Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy

Journal of Experimental Medicine

Volumn 194, Issue 9, 2001, Pages 1277-1287

  Mohri, Hiroshi ^a   Perelson, Alan S ^b   Tung, Keith ^a   Ribeiro, Ruy M ^b   Ramratnam, Bharat ^a   Markowitz, Martin ^a   Kost, Rhonda ^a   Hurley, Arlene ^a   Weinberger, Leor ^b   Cesar, Denise ^c,d   Hellerstein, Marc K ^c,d   Ho, David D ^a,e  

^a ROCKEFELLER UNIVERSITY   (United States)

^b LOS ALAMOS NATIONAL LABORATORY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e AARON DIAMOND AIDS RESEARCH CENTER   (United States)

Author keywords

Apoptosis; Deuterated glucose; Longitudinal study; Mathematical model; Mechanisms of CD4+ T cell depletion

Indexed keywords

ABACAVIR; ANTIRETROVIRUS AGENT; CD4 ANTIGEN; CD8 ANTIGEN; DEUTERIUM; EFAVIRENZ; GLUCOSE; LAMIVUDINE; NELFINAVIR;

ADULT; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONGITUDINAL STUDY; LYMPHOCYTE DEPLETION; LYMPHOCYTE PROLIFERATION; MALE; MATHEMATICAL MODEL; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS INFECTION;

ADULT; APOPTOSIS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; FEMALE; GENE EXPRESSION; HEALTH STATUS; HIV INFECTIONS; HIV-1; HUMANS; IN SITU NICK-END LABELING; KI-67 ANTIGEN; KINETICS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MONOCYTES; TIME FACTORS; VIRAL LOAD;

EID: 0035169609     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.9.1277     Document Type: Article

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