Molecular genetics of the swine major histocompatibility complex, the SLA complex

Developmental and Comparative Immunology

Volumn 33, Issue 3, 2009, Pages 362-374

  Lunney, Joan K ^a   Ho, Chak Sum ^b   Wysocki, Michal ^a   Smith, Douglas M ^b  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Class I MHC; Class II MHC; Genetic control of immunity; SLA haplotypes; Swine leukocyte antigen complex; Swine MHC; Transplantation; Vaccination

Indexed keywords

LEUKOCYTE ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLELE; ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CENTROMERE; DNA POLYMORPHISM; GENE CLUSTER; GENE EXPRESSION; GENE FREQUENCY; GENE MAPPING; GENE SEQUENCE; GENE STRUCTURE; GENOME; IMMUNE RESPONSE; IMMUNOREGULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE; TRANSPLANTATION; XENOTRANSPLANTATION;

MAMMALIA; SUIDAE;

EID: 57149105712     PISSN: 0145305X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dci.2008.07.002     Document Type: Article

References (182)

1. Geffrotin C., Popescu C.P., Cribiu E.P., Boscher J., Renard C., Chardon P., et al. Assignment of MHC in swine to chromosome 7 by in situ hybridization and serological typing. Ann Genet 27 (1984) 213-219
2. Rabin M., Fries R., Singer D., and Ruddle F.H. Assignment of the porcine major histocompatibility complex to chromosome 7 by in situ hybridization. Cytogenet Cell Genet 39 (1985) 206-209
3. Smith T.P., Rohrer G.A., Alexander L.J., Troyer D.L., Kirby-Dobbels K.R., Janzen M.A., et al. Directed integration of the physical and genetic linkage maps of swine chromosome 7 reveals that the SLA spans the centromere. Genome Res 5 (1995) 259-271
4. Renard C., Hart E., Sehra H., Beasley H., Coggill P., Howe K., et al. The genomic sequence and analysis of the swine major histocompatibility complex. Genomics 88 (2006) 96-110
5. Renard C., Chardon P., and Vaiman M. The phylogenetic history of the MHC class I gene families in pig, including a fossil gene predating mammalian radiation. J Mol Evol 57 (2003) 420-434
6. Shigenari A., Ando A., Renard C., Chardon P., Shiina T., Kulski J.K., et al. Nucleotide sequencing analysis of the swine 433-kb genomic segment located between the non-classical and classical SLA class I gene clusters. Immunogenetics 55 (2004) 695-705
7. Chardon P., Rogel-Gaillard C., Cattolico L., Duprat S., Vaiman M., and Renard C. Sequence of the swine major histocompatibility complex region containing all non-classical class I genes. Tissue Antigens 57 (2001) 55-65
8. Renard C., Vaiman M., Chiannilkulchai N., Cattolico L., Robert C., and Chardon P. Sequence of the pig major histocompatibility region containing the classical class I genes. Immunogenetics 53 (2001) 490-500
9. Velten F., Rogel-Gaillard C., Renard C., Pontarotti P., Tazi-Ahnini R., Vaiman M., et al. A first map of the porcine major histocompatibility complex class I region. Tissue Antigens 51 (1998) 183-194
10. Warner C.M., Meeker D.L., and Rothschild M.F. Genetic control of immune responsiveness: a review of its use as a tool for selection for disease resistance. J Anim Sci 64 (1987) 394-406
11. Lunney J.K. The swine leukocyte antigen (SLA) complex. Vet Immunol Immunopathol 43 (1994) 19-28
12. Schook L.B., Rutherford M.S., Lee J.-K., Shia Y.-C., Bradshaw M., and Lunney J.K. The swine major histocompatibility complex. In: Schook L.B., and Lamont S.J. (Eds). The major histocompatibility complex of domestic animal species (1996), CRC Press, New York 212-244
13. Lunney J.K., and Butler J.E. Immunogenetics. In: Rothschild M.F., and Ruvinsky A. (Eds). Genetics of the pig (1998), CAB International, Wallingford, UK 163-197
14. Chardon P., Renard C., and Vaiman M. The major histocompatibility complex in swine. Immunol Rev 167 (1999) 179-192
15. Chardon P., Renard C., Rogel-Gaillard C., and Vaiman M. The porcine major histocompatibility complex and related paralogous regions: a review. Genet Sel Evol 32 (2000) 109-128
16. Smith D.M., Lunney J.K., Martens G.W., Ando A., Lee J.H., Ho C.S., et al. Nomenclature for factors of the SLA class-I system, 2004. Tissue Antigens 65 (2005) 136-149
17. Horton R., Wilming L., Rand V., Lovering R.C., Bruford E.A., Khodiyar V.K., et al. Gene map of the extended human MHC. Nat Rev Genet 5 (2004) 889-899
18. Horton R., Gibson R., Coggill P., Miretti M., Allcock R.J., Almeida J., et al. Variation analysis and gene annotation of eight MHC haplotypes: the MHC haplotype project. Immunogenetics 60 (2008) 1-18
19. Smith D.M., Lunney J.K., Ho C.S., Martens G.W., Ando A., Lee J.H., et al. Nomenclature for factors of the swine leukocyte antigen class II system, 2005. Tissue Antigens 66 (2005) 623-639
20. Brule A., Chardon P., Rogel-Gaillard C., Mattheeuws M., and Peelman L.J. Cloning of the G18-C2 porcine MHC class III subregion. Anim Genet 27 Suppl. 2 (1996) 76
21. Peelman L.J., Chardon P., Vaiman M., Mattheeuws M., Van Zeveren A., Van de Weghe A., et al. A detailed physical map of the porcine major histocompatibility complex (MHC) class III region: comparison with human and mouse MHC class III regions. Mamm Genome 7 (1996) 363-367
22. Rogel-Gaillard C., Vaiman M., Renard C., Chardon P., and Yerle M. Localization of the beta 2-microglobulin gene to pig chromosome 1q17. Mamm Genome 8 (1997) 948
23. Kwiatkowski P., Artrip J.H., John R., Edwards N.M., Wang S.F., Michler R.E., et al. Induction of swine major histocompatibility complex class I molecules on porcine endothelium by tumor necrosis factor-alpha reduces lysis by human natural killer cells. Transplantation 67 (1999) 211-218
24. Frels W.I., Bordallo C., Golding H., Rosenberg A., Rudikoff S., and Singer D.S. Expression of a class I MHC transgene: regulation by a tissue-specific negative regulatory DNA sequence element. New Biol 2 (1990) 1024-1033
25. Tennant L.M., Renard C., Chardon P., and Powell P.P. Regulation of porcine classical and nonclassical MHC class I expression. Immunogenetics 59 (2007) 377-389
26. Ivanoska D., Sun D.C., and Lunney J.K. Production of monoclonal antibodies reactive with polymorphic and monomorphic determinants of SLA class I gene products. Immunogenetics 33 (1991) 220-223
27. Ehrlich R., Lifshitz R., Pescovitz M.D., Rudikoff S., and Singer D.S. Tissue-specific expression and structure of a divergent member of a class I MHC gene family. J Immunol 139 (1987) 593-602
28. Crew M.D., Phanavanh B., and Garcia-Borges C.N. Sequence and mRNA expression of nonclassical SLA class I genes SLA-7 and SLA-8. Immunogenetics 56 (2004) 111-114
29. Collins R.W. Human MHC class I chain related (MIC) genes: their biological function and relevance to disease and transplantation. Eur J Immunogenet 31 (2004) 105-114
30. Seliger B., Abken H., and Ferrone S. HLA-G and MIC expression in tumors and their role in anti-tumor immunity. Trends Immunol 24 (2003) 82-87
31. Chamorro S., Revilla C., Alvarez B., López-Fuertes L., Ezquerra A., and Domínguez J. Phenotypic characterization of monocyte subpopulations in the pig. Immunobiology 202 (2000) 82-93
32. Summerfield A., Guzylack-Piriou L., Schaub A., Carrasco C.P., Tâche V., Charley B., et al. Porcine peripheral blood dendritic cells and natural interferon-producing cells. Immunology 110 (2003) 440-449
33. Wilson A.D., Haverson K., Southgate K., Bland P.W., Stokes C.R., and Bailey M. Expression of major histocompatibility complex class II antigens on normal porcine intestinal endothelium. Immunology 88 (1996) 98-103
34. Saalmüller A., Weiland F., and Reddehase M.J. Resting porcine T lymphocytes expressing class II major histocompatibility antigen. Immunobiology 183 (1991) 102-114
35. Saalmüller A., and Maurer S. Major histocompatibility antigen class II expressing resting porcine T lymphocytes are potent antigen-presenting cells in mixed leukocyte culture. Immunobiology 190 (1994) 23-34
36. Pescovitz M.D., Popitz F., Sachs D.H., and Lunney J.K. Expression of Ia antigens on resting porcine T cells: a marker of functional T cells subsets. In: Streilein J.W., et al. (Ed). Advances in gene technology: molecular biology of the immune system (1985), ICSU Press, FL 271-272
37. Dillender M.J., and Lunney J.K. Characteristics of T lymphocyte cell lines established from NIH minipigs challenge inoculated with Trichinella spiralis. Vet Immunol Immunopathol 35 (1992) 301-319
38. Takamatsu H.H., Denyer M.S., and Wileman T.E. A subpopulation of circulating porcine γδ T cells can act as professional antigen presenting cells. Vet Immunol Immunopathol 87 (2002) 223-224
39. Satz M.L., Wang L.C., Singer D.S., and Rudikoff S. Structure and expression of two porcine genomic clones encoding class I MHC antigens. J Immunol 135 (1985) 2167-2175
40. Hirsch F., Sachs D.H., Gustafsson K., Pratt K., Germana S., and LeGuern C. Class II genes of miniature swine. III. Characterization of an expressed pig class II gene homologous to HLA-DQA. Immunogenetics 31 (1990) 52-56
41. Hirsch F., Germana S., Gustafsson K., Pratt K., Sachs D.H., and Leguern C. Structure and expression of class II alpha genes in miniature swine. J Immunol 149 (1992) 841-846
42. Gustafsson K., LeGuern C., Hirsch F., Germana S., Pratt K., and Sachs D.H. Class II genes of miniature swine. IV. Characterization and expression of two allelic class II DQB cDNA clones. J Immunol 145 (1990) 1946-1951
43. Gustafsson K., Germana S., Hirsch F., Pratt K., LeGuern C., and Sachs D.H. Structure of miniature swine class II DRB genes: conservation of hypervariable amino acid residues between distantly related mammalian species. Proc Natl Acad Sci USA 87 (1990) 9798-9802
44. Ellis S.A., Bontrop R.E., Antczak D.F., Ballingall K., Davies C.J., Kaufman J., et al. ISAG/IUIS-VIC comparative MHC nomenclature committee report, 2005. Immunogenetics 57 (2006) 953-958
45. Sullivan J.A., Oettinger H.F., Sachs D.H., and Edge A.S. Analysis of polymorphism in porcine MHC class I genes: alterations in signals recognized by human cytotoxic lymphocytes. J Immunol 159 (1997) 2318-2326
46. Smith D.M., Martens G.W., Ho C.S., and Asbury J.M. DNA sequence based typing of swine leukocyte antigens in Yucatan miniature pigs. Xenotransplantation 12 (2005) 481-488
47. IMGT/HLA sequence database (http://www.ebi.ac.uk/imgt/hla/index.html).
48. Potts W.K., and Slev P.R. Pathogen-based models favoring MHC genetic diversity. Immunol Rev 143 (1995) 181-197
49. Ando A., Kawata H., Murakami T., Shigenari A., Shiina T., Sada M., et al. cDNA cloning and genetic polymorphism of the swine major histocompatibility complex (SLA) class II DMA gene. Anim Genet 32 (2001) 73-77
50. Renard C., Kristensen B., Gautschi C., Hruban V., Fredholm M., and Vaiman M. Joint report of the first international comparison test on swine lymphocyte alloantigens (SLA). Anim Genet 19 (1988) 63-72
51. Sachs D.H., Leight G., Cone J., Schwarz S., Stuart L., and Rosenberg S. Transplantation in miniature swine. I. Fixation of the major histocompatibility complex. Transplantation 22 (1976) 559-567
52. Lunney J.K., Pescovitz M.P., and Sachs D.H. The swine major histocompatibility complex: its structure and function. In: Tumbleson M.E. (Ed). Swine in biomedical research vol. 3 (1986), Plenum Press, New York 1821-1836
53. Tang W.R., Kiyokawa N., Eguchi T., Matsui J., Takenouchi H., Honma D., et al. Development of novel monoclonal antibody 4G8 against swine leukocyte antigen class I alpha chain. Hybrid Hybridomics 23 (2004) 187-191
54. Vaiman M., Chardon P., and Renard C. Genetic organization of the pig SLA complex. Studies on nine recombinants and biochemical and lysostrip analysis. Immunogenetics 9 (1979) 356-361
55. Termijtelen A., and van Rood J.J. Complexity of stimulation in MLC and the influence of matching for HLA-A and -B. Scand J Immunol 14 (1981) 459-466
56. DeWolf W.C., Carroll P.G., Mehta C.R., Martin S.L., and Yunis E.J. The genetics of PLT response. II. HLA-DRw is a major PLT-stimulating determinant. J Immunol 123 (1979) 37-42
57. Thistlethwaite Jr. J.R., Auchincloss Jr. H., Pescovitz M.D., and Sachs D.H. Immunologic characterization of MHC recombinant swine: role of class I and II antigens in in vitro immune responses. J Immunogenet 11 (1984) 9-19
58. Tissot R.G., Beattie C.W., and Amoss Jr. M.S. Inheritance of Sinclair swine cutaneous malignant melanoma. Cancer Res 47 (1987) 5542-5545
59. Hosokawa-Kanai T., Tanioka Y., Tanigawa M., Matsumoto Y., Ueda S., and Onodera T. Differential alloreactivity at SLA-DR and -DQ matching in two-way mixed lymphocyte culture. Vet Immunol Immunopathol 85 (2002) 77-84
60. Ando A., Kawata H., Shigenari A., Anzai T., Ota M., Katsuyama Y., et al. Genetic polymorphism of the swine major histocompatibility complex (SLA) class I genes, SLA-1, -2 and -3. Immunogenetics 55 (2003) 583-593
61. Ho C.-S., Rochelle E.S., Martens G.W., Schook L.B., and Smith D.M. Characterization of swine leukocyte antigen polymorphism by sequence-based and PCR-SSP methods in Meishan pigs. Immunogenetics 58 (2006) 873-882
62. Martens G.W., Lunney J.K., Baker J.E., and Smith D.M. Rapid assignment of swine leukocyte antigen haplotypes in pedigreed herds using a polymerase chain reaction-based assay. Immunogenetics 55 (2003) 395-401
63. Ando A., Ota M., Sada M., Katsuyama Y., Goto R., Shigenari A., et al. Rapid assignment of the swine major histocompatibility complex (SLA) class I and II genotypes in Clawn miniature swine using PCR-SSP and PCR-RFLP methods. Xenotransplantation 12 (2005) 121-126
64. Nunez Y., Ponz F., and Gallego F.J. Microsatellite-based genotyping of the swine lymphocyte alloantigens (SLA) in miniature pigs. Res Vet Sci 77 (2004) 59-62
65. Tanaka M., Ando A., Renard C., Chardon P., Domukai M., Okumura N., et al. Development of dense microsatellite markers in the entire SLA region and evaluation of their polymorphisms in porcine breeds. Immunogenetics 57 (2005) 690-696
66. Ando A., Uenishi H., Kawata H., Tanaka M., Shigenari A., Flori L., et al. Microsatellite diversity and crossover regions within homozygous and heterozygous SLA haplotypes of different pig breeds. Immunogenetics 60 (2008) 399-407
67. Demars J.J., Riquet J.J., Feve K.K., Gautier M.M., Morisson M.M., Demeure O.O., et al. High resolution physical map of porcine chromosome 7 QTL region and comparative mapping of this region among vertebrate genomes. BMC Genom 7 (2006) 13
68. Pennington L.R., Lunney J.K., and Sachs D.H. Transplantation in miniature swine. VIII. Recombination within the major histocompatibility complex of miniature swine. Transplantation 31 (1981) 66-71
69. Edfors-Lilja I., Ellegren H., Wintero A.K., Ruohonen-Lehto M., Fredholm M., Gustafsson U., et al. A large linkage group on pig chromosome 7 including the MHC class I, class II (DQB), and class III (TNFB) genes. Immunogenetics 38 (1993) 363-366
70. Afzali B., Lechler R.I., and Hernandez-Fuentes M.P. Allorecognition and the alloresponse: clinical implications. Tissue Antigens 69 (2007) 545-556
71. Cano P., Klitz W., Mack S.J., Maiers M., Marsh S.G., Noreen H., et al. Common and well-documented HLA alleles: report of the Ad-Hoc committee of the American Society for Histocompatibility and Immunogenetics. Hum Immunol 68 (2007) 392-417
72. Choo S.Y. The HLA system: genetics, immunology, clinical testing and clinical implications. Yonsei Med J 48 (2007) 11-23
73. Smyth L.A., Afzali B., Tsang J., Lombardi G., and Lechler R.I. Intercellular transfer of MHC and immunological molecules: molecular mechanisms and biological significance. Am J Transplant 7 (2007) 1442-1449
74. Trivedi H.L. Immunobiology of rejection and adaptation. Transplant Proc 39 (2007) 647-652
75. Kamani N., et al., Spellman S., Hurley C.K., Barker J.N., Smith F.O., Oudshoorn M. State of the art review: HLA matching and outcome of unrelated donor umbilical cord blood transplants. Biol Blood Marrow Transplant 14 (2008) 1-6
76. Cooper D.K., Gollackner B., and Sachs D.H. Will the pig solve the transplantation backlog?. Annu Rev Med 53 (2002) 133-147
77. Sachs D.H., Sykes M., Robson S.C., and Cooper D.K. Xenotransplantation. Adv Immunol 79 (2001) 129-223
78. Tseng Y.L., Sachs D.H., and Cooper D.K. Porcine hematopoietic progenitor cell transplantation in nonhuman primates: a review of progress. Transplantation 79 (2005) 1-9
79. Vallabhajosyula P., Griesemer A., Yamada K., and Sachs D.H. Vascularized composite islet-kidney transplantation in a miniature swine model. Cell Biochem Biophys 48 2-3 (2007) 201-207
80. Olack B., Manna P., Jaramillo A., Steward N., Swanson C., Kaesberg D., et al. Indirect recognition of porcine swine leukocyte Ag class I molecules expressed on islets by human CD4+ T lymphocytes. J Immunol 165 (2000) 1294-1299
81. Xu X.C., Howard T., and Mohanakumar T. Tissue-specific peptides influence human T cell repertoire to porcine xenoantigens. Transplantation 72 (2001) 1205-1212
82. Roussi J., Samama M., Vaiman M., Nichols T., Pignaud G., Bonneau M., et al. An experimental model for testing von Willebrand factor function: successful SLA-matched crossed bone marrow transplantations between normal and von Willebrand pigs. Exp Hematol 24 (1996) 585-591
83. Aptsiauri N., Cabrera T., Mendez R., Garcia-Lora A., Ruiz-Cabello F., and Garrido F. Role of altered expression of HLA class I molecules in cancer progression. Adv Exp Med Biol 601 (2007) 123-131
84. Gardiner C.M. Killer cell immunoglobulin-like receptors on NK cells: the how, where and why. Int J Immunogenet 35 (2008) 1-8
85. Gomes A.Q., Correia D.V., and Silva-Santos B. Non-classical major histocompatibility complex proteins as determinants of tumour immunosurveillance. EMBO Rep 8 (2007) 1024-1030
86. Urosevic M. HLA-G in the skin-friend or foe?. Semin Cancer Biol 17 (2007) 480-484
87. Urosevic M., and Dummer R. Human leukocyte antigen-G and cancer immunoediting. Cancer Res 68 (2008) 627-630
88. Tissot R.G., Beattie C.W., and Amoss Jr. M.S. The swine leucocyte antigen (SLA) complex and Sinclair swine cutaneous malignant melanoma. Anim Genet 20 (1989) 51-57
89. Tissot R.G., Beattie C.W., Amoss Jr. M.S., Williams J.D., and Schumacher J. Common swine leucocyte antigen (SLA) haplotypes in NIH and Sinclair miniature swine have similar effects on the expression of an inherited melanoma. Anim Genet 24 (1993) 191-193
90. Blangero J., Tissot R.G., Beattie C.W., and Amoss Jr. M.S. Genetic determinants of cutaneous malignant melanoma in Sinclair swine. Br J Cancer 73 (1996) 667-671
91. Geffrotin C., Crechet F., Le Roy P., Le Chalony C., Leplat J.J., Iannuccelli N., et al. Identification of five chromosomal regions involved in predisposition to melanoma by genome-wide scan in the MeLiM swine model. Int J Cancer 110 (2004) 39-50
92. Zhi-Qiang D., Silvia V.N., Gilbert H., Vignoles F., Créchet F., Shimogiri T., et al. Detection of novel quantitative trait loci for cutaneous melanoma by genome-wide scan in the MeLiM swine model. Int J Cancer 120 (2007) 303-320
93. The Wellcome Trust Case Control Consortium. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 39 (2007) 1329-1337
94. The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447 (2007) 661-678
95. Butler J.E., Sinkora M., Wertz N., Holtmeier W., and Lemke C.D. Development of the neonatal B and T cell repertoire in swine: implications for comparative and veterinary immunology. Vet Res 37 (2006) 417-441
96. Rupa P., Hamilton K., Cirinna M., and Wilkie B.N. A neonatal swine model of allergy induced by the major food allergen chicken ovomucoid (Gal d 1). Int Arch Allergy Immunol 146 (2007) 11-18
97. Szebeni J., Alving C.R., Rosivall L., Bünger R., Baranyi L., Bedöcs P., et al. Animal models of complement-mediated hypersensitivity reactions to liposomes and other lipid-based nanoparticles. J Liposome Res 17 (2007) 107-117
98. Lin A., Xu H., and Yan W. Modulation of HLA expression in human cytomegalovirus immune evasion. Cell Mol Immunol 4 (2007) 91-98
99. Neumann-Haefelin C., and Thimme R. Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection. Genes Immun 8 (2007) 181-192
100. Sundberg E.J., Deng L., and Mariuzza R.A. TCR recognition of peptide/MHC class II complexes and superantigens. Semin Immunol 19 (2007) 262-271
101. Lünemann J.D., Kamradt T., Martin R., and Münz C. Epstein-Barr virus: environmental trigger of multiple sclerosis?. J Virol 81 (2007) 6777-6784
102. Singh R., Kaul R., Kaul A., and Khan K. A comparative review of HLA associations with hepatitis B and C viral infections across global populations. World J Gastroenterol 13 (2007) 1770-1787
103. Tibayrenc M. Human genetic diversity and the epidemiology of parasitic and other transmissible diseases. Adv Parasitol 64 (2007) 377-422
104. Kimman T.G., Vandebriel R.J., and Hoebee B. Genetic variation in the response to vaccination. Community Genet 10 (2007) 201-217
105. Ovsyannikova I.G., Johnson K.L., Bergen III H.R., and Poland G.A. Mass spectrometry and peptide-based vaccine development. Clin Pharmacol Ther 82 (2007) 644-652
106. Poland G.A., Ovsyannikova I.G., Jacobson R.M., and Smith D.I. Heterogeneity in vaccine immune response: the role of immunogenetics and the emerging field of vaccinomics. Clin Pharmacol Ther 82 (2007) 653-664
107. Tripathi P., and Agrawal S. Immunobiology of human immunodeficiency virus infection. Indian J Med Microbiol 25 (2007) 311-322
108. Chopera, et al. Transmission of HIV-1 CTL escape variants provides HLA mismatched recipients with a survival advantage. PLoS Pathogens 4 3 (2008) e100033
109. Klenerman P., and McMichael A. AIDS/HIV. Finding footprints among the trees. Science 296 (2007) 1583-1586
110. Lunney J.K., Osborne B.A., Sharrow S.O., Devaux C., Pierres M., and Sachs D.H. Sharing of Ia antigens between species. IV. Interspecies cross reactivity of monoclonal antibodies directed against polymorphic, mouse Ia determinants. J Immunol 130 (1983) 2786-2793
111. Osborne B.A., Lunney J.K., Pennington L.R., Sachs D.H., and Rudikoff S. Two dimensional gel analysis of gene products of miniature swine major histocompatibility complex. J Immunol 131 (1983) 2939-2944
112. Sinkora M., Sinkorova J., and Butler J.E. B cell development and VDJ rearrangement in the fetal pig. Vet Immunol Immunopathol 87 (2002) 341-346
113. Pescovitz M.D., Sachs D.H., Lunney J.K., and Hsu S.M. Localization of class II MHC antigens on porcine renal vascular endothelium. Transplantation 37 (1984) 627-631
114. Seebach J.D., Schneider M.K., Comrack C.A., LeGuern A., Kolb S.A., Knolle P.A., et al. Immortalized bone-marrow derived pig endothelial cells. Xenotransplantation 8 (2001) 48-61
115. Kim D., Kim J.Y., Koh H.S., Lee J.P., Kim Y.T., Kang H.J., et al. Establishment and characterization of endothelial cell lines from the aorta of miniature pig for the study of xenotransplantation. Cell Biol Int 29 (2005) 638-646
116. Carrillo A., Chamorro S., Rodríguez-Gago M., Alvarez B., Molina M.J., Rodríguez-Barbosa J.I., et al. Isolation and characterization of immortalized porcine aortic endothelial cell lines. Vet Immunol Immunopathol 89 (2002) 91-98
117. Pérez C., Moreno S., Summerfield A., Domenech N., Alvarez B., Correa C., et al. Characterisation of porcine bone marrow progenitor cells identified by the anti-c-kit (CD117) monoclonal antibody 2B8/BM. J Immunol Methods 321 (2007) 70-79
118. Wang L., Lu X.F., Lu Y.R., Liu J., Gao K., Zeng Y.Z., et al. Immunogenicity and immune modulation of osteogenic differentiated mesenchymal stem cells from Banna minipig inbred line. Transplant Proc 38 (2006) 2267-2269
119. Guo K.T., SchAfer R., Paul A., Gerber A., Ziemer G., and Wendel H.P. A new technique for the isolation and surface immobilization of mesenchymal stem cells from whole bone marrow using high-specific DNA aptamers. Stem Cells 24 (2006) 2220-2231
120. Chamorro S., Revilla C., Gómez N., Alvarez B., Alonso F., Ezquerra A., et al. In vitro differentiation of porcine blood CD163- and CD163+ monocytes into functional dendritic cells. Immunobiology 209 (2004) 57-65
121. Calvert J.G., Slade D.E., Shields S.L., Jolie R., Mannan R.M., Ankenbauer R.G., et al. CD163 expression confers susceptibility to porcine reproductive and respiratory syndrome viruses. J Virol 81 (2007) 7371-7379
122. Sánchez-Torres C., Gómez-Puertas P., Gómez-del-Moral M., Alonso F., Escribano J.M., Ezquerra A., et al. Expression of porcine CD163 on monocytes/macrophages correlates with permissiveness to African swine fever infection. Arch Virol 148 (2003) 2307-2323
123. Raymond C.R., and Wilkie B.N. Toll-like receptor, MHC II, B7 and cytokine expression by porcine monocytes and monocyte-derived dendritic cells in response to microbial pathogen-associated molecular patterns. Vet Immunol Immunopathol 107 (2005) 235-247
124. Basta S., Carrasco C.P., Knoetig S.M., Rigden R.C., Gerber H., Summerfield A., et al. Porcine alveolar macrophages: poor accessory or effective suppressor cells for T-lymphocytes. Vet Immunol Immunopathol 77 (2000) 177-190
125. Haverson K., Singha S., Stokes C.R., and Bailey M. Professional and non-professional antigen-presenting cells in the porcine small intestine. Immunology 101 4 (2000) 492-500
126. Riffault S., Carrat C., van Reeth K., Pensaert M., and Charley B. Interferon-alpha-producing cells are localized in gut-associated lymphoid tissues in transmissible gastroenteritis virus (TGEV) infected piglets. Vet Res 32 (2001) 71-79
127. Bimczok D., Sowa E.N., Faber-Zuschratter H., Pabst R., and Rothkötter H.J. Site-specific expression of CD11b and SIRPalpha (CD172a) on dendritic cells: implications for their migration patterns in the gut immune system. Eur J Immunol 35 (2005) 1418-1427
128. Bimczok D., Rau H., Wundrack N., Naumann M., Rothkötter H.J., McCullough K., et al. Cholera toxin promotes the generation of semi-mature porcine monocyte-derived dendritic cells that are unable to stimulate T cells. Vet Res 38 (2007) 597-612
129. Mallard B.A., Kennedy B.W., and Wilkie B.N. The effect of swine leukocyte antigen haplotype on birth and weaning weights in miniature pigs and the role of statistical analysis in this estimation. J Anim Sci 69 (1991) 559-564
130. Stear M.J., Bishop S.C., Mallard B.A., and Raadsma H. The sustainability, feasibility and desirability of breeding livestock for disease resistance. Res Vet Sci 71 (2001) 1-7
131. Rothschild M.F. From a sow's ear to a silk purse: real progress in porcine genomics. Cytogenet Genome Res 102 1-4 (2003) 95-99
132. Gibson J.P., and Bishop S.C. Use of molecular markers to enhance resistance of livestock to disease: a global approach. Rev Sci Tech 24 (2005) 343-353
133. Rothschild M.F., Hu Z.L., and Jiang Z. Advances in QTL mapping in pigs. Int J Biol Sci 3 (2007) 192-197
134. Lewis C.R., Ait-Ali T., Clapperton M., Archibald A.L., and Bishop S. Genetic perspectives on host responses to porcine reproductive and respiratory syndrome (PRRS). Viral Immunol 20 (2007) 343-358
135. Lunney J.K. Advances in swine biomedical model genomics. Int J Biol Sci 3 (2007) 179-184
136. Mallard B.A., Wilkie B.N., and Kennedy B.W. Genetic and other effects on antibody and cell mediated immune response in swine leucocyte antigen (SLA)-defined miniature pigs. Anim Genet 20 (1989) 167-178
137. Magnusson U., Wilkie B., Mallard B., Rosendal S., and Kennedy B. Mycoplasma hyorhinis infection of pigs selectively bred for high and low immune response. Vet Immunol Immunopathol 61 (1998) 83-96
138. Wilkie B., and Mallard B. Selection for high immune response: an alternative approach to animal health maintenance?. Vet Immunol Immunopathol 72 (1999) 231-235
139. Edfors-Lilja I., Wattrang E., Andersson L., and Fossum C. Mapping quantitative trait loci for stress induced alterations in porcine leukocyte numbers and functions. Anim Genet 31 (2000) 186-193
140. Bidanel J.P., Milan D., Iannuccelli N., Amigues Y., Boscher M.Y., Bourgeois F., et al. Detection of quantitative trait loci for growth and fatness in pigs. Genet Sel Evol 33 (2001) 289-309
141. Malek M., Dekkers J.C., Lee H.K., Baas T.J., Prusa K., Huff-Lonergan E., et al. A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. II. Meat and muscle composition. Mamm Genome 12 (2001) 637-645
142. Milan D., Bidanel J.P., Iannuccelli N., Riquet J., Amigues Y., Gruand J., et al. Detection of quantitative trait loci for carcass composition traits in pigs. Genet Sel Evol 34 (2002) 705-728
143. Rattink A.P., De Koning D.J., Faivre M., Harlizius B., van Arendonk J.A., and Groenen M.A. Fine mapping and imprinting analysis for fatness trait QTLs in pigs. Mamm Genome 11 (2000) 656-661
144. Wada Y., Akita T., Awata T., Furukawa T., Sugai N., Inage Y., et al. Quantitative trait loci (QTL) analysis in a Meishan × Gottingen cross population. Anim Genet 31 (2000) 376-384
145. Quintanilla R., Demeure O., Bidanel J.P., Milan D., Iannuccelli N., Amigues Y., et al. Detection of quantitative trait loci for fat androstenone levels in pigs. J Anim Sci 81 (2003) 385-394
146. Gilbert H., Le Roy P., Milan D., and Bidanel J.P. Linked and pleiotropic QTLs influencing carcass composition traits detected on porcine chromosome 7. Genet Res 89 (2007) 65-72
147. Demeure O., Sanchez M.P., Riquet J., Iannuccelli N., Demars J., Fève K., et al. Exclusion of the swine leukocyte antigens as candidate region and reduction of the position interval for the Sus scrofa chromosome 7 QTL affecting growth and fatness. J Anim Sci 83 (2005) 1979-1987
148. Galina-Pantoja L., Mellencamp M.A., Bastiaansen J., Cabrera R., Solano-Aguilar G.I., and Lunney J.K. Relationship between immune cell phenotypes and pig growth on a commercial farm. Anim Biotechnol 17 (2006) 81-98
149. Vaiman M., Metzger J., Renard C., and Vila J. Immune response gene(s) controlling the humoral anti-lysozyme response (Ir-Lys) linked to the major histocompatibility complex SLA in the pig. Immunogenetics 7 (1978) 231-243
150. Mallard B.A., Wilkie B.N., and Kennedy B.W. The influence of the swine major histocompatibility genes (SLA) on variation in serum immunoglobulin (Ig) concentration. Vet Immunol Immunopathol 21 (1989) 139-151
151. Meeker D.L., Rothschild M.F., Christian L.L., Warner C.M., and Hill H.T. Genetic control of immune response to pseudorabies and atrophic rhinitis vaccines. I, II. J Anim Sci 64 (1987) p. 407-13; 414-9
152. Rothschild M.F., Chen H.L., Christian L.L., Lie W.R., Venier L., Cooper M., et al. Breed and swine lymphocyte antigen haplotype differences in agglutination titers following vaccination with B. bronchiseptica. J Anim Sci 59 (1984) 643-649
153. Lumsden J.S., Kennedy B.W., Mallard B.A., and Wilkie B.N. The influence of the swine major histocompatibility genes on antibody and cell-mediated immune responses to immunization with an aromatic-dependent mutant of Salmonella typhimurium. Can J Vet Res 57 (1993) 14-18
154. Lunney J.K., and Murrell K.D. Immunogenetic analysis of Trichinella spiralis infection in swine. Vet Parasitol 29 (1988) 179-199
155. Jordan L.T., Derbyshire J.B., and Mallard B.A. Interferon induction in swine lymphocyte antigen-defined miniature pigs. Res Vet Sci 58 (1995) 282-283
156. Lacey C., Wilkie B.N., Kennedy B.W., and Mallard B.A. Genetic and other effects on bacterial phagocytosis and killing by cultured peripheral blood monocytes of SLA-defined miniature pigs. Anim Genet 20 (1989) 371-381
157. Groves T.C., Wilkie B.N., Kennedy B.W., and Mallard B.A. Effect of selection of swine for high and low immune responsiveness on monocyte superoxide anion production and class II MHC antigen expression. Vet Immunol Immunopathol 36 4 (1993) 347-358
158. Hruban V., Horák V., and Fortýn K. Presence of specific MHC haplotypes in melanoblastoma-bearing minipigs. Anim Genet 25 (1994) C10
159. Madden K.B., Moeller Jr. R.F., Goldman T., and Lunney J.K. Trichinella spiralis: genetic basis and kinetics of the anti-encysted muscle larval response in miniature swine. Exp Parasitol 77 (1993) 23-35
160. Madden K.B., Murrell K.D., and Lunney J.K. Trichinella spiralis: MHC associated elimination of encysted muscle larvae in swine. Exp Parasitol 70 (1990) 443-451
161. Dubey J.P., Lunney J.K., Shen S.K., Kwok O.C.H., Ashford D.A., and Thulliez P. Infectivity of low numbers of Toxoplasma gondii oocysts to pigs. J Parasitol 82 (1996) 438-443
162. Bugarski D., Cuperlovic K., and Lunney J.K. MHC (SLA) class I antigen phenotype and resistance to Trichinella spiralis infection in swine: a potential relationship. Acta Vet Beograd 46 (1996) 115-126
163. Gonzalez-Juarrero M., Lunney J.K., Sanchez-Vizcaino J.M., and Mebus C. Modulation of splenic swine leukocyte antigen (SLA) and viral antigen expression following ASFV inoculation. Arch Virol 123 (1992) 145-156
164. Gonzalez-Juarrero M., Mebus C., Pan R., Revilla Y., Alonso J.M., and Lunney J.K. Swine leukocyte antigen (SLA) and macrophage marker expression on both African swine fever virus (ASFV) infected and non-infected primary porcine macrophage cultures. Vet Immunol Immunopathol 32 (1992) 243-259
165. Campos E., Revilla C., Chamorro S., Alvarez B., Ezquerra A., Domínguez J., et al. In vitro effect of classical swine fever virus on a porcine aortic endothelial cell line. Vet Res 35 (2004) 625-633
166. Bauhofer O., Summerfield A., McCullough K.C., and Ruggli N. Role of double-stranded RNA and Npro of classical swine fever virus in the activation of monocyte-derived dendritic cells. Virology 343 (2005) 93-105
167. Vincent I.E., Carrasco C.P., Guzylack-Piriou L., Herrmann B., McNeilly F., Allan G.M., et al. Subset-dependent modulation of dendritic cell activity by circovirus type 2. Immunology 115 (2005) 388-398
168. Bautista E.M., Ferman G.S., Gregg D., Brum M.C., Grubman M.J., and Golde W.T. Constitutive expression of alpha interferon by skin dendritic cells confers resistance to infection by foot-and-mouth disease virus. J Virol 79 (2005) 4838-4847
169. Rau H., Revets H., Cornelis P., Titzmann A., Ruggli N., McCullough K.C., et al. Efficacy and functionality of lipoprotein OprI from Pseudomonas aeruginosa as adjuvant for a subunit vaccine against classical swine fever. Vaccine 24 (2006) 4757-4768
170. Leitão A., Malur A., Cartaxeiro C., Vasco G., Cruz B., Cornelis P., et al. Bacterial lipoprotein based expression vectors as tools for the characterisation of African swine fever virus (ASFV) antigens. Arch Virol 145 (2000) 1639-1657
171. Appleyard G.D., Furesz S.E., and Wilkie B.N. Blood lymphocyte subsets in pigs vaccinated and challenged with Actinobacillus pleuropneumoniae. Vet Immunol Immunopathol 86 (2002) 221-228
172. Solano-Aguilar G.I., Beshah E., Vengroski K., Zarlenga D., Jauregui L., Cosio M., et al. Cytokine and lymphocyte profile in miniature swine after oral infection with Toxoplasma gondii oocysts. Int J Parasitol 31 (2001) 187-195
173. Zhao S.-H., Kuhar D., Lunney J.K., Dawson H.D., Guidry C., Uthe J., et al. Gene expression profiling in Salmonella choleraesuis infected porcine lung using a long oligonucleotide microarray. Mamm Genome 17 (2006) 777-789
174. Wang Y.F., Qu L., Uthe J.J., Royaee A.R., Bearson S.M.D., Kuhar D., et al. Global transcriptional response of porcine mesenteric lymph nodes to Salmonella enterica serovar typhimurium. Genomics 90 (2007) 72-84
175. Chowdhury S.R., King D.E., Willing B.P., Band M.R., Beever J.E., Lane A.B., et al. Transcriptome profiling of the small intestinal epithelium in germfree versus conventional piglets. BMC Genom 8 (2007) 215
176. Flori L., Rogel-Gaillard C., Cochet M., Lemonnier G., Hugot K., Chardon P., et al. Transcriptomic analysis of the dialogue between pseudorabies virus and porcine epithelial cells during infection. BMC Genom 9 (2008) 123
177. Nielsen J., Bøtner A., Tingstedt J.E., Aasted B., Johnsen C.K., Riber U., et al. In utero infection with porcine reproductive and respiratory syndrome virus modulates leukocyte subpopulations in peripheral blood and bronchoalveolar fluid of surviving piglets. Vet Immunol Immunopathol 93 (2003) 135-151
178. Wang X., Eaton M., Mayer M., Li H., He D., Nelson E., et al. Porcine reproductive and respiratory syndrome virus productively infects monocyte-derived dendritic cells and compromises their antigen-presenting ability. Arch Virol 152 (2007) 289-303
179. Gerner W., Denyer M.S., Takamatsu H.H., Wileman T.E., Wiesmüller K.H., Pfaff E., et al. Identification of novel foot-and-mouth disease virus specific T-cell epitopes in c/c and d/d haplotype miniature swine. Virus Res 121 (2006) 223-228
180. Ramachandran S., Jaramillo A., Xu X.C., McKane B.W., Chapman W.C., and Mohanakumar T. Human immune responses to porcine endogenous retrovirus-derived peptides presented naturally in the context of porcine and human major histocompatibility complex class I molecules: implications in xenotransplantation of porcine organs. Transplantation 77 (2004) 1580-1588
181. Oleksiewicz M.B., Kristensen B., Ladekjaer-Mikkelsen A.S., and Nielsen J. Development of a rapid in vitro protein refolding assay which discriminates between peptide-bound and peptide-free forms of recombinant porcine major histocompatibility class I complex (SLA-I). Vet Immunol Immunopathol 86 (2002) 55-77
182. Gao F.S., Fang Q.M., Li Y.G., Li X.S., Hao H.F., and Xia C. Reconstruction of a swine SLA-I protein complex and determination of binding nonameric peptides derived from the foot-and-mouth disease virus. Vet Immunol Immunopathol 113 (2006) 328-338