Defective bone formation in Krox-20 mutant mice

Development

Volumn 122, Issue 1, 1996, Pages 113-120

  Levi, Giovanni ^a,b   Topilko, Piotr ^a   Schneider Maunoury, Sylvie ^a   Lasagna, Marco ^b   Mantero, Stefano ^b   Cancedda, Ranieri ^b   Charnay, Patrick ^a  

^a ECOLE NORMALE SUPÉRIEURE   (France)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Bone formation; Gene disruption; Krox 20; Mouse; Transcriptional control

Indexed keywords

TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; CARTILAGE CELL; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMBRYO; ENCHONDRAL OSSIFICATION; ESCHERICHIA COLI; MOUSE; MUTANT; MYELINATION; NONHUMAN; PRIORITY JOURNAL; RHOMBENCEPHALON; TRABECULAR BONE;

ANIMALIA; ESCHERICHIA COLI; VERTEBRATA;

EID: 0030060372     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Amizuka, N., Warshawsky, H., Henderson, J. E., Goltzman, D., and Karaplis, A. C. (1994). Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage decelopment and alterred endochondral bone formation. J. Cell Biol 126, 1611-1623.
2. Beresford, J. N. (1989). Osteogenic stem cells and the stromal system of bone and marrow. Clin. Orthop. Rel. Res. 240, 270-280.
3. Chavrier, P., Zerial, M., Lemaire, P., Almendral, J., Bravo, R., and Charnay, P. (1988a). A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells. EMBO J. 7, 29-35
4. Chavrier, P., Lemaire, P., Revelant, O., Bravo, R., and Charnay, P. (1988b). Characterization of a mouse multigene family encoding zinc finger structures Mol. Cell. Biol. 8, 1319-1326.
5. Chavrier, P., Vesque, C., Galliot, B., Vigneron, M., Dollé, P., Duboule, D., and Charnay, P. (1990). The segment-specific gene Krox-20 encodes a transcription factor with binding sites in the promoter region of the Hox-I. 4 gene. EMBO J. 9, 1209-1218
6. Christy, B. A., Lau, L. F., and Nathans, D. (1988). A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences. Proc. Natl. Acad. Sci USA 85, 7857-7861.
7. Closs, E. I., Murray, A. B. and Strauss, J. P. G. (1990). C-fos expression precedes osteogenic differentiation of the cartilage cells in vitro. J. Cell Biol. 111, 1313-1323.
8. Davidson, D. R., Crawley, A., Hill, R. E. and Tickle, C. (1991). Position dependent expression of two related homeobox genes in developing vertebrate limbs Nature 352, 429-431
9. Descalzi Cancedda,F., Gentili, C., Manduca, P. and Cancedda, R. (1992). Hypertrophic chondrocytes undergo further differentiation in culture. J. Cell Biol. 117, 427-435
10. Dollé, P., Dierich, A., LeMeur, M., Schimmang, T., Schuhbaur, B., Chambon, P. and Duboule, D. (1993) Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell 75, 431-441.
11. Erlebacher, A., Filvaroff, E. H., Gitelman, S. E. and Derynck, R. (1995). Toward a molecular understanding of skeletal development. Cell 80, 371-378.
12. Fan, C.-M. and Tessier-Lavigne, M. (1994). Patterning of mammalian somites by surface ectoderm and notochord. Evidence for sclerotome induction by a hedgehog homolog. Cell 79, 1317-1186.
13. Fawcett, D. W. (1994). A Textbook of Histology 12th edn. (Bloom and Fawcett), pp. 194-233. New York, NY: Chapman and Hall.
14. Galotto, M., Campanile, G., Robino, G., Descalzi-Cancedda, F., Bianco, P. and Cancedda, R. (1994). Hypertrophic chondrocytes undergo further differentiation to osteoblast-like cells and participate in the initial bone formation in developing embryo. J. Bone Min. Res. 9, 1239-1240.
15. Gentili, C., Bianco, P., Neri, M., Malpeli, M., Campanile, G., Castagnola, P., Cancedda, R. and Descalzi Cancedda, F. (1993). Cell prolipheration, extracellular matrix mineralization, and ovotransferrin transient expression during in vitro differentiation of chic hypetrophic chondrocytes into osteoblast-like cells J. Cell Biol. 122, 703-712.
16. Gilardi, P., Schneider-Maunoury, S. and Charnay, P. (1991). Krox-20: a candidate gene for the regulation of pattern formation in the hindbrain. Biochimie 73, 85-91.
17. Hunt, P., Gulisano, M. Cook, M., Sham, M.-H., Faiella, A., Wilkinson, D., Boncirielli, E. and Krumlauf, R. (1991). A distinct Hox code for the branchial region of the vertebrate head. Nature 353, 861-864.
18. Jabs, E. W., Li, X., Scott, A. F., Meyers, G., Chen, W., Eccles, M., Mao, J., Charnas, L. R., Jackson, C. E. and Jaye, M. (1994). Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2. Nature Gener. 8, 275-279.
19. Jacenko, O., Olsen, B. R. and LuValle, P. (1991). Organisation and regulation of collagen genes. Crit. Rev. Eukaryotic Gene Exp. 1, 327-353.
20. Jacenko, O., LuValle, P. A. and Olsen, B. R. (1993). Spondylometaphyseal dysplasia in mice carrying a dominant negative mutation in a matrix protein specific for cartilage-to-bone transition. Nature 365, 56-60.
21. Johnson, R. L., Laufer, E., Riddle, R. D., and Tabin, C. (1994). Ectopic expression of sonic hedgehog alters dorsal-ventral patterning of somites. Cell 79, 1165-1173.
22. Karaplis, A. C., Luz, A., Glowacki, J., Bronson, R. T., Tybulewicz, V. L., Kronenberg, H. M. and Mulligan, R. C. (1994). Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev. 8, 277-289
23. Kaufman., M. H. (1992). The Atlas of Mouse Development p. p. 495-506. San Diego, CA: Academic Press.
24. Kingsley, D. M. (1994). What do BMPs do in mammals?: clues from the mouse short-ear mutation. Trends Genet. 10, 16-21.
25. Kirsch, T. and Von Der Mark, K. (1991). Isolation of human type X collagen and immunolocalization in foetal human cartilage. Eur J. Biochem. 196, 575-580
26. Krumlauf, R. (1994). Hox genes in vertebrate development. Cell 78, 191-201.
27. Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A. and Tabin, C. (1994). Sonic hedgehog and Fgf-4 act through a signalling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79, 993-1003.
28. Lemaire, P., Relevant, O., Bravo, R. and Charnay, P. (1988). Two genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells. Proc. Natl. Acad Sci USA 85, 4691-4695.
29. Lemaire, P., Vesque, C., Schmitt, J., Stennenberg, H., Frank, R. and Charnay, P. (1990). The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcription activator. Mol. Cell Biol. 10, 3456-3467
30. Mackowiak, S. J., Troiano, N. and Gundberg, C. M. (1992). Osteocalcin and its message, relationship to bone histology in magnesium-deprived rats. Am. J. Physiol. 263, 107-114.
31. Martin, J. F., Bradley, A. and Olson, E. N. (1995). The paired-like horneo box gene MHox is required for early events of skeletogenesis in multiple lineages. Genes Dev 9, 1237-1249
32. Milbrandt, J. (1988). A nerve growth factor-induced gene encodes a possible transcriptional regulator factor Science 238, 797-799.
33. McMahon, A. P., Champion, J. E., McMahon, J. A. and Sukhatme, V. P. (1990) Developmental expression of the putative transcription factor Egr-1 suggests that Egr-1 and c-fos are coregulated in some tissues Development 108, 281-287.
34. Morgan, B. A. and Tabin, C. (1993). The role of homeobox genes in limb development. Curr. Opin, Genet. Dev. 3, 668-674.
35. Morgan, B. A. and Tabin, C. (1994). Hox genes and growth: early and late roles in limb bud morphogenesis. In The Evolution of Developmental Mechanisms (ed. Akam, M., Holland, P., Ingham, P. and Wray, G.), pp 181-186. Development 1994 Supplement. The Company of Biologists Limited, Cambridge, UK.
36. Morgan, B. A. and Tabin, C. (1994). Hox genes and growth: early and late roles in limb bud morphogenesis. In The Evolution of Developmental Mechanisms (ed. Akam, M., Holland, P., Ingham, P. and Wray, G.), pp 181-186. Development 1994 Supplement. The Company of Biologists Limited, Cambridge, UK.
37. Moskalewski, S. and Malejczyk, J. (1989). Bone formation following intrarenal transplantation of isolated murine chondrocytes. chondrocytebone cell transdifferentiation? Development 107, 473-480.
38. Muenke, M., Schell, U., Hehr, A., Robin, N. H., Losken, H. W., Schinzel, A., Pulleyn, L. J. n Rutland., W., Malcom., S., and Winter, R. M. (1994). A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome. Nature Genet. 8, 269-274.
39. Nardelli, J., Gibson, T., Vesque, C., and Charnay, P. (1991). Base sequence discrimination by zinc-finger DNA-binding domains. Nature 349, 175-178.
40. Niswander, L., Jeffrey, S., Martin, G. R. and Tickle, C. (1994). A positive feedback loop coordinates growth and patterning in the vertebrate limb. Nature 371, 609-612.
41. Pechak, D. G., Ilujawa, M. J., and Caplan, A. I. (1986). Morphology of bone development and bone remodeling in embryonic chick limbs. Bone 7, 459-472.
42. Peters, K., Ornitz, D., Werner, S., and Williams, L. T. (1993). Unique expression pattern of the FGF receptor 3 gene during mouse organoeenesis. Dev. Biol. 155, 423-430.
43. Roach, H. I. (1992). Trans-differentiation of hypertrophic chondrocytes into cells capable of producung a mineralized bone matrix. Bone Miner. 19, 1-20.
44. Rousseau, F., Bonaventure, J., Legeai-Mallet, L., Pelet, A., Rozet, J. M., Moroteaux, P., Le Merrer, M., and Munnich, A. (1994). Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia Nature 371, 252-254.
45. Satokata, I. and Maas, R. (1994). Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Nature Genet 6, 348-355.
46. Sham, M. H., Vesque, C., Nonchev, S., Marshall, H., Frain, M., Dasgupta, R., Whiting, J., Wilkinson, D., Charnay, P. and Krumlauf, R. (1993). The zinc finger gene Kros-20 regulates Hoxb-2 (Hox2.8) during hindbrain segmentation. Cell 72, 183-196.
47. Shiang, R., Thompson, L. M., Zhu, Y. Z., Church, D. M., Fielder, T. J., Bocian, M., Winokur, S. T. and Wasmuth, J. J. (1994). Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell 78, 335-342.
48. Schneider-Maunoury, S., Topilko, P., Seitanidou, T., Levi, G., Cohen-Tannoudji, M., Pournin, S., Babinet, C. and Charnay, P. (1993). Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain. Cell 75, 1199-1214.
49. Sham, M. H., Vesque, C., Nonchev, S., Marshall, H., Frain, M., Das Gupta, R., Whiting, J., Wilkinson, D., Charnay, P., and Krumlauf, R. (1993). The zinc finger gene Krox20 regulates HoxB2 (Hox2. 8) during hindbrain segmentation. Cell 72, 183-196.
50. Strauss, P. G., Closs, E. I., Schmidt, J., and Erfle, V. (1990). Gene expression during osteogenic differentiation in mandibular condyles in vitro. J Cell Biol. 110, 1369-1378.
51. Sukhatme, V. P., Cao, X., Chang, L. C., Tsai-Morris, C.-H., Stamekovich, D., Ferreira, P. C. P., Cohen, D. R., Edwards, S. A., Shows, T. B., Curran, T., Le Beau, M. M. and Adamson, E. D. (1988). A zinc fingerencoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell 53, 37-43.
52. Swiatek, P. J. and Gridley, T. (1993). Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox-20. Genes Dev. 7, 2071-2084.
53. Thesingh, C. W., and Scherft, J. P. (1986). Bone matrix formation by transformed chondrocytes in organ cultures of stripped embryonic metatarsalia. Cell Mediated Calcification and Matrix Vesicles, (ed. Ali. S. Y.) p.p. 309-314. Amsterdam. Elsevier Science.
54. Thesingh, C. W., Groot, C. G., and Wassenaar, A. M. (1991). Transdifferentianon of hypertrophic chondrocytes in murine metatarsal bones, induced by co-cultured cerebrum. Bone Min. 12, 25-40.
55. Topilko, P., Schneider-Maunoury, S., Levi, G., Baron-Van Evercooren, A., Chennoufi, A. B. Y., Seitanidou, T., Babinet, C., and Charnay, P. (1994). Krox-20 controls myelination in the peripheral nervous system Nature 371. 796-799.
56. Vainio, S., Karavanova, I., Jowett, A., and Thesleff, I. (1993). Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 75, 45-58.
57. Vesque, C. and Charnay, P. (1992). Mapping functional regions of the segment-specific transcription factor Krox-20. Nucleic Acid Res. 20, 2485-2492.
58. Wallin, J., Wilting, H., Koseki, R., Fistsk, B., Christ, B. and Balling, R. (1994). The role of Pax-I in axial skeleton development. Development 120, 1109-1121.
59. Warman, M. L., Abbott, M., Apte, S. S., Hefferon, T., McIntosh, I., Cohn, D. H., Hecht, J. T., Olsen, B. R. and Francomano, C. A. (1993). A type X collagen mutation causes Schmid metaphyseal chondrodysplasia Nature genetics 5, 79-82.
60. Weiss, A. Von der Merk, K., and Silbermann, M. (1987). Fully differentiated chondrocytes alter their phenotype expression in vitro and transform into bone cells Current advances in Skeletogenesis-3. (ed. Hurwitz. S and Sela. J.) p. p. 40-43. Jerusalem: Heiliger Publishing.
61. Wilkinson, D., Bhatt, S., Chavrier, P., Bravo, R., and Charnay, P. (1989) Segment-specific expression of a zinc finger gene in the developing nervous system of the mouse Nature 337, 461-464
62. Yoshioka, C., and Yagi, T. (1988). Electron microscopic observation of the fate of hypertrophie chondrocytes in condylar cartilage of rat mandible. J. Craniofacial Genet. Dev. Biol. 8, 253-264.