Gene expression analysis of the Hedgehog signaling cascade in the chick midbrain and spinal cord

Developmental Dynamics

Volumn 236, Issue 5, 2007, Pages 1363-1373

  Aglyamova, Galina V ^a   Agarwala, Seema ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Boc; Btrc slimb; disp1; Dzip; Floor plate; Gli; Hhip; Ihh; Megalin; Midbrain hindbrain boundary; Ptc; Smo; SuFu

Indexed keywords

MEGALIN; SONIC HEDGEHOG PROTEIN;

ARTICLE; CHICK; EMBRYO DEVELOPMENT; GENE EXPRESSION; MESENCEPHALON; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD;

ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; CHICK EMBRYO; CLONING, MOLECULAR; DNA PRIMERS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; IN SITU HYBRIDIZATION; MESENCEPHALON; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SPINAL CORD;

ERINACEIDAE; VERTEBRATA;

EID: 34248580985     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.21146     Document Type: Article

References (67)

1. Agarwala S, Ragsdale CW. 2002. A role for midbrain arcs in nucleogenesis. Development 129:5779-5788.
2. Agarwala S, Sanders TA, Ragsdale CW. 2001. Sonic hedgehog control of size and shape in midbrain pattern formation. Science 291:2147-2150.
3. Agarwala S, Aglyamova GV, Marma AK, Fallon JF, Ragsdale CW. 2005. Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant. Dev Biol 288:206-220.
4. Akiyama H, Shigeno C, Hiraki Y, Shukunami C, Kohno H, Akagi M, Konishi J, Nakamura T. 1997. Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5. Biochem Biophys Res Commun 235:142-147.
5. Alcedo J, Noll M. 1997. Hedgehog and its patched-smoothened receptor complex: a novel signalling mechanism at the cell surface. Biol Chem 378:583-590.
6. Aoto K, Nishimura T, Eto K, Motoyama J. 2002. Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud. Dev Biol 251:320-332.
7. Bai CB, Stephen D, Joyner AL. 2004. All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev Cell 6:103-115.
8. Bayly RD, Ngo M, Aglyamova GV, Agarwala S. 2007. Midbrain patterning by Hedgehog signallling. Development (in press).
9. Bellairs R, Osmond MK. 2005. The atlas of chick development. London: Elsevier. 470 p.
10. Bitgood MJ, McMahon AP. 1995. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 172:126-138.
11. Blaess S, Corrales JD, Joyner AL. 2006. Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 133:1799-1809.
12. Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong WT, Tickle C, Brown WR, Wilson SA, Hubbard SJ. 2002. A comprehensive collection of chicken cDNAs. Curr Biol 12:1965-1969.
13. Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P, Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci P, Hayashizaki Y, Buerstedde JM. 2005. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Genome Biol 6:R6.
14. Cayuso J, Ulloa F, Cox B, Briscoe J, Marti E. 2006. The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity. Development 133:517-528.
15. Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA. 1996. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383:407-413.
16. Chuang PT, McMahon AP. 1999. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 397:617-621.
17. Dathe V, Gamel A, Manner J, Brand-Saberi B, Christ B. 2002. Morphological left-right asymmetry of Hensen's node precedes the asymmetric expression of Shh and Fgf8 in the chick embryo. Anat Embryol (Berl) 205:343-354.
18. Ding Q, Motoyama J, Gasca S, Mo R, Sasaki H, Rossant J, Hui CC. 1998. Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125:2533-2543.
19. Ericson J, Morton S, Kawakami A, Roelink H, Jessell TM. 1996. Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell 87:661-673.
20. Ericson J, Briscoe J, Rashbass P, van Heyningen V, Jessell TM. 1997. Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube. Cold Spring Harb Symp Quant Biol 62:451-466.
21. Fedtsova N, Turner EE. 2001. Signals from the ventral midline and isthmus regulate the development of Brn3.0-expressing neurons in the midbrain. Mech Dev 105:129-144.
22. Goodrich LV, Milenkovic L, Higgins KM, Scott MP. 1997. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277:1109-1113.
23. Granata A, Quaderi NA. 2005. Asymmetric expression of Gli transcription factors in Hensen's node. Gene Expr Patterns 5: 529-531.
24. Hamburger V, Hamilton HL. 1951. A series of normal stages in the development of the chick embryo. J Morphol 88:49-92.
25. Hooper JE, Scott MP. 2005. Communicating with Hedgehogs. Nat Rev Mol Cell Biol 6:306-317.
26. Huangfu D, Anderson KV. 2006. Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development 133:3-14.
27. Hui CC, Joyner AL. 1993. A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat Genet 3:241-246.
28. Ingham PW, McMahon AP. 2001. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 15: 3059-3087.
29. Ishibashi M, McMahon AP. 2002. A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo. Development 129:4807-4819.
30. Jessell TM. 2000. Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat Rev Genet 1: 20-29.
31. Jiang J. 2002. Degrading Ci: who is Culpable? Genes Dev 16:2315-2321.
32. Joyner AL. 1996. Engrailed, Wnt and Pax genes regulate midbrain - hindbrain development. Trends Genet 12:15-20.
33. Khokha MK, Hsu D, Brunet LJ, Dionne MS, Harland RM. 2003. Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat Genet 34:303-307.
34. Kogerman P, Grimm T, Kogerman L, Krause D, Unden AB, Sandstedt B, Toftgard R, Zaphiropoulos PG. 1999. Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1. Nat Cell Biol 1:312-319.
35. Lawson A, Colas JF, Schoenwolf GC. 2001. Classification scheme for genes expressed during formation and progression of the avian primitive streak. Anat Ree 262:221-226.
36. Lum L, Zhang C, Oh S, Mann RK, von Kessler DP, Taipale J, Weis-Garcia F, Gong R, Wang B, Beachy PA. 2003. Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell 12:1261-1274.
37. Marigo V, Tabin CJ. 1996. Regulation of patched by sonic hedgehog in the developing neural tube. Proc Natl Acad Sci USA 93:9346-9351.
38. Marigo V, Davey RA, Zuo Y, Cunningham JM, Tabin CJ. 1996. Biochemical evidence that patched is the Hedgehog receptor. Nature 384:176-179.
39. Marti E, Takada R, Bumcrot DA, Sasaki H, McMahon AP. 1995. Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development 121:2537-2547.
40. Matise MP, Epstein DJ, Park HL, Platt KA, Joyner AL. 1998. Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125:2759-2770.
41. McCarthy RA, Barth JL, Chintalapudi MR, Knaak C, Argraves WS. 2002. Megalin functions as an endocytic sonic hedgehog receptor. J Biol Chem 277: 25660-25667.
42. Meier S, Jacobson AG. 1982. Experimental studies of the origin and expression of metameric pattern in the chick embryo. J Exp Zool 219:217-232.
43. Methot N, Basler K. 2001. An absolute requirement for Cubitus interruptus in Hedgehog signaling. Development 128: 733-742.
44. Mulieri PJ, Kang JS, Sassoon DA, Krauss RS. 2002. Expression of the boc gene during murine embryogenesis. Dev Dyn 223: 379-388.
45. Murone M, Luoh SM, Stone D, Li W, Gurney A, Armanini M, Grey C, Rosenthal A, de Sauvage FJ. 2000. Gli regulation by the opposing activities of fused and suppressor of fused. Nat Cell Biol 2:310-312.
46. Ohlmeyer JT, Kalderon D. 1998. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 396:749-753.
47. Okada A, Charron F, Morin S, Shin DS, Wong K, Fabre PJ, Tessier-Lavigne M, McConnell SK. 2006. Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature 444:369-373.
48. Patten I, Kulesa P, Shen MM, Fraser S, Placzek M. 2003. Distinct modes of floor plate induction in the chick embryo. Development 130:4809-4821.
49. Pearse RV Jr, Vogan KJ, Tabin CJ. 2001. Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis. Dev Biol 239:15-29.
50. Sanders TA. 2001. Arcuate Patterning as a central feature of ventral midbrain development during early embryogenesis. In: Committee on neurobiology. Chicago: University of Chicago.
51. Sanders TA, Lumsden A, Ragsdale CW. 2002. Arcuate plan of chick midbrain development. J Neurosci 22:10742-10750.
52. Schoenwolf GC. 1995. Laboratory studies of vertebrate and invertebrate embryos. Upper Saddle River: Prentice Hall. 360 p.
53. Schweitzer R, Vogan KJ, Tabin CJ. 2000. Similar expression and regulation of Gli2 and Gli3 in the chick limb bud. Mech Dev 98:171-174.
54. Sekimizu K, Nishioka N, Sasaki H, Takeda H, Karlstrom RO, Kawakami A. 2004. The zebrafish iguana locus encodes Dzipl, a novel zinc-finger protein required for proper regulation of Hedgehog signaling. Development 131:2521-2532.
55. Simeone A. 2005. Genetic control of dopaminergic neuron differentiation. Trends Neurosci 28:62-65; discussion 65-66.
56. Spoelgen R, Hammes A, Anzenberger U, Zechner D, Andersen OM, Jerchow B, Willnow TE. 2005. LRP2/megalin is required for patterning of the ventral telencephalon. Development 132:405-414.
57. Stoeckli ET. 2006. Longitudinal axon guidance. Curr Opin Neurobiol 16:35-39.
58. Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL, Scott MP, Pennica D, Goddard A, Phillips H, Noll M, Hooper JE, de Sauvage F, Rosenthal A. 1996. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384:129-134.
59. Svard J, Heby-Henricson K, Persson-Lek M, Rozell B, Lauth M, Bergstrom A, Ericson J, Toftgard R, Teglund S. 2006. Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell 10:187-197.
60. Tenzen T, Allen BL, Cole F, Kang JS, Krauss RS, McMahon AP. 2006. The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell 10:647-656.
61. Vokes SA, McMahon AP. 2004. Hedgehog signaling: iguana debuts as a nuclear gatekeeper. Curr Biol 14:R668-R670.
62. Wang QT, Holmgren RA. 2000. Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation. Development 127:3131-3139.
63. Wijgerde M, McMahon JA, Rule M, McMahon AP. 2002. A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev 16:2849-2864.
64. Wolff C, Roy S, Lewis KE, Schauerte H, Joerg-Rauch G, Kirn A, Weiler C, Geisler R, Haffter P, Ingham PW. 2004. iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Genes Dev 18:1565-1576.
65. Wong GK, Liu B, Wang J, Zhang Y, Yang X, Zhang Z, Meng Q, Zhou J, Li D, Zhang J, Ni P, Li S, Ran L, Li H, Zhang J, Li R, Li S, Zheng H, Lin W, Li G, Wang X, Zhao W, Li J, Ye C, Dai M, Ruan J, Zhou Y, Li Y, He X, Zhang Y, Wang J, Huang X, Tong W, Chen J, Ye J, Chen C, Wei N, Li G, Dong L, Lan F, Sun Y, Zhang Z, Yang Z, Yu Y, Huang Y, He D, Xi Y, Wei D, Qi Q, Li W, Shi J, Wang M, Xie F, Wang J, Zhang X, Wang P, Zhao Y, Li N, Yang N, Dong W, Hu S, Zeng C, Zheng W, Hao B, Hillier LW, Yang SP, Warren WC, Wilson RK, Brandstrom M, Ellegren H, Crooijmans RP, van der Poel JJ, Bovenhuis H, Groenen MA, Ovcharenko I, Gordon L, Stubbs L, Lucas S, Glavina T, Aerts A, Kaiser P, Rothwell L, Young JR, Rogers S, Walker BA, van Hateren A, Kaufman J, Bumstead N, Lamont SJ, Zhou H, Hocking PM, Morrice D, de Koning DJ, Law A, Bartley N, Burt DW, Hunt H, Cheng HH, Gunnarsson U, Wahlberg P, Andersson L, Kindlund E, Tammi MT, Andersson B, Webber C, Ponting CP, Overton IM, Boardman PE, Tang H, Hubbard SJ, Wilson SA, Yu J, Wang J, Yang H. 2004. A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature 432:717-722.
66. Yao S, Lum L, Beachy P. 2006. The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell 125: 343-357.
67. Zhang XM, Ramalho-Santos M, McMahon AP. 2001. Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell 105:781-792.