRRSV) challenge in vaccinated and unvaccinated pigs. BioMed Res Int 2014, 2014:416727.
16. Park C., Choi K., Jeong J., Chae C. Cross-protection of a new type 2 porcine reproductive and respiratory syndrome virus (PRRSV) modified live vaccine (Fostera PRRS) against heterologous type 1 PRRSV challenge in growing pigs. Vet Microbiol 2015, 177:87-94.
17. Dwivedi V., Manickam C., Patterson R., Dodson K., Murtaugh M., Torrelles J.B., et al. Cross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvant. Vaccine 2011, 29:4058-4066.
18. Martelli P., Gozio S., Ferrari L., Rosina S., De Angelis E., Quintavalla C., et al. Efficacy of a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in pigs naturally exposed to a heterologous European (Italian cluster) field strain: clinical protection and cell-mediated immunity. Vaccine 2009, 27:3788-3799.
19. Martelli P., Cordioli P., Alborali L.G., Gozio S., De Angelis E., Ferrari L., et al. Protection and immune response in pigs intradermally vaccinated against porcine reproductive and respiratory syndrome (PRRS) and subsequently exposed to a heterologous European (Italian cluster) field strain. Vaccine 2007, 25:3400-3408.
20. Rose N., Renson P., Andraud M., Paboeuf F., Le Potier M.F., Bourry O. Porcine reproductive and respiratory syndrome virus (PRRSv) modified-live vaccine reduces virus transmission in experimental conditions. Vaccine 2015, 33:2493-2499.
21. Cano J.P., Dee S.A., Murtaugh M.P., Pijoan C. Impact of a modified-live porcine reproductive and respiratory syndrome virus vaccine intervention on a population of pigs infected with a heterologous isolate. Vaccine 2007, 25:4382-4391.
22. Ellingson J.S., Wang Y., Layton S., Ciacci-Zanella J., Roof M.B., Faaberg K.S. Vaccine efficacy of porcine reproductive and respiratory syndrome virus chimeras. Vaccine 2010, 28:2679-2686.
23. Linhares D.C., Cano J.P., Wetzell T., Nerem J., Torremorell M., Dee S.A. Effect of modified-live porcine reproductive and respiratory syndrome virus (PRRSv) vaccine on the shedding of wild-type virus from an infected population of growing pigs. Vaccine 2012, 30:407-413.
24. Tian Z.J., An T.Q., Zhou Y.J., Peng J.M., Hu S.P., Wei T.C., et al. An attenuated live vaccine based on highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) protects piglets against HP-PRRS. Vet Microbiol 2009, 138:34-40.
25. Li X., Qiu L., Yang Z., Dang R., Wang X. Emergency vaccination alleviates highly pathogenic porcine reproductive and respiratory syndrome virus infection after contact exposure. BMC Vet Res 2013, 9:26.
26. Leng X., Li Z., Xia M., He Y., Wu H. Evaluation of the efficacy of an attenuated live vaccine against highly pathogenic porcine reproductive and respiratory syndrome virus in young pigs. Clin Vaccine Immunol 2012, 19:1199-1206.
27. Wei Z., Zhang J., Zhuang J., Sun Z., Gao F., Yuan S. Immunization of pigs with a type 2 modified live PRRSV vaccine prevents the development of a deadly long lasting hyperpyrexia in a challenge study with highly pathogenic PRRSV JX143. Vaccine 2013, 31:2062-2066.
28. Okuda Y., Kuroda M., Ono M., Chikata S., Shibata I. Efficacy of vaccination with porcine reproductive and respiratory syndrome virus following challenges with field isolates in Japan. J Vet Med Sci 2008, 70:1017-1025.
29. Zhao Z., Qin Y., Lai Z., Peng L., Cai X., Wang L., et al. Microbial ecology of swine farms and PRRS vaccine vaccination strategies. Vet Microbiol 2012, 155:247-256.
30. Labarque G., Reeth K.V., Nauwynck H., Drexler C., Van Gucht S., Pensaert M. Impact of genetic diversity of European-type porcine reproductive and respiratory syndrome virus strains on vaccine efficacy. Vaccine 2004, 22:4183-4190.
31. Prieto C., Alvarez E., Martinez-Lobo F.J., Simarro I., Castro J.M. Similarity of European porcine reproductive and respiratory syndrome virus strains to vaccine strain is not necessarily predictive of the degree of protective immunity conferred. Vet J 2008, 175:356-363.
32. Renukaradhya G.J., Dwivedi V., Manickam C., Binjawadagi B., Benfield D. Mucosal vaccines to prevent porcine reproductive and respiratory syndrome: a new perspective. Anim Health Res Rev 2012, 13:21-37.
33. Murtaugh M.P., Genzow M. Immunological solutions for treatment and prevention of porcine reproductive and respiratory syndrome (PRRS). Vaccine 2011, 29:8192-8204.
34. Lee C., Calvert J.G., Welch S.K., Yoo D. A DNA-launched reverse genetics system for porcine reproductive and respiratory syndrome virus reveals that homodimerization of the nucleocapsid protein is essential for virus infectivity. Virology 2005, 331:47-62.
35. Shi M., Lam T.T., Hon C.C., Murtaugh M.P., Davies P.R., Hui R.K., et al. Phylogeny-based evolutionary, demographical, and geographical dissection of North American type 2 porcine reproductive and respiratory syndrome viruses. J Virol 2010, 84:8700-8711.
36. Cruz J.L., Zuniga S., Becares M., Sola I., Ceriani J.E., Juanola S., et al. Vectored vaccines to protect against PRRSV. Virus Res 2010, 154:150-160.
37. Cai J., Ma Y., Li J., Yan C., Hu R., Zhang J. Construction and characterization of a recombinant canine adenovirus expressing GP5 and M proteins of porcine reproductive and respiratory syndrome virus. J Vet Med Sci 2010, 72:1035-1040.
38. Zhou J.X., Xue J.D., Yu T., Zhang J.B., Liu Y., Jiang N., et al. Immune responses in pigs induced by recombinant canine adenovirus 2 expressing the glycoprotein 5 of porcine reproductive and respiratory syndrome virus. Vet Res Commun 2010, 34:371-380.
39. Wang X., Li J., Jiang P., Li Y., Zeshan B., Cao J., et al. GM-CSF fused with GP3 and GP5 of porcine reproductive and respiratory syndrome virus increased the immune responses and protective efficacy against virulent PRRSV challenge. Virus Res 2009, 143:24-32.
40. Cao J., Wang X., Du Y., Li Y., Wang X., Jiang P. CD40 ligand expressed in adenovirus can improve the immunogenicity of the GP3 and GP5 of porcine reproductive and respiratory syndrome virus in swine. Vaccine 2010, 28:7514-7522.
41. Jiang Y., Fang L., Xiao S., Zhang H., Pan Y., Luo R., et al. Immunogenicity and protective efficacy of recombinant pseudorabies virus expressing the two major membrane-associated proteins of porcine reproductive and respiratory syndrome virus. Vaccine 2007, 25:547-560.
42. Qiu H.J., Tian Z.J., Tong G.Z., Zhou Y.J., Ni J.Q., Luo Y.Z., et al. Protective immunity induced by a recombinant pseudorabies virus expressing the GP5 of porcine reproductive and respiratory syndrome virus in piglets. Vet Immunol Immunopathol 2005, 106:309-319.
43. Alonso S., Sola I., Teifke J.P., Reimann I., Izeta A., Balasch M., et al. In vitro and in vivo expression of foreign genes by transmissible gastroenteritis coronavirus-derived minigenomes. J Gen Virol 2002, 83:567-579.
44. Lu Z., Zhang J., Huang C.M., Go Y.Y., Faaberg K.S., Rowland R.R., et al. Chimeric viruses containing the N-terminal ectodomains of GP5 and M proteins of porcine reproductive and respiratory syndrome virus do not change the cellular tropism of equine arteritis virus. Virology 2012, 432:99-109.
45. Bastos R.G., Dellagostin O.A., Barletta R.G., Doster A.R., Nelson E., Osorio F.A. Construction and immunogenicity of recombinant Mycobacterium bovis BCG expressing GP5 and M protein of porcine reproductive respiratory syndrome virus. Vaccine 2002, 21:21-29.
46. Henderson L.M. Overview of marker vaccine and differential diagnostic test technology. Biologicals 2005, 33:203-209. (Journal of the International Association of Biological Standardization).
47. Foley P.L., Hill R.E. Regulatory considerations for marker vaccines and diagnostic tests in the U.S. Biologicals 2005, 33:253-256. (Journal of the International Association of Biological Standardization).
48. Yoo D., Welch S.K., Lee C., Calvert J.G. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and their potential as vaccine vectors. Vet Immunol Immunopathol 2004, 102:143-154.
49. Leng X., Li Z., Xia M., Li X., Wang F., Wang W., et al. Mutations in the genome of the highly pathogenic porcine reproductive and respiratory syndrome virus potentially related to attenuation. Vet Microbiol 2012, 157:50-60.
50. Leng X., Li Z.G., Li X.Y., Wang F.X., Zhang X.H., Wu H. [Genetic variation and pathogenicity analysis of highly pathogenic porcine reproductive and respiratory syndrome virus strain TJ in the course of attenuation]. Bing du xue bao=Chinese Journal of Virology/[bian ji, Bing du xue bao bian ji wei yuan hui] 2012, 28:136-142.
51. Fang Y., Christopher-Hennings J., Brown E., Liu H., Chen Z., Lawson S.R., et al. Development of genetic markers in the non-structural protein 2 region of a US type 1 porcine reproductive and respiratory syndrome virus: implications for future recombinant marker vaccine development. J Gen Virol 2008, 89:3086-3096.
52. Kim D.Y., Kaiser T.J., Horlen K., Keith M.L., Taylor L.P., Jolie R., et al. Insertion and deletion in a non-essential region of the nonstructural protein 2 (nsp2) of porcine reproductive and respiratory syndrome (PRRS) virus: effects on virulence and immunogenicity. Virus Genes 2009, 38:118-128.
53. Xu Y.Z., Zhou Y.J., Zhang S.R., Jiang Y.F., Tong W., Yu H., et al. Stable expression of foreign gene in nonessential region of nonstructural protein 2 (nsp2) of porcine reproductive and respiratory syndrome virus: applications for marker vaccine design. Vet Microbiol 2012, 159:1-10.
54. Han J., Liu G., Wang Y., Faaberg K.S. Identification of nonessential regions of the nsp2 replicase protein of porcine reproductive and respiratory syndrome virus strain VR-2332 for replication in cell culture. J Virol 2007, 81:9878-9890.
55. Groot Bramel-Verheije M.H., Rottier P.J., Meulenberg J.J. Expression of a foreign epitope by porcine reproductive and respiratory syndrome virus. Virology 2000, 278:380-389.
56. Pei Y., Hodgins D.C., Wu J., Welch S.K., Calvert J.G., Li G., et al. Porcine reproductive and respiratory syndrome virus as a vector: immunogenicity of green fluorescent protein and porcine circovirus type 2 capsid expressed from dedicated subgenomic RNAs. Virology 2009, 389:91-99.
57. Sang Y., Shi J., Sang W., Rowland R.R., Blecha F. Replication-competent recombinant porcine reproductive and respiratory syndrome (PRRS) viruses expressing indicator proteins and antiviral cytokines. Viruses 2012, 4:102-116.
58. Wang C., Huang B., Kong N., Li Q., Ma Y., Li Z., et al. A novel porcine reproductive and respiratory syndrome virus vector system that stably expresses enhanced green fluorescent protein as a separate transcription unit. Vet Res 2013, 44:104.
59. Fang Y., Faaberg K.S., Rowland R.R., Christopher-Hennings J., Pattnaik A.K., Osorio F., et al. Construction of a full-length cDNA infectious clone of a European-like Type 1 PRRSV isolated in the U.S. Adv Exp Med Biol 2006, 581:605-608.
60. Choi Y.J., Yun S.I., Kang S.Y., Lee Y.M. Identification of 5' and 3' cis-acting elements of the porcine reproductive and respiratory syndrome virus: acquisition of novel 5' AU-rich sequences restored replication of a 5'-proximal 7-nucleotide deletion mutant. J Virol 2006, 80:723-736.
61. Kim D.Y., Calvert J.G., Chang K.O., Horlen K., Kerrigan M., Rowland R.R. Expression and stability of foreign tags inserted into nsp2 of porcine reproductive and respiratory syndrome virus (PRRSV). Virus Res 2007, 128:106-114.
62. Wang L., Zhang K., Lin H., Li W., Wen J., Zhang J., et al. Preparation of North American type II PRRSV infectious clone expressing green fluorescent protein. BioMed Res Int 2014, 2014:368581.
63. Lin T., Li X., Yao H., Wei Z., Tan F., Liu R., et al. Use of reverse genetics to develop a novel marker porcine reproductive and respiratory syndrome virus. Virus Genes 2012, 45:548-555.
64. de Lima M., Kwon B., Ansari I.H., Pattnaik A.K., Flores E.F., Osorio F.A. Development of a porcine reproductive and respiratory syndrome virus differentiable (DIVA) strain through deletion of specific immunodominant epitopes. Vaccine 2008, 26:3594-3600.
65. Tan F., Wei Z., Li Y., Zhang R., Zhuang J., Sun Z., et al. Identification of non-essential regions in nucleocapsid protein of porcine reproductive and respiratory syndrome virus for replication in cell culture. Virus Res 2011, 158:62-71.
66. Chen Z., Zhou X., Lunney J.K., Lawson S., Sun Z., Brown E., et al. Immunodominant epitopes in nsp2 of porcine reproductive and respiratory syndrome virus are dispensable for replication, but play an important role in modulation of the host immune response. J Gen Virol 2010, 91:1047-1057.
67. Ran Z.G., Chen X.Y., Guo X., Ge X.N., Yoon K.J., Yang H.C. Recovery of viable porcine reproductive and respiratory syndrome virus from an infectious clone containing a partial deletion within the Nsp2-encoding region. Arch Virol 2008, 153:899-907.
68. Xu Y.Z., Zhou Y.J., Zhang S.R., Tong W., Li L., Jiang Y.F., et al. Identification of nonessential regions of the nsp2 protein of an attenuated vaccine strain (HuN4-F112) of highly pathogenic porcine reproductive and respiratory syndrome virus for replication in marc-145 cell. Virol J 2012, 9:141.
69. Huang Y.W., Meng X.J. Novel strategies and approaches to develop the next generation of vaccines against porcine reproductive and respiratory syndrome virus (PRRSV). Virus Res 2010, 154:141-149.
70. van Dinten L.C., den Boon J.A., Wassenaar A.L., Spaan W.J., Snijder E.J. An infectious arterivirus cDNA clone: identification of a replicase point mutation that abolishes discontinuous mRNA transcription. Proc Natl Acad Sci USA 1997, 94:991-996.
71. de Vries A.A., Glaser A.L., Raamsman M.J., de Haan C.A., Sarnataro S., Godeke G.J., et al. Genetic manipulation of equine arteritis virus using full-length cDNA clones: separation of overlapping genes and expression of a foreign epitope. Virology 2000, 270:84-97.
72. Balasuriya U.B., Snijder E.J., van Dinten L.C., Heidner H.W., Wilson W.D., Hedges J.F., et al. Equine arteritis virus derived from an infectious cDNA clone is attenuated and genetically stable in infected stallions. Virology 1999, 260:201-208.
73. Snijder E.J., van Tol H., Pedersen K.W., Raamsman M.J., de Vries A.A. Identification of a novel structural protein of arteriviruses. J Virol 1999, 73:6335-6345.
74. van Dinten L.C., Rensen S., Gorbalenya A.E., Snijder E.J. Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and Is essential for virus replication. J Virol 1999, 73:2027-2037.
75. van Marle G., Dobbe J.C., Gultyaev A.P., Luytjes W., Spaan W.J., Snijder E.J. Arterivirus discontinuous mRNA transcription is guided by base pairing between sense and antisense transcription-regulating sequences. Proc Natl Acad Sci USA 1999, 96:12056-12061.
76. van Marle G., van Dinten L.C., Spaan W.J., Luytjes W., Snijder E.J. Characterization of an equine arteritis virus replicase mutant defective in subgenomic mRNA synthesis. J Virol 1999, 73:5274-5281.
77. Firth A.E., Zevenhoven-Dobbe J.C., Wills N.M., Go Y.Y., Balasuriya U.B., Atkins J.F., et al. Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production. J Gen Virol 2011, 92:1097-1106.
78. Meulenberg J.J., Bos-de Ruijter J.N., Wensvoort G., Moormann R.J. An infectious cDNA clone of porcine reproductive and respiratory syndrome virus. Adv Exp Med Biol 1998, 440:199-206.
79. Meulenberg J.J., Bos-de Ruijter J.N., van de Graaf R., Wensvoort G., Moormann R.J. Infectious transcripts from cloned genome-length cDNA of porcine reproductive and respiratory syndrome virus. J Virol 1998, 72:380-387.
80. Schommer S.K., Kleiboeker S.B. Use of a PRRSV infectious clone to evaluate in vitro quasispecies evolution. Adv Exp Med Biol 2006, 581:435-438.
81. Dobbe J.C., van der Meer Y., Spaan W.J., Snijder E.J. Construction of chimeric arteriviruses reveals that the ectodomain of the major glycoprotein is not the main determinant of equine arteritis virus tropism in cell culture. Virology 2001, 288:283-294.
82. Verheije M.H., Welting T.J., Jansen H.T., Rottier P.J., Meulenberg J.J. Chimeric arteriviruses generated by swapping of the M protein ectodomain rule out a role of this domain in viral targeting. Virology 2002, 303:364-373.
83. Verheije M.H., Kroese M.V., van der Linden I.F., de Boer-Luijtze E.A., van Rijn P.A., Pol J.M., et al. Safety and protective efficacy of porcine reproductive and respiratory syndrome recombinant virus vaccines in young pigs. Vaccine 2003, 21:2556-2563.
84. Tian D., Wei Z., Zevenhoven-Dobbe J.C., Liu R., Tong G., Snijder E.J., et al. Arterivirus minor envelope proteins are a major determinant of viral tropism in cell culture. J Virol 2012, 86:3701-3712.
85. Kim W.I., Yoon K.J. Molecular assessment of the role of envelope-associated structural proteins in cross neutralization among different PRRS viruses. Virus Genes 2008, 37:380-391.
86. Kwon B., Ansari I.H., Pattnaik A.K., Osorio F.A. Identification of virulence determinants of porcine reproductive and respiratory syndrome virus through construction of chimeric clones. Virology 2008, 380:371-378.
87. Li X., Zhang J., Lu J., Yu D., Yao H., Yuan S. [Construction and application of chimeric infectious clones of porcine reproductive and respiratory syndrome virus]. Sheng wu gong cheng xue bao 2008, 24:1573-1581.
88. Wang Y., Liang Y., Han J., Burkhart K.M., Vaughn E.M., Roof M.B., et al. Attenuation of porcine reproductive and respiratory syndrome virus strain MN184 using chimeric construction with vaccine sequence. Virology 2008, 371:418-429.
89. Lee J.A., Lee N.H., Lee S.W., Park S.Y., Song C.S., Choi I.S., et al. Development of a chimeric strain of porcine reproductive and respiratory syndrome virus with an infectious clone and a Korean dominant field strain. J Microbiol 2014, 52:345-349.
90. Jeeva S., Lee J.A., Park S.Y., Song C.S., Choi I.S., Lee J.B. Development of porcine respiratory and reproductive syndrome virus replicon vector for foot-and-mouth disease vaccine. Clin Exp Vaccine Res 2014, 3:100-109.
91. Ni Y.Y., Zhao Z., Opriessnig T., Subramaniam S., Zhou L., Cao D., et al. Computer-aided codon-pairs deoptimization of the major envelope GP5 gene attenuates porcine reproductive and respiratory syndrome virus. Virology 2014, 450-451:132-139.
92. Coleman J.R., Papamichail D., Skiena S., Futcher B., Wimmer E., Mueller S. Virus attenuation by genome-scale changes in codon pair bias. Science 2008, 320:1784-1787.
93. Mueller S., Coleman J.R., Papamichail D., Ward C.B., Nimnual A., Futcher B., et al. Live attenuated influenza virus vaccines by computer-aided rational design. Nat Biotechnol 2010, 28:723-726.
94. Ni Y.Y., Opriessnig T., Zhou L., Cao D., Huang Y.W., Halbur P.G., et al. Attenuation of porcine reproductive and respiratory syndrome virus by molecular breeding of virus envelope genes from genetically divergent strains. J Virol 2013, 87:304-313.
95. Zhou L., Ni Y.Y., Pineyro P., Sanford B.J., Cossaboom C.M., Dryman B.A., et al. DNA shuffling of the GP3 genes of porcine reproductive and respiratory syndrome virus (PRRSV) produces a chimeric virus with an improved cross-neutralizing ability against a heterologous PRRSV strain. Virology 2012, 434:96-109.
96. Zhou L., Ni Y.Y., Pineyro P., Cossaboom C.M., Subramaniam S., Sanford B.J., et al. Broadening the heterologous cross-neutralizing antibody inducing ability of porcine reproductive and respiratory syndrome virus by breeding the GP4 or M genes. PLoS ONE 2013, 8:e66645.
97. Meng X.J. Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development. Vet Microbiol 2000, 74:309-329.
98. Murtaugh M.P., Stadejek T., Abrahante J.E., Lam T.T., Leung F.C. The ever-expanding diversity of porcine reproductive and respiratory syndrome virus. Virus Res 2010, 154:18-30.
99. Pei Y., Hodgins D.C., Lee C., Calvert J.G., Welch S.K., Jolie R., et al. Functional mapping of the porcine reproductive and respiratory syndrome virus capsid protein nuclear localization signal and its pathogenic association. Virus Res 2008, 135:107-114.
100. Lee C., Yoo D. The small envelope protein of porcine reproductive and respiratory syndrome virus possesses ion channel protein-like properties. Virology 2006, 355:30-43.
101. Lee C., Yoo D. Cysteine residues of the porcine reproductive and respiratory syndrome virus small envelope protein are non-essential for virus infectivity. J Gen Virol 2005, 86:3091-3096.
102. Lee C., Hodgins D., Calvert J.G., Welch S.K., Jolie R., Yoo D. Mutations within the nuclear localization signal of the porcine reproductive and respiratory syndrome virus nucleocapsid protein attenuate virus replication. Virology 2006, 346:238-250.
103. Lee C., Hodgins D.C., Calvert J.G., Welch S.K., Jolie R., Yoo D. The nuclear localization signal of the PRRS virus nucleocapsid protein viral replication in vitro and antibody response in vivo. Adv Exp Med Biol 2006, 581:145-148.
104. Lawson S.R., Li Y., Patton J.B., Langenhorst R.J., Sun Z., Jiang Z., et al. Interleukin-1beta expression by a recombinant porcine reproductive and respiratory syndrome virus. Virus Res 2012, 163:461-468.
105. Nielsen H.S., Liu G., Nielsen J., Oleksiewicz M.B., Botner A., Storgaard T., et al. Generation of an infectious clone of VR-2332, a highly virulent North American-type isolate of porcine reproductive and respiratory syndrome virus. J Virol 2003, 77:3702-3711.
106. Kim W.I., Kim J.J., Cha S.H., Wu W.H., Cooper V., Evans R., et al. Significance of genetic variation of PRRSV ORF5 in virus neutralization and molecular determinants corresponding to cross neutralization among PRRS viruses. Vet Microbiol 2013, 162:10-22.
107. Kim W.I., Kim J.J., Cha S.H., Yoon K.J. Different biological characteristics of wild-type porcine reproductive and respiratory syndrome viruses and vaccine viruses and identification of the corresponding genetic determinants. J Clin Microbiol 2008, 46:1758-1768.
108. Han J., Wang Y., Faaberg K.S. Complete genome analysis of RFLP 184 isolates of porcine reproductive and respiratory syndrome virus. Virus Res 2006, 122:175-182.
109. Grebennikova T.V., Zaberezhnyi A.D., Musienko M.I., Mengeling W., Lager K., Aliper T.I., et al. [Analysis of genome determinants of virulence and setting-up of a library of full-size genome copies of the attenuated virus strain of the porcine reproductive and respiratory syndrome virus North American type]. Voprosy virusologii 2004, 49:56-63.
110. Kwon B., Ansari I.H., Osorio F.A., Pattnaik A.K. Infectious clone-derived viruses from virulent and vaccine strains of porcine reproductive and respiratory syndrome virus mimic biological properties of their parental viruses in a pregnant sow model. Vaccine 2006, 24:7071-7080.
111. Truong H.M., Lu Z., Kutish G.F., Galeota J., Osorio F.A., Pattnaik A.K. A highly pathogenic porcine reproductive and respiratory syndrome virus generated from an infectious cDNA clone retains the in vivo virulence and transmissibility properties of the parental virus. Virology 2004, 325:308-319.
112. Vu H.L., Kwon B., Yoon K.J., Laegreid W.W., Pattnaik A.K., Osorio F.A. Immune evasion of porcine reproductive and respiratory syndrome virus through glycan shielding involves both glycoprotein 5 as well as glycoprotein 3. J Virol 2011, 85:5555-5564.
113. Lee J.A., Kwon B., Osorio F.A., Pattnaik A.K., Lee N.H., Lee S.W., et al. Protective humoral immune response induced by an inactivated porcine reproductive and respiratory syndrome virus expressing the hypo-glycosylated glycoprotein 5. Vaccine 2014, 32:3617-3622.
114. Ansari I.H., Kwon B., Osorio F.A., Pattnaik A.K. Influence of N-linked glycosylation of porcine reproductive and respiratory syndrome virus GP5 on virus infectivity, antigenicity, and ability to induce neutralizing antibodies. J Virol 2006, 80:3994-4004.
115. Subramaniam S., Sur J.H., Kwon B., Pattnaik A.K., Osorio F.A. A virulent strain of porcine reproductive and respiratory syndrome virus does not up-regulate interleukin-10 levels in vitro or in vivo. Virus Res 2011, 155:415-422.
116. Beura L.K., Subramaniam S., Vu H.L., Kwon B., Pattnaik A.K., Osorio F.A. Identification of amino acid residues important for anti-IFN activity of porcine reproductive and respiratory syndrome virus non-structural protein 1. Virology 2012, 433:431-439.
117. Fang Y., Rowland R.R., Roof M., Lunney J.K., Christopher-Hennings J., Nelson E.A. A full-length cDNA infectious clone of North American type 1 porcine reproductive and respiratory syndrome virus: expression of green fluorescent protein in the Nsp2 region. J Virol 2006, 80:11447-11455.
118. Sun Z., Chen Z., Lawson S.R., Fang Y. The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions. J Virol 2010, 84:7832-7846.
119. Li Y., Zhu L., Lawson S.R., Fang Y. Targeted mutations in a highly conserved motif of the nsp1beta protein impair the interferon antagonizing activity of porcine reproductive and respiratory syndrome virus. J Gen Virol 2013, 94:1972-1983.
120. Ni Y.Y., Huang Y.W., Cao D., Opriessnig T., Meng X.J. Establishment of a DNA-launched infectious clone for a highly pneumovirulent strain of type 2 porcine reproductive and respiratory syndrome virus: identification and in vitro and in vivo characterization of a large spontaneous deletion in the nsp2 region. Virus Res 2011, 160:264-273.
121. Yuan S., Wei Z. Construction of infectious cDNA clones of PRRSV: separation of coding regions for nonstructural and structural proteins. Sci. China, Ser. C Life Sci. 2008, 51:271-279.
122. Yu D., Lv J., Sun Z., Zheng H., Lu J., Yuan S. Reverse genetic manipulation of the overlapping coding regions for structural proteins of the type II porcine reproductive and respiratory syndrome virus. Virology 2009, 383:22-31.
123. Lv J., Zhang J., Sun Z., Liu W., Yuan S. An infectious cDNA clone of a highly pathogenic porcine reproductive and respiratory syndrome virus variant associated with porcine high fever syndrome. J Gen Virol 2008, 89:2075-2079.
124. Guo B., Lager K.M., Schlink S.N., Kehrli M.E., Brockmeier S.L., Miller L.C., et al. Chinese and Vietnamese strains of HP-PRRSV cause different pathogenic outcomes in United States high health swine. Virology 2013, 446:238-250.
125. Guo B., Lager K.M., Henningson J.N., Miller L.C., Schlink S.N., Kappes M.A., et al. Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus. Virology 2013, 435:372-384.
126. Zhou L., Zhang J., Zeng J., Yin S., Li Y., Zheng L., et al. The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence. J Virol 2009, 83:5156-5167.
127. Ran Z.G., Chen X.Y., Yang H.C., Guo X., Gai X.N. [Recovery of an infectious virus from the full-length cDNA of PRRSV BJ-4]. Wei Sheng Wu Xue Bao 2007, 47:423-429.
128. Zhang S., Zhou Y., Jiang Y., Li G., Yan L., Yu H., et al. Generation of an infectious clone of HuN4-F112, an attenuated live vaccine strain of porcine reproductive and respiratory syndrome virus. Virol J 2011, 8:410.
129. Gao F., Yao H., Lu J., Wei Z., Zheng H., Zhuang J., et al. Replacement of the heterologous 5' untranslated region allows preservation of the fully functional activities of type 2 porcine reproductive and respiratory syndrome virus. Virology 2013, 439:1-12.
130. Han J., Rutherford M.S., Faaberg K.S. The porcine reproductive and respiratory syndrome virus nsp2 cysteine protease domain possesses both trans- and cis-cleavage activities. J Virol 2009, 83:9449-9463.
131. Subramaniam S., Beura L.K., Kwon B., Pattnaik A.K., Osorio F.A. Amino acid residues in the non-structural protein 1 of porcine reproductive and respiratory syndrome virus involved in down-regulation of TNF-alpha expression in vitro and attenuation in vivo. Virology 2012, 432:241-249.
132. Sun Z., Li Y., Ransburgh R., Snijder E.J., Fang Y. Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15. J Virol 2012, 86:3839-3850.
133. Fang Y., Treffers E.E., Li Y., Tas A., Sun Z., van der Meer Y., et al. Efficient-2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein. Proc Natl Acad Sci USA 2012, 109:E2920-E2928.
134. Li Y., Treffers E.E., Napthine S., Tas A., Zhu L., Sun Z., et al. Transactivation of programmed ribosomal frameshifting by a viral protein. Proc Natl Acad Sci USA 2014, 111:E2172-E2181.
135. Welch S.K., Calvert J.G. A brief review of CD163 and its role in PRRSV infection. Virus Res 2010, 154:98-103.
136. Jourdan S.S., Osorio F., Hiscox J.A. An interactome map of the nucleocapsid protein from a highly pathogenic North American porcine reproductive and respiratory syndrome virus strain generated using SILAC-based quantitative proteomics. Proteomics 2012, 12:1015-1023.
137. Zheng H., Sun Z., Zhu X.Q., Long J., Lu J., Lv J., et al. Recombinant PRRSV expressing porcine circovirus sequence reveals novel aspect of transcriptional control of porcine arterivirus. Virus Res 2010, 148:8-16.
138. Yu L., Zhou Y., Jiang Y., Tong W., Gao F., Xia T., et al. Construction and identification of a recombinant live attenuated PRRSV expressing porcine GM-CSF. Zhongguo Yufang Shouyi Xuebao 2014, 36:260-264.