-
1
-
-
82755166890
-
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
-
Anastasiou, D., G. Poulogiannis, J.M. Asara, M.B. Boxer, J.K. Jiang, M. Shen, G. Bellinger, A.T. Sasaki, J.W. Locasale, D.S. Auld, et al. 2011. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science. 334:1278-1283. http://dx.doi.org/10.1126/science.1211485
-
(2011)
Science
, vol.334
, pp. 1278-1283
-
-
Anastasiou, D.1
Poulogiannis, G.2
Asara, J.M.3
Boxer, M.B.4
Jiang, J.K.5
Shen, M.6
Bellinger, G.7
Sasaki, A.T.8
Locasale, J.W.9
Auld, D.S.10
-
2
-
-
80052731244
-
No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis
-
Bluemlein, K., N.M. Grüning, R.G. Feichtinger, H. Lehrach, B. Kofler, and M. Ralser. 2011. No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis. Oncotarget. 2:393-400.
-
(2011)
Oncotarget
, vol.2
, pp. 393-400
-
-
Bluemlein, K.1
Grüning, N.M.2
Feichtinger, R.G.3
Lehrach, H.4
Kofler, B.5
Ralser, M.6
-
3
-
-
79961215490
-
Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality
-
Chan, D.A., P.D. Sutphin, P. Nguyen, S. Turcotte, E.W. Lai, A. Banh, G.E. Reynolds, J.T. Chi, J. Wu, D.E. Solow-Cordero, et al. 2011. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci. Transl. Med. 3:ra70.
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Chan, D.A.1
Sutphin, P.D.2
Nguyen, P.3
Turcotte, S.4
Lai, E.W.5
Banh, A.6
Reynolds, G.E.7
Chi, J.T.8
Wu, J.9
Solow-Cordero, D.E.10
-
4
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk, H.R., M.G. Vander Heiden, M.H. Harris, A. Ramanathan, R.E. Gerszten, R. Wei, M.D. Fleming, S.L. Schreiber, and L.C. Cantley. 2008a. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 452:230-233. http://dx.doi.org/10.1038/nature06734
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
5
-
-
40749099894
-
Pyruvate kinase M2 is a phosphotyrosinebinding protein
-
Christofk, H.R., M.G. Vander Heiden, N. Wu, J.M. Asara, and L.C. Cantley. 2008b. Pyruvate kinase M2 is a phosphotyrosinebinding protein. Nature. 452:181-186. http://dx.doi.org/10.1038/nature06667
-
(2008)
Nature
, vol.452
, pp. 181-186
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Wu, N.3
Asara, J.M.4
Cantley, L.C.5
-
6
-
-
78650491025
-
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes
-
Colombo, S.L., M. Palacios-Callender, N. Frakich, J. De Leon, C.A. Schmitt, L. Boorn, N. Davis, and S. Moncada. 2010. Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes. Proc. Natl. Acad. Sci. USA. 107:18868-18873. http://dx.doi.org/10.1073/pnas.1012362107
-
(2010)
Proc. Natl. Acad. Sci. USA.
, vol.107
, pp. 18868-18873
-
-
Colombo, S.L.1
Palacios-Callender, M.2
Frakich, N.3
De Leon, J.4
Schmitt, C.A.5
Boorn, L.6
Davis, N.7
Moncada, S.8
-
7
-
-
60249085118
-
Mitochondria in cancer: not just innocent bystanders
-
Frezza, C., and E. Gottlieb. 2009. Mitochondria in cancer: not just innocent bystanders. Semin. Cancer Biol. 19:4-11. http://dx.doi.org/10.1016/j.semcancer.2008.11.008
-
(2009)
Semin. Cancer Biol.
, vol.19
, pp. 4-11
-
-
Frezza, C.1
Gottlieb, E.2
-
8
-
-
0036717382
-
Molecular imaging of cancer with positron emission tomography
-
Gambhir, S.S. 2002. Molecular imaging of cancer with positron emission tomography. Nat. Rev. Cancer. 2:683-693. http://dx.doi.org/10.1038/nrc882
-
(2002)
Nat. Rev. Cancer.
, vol.2
, pp. 683-693
-
-
Gambhir, S.S.1
-
9
-
-
84856913587
-
Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression
-
doi:10.1084/jem.20111487
-
Goldberg, M.S., and P.A. Sharp. 2012. Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression. J. Exp. Med. 209:217-224. doi: 10.1084/jem.20111487.
-
(2012)
J. Exp. Med.
, vol.209
, pp. 217-224
-
-
Goldberg, M.S.1
Sharp, P.A.2
-
10
-
-
77449131347
-
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
-
Hitosugi, T., S. Kang, M.G. Vander Heiden, T.W. Chung, S. Elf, K. Lythgoe, S. Dong, S. Lonial, X. Wang, G.Z. Chen, et al. 2009. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci. Signal. 2:ra73. http://dx.doi.org/10.1126/scisignal.2000431
-
(2009)
Sci. Signal.
, vol.2
-
-
Hitosugi, T.1
Kang, S.2
Vander Heiden, M.G.3
Chung, T.W.4
Elf, S.5
Lythgoe, K.6
Dong, S.7
Lonial, S.8
Wang, X.9
Chen, G.Z.10
-
11
-
-
73449085470
-
The antitumor effect and hepatotoxicity of a hexokinase II inhibitor 3-bromopyruvate: in vivo investigation of intraarterial administration in a rabbit VX2 hepatoma model
-
Jae, H.J., J.W. Chung, H.S. Park, M.J. Lee, K.C. Lee, H.C. Kim, J.H. Yoon, H. Chung, and J.H. Park. 2009. The antitumor effect and hepatotoxicity of a hexokinase II inhibitor 3-bromopyruvate: in vivo investigation of intraarterial administration in a rabbit VX2 hepatoma model. Korean J. Radiol. 10:596-603. http://dx.doi.org/10.3348/kjr.2009.10.6.596
-
(2009)
Korean J. Radiol.
, vol.10
, pp. 596-603
-
-
Jae, H.J.1
Chung, J.W.2
Park, H.S.3
Lee, M.J.4
Lee, K.C.5
Kim, H.C.6
Yoon, J.H.7
Chung, H.8
Park, J.H.9
-
12
-
-
76649126249
-
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
-
Le, A., C.R. Cooper, A.M. Gouw, R. Dinavahi, A. Maitra, L.M. Deck, R.E. Royer, D.L. Vander Jagt, G.L. Semenza, and C.V. Dang. 2010. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc. Natl. Acad. Sci. USA. 107:2037-2042. http://dx.doi.org/10.1073/pnas.0914433107
-
(2010)
Proc. Natl. Acad. Sci. USA.
, vol.107
, pp. 2037-2042
-
-
Le, A.1
Cooper, C.R.2
Gouw, A.M.3
Dinavahi, R.4
Maitra, A.5
Deck, L.M.6
Royer, R.E.7
Vander Jagt, D.L.8
Semenza, G.L.9
Dang, C.V.10
-
13
-
-
40149095758
-
Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription
-
Lee, J., H.K. Kim, Y.M. Han, and J. Kim. 2008. Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. Int. J. Biochem. Cell Biol. 40:1043-1054. http://dx.doi.org/10.1016/j.biocel.2007.11.009
-
(2008)
Int. J. Biochem. Cell Biol.
, vol.40
, pp. 1043-1054
-
-
Lee, J.1
Kim, H.K.2
Han, Y.M.3
Kim, J.4
-
14
-
-
80053922625
-
Metabolic flux and the regulation of mammalian cell growth
-
Locasale, J.W., and L.C. Cantley. 2011. Metabolic flux and the regulation of mammalian cell growth. Cell Metab. 14:443-451. http://dx.doi.org/10.1016/j.cmet.2011.07.014
-
(2011)
Cell Metab
, vol.14
, pp. 443-451
-
-
Locasale, J.W.1
Cantley, L.C.2
-
15
-
-
80052258995
-
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
-
Locasale, J.W., A.R. Grassian, T. Melman, C.A. Lyssiotis, K.R. Mattaini, A.J. Bass, G. Heffron, C.M. Metallo, T. Muranen, H. Sharfi, et al. 2011. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat. Genet. 43:869-874. http://dx.doi.org/10.1038/ng.890
-
(2011)
Nat. Genet.
, vol.43
, pp. 869-874
-
-
Locasale, J.W.1
Grassian, A.R.2
Melman, T.3
Lyssiotis, C.A.4
Mattaini, K.R.5
Bass, A.J.6
Heffron, G.7
Metallo, C.M.8
Muranen, T.9
Sharfi, H.10
-
16
-
-
80054046029
-
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
-
Lunt, S.Y., and M.G. Vander Heiden. 2011. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu. Rev. Cell Dev. Biol. 27:441-464. http://dx.doi.org/10.1146/annurev-cellbio-092910-154237
-
(2011)
Annu. Rev. Cell Dev. Biol.
, vol.27
, pp. 441-464
-
-
Lunt, S.Y.1
Vander Heiden, M.G.2
-
17
-
-
79957567239
-
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxiainducible factor 1
-
Luo, W., H. Hu, R. Chang, J. Zhong, M. Knabel, R. O'Meally, R.N. Cole, A. Pandey, and G.L. Semenza. 2011. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxiainducible factor 1. Cell. 145:732-744. http://dx.doi.org/10.1016/j.cell.2011.03.054
-
(2011)
Cell
, vol.145
, pp. 732-744
-
-
Luo, W.1
Hu, H.2
Chang, R.3
Zhong, J.4
Knabel, M.5
O'Meally, R.6
Cole, R.N.7
Pandey, A.8
Semenza, G.L.9
-
18
-
-
79959371914
-
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
-
Lv, L., D. Li, D. Zhao, R. Lin, Y. Chu, H. Zhang, Z. Zha, Y. Liu, Z. Li, Y. Xu, et al. 2011. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol. Cell. 42:719- 730. http://dx.doi.org/10.1016/j.molcel. 2011.04.025
-
(2011)
Mol. Cell
, vol.42
, pp. 719-730
-
-
Lv, L.1
Li, D.2
Zhao, D.3
Lin, R.4
Chu, Y.5
Zhang, H.6
Zha, Z.7
Liu, Y.8
Li, Z.9
Xu, Y.10
-
19
-
-
81255157465
-
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
-
Nieman, K.M., H.A. Kenny, C.V. Penicka, A. Ladanyi, R. Buell-Gutbrod, M.R. Zillhardt, I.L. Romero, M.S. Carey, G.B. Mills, G.S. Hotamisligil, et al. 2011. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat. Med. 17:1498-1503. http://dx.doi.org/10.1038/nm.2492
-
(2011)
Nat. Med.
, vol.17
, pp. 1498-1503
-
-
Nieman, K.M.1
Kenny, H.A.2
Penicka, C.V.3
Ladanyi, A.4
Buell-Gutbrod, R.5
Zillhardt, M.R.6
Romero, I.L.7
Carey, M.S.8
Mills, G.B.9
Hotamisligil, G.S.10
-
20
-
-
0035917865
-
Cooperation and competition in the evolution of ATP-producing pathways
-
Pfeiffer, T., S. Schuster, and S. Bonhoeffer. 2001. Cooperation and competition in the evolution of ATP-producing pathways. Science. 292:504-507. http://dx.doi.org/10.1126/science.1058079
-
(2001)
Science
, vol.292
, pp. 504-507
-
-
Pfeiffer, T.1
Schuster, S.2
Bonhoeffer, S.3
-
21
-
-
80051923932
-
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
-
Possemato, R., K.M. Marks, Y.D. Shaul, M.E. Pacold, D. Kim, K. Birsoy, S. Sethumadhavan, H.K. Woo, H.G. Jang, A.K. Jha, et al. 2011. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 476:346-350. http://dx.doi.org/10.1038/nature10350
-
(2011)
Nature
, vol.476
, pp. 346-350
-
-
Possemato, R.1
Marks, K.M.2
Shaul, Y.D.3
Pacold, M.E.4
Kim, D.5
Birsoy, K.6
Sethumadhavan, S.7
Woo, H.K.8
Jang, H.G.9
Jha, A.K.10
-
22
-
-
0018386209
-
Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells
-
Reitzer, L.J., B.M. Wice, and D. Kennell. 1979. Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J. Biol. Chem. 254:2669-2676.
-
(1979)
J. Biol. Chem.
, vol.254
, pp. 2669-2676
-
-
Reitzer, L.J.1
Wice, B.M.2
Kennell, D.3
-
23
-
-
33746927077
-
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
-
Robey, R.B., and N. Hay. 2006. Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene. 25:4683-4696. http://dx.doi.org/
-
(2006)
Oncogene
, vol.25
, pp. 4683-4696
-
-
Robey, R.B.1
Hay, N.2
-
24
-
-
0030921103
-
c-Myc transactivation of LDH-A: implications for tumor metabolism and growth
-
Shim, H., C. Dolde, B.C. Lewis, C.S. Wu, G. Dang, R.A. Jungmann, R. Dalla-Favera, and C.V. Dang. 1997. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc. Natl. Acad. Sci. USA. 94:6658-6663. http://dx.doi.org/10.1073/pnas.94.13.6658
-
(1997)
Proc. Natl. Acad. Sci. USA.
, vol.94
, pp. 6658-6663
-
-
Shim, H.1
Dolde, C.2
Lewis, B.C.3
Wu, C.S.4
Dang, G.5
Jungmann, R.A.6
Dalla-Favera, R.7
Dang, C.V.8
-
25
-
-
68949098403
-
Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply
-
Spoden, G.A., U. Rostek, S. Lechner, M. Mitterberger, S. Mazurek, and W. Zwerschke. 2009. Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply. Exp. Cell Res. 315:2765-2774. http://dx.doi.org/10.1016/j.yexcr.2009.06.024
-
(2009)
Exp. Cell Res.
, vol.315
, pp. 2765-2774
-
-
Spoden, G.A.1
Rostek, U.2
Lechner, S.3
Mitterberger, M.4
Mazurek, S.5
Zwerschke, W.6
-
26
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden, M.G., L.C. Cantley, and C.B. Thompson. 2009. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 324: 1029-1033. http://dx.doi.org/10.1126/science.1160809
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
27
-
-
77956674635
-
Evidence for an alternative glycolytic pathway in rapidly proliferating cells
-
Vander Heiden, M.G., J.W. Locasale, K.D. Swanson, H. Sharfi, G.J. Heffron, D. Amador-Noguez, H.R. Christofk, G. Wagner, J.D. Rabinowitz, J.M. Asara, and L.C. Cantley. 2010. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science. 329:1492-1499. http://dx.doi.org/10.1126/science.1188015
-
(2010)
Science
, vol.329
, pp. 1492-1499
-
-
Vander Heiden, M.G.1
Locasale, J.W.2
Swanson, K.D.3
Sharfi, H.4
Heffron, G.J.5
Amador-Noguez, D.6
Christofk, H.R.7
Wagner, G.8
Rabinowitz, J.D.9
Asara, J.M.10
Cantley, L.C.11
-
28
-
-
0021873592
-
Alterations in the activity and isozymic profile of human phosphofructokinase during malignant transformation in vivo and in vitro: transformation-and progression-linked discriminants of malignancy
-
Vora, S., J.P. Halper, and D.M. Knowles. 1985. Alterations in the activity and isozymic profile of human phosphofructokinase during malignant transformation in vivo and in vitro: transformation-and progression-linked discriminants of malignancy. Cancer Res. 45:2993-3001.
-
(1985)
Cancer Res
, vol.45
, pp. 2993-3001
-
-
Vora, S.1
Halper, J.P.2
Knowles, D.M.3
-
30
-
-
12444279265
-
On the origin of cancer cells
-
Warburg, O. 1956. On the origin of cancer cells. Science. 123:309-314. http://dx.doi.org/10.1126/science.123.3191.309
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
31
-
-
82555170271
-
Nuclear PKM2 regulates b-catenin transactivation upon EGFR activation
-
Yang, W., Y. Xia, H. Ji, Y. Zheng, J. Liang, W. Huang, X. Gao, K. Aldape, and Z. Lu. 2011. Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. Nature. 480:118-122. http://dx.doi.org/10.1038/nature10598
-
(2011)
Nature
, vol.480
, pp. 118-122
-
-
Yang, W.1
Xia, Y.2
Ji, H.3
Zheng, Y.4
Liang, J.5
Huang, W.6
Gao, X.7
Aldape, K.8
Lu, Z.9
-
32
-
-
0030023026
-
Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers
-
Younes, M., L.V. Lechago, J.R. Somoano, M. Mosharaf, and J. Lechago. 1996. Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers. Cancer Res. 56:1164-1167.
-
(1996)
Cancer Res
, vol.56
, pp. 1164-1167
-
-
Younes, M.1
Lechago, L.V.2
Somoano, J.R.3
Mosharaf, M.4
Lechago, J.5
-
33
-
-
0347694776
-
Cancer metabolism: facts, fantasy, and fiction
-
Zu, X.L., and M. Guppy. 2004. Cancer metabolism: facts, fantasy, and fiction. Biochem. Biophys. Res. Commun. 313:459-465. http://dx.doi.org/10.1016/j.bbrc.2003.11.136
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.313
, pp. 459-465
-
-
Zu, X.L.1
Guppy, M.2
|