메뉴 건너뛰기




Volumn 16, Issue 1, 2016, Pages

Computational prediction and experimental validation of novel Hedgehog-responsive enhancers linked to genes of the Hedgehog pathway Integrative control of development

Author keywords

Enhancers; GLI; Hedgehog signaling; Machine learning

Indexed keywords

ONCOPROTEIN; PROTEIN BINDING; SONIC HEDGEHOG PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI1;

EID: 84958952560     PISSN: None     EISSN: 1471213X     Source Type: Journal    
DOI: 10.1186/s12861-016-0106-0     Document Type: Article
Times cited : (8)

References (52)
  • 1
    • 84879414522 scopus 로고    scopus 로고
    • The mechanisms of Hedgehog signalling and its roles in development and disease
    • 23719536
    • Briscoe J, Thérond PP. The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol. 2013;14:416-29.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 416-429
    • Briscoe, J.1    Thérond, P.P.2
  • 2
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • 1:CAS:528:DC%2BD1cXhsFWgsbjN 19081070
    • Jiang J, Hui CC. Hedgehog signaling in development and cancer. Dev Cell. 2008;15:801-12.
    • (2008) Dev Cell , vol.15 , pp. 801-812
    • Jiang, J.1    Hui, C.C.2
  • 3
    • 0002452569 scopus 로고    scopus 로고
    • Developmental roles and clinical significance of hedgehog signaling
    • 1:CAS:528:DC%2BD3sXht1ertro%3D 12509125
    • McMahon AP, Ingham PW, Tabin CJ. Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol. 2003;53:1-114.
    • (2003) Curr Top Dev Biol , vol.53 , pp. 1-114
    • McMahon, A.P.1    Ingham, P.W.2    Tabin, C.J.3
  • 4
    • 84906875879 scopus 로고    scopus 로고
    • Roles for Hedgehog signaling in adult organ homeostasis and repair
    • 1:CAS:528:DC%2BC2cXhvVWltr%2FK 25183867 4197719
    • Petrova R, Joyner AL. Roles for Hedgehog signaling in adult organ homeostasis and repair. Development. 2014;141:3445-57.
    • (2014) Development , vol.141 , pp. 3445-3457
    • Petrova, R.1    Joyner, A.L.2
  • 5
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: functions and mechanisms
    • 1:CAS:528:DC%2BD1cXht1ClsbjN 18794343
    • Varjosalo M, Taipale J. Hedgehog: functions and mechanisms. Genes Dev. 2008;22:2454-72.
    • (2008) Genes Dev , vol.22 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 6
    • 84862594879 scopus 로고    scopus 로고
    • Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form
    • 1:CAS:528:DC%2BC38XhtVegs7%2FF 22677548 3387659
    • Creanga A, Glenn TD, Mann RK, Saunders AM, Talbot WS, Beachy PA. Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. Genes Dev. 2012;26:1312-25.
    • (2012) Genes Dev , vol.26 , pp. 1312-1325
    • Creanga, A.1    Glenn, T.D.2    Mann, R.K.3    Saunders, A.M.4    Talbot, W.S.5    Beachy, P.A.6
  • 7
    • 84898896289 scopus 로고    scopus 로고
    • Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells
    • 1:CAS:528:DC%2BC2cXos1Chtbc%3D 24522195
    • Jakobs P, Exner S, Schurmann S, Pickhinke U, Bandari S, Ortmann C, et al. Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells. J Cell Sci. 2014;127:1726-37.
    • (2014) J Cell Sci , vol.127 , pp. 1726-1737
    • Jakobs, P.1    Exner, S.2    Schurmann, S.3    Pickhinke, U.4    Bandari, S.5    Ortmann, C.6
  • 8
    • 0033598964 scopus 로고    scopus 로고
    • Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
    • 1:CAS:528:DC%2BD3cXislSlug%3D%3D 10619433
    • Burke R, Nellen D, Bellotto M, Hafen E, Senti KA, Dickson BJ, et al. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell. 1999;99:803-15.
    • (1999) Cell , vol.99 , pp. 803-815
    • Burke, R.1    Nellen, D.2    Bellotto, M.3    Hafen, E.4    Senti, K.A.5    Dickson, B.J.6
  • 9
    • 0036733753 scopus 로고    scopus 로고
    • Cholesterol modification of Hedgehog family proteins
    • 1:CAS:528:DC%2BD38XmslyisbY%3D 12208857 151115
    • Jeong J, McMahon AP. Cholesterol modification of Hedgehog family proteins. J Clin Invest. 2002;110:591-6.
    • (2002) J Clin Invest , vol.110 , pp. 591-596
    • Jeong, J.1    McMahon, A.P.2
  • 10
    • 79958210024 scopus 로고    scopus 로고
    • Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation
    • 1:CAS:528:DC%2BC3MXnsVCns7w%3D 21664577 3432913
    • Izzi L, Levesque M, Morin S, Laniel D, Wilkes BC, Mille F, et al. Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Dev Cell. 2011;20:788-801.
    • (2011) Dev Cell , vol.20 , pp. 788-801
    • Izzi, L.1    Levesque, M.2    Morin, S.3    Laniel, D.4    Wilkes, B.C.5    Mille, F.6
  • 11
    • 79958207835 scopus 로고    scopus 로고
    • Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function
    • 1:CAS:528:DC%2BC3MXnsVCns78%3D 21664576 3121104
    • Allen BL, Song JY, Izzi L, Althaus IW, Kang JS, Charron F, et al. Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function. Dev Cell. 2011;20:775-87.
    • (2011) Dev Cell , vol.20 , pp. 775-787
    • Allen, B.L.1    Song, J.Y.2    Izzi, L.3    Althaus, I.W.4    Kang, J.S.5    Charron, F.6
  • 12
    • 0033580269 scopus 로고    scopus 로고
    • Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
    • 1:CAS:528:DyaK1MXhtlyitLg%3D 10050855
    • Chuang PT, McMahon AP. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature. 1999;397:617-21.
    • (1999) Nature , vol.397 , pp. 617-621
    • Chuang, P.T.1    McMahon, A.P.2
  • 13
    • 76049114315 scopus 로고    scopus 로고
    • Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
    • 1:CAS:528:DC%2BC3cXltlKjtQ%3D%3D 19996169 2790365
    • Kim J, Kato M, Beachy PA. Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proc Natl Acad Sci U S A. 2009;106:21666-71.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 21666-21671
    • Kim, J.1    Kato, M.2    Beachy, P.A.3
  • 14
    • 77951101203 scopus 로고    scopus 로고
    • The primary cilium: a signalling centre during vertebrate development
    • 1:CAS:528:DC%2BC3cXkvVSqs74%3D 20395968 3121168
    • Goetz SC, Anderson KV. The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet. 2010;11:331-44.
    • (2010) Nat Rev Genet , vol.11 , pp. 331-344
    • Goetz, S.C.1    Anderson, K.V.2
  • 15
    • 0033583035 scopus 로고    scopus 로고
    • Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
    • 1:CAS:528:DyaK1MXitFSrs7w%3D 10075717
    • Dai P, Akimaru H, Tanaka Y, Maekawa T, Nakafuku M, Ishii S. Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J Biol Chem. 1999;274:8143-52.
    • (1999) J Biol Chem , vol.274 , pp. 8143-8152
    • Dai, P.1    Akimaru, H.2    Tanaka, Y.3    Maekawa, T.4    Nakafuku, M.5    Ishii, S.6
  • 16
    • 0001466654 scopus 로고    scopus 로고
    • GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization
    • 1:CAS:528:DyaK1MXhvFyks7w%3D 10077605 15863
    • Shin SH, Kogerman P, Lindstrom E, Toftgard R, Biesecker LG. GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization. Proc Natl Acad Sci U S A. 1999;96:2880-4.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 2880-2884
    • Shin, S.H.1    Kogerman, P.2    Lindstrom, E.3    Toftgard, R.4    Biesecker, L.G.5
  • 17
    • 0032848136 scopus 로고    scopus 로고
    • Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
    • 1:CAS:528:DyaK1MXmtlOit7s%3D 10433919
    • Sasaki H, Nishizaki Y, Hui C, Nakafuku M, Kondoh H. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development. 1999;126:3915-24.
    • (1999) Development , vol.126 , pp. 3915-3924
    • Sasaki, H.1    Nishizaki, Y.2    Hui, C.3    Nakafuku, M.4    Kondoh, H.5
  • 18
    • 77956814604 scopus 로고    scopus 로고
    • Interactions between Hedgehog proteins and their binding partners come into view
    • 1:CAS:528:DC%2BC3cXht1KjtLbM 20844013 2939362
    • Beachy PA, Hymowitz SG, Lazarus RA, Leahy DJ, Siebold C. Interactions between Hedgehog proteins and their binding partners come into view. Genes Dev. 2010;24:2001-12.
    • (2010) Genes Dev , vol.24 , pp. 2001-2012
    • Beachy, P.A.1    Hymowitz, S.G.2    Lazarus, R.A.3    Leahy, D.J.4    Siebold, C.5
  • 19
    • 69449099121 scopus 로고    scopus 로고
    • Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling
    • 1:CAS:528:DC%2BD1MXhtVOitrzF 19666503 2726420
    • Liem Jr KF, He M, Ocbina PJ, Anderson KV. Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proc Natl Acad Sci U S A. 2009;106:13377-82.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 13377-13382
    • Liem, K.F.1    He, M.2    Ocbina, P.J.3    Anderson, K.V.4
  • 20
    • 34248580985 scopus 로고    scopus 로고
    • Gene expression analysis of the hedgehog signaling cascade in the chick midbrain and spinal cord
    • 1:CAS:528:DC%2BD2sXmtlSis7o%3D 17436280
    • Aglyamova GV, Agarwala S. Gene expression analysis of the hedgehog signaling cascade in the chick midbrain and spinal cord. Dev Dyn. 2007;236:1363-73.
    • (2007) Dev Dyn , vol.236 , pp. 1363-1373
    • Aglyamova, G.V.1    Agarwala, S.2
  • 21
    • 33646103902 scopus 로고    scopus 로고
    • The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice
    • 1:CAS:528:DC%2BD28XltVyktrk%3D 16647304
    • Tenzen T, Allen BL, Cole F, Kang JS, Krauss RS, McMahon AP. The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell. 2006;10:647-56.
    • (2006) Dev Cell , vol.10 , pp. 647-656
    • Tenzen, T.1    Allen, B.L.2    Cole, F.3    Kang, J.S.4    Krauss, R.S.5    McMahon, A.P.6
  • 22
    • 34249011892 scopus 로고    scopus 로고
    • Gas1 extends the range of Hedgehog action by facilitating its signaling
    • 1:CAS:528:DC%2BD2sXls1aqu7Y%3D 17504940 1865494
    • Martinelli DC, Fan CM. Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev. 2007;21:1231-43.
    • (2007) Genes Dev , vol.21 , pp. 1231-1243
    • Martinelli, D.C.1    Fan, C.M.2
  • 23
    • 12144288863 scopus 로고    scopus 로고
    • Distinct roles of PTCH2 splice variants in Hedgehog signalling
    • 1:CAS:528:DC%2BD2cXisVajsLw%3D 14613484 1223965
    • Rahnama F, Toftgard R, Zaphiropoulos PG. Distinct roles of PTCH2 splice variants in Hedgehog signalling. Biochem J. 2004;378:325-34.
    • (2004) Biochem J , vol.378 , pp. 325-334
    • Rahnama, F.1    Toftgard, R.2    Zaphiropoulos, P.G.3
  • 24
    • 1842839986 scopus 로고    scopus 로고
    • Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site
    • 1:CAS:528:DC%2BD2cXjtFGnsrg%3D 15087129
    • Agren M, Kogerman P, Kleman MI, Wessling M, Toftgard R. Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site. Gene. 2004;330:101-14.
    • (2004) Gene , vol.330 , pp. 101-114
    • Agren, M.1    Kogerman, P.2    Kleman, M.I.3    Wessling, M.4    Toftgard, R.5
  • 25
    • 84871587536 scopus 로고    scopus 로고
    • Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning
    • 1:CAS:528:DC%2BC3sXnvVOjug%3D%3D 23249739 3533082
    • Peterson KA, Nishi Y, Ma W, Vedenko A, Shokri L, Zhang X, et al. Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning. Genes Dev. 2012;26:2802-16.
    • (2012) Genes Dev , vol.26 , pp. 2802-2816
    • Peterson, K.A.1    Nishi, Y.2    Ma, W.3    Vedenko, A.4    Shokri, L.5    Zhang, X.6
  • 26
    • 34250612602 scopus 로고    scopus 로고
    • Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning
    • 1:CAS:528:DC%2BD2sXmvFeit78%3D 17442700
    • Vokes SA, Ji H, McCuine S, Tenzen T, Giles S, Zhong S, et al. Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development. 2007;134:1977-89.
    • (2007) Development , vol.134 , pp. 1977-1989
    • Vokes, S.A.1    Ji, H.2    McCuine, S.3    Tenzen, T.4    Giles, S.5    Zhong, S.6
  • 27
    • 53549125545 scopus 로고    scopus 로고
    • A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
    • 1:CAS:528:DC%2BD1cXht1ClsbvP 18832070 2559910
    • Vokes SA, Ji H, Wong WH, McMahon AP. A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev. 2008;22:2651-63.
    • (2008) Genes Dev , vol.22 , pp. 2651-2663
    • Vokes, S.A.1    Ji, H.2    Wong, W.H.3    McMahon, A.P.4
  • 28
    • 84880934981 scopus 로고    scopus 로고
    • Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning
    • 1:CAS:528:DC%2BC3sXhsFelsL%2FO 23900540 3737722
    • Holtz AM, Peterson KA, Nishi Y, Morin S, Song JY, Charron F, et al. Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning. Development. 2013;140:3423-34.
    • (2013) Development , vol.140 , pp. 3423-3434
    • Holtz, A.M.1    Peterson, K.A.2    Nishi, Y.3    Morin, S.4    Song, J.Y.5    Charron, F.6
  • 29
    • 77953113675 scopus 로고    scopus 로고
    • Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis
    • 1:CAS:528:DC%2BC3cXntFGqsbY%3D 20460306 2906878
    • Lee EY, Ji H, Ouyang Z, Zhou B, Ma W, Vokes SA, et al. Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis. Proc Natl Acad Sci U S A. 2010;107:9736-41.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 9736-9741
    • Lee, E.Y.1    Ji, H.2    Ouyang, Z.3    Zhou, B.4    Ma, W.5    Vokes, S.A.6
  • 30
    • 84883588081 scopus 로고    scopus 로고
    • Kmer-SVM: a web server for identifying predictive regulatory sequence features in genomic data sets
    • 23771147 3692045
    • Fletez-Brant C, Lee D, McCallion AS, Beer MA. kmer-SVM: a web server for identifying predictive regulatory sequence features in genomic data sets. Nucleic Acids Res. 2013;41:W544-56.
    • (2013) Nucleic Acids Res , vol.41 , pp. W544-W556
    • Fletez-Brant, C.1    Lee, D.2    McCallion, A.S.3    Beer, M.A.4
  • 31
    • 83055181959 scopus 로고    scopus 로고
    • Discriminative prediction of mammalian enhancers from DNA sequence
    • 1:CAS:528:DC%2BC3MXhs1WlurzK 21875935 3227105
    • Lee D, Karchin R, Beer MA. Discriminative prediction of mammalian enhancers from DNA sequence. Genome Res. 2011;21:2167-80.
    • (2011) Genome Res , vol.21 , pp. 2167-2180
    • Lee, D.1    Karchin, R.2    Beer, M.A.3
  • 32
    • 84865249952 scopus 로고    scopus 로고
    • Transcription factors: from enhancer binding to developmental control
    • 1:CAS:528:DC%2BC38XhtFCrtrbM 22868264
    • Spitz F, Furlong EE. Transcription factors: from enhancer binding to developmental control. Nat Rev Genet. 2012;13:613-26.
    • (2012) Nat Rev Genet , vol.13 , pp. 613-626
    • Spitz, F.1    Furlong, E.E.2
  • 34
    • 30344439849 scopus 로고    scopus 로고
    • Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity
    • Hallikas O, Palin K, Sinjushina N, Rautiainen R, Partanen J, Ukkonen E, et al. Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell. 2006;124:1-13.
    • (2006) Cell , vol.124 , pp. 1-13
    • Hallikas, O.1    Palin, K.2    Sinjushina, N.3    Rautiainen, R.4    Partanen, J.5    Ukkonen, E.6
  • 35
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    • 1:CAS:528:DC%2BC3cXns1SlsLc%3D 20513432 2898526
    • Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010;38:576-89.
    • (2010) Mol Cell , vol.38 , pp. 576-589
    • Heinz, S.1    Benner, C.2    Spann, N.3    Bertolino, E.4    Lin, Y.C.5    Laslo, P.6
  • 36
    • 79958090979 scopus 로고    scopus 로고
    • DREME: motif discovery in transcription factor ChIP-seq data
    • 1:CAS:528:DC%2BC3MXntFGkurg%3D 21543442 3106199
    • Bailey TL. DREME: motif discovery in transcription factor ChIP-seq data. Bioinformatics. 2011;27:1653-9.
    • (2011) Bioinformatics , vol.27 , pp. 1653-1659
    • Bailey, T.L.1
  • 38
    • 2142738304 scopus 로고    scopus 로고
    • WebLogo: a sequence logo generator
    • 1:CAS:528:DC%2BD2cXkvFGht7Y%3D 15173120 419797
    • Crooks GE, Hon G, Chandonia JM, Brenner SE. WebLogo: a sequence logo generator. Genome Res. 2004;14:1188-90.
    • (2004) Genome Res , vol.14 , pp. 1188-1190
    • Crooks, G.E.1    Hon, G.2    Chandonia, J.M.3    Brenner, S.E.4
  • 40
    • 79958117256 scopus 로고    scopus 로고
    • MEME-ChIP: motif analysis of large DNA datasets
    • 1:CAS:528:DC%2BC3MXntFGkurw%3D 21486936 3106185
    • Machanick P, Bailey TL. MEME-ChIP: motif analysis of large DNA datasets. Bioinformatics. 2011;27:1696-7.
    • (2011) Bioinformatics , vol.27 , pp. 1696-1697
    • Machanick, P.1    Bailey, T.L.2
  • 41
    • 84866937220 scopus 로고    scopus 로고
    • Inferring direct DNA binding from ChIP-seq
    • 1:CAS:528:DC%2BC38XhsVeht7jK 22610855 3458523
    • Bailey TL, Machanick P. Inferring direct DNA binding from ChIP-seq. Nucleic Acids Res. 2012;40:e128.
    • (2012) Nucleic Acids Res , vol.40 , pp. e128
    • Bailey, T.L.1    Machanick, P.2
  • 42
    • 78650758676 scopus 로고    scopus 로고
    • Histone H3K27ac separates active from poised enhancers and predicts developmental state
    • 1:CAS:528:DC%2BC3cXhs1Wjs7bP 21106759 3003124
    • Creyghton MP, Cheng AW, Welstead GG, Kooistra T, Carey BW, Steine EJ, et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A. 2010;107:21931-6.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 21931-21936
    • Creyghton, M.P.1    Cheng, A.W.2    Welstead, G.G.3    Kooistra, T.4    Carey, B.W.5    Steine, E.J.6
  • 43
    • 33847334699 scopus 로고    scopus 로고
    • Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
    • 1:CAS:528:DC%2BD2sXitVOksbc%3D 17277777
    • Heintzman ND, Stuart RK, Hon G, Fu Y, Ching CW, Hawkins RD, et al. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet. 2007;39:311-8.
    • (2007) Nat Genet , vol.39 , pp. 311-318
    • Heintzman, N.D.1    Stuart, R.K.2    Hon, G.3    Fu, Y.4    Ching, C.W.5    Hawkins, R.D.6
  • 44
    • 0346494761 scopus 로고    scopus 로고
    • GenePaint.org: an atlas of gene expression patterns in the mouse embryo
    • 1:CAS:528:DC%2BD3sXhtVSrur%2FE 14681479 308763
    • Visel A, Thaller C, Eichele G. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004;32:D552-6.
    • (2004) Nucleic Acids Res , vol.32 , pp. D552-D556
    • Visel, A.1    Thaller, C.2    Eichele, G.3
  • 45
    • 79851473886 scopus 로고    scopus 로고
    • A high-resolution anatomical atlas of the transcriptome in the mouse embryo
    • 1:CAS:528:DC%2BC3MXht1Ohsr8%3D 21267068 3022534
    • Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, et al. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9:e1000582.
    • (2011) PLoS Biol , vol.9
    • Diez-Roux, G.1    Banfi, S.2    Sultan, M.3    Geffers, L.4    Anand, S.5    Rozado, D.6
  • 46
    • 77952214662 scopus 로고    scopus 로고
    • GREAT improves functional interpretation of cis-regulatory regions
    • 1:CAS:528:DC%2BC3cXlsVyhs7w%3D 20436461
    • McLean CY, Bristor D, Hiller M, Clarke SL, Schaar BT, Lowe CB, et al. GREAT improves functional interpretation of cis-regulatory regions. Nat Biotechnol. 2010;28:495-501.
    • (2010) Nat Biotechnol , vol.28 , pp. 495-501
    • McLean, C.Y.1    Bristor, D.2    Hiller, M.3    Clarke, S.L.4    Schaar, B.T.5    Lowe, C.B.6
  • 47
    • 33847182373 scopus 로고    scopus 로고
    • The hedgehog regulated oncogenes Gli1 and Gli2 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activation
    • 1:CAS:528:DC%2BD2sXhvF2juro%3D 16964293 3325095
    • Gerber AN, Wilson CW, Li YJ, Chuang PT. The hedgehog regulated oncogenes Gli1 and Gli2 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activation. Oncogene. 2007;26:1122-36.
    • (2007) Oncogene , vol.26 , pp. 1122-1136
    • Gerber, A.N.1    Wilson, C.W.2    Li, Y.J.3    Chuang, P.T.4
  • 48
    • 33746987081 scopus 로고    scopus 로고
    • The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling
    • 1:CAS:528:DC%2BD28Xot1yltLw%3D 16880529 1592805
    • Zhao M, Qiao M, Harris SE, Chen D, Oyajobi BO, Mundy GR. The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol Cell Biol. 2006;26:6197-208.
    • (2006) Mol Cell Biol , vol.26 , pp. 6197-6208
    • Zhao, M.1    Qiao, M.2    Harris, S.E.3    Chen, D.4    Oyajobi, B.O.5    Mundy, G.R.6
  • 50
    • 9544222720 scopus 로고    scopus 로고
    • The conserved role of Krox-20 in directing Hox gene expression during vertebrate hindbrain segmentation
    • 1:CAS:528:DyaK28XlsFeju74%3D 8790331 38429
    • Nonchev S, Maconochie M, Vesque C, Aparicio S, Ariza-McNaughton L, Manzanares M, et al. The conserved role of Krox-20 in directing Hox gene expression during vertebrate hindbrain segmentation. Proc Natl Acad Sci U S A. 1996;93:9339-45.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 9339-9345
    • Nonchev, S.1    Maconochie, M.2    Vesque, C.3    Aparicio, S.4    Ariza-McNaughton, L.5    Manzanares, M.6
  • 51
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012;489:57-74.
    • (2012) Nature , vol.489 , pp. 57-74
  • 52
    • 49449100251 scopus 로고    scopus 로고
    • Building it up and taking it down: the regulation of vertebrate ciliogenesis
    • 18435467 3304540
    • Santos N, Reiter JF. Building it up and taking it down: the regulation of vertebrate ciliogenesis. Dev Dyn. 2008;237:1972-81.
    • (2008) Dev Dyn , vol.237 , pp. 1972-1981
    • Santos, N.1    Reiter, J.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.