Metabolic Reprogramming and Dependencies Associated with Epithelial Cancer Stem Cells Independent of the Epithelial-Mesenchymal Transition Program

Stem Cells

Volumn 34, Issue 5, 2016, Pages 1163-1176

  Aguilar, Esther ^a   Marin De Mas, Igor ^a   Zodda, Erika ^a,b   Marin, Silvia ^a   Morrish, Fionnuala ^c   Selivanov, Vitaly ^a   Meca Cortés, Óscar ^b   Delowar, Hossain ^b   Pons, Mònica ^b   Izquierdo, Inés ^a   Celià Terrassa, Toni ^b   De Atauri, Pedro ^a   Centelles, Josep J ^a   Hockenbery, David ^c   Thomson, Timothy M ^b   Cascante, Marta ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Cancer stem cells; Epithelial mesenchymal transition; Glutaminolysis; Metabolic flux analysis; Mitochondrial metabolism; Warburg effect

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; CARBON; FATTY ACID; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTAMINE; GLUTATHIONE; GLYCINE; LACTATE DEHYDROGENASE; PROTON; PYRUVATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SERINE; TRANSKETOLASE; TRICARBOXYLIC ACID; TUMOR MARKER; UBIQUINOL CYTOCHROME C REDUCTASE; AMINO ACID; GLUCOSE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PYRUVATE DEHYDROGENASE COMPLEX;

AMINO ACID METABOLISM; ARTICLE; CANCER STEM CELL; CARBON SOURCE; CELL GROWTH; CONTROLLED STUDY; ENERGY RESOURCE; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; GLYCOLYSIS; HUMAN; HUMAN CELL; MALE; METABOLOMICS; METASTASIS; MITOCHONDRIAL RESPIRATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PENTOSE PHOSPHATE CYCLE; PROSTATE CANCER; TRANSCRIPTOMICS; BIOSYNTHESIS; CELL PROLIFERATION; CITRIC ACID CYCLE; DISEASE EXACERBATION; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GENETICS; MESODERM; METABOLISM; MITOCHONDRION; MULTICELLULAR SPHEROID; PATHOLOGY; PH; TUMOR CELL LINE; TUMOR GENE;

AMINO ACIDS; CELL LINE, TUMOR; CELL PROLIFERATION; CITRIC ACID CYCLE; DISEASE PROGRESSION; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FATTY ACIDS; GENE EXPRESSION PROFILING; GENES, NEOPLASM; GLUCOSE; GLYCOLYSIS; HUMANS; HYDROGEN-ION CONCENTRATION; MESODERM; METABOLOMICS; MITOCHONDRIA; NADP; NEOPLASTIC STEM CELLS; OXIDATIVE STRESS; PYRUVATE DEHYDROGENASE COMPLEX; SPHEROIDS, CELLULAR; TRANSCRIPTION, GENETIC;

EID: 84959043221     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2286     Document Type: Article

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