Slow turnover of HIV-1 receptors on quiescent CD4+ T cells causes prolonged surface retention of gp120 immune complexes in vivo

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Suzuki, Yasuhiro ^a,b   Gatanaga, Hiroyuki ^b   Tachikawa, Natsuo ^b,c   Oka, Shinichi ^b  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^c YOKOHAMA MUNICIPAL CITIZEN'S HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CD3 ANTIBODY; CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; ENVELOPE ANTIBODY; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS 1 RECEPTOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS RECEPTOR; ANTIGEN ANTIBODY COMPLEX; FC RECEPTOR; PROTEIN BINDING;

ACUTE DISEASE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL COUNT; CELL DEATH; CELL ISOLATION; CELL SURFACE; CELL VIABILITY; CHRONIC DISEASE; CONTROLLED STUDY; EXPOSURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LYMPH NODE; LYMPHOCYTE ACTIVATION; MACROPHAGE; MAJOR CLINICAL STUDY; PATHOPHYSIOLOGY; PERIPHERAL LYMPHOCYTE; PHAGOCYTOSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; SPLENECTOMY; SURFACE PROPERTY; SURFACE RETENTION; VIREMIA; VIRION; BIOLOGICAL MODEL; BLOOD; CELL MEMBRANE; CHEMISTRY; COHORT ANALYSIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; KINETICS; LYMPHOCYTE COUNT; METABOLISM; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS; SPLEEN; SURGERY; TIME;

ANTIGEN-ANTIBODY COMPLEX; CD4-POSITIVE T-LYMPHOCYTES; CELL MEMBRANE; CHRONIC DISEASE; COHORT STUDIES; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV SERONEGATIVITY; HIV-1; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; KINETICS; LYMPHOCYTE COUNT; MACROPHAGES; MODELS, IMMUNOLOGICAL; PHAGOCYTOSIS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, FC; RECEPTORS, HIV; SPLEEN; TIME FACTORS; VIREMIA;

EID: 84895525740     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086479     Document Type: Article

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