MiR-125b Reduces Porcine Reproductive and Respiratory Syndrome Virus Replication by Negatively Regulating the NF-κB Pathway

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Wang, Dang ^a   Cao, Lu ^a   Xu, Zheng ^a   Fang, Liurong ^a   Zhong, Yao ^a   Chen, Quangang ^a   Luo, Rui ^a   Chen, Huanchun ^a   Li, Kui ^b   Xiao, Shaobo ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA 125B; VIRUS RNA;

ANIMAL CELL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTERIVIRUS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE FUNCTION; GENE TARGETING; HAPLORHINI; INNATE IMMUNITY; LUNG ALVEOLUS MACROPHAGE; MICROBIOLOGICAL PARAMETERS; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN SYNTHESIS INHIBITION; REGULATORY MECHANISM; RNA ANALYSIS; SIGNAL TRANSDUCTION; SWINE; VIRUS GENE; VIRUS GENOME; VIRUS REPLICATION; VIRUS TITER;

ANIMALS; BASE SEQUENCE; CELL LINE; GENE ORDER; GENOME, VIRAL; HAPLORHINI; INTERFERONS; MACROPHAGES, ALVEOLAR; MICRORNAS; NF-KAPPA B; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SIGNAL TRANSDUCTION; SWINE; VIRUS REPLICATION;

EID: 84873586638     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055838     Document Type: Article

References (65)

1. Ambros V, (2004) The functions of animal microRNAs. Nature 431: 350-355.
2. Lee Y, Jeon K, Lee JT, Kim S, Kim VN, (2002) MicroRNA maturation: stepwise processing and subcellular localization. Embo J 21: 4663-4670.
3. Yi R, Qin Y, Macara IG, Cullen BR, (2003) Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 17: 3011-3016.
4. Lee Y, Ahn C, Han J, Choi H, Kim J, et al. (2003) The nuclear RNase III Drosha initiates microRNA processing. Nature 425: 415-419.
5. Bartel DP, (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
6. Kiriakidou M, Nelson PT, Kouranov A, Fitziev P, Bouyioukos C, et al. (2004) A combined computational-experimental approach predicts human microRNA targets. Genes Dev 18: 1165-1178.
7. Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB, (2003) Prediction of mammalian microRNA targets. Cell 115: 787-798.
8. Boss IW, Renne R, (2010) Viral miRNAs: tools for immune evasion. Curr Opin Microbiol 13: 540-545.
9. Gottwein E, Cullen BR, (2008) Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe 3: 375-387.
10. Muller S, Imler JL, (2007) Dicing with viruses: microRNAs as antiviral factors. Immunity 27: 1-3.
11. Roberts AP, Jopling CL, (2010) Targeting viral infection by microRNA inhibition. Genome Biol 11: 201.
12. Sarnow P, Jopling CL, Norman KL, Schutz S, Wehner KA, (2006) MicroRNAs: expression, avoidance and subversion by vertebrate viruses. Nat Rev Microbiol 4: 651-659.
13. Chang J, Guo JT, Jiang D, Guo H, Taylor JM, et al. (2008) Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells. J Virol 82: 8215-8223.
14. Norman KL, Sarnow P, (2010) Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms. J Virol 84: 666-670.
15. Skalsky RL, Cullen BR, (2010) Viruses, microRNAs, and host interactions. Annu Rev Microbiol 64: 123-141.
16. Wang FZ, Weber F, Croce C, Liu CG, Liao X, et al. (2008) Human cytomegalovirus infection alters the expression of cellular microRNA species that affect its replication. J Virol 82: 9065-9074.
17. Jangra RK, Yi M, Lemon SM, (2010) Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122. J Virol 84: 6615-6625.
18. Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarnow P, (2005) Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science 309: 1577-1581.
19. Murakami Y, Aly HH, Tajima A, Inoue I, Shimotohno K, (2009) Regulation of the hepatitis C virus genome replication by miR-199a. J Hepatol 50: 453-460.
20. Pedersen IM, Cheng G, Wieland S, Volinia S, Croce CM, et al. (2007) Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature 449: 919-922.
21. Lecellier CH, Dunoyer P, Arar K, Lehmann-Che J, Eyquem S, et al. (2005) A cellular microRNA mediates antiviral defense in human cells. Science 308: 557-560.
22. Song L, Liu H, Gao S, Jiang W, Huang W, (2010) Cellular microRNAs inhibit replication of the H1N1 influenza A virus in infected cells. J Virol 84: 8849-8860.
23. Huang J, Wang F, Argyris E, Chen K, Liang Z, et al. (2007) Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes. Nat Med 13: 1241-1247.
24. Zhang GL, Li YX, Zheng SQ, Liu M, Li X, et al. (2010) Suppression of hepatitis B virus replication by microRNA-199a-3p and microRNA-210. Antiviral Res 88: 169-175.
25. Otsuka M, Jing Q, Georgel P, New L, Chen J, et al. (2007) Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity 27: 123-134.
26. Wang P, Hou J, Lin L, Wang C, Liu X, et al. (2010) Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1. J Immunol 185: 6226-6233.
27. Rossow KD, (1998) Porcine reproductive and respiratory syndrome. Vet Pathol 35: 1-20.
28. Meulenberg JJ, (2000) PRRSV, the virus. Vet Res 31: 11-21.
29. Murtaugh MP, Stadejek T, Abrahante JE, Lam TT, Leung FC, (2010) The ever-expanding diversity of porcine reproductive and respiratory syndrome virus. Virus Res 154: 18-30.
30. Darwich L, Diaz I, Mateu E, (2010) Certainties, doubts and hypotheses in porcine reproductive and respiratory syndrome virus immunobiology. Virus Res 154: 123-132.
31. Meng XJ, (2000) Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development. Vet Microbiol 74: 309-329.
32. Calzada-Nova G, Schnitzlein WM, Husmann RJ, Zuckermann FA, (2011) North American porcine reproductive and respiratory syndrome viruses inhibit type I interferon production by plasmacytoid dendritic cells. J Virol 85: 2703-2713.
33. Kimman TG, Cornelissen LA, Moormann RJ, Rebel JM, Stockhofe-Zurwieden N, (2009) Challenges for porcine reproductive and respiratory syndrome virus (PRRSV) vaccinology. Vaccine 27: 3704-3718.
34. Yoo D, Song C, Sun Y, Du Y, Kim O, et al. (2010) Modulation of host cell responses and evasion strategies for porcine reproductive and respiratory syndrome virus. Virus Res 154: 48-60.
35. Beura LK, Sarkar SN, Kwon B, Subramaniam S, Jones C, et al. (2010) Porcine reproductive and respiratory syndrome virus nonstructural protein 1beta modulates host innate immune response by antagonizing IRF3 activation. J Virol 84: 1574-1584.
36. Chen Z, Zhou X, Lunney JK, Lawson S, Sun Z, et al. (2010) Immunodominant epitopes in nsp2 of porcine reproductive and respiratory syndrome virus are dispensable for replication, but play an important role in modulation of the host immune response. J Gen Virol 91: 1047-1057.
37. Kim O, Sun Y, Lai FW, Song C, Yoo D, (2010) Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells. Virology 402: 315-326.
38. Murtaugh MP, Xiao Z, Zuckermann F, (2002) Immunological responses of swine to porcine reproductive and respiratory syndrome virus infection. Viral Immunol 15: 533-547.
39. Patel D, Nan Y, Shen M, Ritthipichai K, Zhu X, et al. (2010) Porcine reproductive and respiratory syndrome virus inhibits type I interferon signaling by blocking STAT1/STAT2 nuclear translocation. J Virol 84: 11045-11055.
40. Sun Z, Chen Z, Lawson SR, Fang Y, (2010) The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions. J Virol 84: 7832-7846.
41. Wensvoort G, Terpstra C, Pol JM, ter Laak EA, Bloemraad M, et al. (1991) Mystery swine disease in The Netherlands: the isolation of Lelystad virus. Vet Q 13: 121-130.
42. Li B, Xiao S, Wang Y, Xu S, Jiang Y, et al. (2009) Immunogenicity of the highly pathogenic porcine reproductive and respiratory syndrome virus GP5 protein encoded by a synthetic ORF5 gene. Vaccine 27: 1957-1963.
43. Wang D, Fang L, Luo R, Ye R, Fang Y, et al. (2010) Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced type I interferon transcription by decreasing interferon regulatory factor 3/7 in protein levels. Biochem Biophys Res Commun 399: 72-78.
44. Luo R, Fang L, Jin H, Jiang Y, Wang D, et al. (2011) Antiviral activity of type I and type III interferons against porcine reproductive and respiratory syndrome virus (PRRSV). Antiviral Res 91: 99-101.
45. Asirvatham AJ, Gregorie CJ, Hu Z, Magner WJ, Tomasi TB, (2008) MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery components. Mol Immunol 45: 1995-2006.
46. Wessner B, Gryadunov-Masutti L, Tschan H, Bachl N, Roth E, (2010) Is there a role for microRNAs in exercise immunology? A synopsis of current literature and future developments. Exerc Immunol Rev 16: 22-39.
47. Kawai T, Akira S, (2006) Innate immune recognition of viral infection. Nat Immunol 7: 131-137.
48. Murphy AJ, Guyre PM, Pioli PA, (2010) Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages. J Immunol 184: 5029-5037.
49. Lee SM, Kleiboeker SB, (2005) Porcine arterivirus activates the NF-kappaB pathway through IkappaB degradation. Virology 342: 47-59.
50. Luo R, Xiao S, Jiang Y, Jin H, Wang D, et al. (2008) Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-beta production by interfering with the RIG-I signaling pathway. Mol Immunol 45: 2839-2846.
51. Chaudhuri AA, So AY, Sinha N, Gibson WS, Taganov KD, et al. (2011) MicroRNA-125b Potentiates Macrophage Activation. J Immunol 187: 5062-5068.
52. Malumbres R, Sarosiek KA, Cubedo E, Ruiz JW, Jiang X, et al. (2009) Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas. Blood 113: 3754-3764.
53. Kong F, Sun C, Wang Z, Han L, Weng D, et al. (2011) miR-125b confers resistance of ovarian cancer cells to cisplatin by targeting pro-apoptotic Bcl-2 antagonist killer 1. J Huazhong Univ Sci Technolog Med Sci 31: 543-549.
54. Surdziel E, Cabanski M, Dallmann I, Lyszkiewicz M, Krueger A, et al. (2011) Enforced expression of miR-125b affects myelopoiesis by targeting multiple signaling pathways. Blood 117: 4338-4348.
55. Shi XB, Xue L, Ma AH, Tepper CG, Kung HJ, et al. (2011) miR-125b promotes growth of prostate cancer xenograft tumor through targeting pro-apoptotic genes. Prostate 71: 538-549.
56. Shi XB, Xue L, Yang J, Ma AH, Zhao J, et al. (2007) An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Proc Natl Acad Sci U S A 104: 19983-19988.
57. Hayden MS, Ghosh S, (2008) Shared principles in NF-kappaB signaling. Cell 132: 344-362.
58. Asamitsu K, Yamaguchi T, Nakata K, Hibi Y, Victoriano AF, et al. (2008) Inhibition of human immunodeficiency virus type 1 replication by blocking IkappaB kinase with noraristeromycin. J Biochem 144: 581-589.
59. Ludwig S, Planz O, (2008) Influenza viruses and the NF-kappaB signaling pathway- towards a novel concept of antiviral therapy. Biol Chem 389: 1307-1312.
60. Nimmerjahn F, Dudziak D, Dirmeier U, Hobom G, Riedel A, et al. (2004) Active NF-kappaB signalling is a prerequisite for influenza virus infection. J Gen Virol 85: 2347-2356.
61. Wurzer WJ, Ehrhardt C, Pleschka S, Berberich-Siebelt F, Wolff T, et al. (2004) NF-kappaB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient influenza virus propagation. J Biol Chem 279: 30931-30937.
62. Williams SA, Kwon H, Chen LF, Greene WC, (2007) Sustained induction of NF-kappa B is required for efficient expression of latent human immunodeficiency virus type 1. J Virol 81: 6043-6056.
63. Luo R, Fang L, Jiang Y, Jin H, Wang Y, et al. (2010) Activation of NF-kappaB by nucleocapsid protein of the porcine reproductive and respiratory syndrome virus. Virus Genes 42: 76-81.
64. Song C, Krell P, Yoo D, (2010) Nonstructural protein 1alpha subunit-based inhibition of NF-kappaB activation and suppression of interferon-beta production by porcine reproductive and respiratory syndrome virus. Virology 407: 268-280.
65. Song S, Bi J, Wang D, Fang L, Zhang L, et al. (2012) Porcine reproductive and respiratory syndrome virus infection activates IL-10 production through NF-κB and p38 MAPK pathways in porcine alveolar macrophages. Dev Comp Immunol doi: 10.1016/j.dci.2012.10.001.