Grape seed proanthocyanidin extract protects the retina against early diabetic injury by activating the Nrf2 pathway

Experimental and Therapeutic Medicine

Volumn 11, Issue 4, 2016, Pages 1253-1258

  Sun, Yan ^a   Xiu, Caimei ^b   Liu, Wei ^a   Tao, Yuan ^a   Wang, Jianrong ^a   Qu, Yi ^c  

^a Jinan Second People's Hospital   (China)

^b QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

^c SHANDONG UNIVERSITY   (China)

Author keywords

Apoptosis; Diabetic retinopathy; Grape seed proanthocyanidin extracts; Nuclear erythroid 2 related factor 2; Oxidative stress

Indexed keywords

GLUTATHIONE PEROXIDASE; GRAPE SEED EXTRACT; PROANTHOCYANIDIN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; APOPTOSIS; ARTICLE; BLOOD GLUCOSE MONITORING; CHEMOLUMINESCENCE; CONTROLLED STUDY; DIABETIC ANGIOPATHY; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; MICROSCOPY; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TUNEL ASSAY; WESTERN BLOTTING;

EID: 84958794198     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2016.3033     Document Type: Article

References (28)

1. Ruta LM, Magliano DJ, Lemesurier R, Taylor HR, Zimmet PZ and Shaw JE: Prevalence of diabetic retinopathy in Type 2 diabetes in developing and developed countries. Diabet Med 30: 387-398, 2013.
2. Man RE, Sasongko MB, Wang JJ, MacIsaac R, Wong TY, Sabanayagam C and Lamoureux EL: The Association of Estimated Glomerular Filtration Rate With Diabetic Retinopathy and Macular Edema. Invest Ophthalmol Vis Sci 56: 4810-4816, 2015.
3. Malek M, Khamseh ME, Aghili R, Emami Z, Najafi L and Baradaran HR: Medical management of diabetic retinopathy: An overview. Arch Iran Med 15: 635-640, 2012.
4. Barber AJ, Gardner TW and Abcouwer SF: The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy. Invest Ophthalmol Vis Sci 52: 1156-1163, 2011.
5. Hu WK, Liu R, Pei H and Li B: Endoplasmic reticulum stress-related factors protect against diabetic retinopathy. Exp Diabetes Res 2012: 507986, 2012.
6. Williams M, Hogg RE and Chakravarthy U: Antioxidants and diabetic retinopathy. Curr Diab Rep 13: 481-487, 2013.
7. Ferreira D and Li XC: Oligomeric proanthocyanidins: Naturally occurring O-heterocycles. Nat Prod Rep 17: 193-212, 2000.
8. Houde V, Grenier D and Chandad F: Protective effects of grape seed proanthocyanidins against oxidative stress induced by lipopolysaccharides of periodontopathogens. J Periodontol 77: 1371-1379, 2006.
9. Li M, Ma YB, Gao HQ, Li BY, Cheng M, Xu L, Li XL and Li XH: A novel approach of proteomics to study the mechanism of action of grape seed proanthocyanidin extracts on diabetic retinopathy in rats. Chin Med J (Engl) 121: 2544-2552, 2008.
10. Kaspar JW, Niture SK and Jaiswal AK: Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radic Biol Med 47: 1304-1309, 2009.
11. Zhong Q, Mishra M and Kowluru RA: Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy. Invest Ophthalmol Vis Sci 54: 3941-3948, 2013.
12. Xu Z, Wei Y, Gong J, Cho H, Park JK, Sung ER, Huang H, Wu L, Eberhart C, Handa JT, et al: NRF2 plays a protective role in diabetic retinopathy in mice. Diabetologia 57: 204-213, 2014.
13. Tan SM and De Haan JB: Combating oxidative stress in diabetic complications with Nrf2 activators: How much is too much? Redox Rep 19: 107-117, 2014.
14. Wang S, Park JK and Duh EJ: Novel targets against retinal angiogenesis in diabetic retinopathy. Curr Diab Rep 12: 355-363, 2012.
15. Scapagnini G, Vasto S, Abraham NG, Caruso C, Zella D and Fabio G: Modulation of Nrf2/ARE pathway by food polyphenols: A nutritional neuroprotective strategy for cognitive and neurode- generative disorders. Mol Neurobiol 44: 192-201, 2011.
16. Jeong IK and King GL: New perspectives on diabetic vascular complications: The loss of endogenous protective factors induced by hyperglycemia. Diabetes Metab J 35: 8-11, 2011.
17. Sun JK, Keenan HA, Cavallerano JD, Asztalos BF, Schaefer EJ, Sell DR, Strauch CM, Monnier VM, Doria A, Aiello LP and King GL: Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: The joslin 50-year medalist study. Diabetes Care 34: 968-974, 2011.
18. Kojima K, Maki K, Tofani I, Kamitani Y and Kimura M: Effects of grape seed proanthocyanidins extract on rat mandibular condyle. J Musculoskelet Neuronal Interact 4: 301-307, 2004.
19. Mansouri E, Panahi M, Ghaffari MA and Ghorbani A: Effects of grape seed proanthocyanidin extract on oxidative stress induced by diabetes in rat kidney. Iran Biomed J 15: 100-106, 2011.
20. Okudan N, Barışkaner H, Gökbel H, Sahin AS, Belviranlı M and Baysal H: The effect of supplementation of grape seed proan- thocyanidin extract on vascular dysfunction in experimental diabetes. J Med Food 14: 1298-1302, 2011.
21. Ding Y, Dai X, Jiang Y, Zhang Z, Bao L, Li Y, Zhang F, Ma X, Cai X, Jing L, et al: Grape seed proanthocyanidin extracts alleviate oxidative stress and ER stress in skeletal muscle of low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats. Mol Nutr Food Res 57: 365-369, 2013.
22. Cui XP, Li BY, Gao HQ, Wei N, Wang WL and Lu M: Effects of grape seed proanthocyanidin extracts on peripheral nerves in streptozocin-induced diabetic rats. J Nutr Sci Vitaminol (Tokyo) 54: 321-328, 2008.
23. Yamagishi S and Matsui T: Advanced glycation end products (AGEs), oxidative stress and diabetic retinopathy. Curr Pharm Biotechnol 12: 362-368, 2011.
24. Bagchi D, Sen CK, Ray SD, Das DK, Bagchi M, Preuss HG and Vinson JA: Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Mutat Res 523-524: 87-97, 2003.
25. Zou X, Feng Z, Li Y, Wang Y, Wertz K, Weber P, Weber P, Fu Y and Liu J: Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: Activation of Nrf2 and JNK-p62/SQSTM1 pathways. J Nutr Biochem 23: 994-1006, 2012.
26. Pehar M, Vargas MR, Robinson KM, Cassina P, Díaz-Amarilla PJ, Hagen TM, Radi R, Barbeito L and Beckman JS: Mitochondrial superoxide production and nuclear factor erythroid 2-related factor 2 activation in p75 neurotrophin receptor-induced motor neuron apoptosis. J Neurosci 27: 7777-7785, 2007.
27. Fan J, Xu G, Jiang T and Qin Y: Pharmacologic induction of heme oxygenase-1 plays a protective role in diabetic retinopathy in rats. Invest Ophthalmol Vis Sci 53: 6541-6556, 2012.
28. He M, Pan H, Chang RC, So KF, Brecha NC and Pu M: Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia reperfusion induced damage. PloS One 9: e84800, 2014.