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Volumn 100, Issue 11, 2015, Pages E1491-E1501

Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; GROWTH FACTOR RECEPTOR BOUND PROTEIN 10; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3; RNA H19;

EID: 84958673442     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-3204     Document Type: Article
Times cited : (153)

References (61)
  • 1
    • 84888321284 scopus 로고    scopus 로고
    • Genetics of diabetes-are we missing the genes or the disease?
    • Groop L, Pociot F. Genetics of diabetes-are we missing the genes or the disease? Mol Cell Endocrinol. 2014;382:726-739.
    • (2014) Mol Cell Endocrinol , vol.382 , pp. 726-739
    • Groop, L.1    Pociot, F.2
  • 2
    • 84897452599 scopus 로고    scopus 로고
    • Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and nondiabetic donors identifies candidate genes that influence insulin secretion
    • Dayeh T, Volkov P, Salo S, et al. Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and nondiabetic donors identifies candidate genes that influence insulin secretion. PLoS Genet. 2014; 10:e1004160.
    • (2014) PLoS Genet , vol.10 , pp. e1004160
    • Dayeh, T.1    Volkov, P.2    Salo, S.3
  • 3
    • 84906707442 scopus 로고    scopus 로고
    • Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes
    • Nilsson E, Jansson PA, Perfilyev A, et al. Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes. Diabetes. 2014;63:2962-2976.
    • (2014) Diabetes , vol.63 , pp. 2962-2976
    • Nilsson, E.1    Jansson, P.A.2    Perfilyev, A.3
  • 4
    • 84870923467 scopus 로고    scopus 로고
    • Genome-wide analysis ofDNAmethylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes
    • Ribel-Madsen R, Fraga MF, Jacobsen S, et al. Genome-wide analysis ofDNAmethylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes. PLoS One. 2012;7:e51302.
    • (2012) PLoS One , vol.7 , pp. e51302
    • Ribel-Madsen, R.1    Fraga, M.F.2    Jacobsen, S.3
  • 5
    • 69149087790 scopus 로고    scopus 로고
    • Non-CpG methylation of the PGC-1-promoter through DNMT3B controls mitochondrial density
    • Barres R, Osler ME, Yan J, et al. Non-CpG methylation of the PGC-1-promoter through DNMT3B controls mitochondrial density. Cell Metab. 2009;10:189-198.
    • (2009) Cell Metab , vol.10 , pp. 189-198
    • Barres, R.1    Osler, M.E.2    Yan, J.3
  • 6
    • 84858800629 scopus 로고    scopus 로고
    • DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
    • Volkmar M, Dedeurwaerder S, Cunha DA, et al. DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J. 2012;31:1405-1426.
    • (2012) EMBO J , vol.31 , pp. 1405-1426
    • Volkmar, M.1    Dedeurwaerder, S.2    Cunha, D.A.3
  • 7
    • 84862248102 scopus 로고    scopus 로고
    • Folate and DNA methylation: A review of molecular mechanisms and the evidence for folate's role
    • Crider KS, Yang TP, Berry RJ, Bailey LB. Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role. Adv Nutr. 2012;3:21-38.
    • (2012) Adv Nutr , vol.3 , pp. 21-38
    • Crider, K.S.1    Yang, T.P.2    Berry, R.J.3    Bailey, L.B.4
  • 8
    • 84908441328 scopus 로고    scopus 로고
    • Obesity accelerates epigenetic aging of human liver
    • Horvath S, Erhart W, Brosch M, et al. Obesity accelerates epigenetic aging of human liver. Proc Natl Acad Sci USA. 2014;111:15538-15543.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 15538-15543
    • Horvath, S.1    Erhart, W.2    Brosch, M.3
  • 9
    • 84881546730 scopus 로고    scopus 로고
    • Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease
    • Pirola CJ, Gianotti TF, Burgueno AL, et al. Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease. Gut. 2013;62:1356-1363.
    • (2013) Gut , vol.62 , pp. 1356-1363
    • Pirola, C.J.1    Gianotti, T.F.2    Burgueno, A.L.3
  • 10
    • 84927155307 scopus 로고    scopus 로고
    • Maternal Vitamin D deficiency during pregnancy results in insulin resistance in rat offspring, which is associated with inflammation and I-b-methylation
    • Zhang H, Chu X, Huang Y, et al. Maternal vitamin D deficiency during pregnancy results in insulin resistance in rat offspring, which is associated with inflammation and I-b-methylation. Diabetologia. 2014;57:2165-2172.
    • (2014) Diabetologia , vol.57 , pp. 2165-2172
    • Zhang, H.1    Chu, X.2    Huang, Y.3
  • 11
    • 77956864571 scopus 로고    scopus 로고
    • Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats
    • Chang X, Yan H, Fei J, et al. Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats. J Lipid Res. 2010;51:2504-2515.
    • (2010) J Lipid Res , vol.51 , pp. 2504-2515
    • Chang, X.1    Yan, H.2    Fei, J.3
  • 12
    • 84919941318 scopus 로고    scopus 로고
    • Lipoprotein subclass metabolism in nonalcoholic steatohepatitis
    • Mannisto VT, Simonen M, Soininen P, et al. Lipoprotein subclass metabolism in nonalcoholic steatohepatitis. J Lipid Res. 2014;55: 2676-2684.
    • (2014) J Lipid Res , vol.55 , pp. 2676-2684
    • Mannisto, V.T.1    Simonen, M.2    Soininen, P.3
  • 13
    • 77952270697 scopus 로고    scopus 로고
    • Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding
    • Pihlajamaki J, Gronlund S, SimonenM,et al. Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding. Metabolism. 2010;59:866-872.
    • (2010) Metabolism , vol.59 , pp. 866-872
    • Pihlajamaki, J.1    Gronlund, S.2    Simonen, M.3
  • 14
    • 84857355693 scopus 로고    scopus 로고
    • Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans
    • Pihlajamaki J, Kuulasmaa T, Kaminska D, et al. Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans. J Hepatol. 2012;56:663-670.
    • (2012) J Hepatol , vol.56 , pp. 663-670
    • Pihlajamaki, J.1    Kuulasmaa, T.2    Kaminska, D.3
  • 15
    • 0031851293 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
    • Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15:539-553.
    • (1998) Diabet Med , vol.15 , pp. 539-553
    • Alberti, K.G.1    Zimmet, P.Z.2
  • 17
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 18
    • 80053304450 scopus 로고    scopus 로고
    • High densityDNAmethylation array with singleCpGsite resolution
    • BibikovaM,Barnes B, Tsan C, et al. High densityDNAmethylation array with singleCpGsite resolution. Genomics. 2011;98:288-295.
    • (2011) Genomics , vol.98 , pp. 288-295
    • Bibikova, M.1    Barnes, B.2    Tsan, C.3
  • 19
    • 84874353239 scopus 로고    scopus 로고
    • Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium Human-Methylation450 microarray
    • Chen YA, Lemire M, Choufani S, et al. Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium Human-Methylation450 microarray. Epigenetics. 2013;8:203-209.
    • (2013) Epigenetics , vol.8 , pp. 203-209
    • Chen, Y.A.1    Lemire, M.2    Choufani, S.3
  • 20
    • 46249088370 scopus 로고    scopus 로고
    • Lumi: A pipeline for processing Illumina microarray
    • Du P, Kibbe WA, Lin SM. lumi: a pipeline for processing Illumina microarray. Bioinformatics. 2008;24:1547-1548.
    • (2008) Bioinformatics , vol.24 , pp. 1547-1548
    • Du, P.1    Kibbe, W.A.2    Lin, S.M.3
  • 21
    • 78649475003 scopus 로고    scopus 로고
    • Comparison of α-value and Mvalue methods for quantifying methylation levels by microarray analysis
    • Du P, Zhang X, Huang CC, et al. Comparison of α-value and Mvalue methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics. 2010;11:587.
    • (2010) BMC Bioinformatics , vol.11 , pp. 587
    • Du, P.1    Zhang, X.2    Huang, C.C.3
  • 22
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: Open software development for computational biology and bioinformatics
    • Gentleman RC, Carey VJ, Bates DM, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 2004;5:R80.
    • (2004) Genome Biol , vol.5 , pp. R80
    • Gentleman, R.C.1    Carey, V.J.2    Bates, D.M.3
  • 23
    • 84872564830 scopus 로고    scopus 로고
    • A-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 kDNAmethylation data
    • Teschendorff AE, Marabita F, Lechner M, et al. A-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 kDNAmethylation data. Bioinformatics. 2013; 29:189-196.
    • (2013) Bioinformatics , vol.29 , pp. 189-196
    • Teschendorff, A.E.1    Marabita, F.2    Lechner, M.3
  • 24
    • 33845432928 scopus 로고    scopus 로고
    • Adjusting batch effects in microarray expression data using empirical Bayes methods
    • Johnson WE, Li C, Rabinovic A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics. 2007;8:118-127.
    • (2007) Biostatistics , vol.8 , pp. 118-127
    • Johnson, W.E.1    Li, C.2    Rabinovic, A.3
  • 25
    • 78149450628 scopus 로고    scopus 로고
    • Hepatic expression patterns of inflammatory andimmuneresponse genes associated with obesity and NASH in morbidly obese patients
    • Bertola A, Bonnafous S, Anty R, et al. Hepatic expression patterns of inflammatory andimmuneresponse genes associated with obesity and NASH in morbidly obese patients. PLoS One. 2010;5:e13577.
    • (2010) PLoS One , vol.5 , pp. e13577
    • Bertola, A.1    Bonnafous, S.2    Anty, R.3
  • 26
    • 84876908622 scopus 로고
    • Generalized collinearity diagnostics
    • Fox J, Monette G. Generalized collinearity diagnostics. J Am Stat Assoc. 1992;87:178-183.
    • (1992) J Am Stat Assoc , vol.87 , pp. 178-183
    • Fox, J.1    Monette, G.2
  • 28
    • 84907842409 scopus 로고    scopus 로고
    • The diabetes drug target MitoNEET governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/iron regulatory protein 1
    • Ferecatu I, Goncalves S, Golinelli-Cohen MP, et al. The diabetes drug target MitoNEET governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/iron regulatory protein 1. J Biol Chem. 2014;289:28070-28086.
    • (2014) J Biol Chem , vol.289 , pp. 28070-28086
    • Ferecatu, I.1    Goncalves, S.2    Golinelli-Cohen, M.P.3
  • 29
    • 34147173677 scopus 로고    scopus 로고
    • Expansion of adult β-cell mass in response to increased metabolic demand is dependent on HNF-4α
    • Gupta RK, Gao N, Gorski RK, et al. Expansion of adult β-cell mass in response to increased metabolic demand is dependent on HNF-4α. Genes Dev. 2007;21:756-769.
    • (2007) Genes Dev , vol.21 , pp. 756-769
    • Gupta, R.K.1    Gao, N.2    Gorski, R.K.3
  • 30
    • 84908108811 scopus 로고    scopus 로고
    • Hepatic monoacylglycerol O-acyltransferase 1 as a promising therapeutic target for steatosis, obesity, and type 2 diabetes
    • Hayashi Y, Suemitsu E, Kajimoto K, et al. Hepatic monoacylglycerol O-acyltransferase 1 as a promising therapeutic target for steatosis, obesity, and type 2 diabetes. Mol Ther Nucleic Acids. 2014;3:e154.
    • (2014) Mol Ther Nucleic Acids , vol.3 , pp. e154
    • Hayashi, Y.1    Suemitsu, E.2    Kajimoto, K.3
  • 31
    • 34248357199 scopus 로고    scopus 로고
    • Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo
    • Hurov JB, Huang M, White LS, et al. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci USA. 2007;104:5680-5685.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5680-5685
    • Hurov, J.B.1    Huang, M.2    White, L.S.3
  • 32
    • 84863503465 scopus 로고    scopus 로고
    • A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations
    • Imamura M, Maeda S, Yamauchi T, et al. A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. Hum Mol Genet. 2012;21:3042-3049.
    • (2012) Hum Mol Genet , vol.21 , pp. 3042-3049
    • Imamura, M.1    Maeda, S.2    Yamauchi, T.3
  • 33
    • 84895556114 scopus 로고    scopus 로고
    • A protein profile of visceral adipose tissues linked to early pathogenesis of type 2 diabetes mellitus
    • Kim SJ, Chae S, Kim H, et al. A protein profile of visceral adipose tissues linked to early pathogenesis of type 2 diabetes mellitus. Mol Cell Proteomics. 2014;13:811-822.
    • (2014) Mol Cell Proteomics , vol.13 , pp. 811-822
    • Kim, S.J.1    Chae, S.2    Kim, H.3
  • 34
    • 84861336754 scopus 로고    scopus 로고
    • Severe diabetes and leptin resistance cause differential hepatic and renal transporter expression in mice
    • More VR, Wen X, Thomas PE, Aleksunes LM, Slitt AL. Severe diabetes and leptin resistance cause differential hepatic and renal transporter expression in mice. Comp Hepatol. 2012;11:1.
    • (2012) Comp Hepatol , vol.11 , pp. 1
    • More, V.R.1    Wen, X.2    Thomas, P.E.3    Aleksunes, L.M.4    Slitt, A.L.5
  • 35
    • 84868337361 scopus 로고    scopus 로고
    • Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
    • Morris AP, Voight BF, Teslovich TM, et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet. 2012;44:981-990.
    • (2012) Nat Genet , vol.44 , pp. 981-990
    • Morris, A.P.1    Voight, B.F.2    Teslovich, T.M.3
  • 36
    • 84858039282 scopus 로고    scopus 로고
    • PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
    • Ohno H, Shinoda K, Spiegelman BM, Kajimura S. PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 2012;15:395-404.
    • (2012) Cell Metab , vol.15 , pp. 395-404
    • Ohno, H.1    Shinoda, K.2    Spiegelman, B.M.3    Kajimura, S.4
  • 37
    • 84875814641 scopus 로고    scopus 로고
    • A computational procedure for identifying master regulator candidates: A case study on diabetes progression in Goto-Kakizaki rats
    • Piao G, Saito S, Sun Y, et al. A computational procedure for identifying master regulator candidates: a case study on diabetes progression in Goto-Kakizaki rats.BMCSyst Biol. 2012;6(suppl 1):S2.
    • (2012) BMC Syst Biol , vol.6 , pp. S2
    • Piao, G.1    Saito, S.2    Sun, Y.3
  • 38
    • 36849023376 scopus 로고    scopus 로고
    • Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: Evidence for replication from diabetesrelated quantitative traits and from independent populations
    • Rampersaud E, Damcott CM, Fu M, et al. Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetesrelated quantitative traits and from independent populations. Diabetes. 2007;56:3053-3062.
    • (2007) Diabetes , vol.56 , pp. 3053-3062
    • Rampersaud, E.1    Damcott, C.M.2    Fu, M.3
  • 40
    • 70349492908 scopus 로고    scopus 로고
    • Regulatory feedback loop between NF-κB and MCP-1-induced protein 1 RNase
    • Skalniak L, Mizgalska D, Zarebski A, Wyrzykowska P, Koj A, Jura J. Regulatory feedback loop between NF-κB and MCP-1-induced protein 1 RNase. FEBS J. 2009;276:5892-5905.
    • (2009) FEBS J , vol.276 , pp. 5892-5905
    • Skalniak, L.1    Mizgalska, D.2    Zarebski, A.3    Wyrzykowska, P.4    Koj, A.5    Jura, J.6
  • 41
    • 33646945907 scopus 로고    scopus 로고
    • Significance and expression of serum and glucocorticoid-inducible kinase in kidney of mice with diabetic nephropathy
    • Wang Q, Zhang X, Wang Y, Deng A, Zhu Z, Feng Y. Significance and expression of serum and glucocorticoid-inducible kinase in kidney of mice with diabetic nephropathy. J Huazhong Univ Sci Technolog Med Sci. 2005;25:170-173.
    • (2005) J Huazhong Univ Sci Technolog Med Sci , vol.25 , pp. 170-173
    • Wang, Q.1    Zhang, X.2    Wang, Y.3    Deng, A.4    Zhu, Z.5    Feng, Y.6
  • 42
    • 84865605602 scopus 로고    scopus 로고
    • Chromatin structure, epigenetic mechanisms and long-range interactions in the human insulin locus
    • Xu Z, Lefevre GM, Felsenfeld G. Chromatin structure, epigenetic mechanisms and long-range interactions in the human insulin locus. Diabetes Obes Metab. 2012;14(suppl 3):1-11.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 1-11
    • Xu, Z.1    Lefevre, G.M.2    Felsenfeld, G.3
  • 43
    • 68049092122 scopus 로고    scopus 로고
    • Enhanced expression of STIM1/Orai1 and TRPC3 in platelets from patients with type 2 diabetes mellitus
    • Zbidi H, Lopez JJ, Amor NB, Bartegi A, Salido GM, Rosado JA. Enhanced expression of STIM1/Orai1 and TRPC3 in platelets from patients with type 2 diabetes mellitus. Blood Cells Mol Dis. 2009; 43:211-213.
    • (2009) Blood Cells Mol Dis , vol.43 , pp. 211-213
    • Zbidi, H.1    Lopez, J.J.2    Amor, N.B.3    Bartegi, A.4    Salido, G.M.5    Rosado, J.A.6
  • 44
    • 84881319858 scopus 로고    scopus 로고
    • DNAmethylation analysis in nonalcoholic fatty liver disease suggests distinct diseasespecific and remodeling signatures after bariatric surgery
    • Ahrens M, Ammerpohl O, von Schonfels W, et al.DNAmethylation analysis in nonalcoholic fatty liver disease suggests distinct diseasespecific and remodeling signatures after bariatric surgery. Cell Metab. 2013;18:296-302.
    • (2013) Cell Metab , vol.18 , pp. 296-302
    • Ahrens, M.1    Ammerpohl, O.2    Von Schonfels, W.3
  • 45
    • 84863986133 scopus 로고    scopus 로고
    • Functions of DNA methylation: Islands, start sites, gene bodies and beyond
    • Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet. 2012;13:484-492.
    • (2012) Nat Rev Genet , vol.13 , pp. 484-492
    • Jones, P.A.1
  • 46
    • 84899908944 scopus 로고    scopus 로고
    • Glibenclamide treatment modulates the expression and localization of myosin-IIB in diabetic rat brain
    • da Costa AV, Calabria LK, de Souza Santos P, Goulart LR, Espindola FS. Glibenclamide treatment modulates the expression and localization of myosin-IIB in diabetic rat brain. J Neurol Sci. 2014; 340:159-164.
    • (2014) J Neurol Sci , vol.340 , pp. 159-164
    • Da Costa, A.V.1    Calabria, L.K.2    De Souza Santos, P.3    Goulart, L.R.4    Espindola, F.S.5
  • 47
    • 77953060025 scopus 로고    scopus 로고
    • Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects
    • Dasu MR, Devaraj S, Park S, Jialal I. Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects. Diabetes Care. 2010;33:861-868.
    • (2010) Diabetes Care , vol.33 , pp. 861-868
    • Dasu, M.R.1    Devaraj, S.2    Park, S.3    Jialal, I.4
  • 48
    • 84899486726 scopus 로고    scopus 로고
    • Maternal obesity and diabetes may cause DNA methylation alteration in the spermatozoa of offspring in mice
    • Ge ZJ, Liang QX, Hou Y, et al. Maternal obesity and diabetes may cause DNA methylation alteration in the spermatozoa of offspring in mice. Reprod Biol Endocrinol. 2014;12:29.
    • (2014) Reprod Biol Endocrinol , vol.12 , pp. 29
    • Ge, Z.J.1    Liang, Q.X.2    Hou, Y.3
  • 49
    • 80755125985 scopus 로고    scopus 로고
    • Role and clinical significance of lymphocyte mitochondrial dysfunction in type 2 diabetes mellitus
    • Khan S, Raghuram GV, Bhargava A, et al. Role and clinical significance of lymphocyte mitochondrial dysfunction in type 2 diabetes mellitus. Transl Res. 2011;158:344-359.
    • (2011) Transl Res , vol.158 , pp. 344-359
    • Khan, S.1    Raghuram, G.V.2    Bhargava, A.3
  • 50
    • 84926457009 scopus 로고    scopus 로고
    • Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia
    • Taneera J, Fadista J, Ahlqvist E, et al. Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia. Hum Mol Genet. 2015;24:1945-1955.
    • (2015) Hum Mol Genet , vol.24 , pp. 1945-1955
    • Taneera, J.1    Fadista, J.2    Ahlqvist, E.3
  • 51
    • 82955201840 scopus 로고    scopus 로고
    • Dietary methyl-consuming compounds and metabolic syndrome
    • Zhou SS, Zhou YM, Li D, Lun YZ. Dietary methyl-consuming compounds and metabolic syndrome. Hypertens Res. 2011;34:1239-1245.
    • (2011) Hypertens Res , vol.34 , pp. 1239-1245
    • Zhou, S.S.1    Zhou, Y.M.2    Li, D.3    Lun, Y.Z.4
  • 52
    • 84882634648 scopus 로고    scopus 로고
    • Effects of parental folate deficiency on the folate content, global DNA methylation, and expressions of FRα, IGF-2 and IGF-1R in the postnatal rat liver
    • Mejos KK, Kim HW, Lim EM, Chang N. Effects of parental folate deficiency on the folate content, global DNA methylation, and expressions of FRα, IGF-2 and IGF-1R in the postnatal rat liver. Nutr Res Pract. 2013;7:281-286.
    • (2013) Nutr Res Pract , vol.7 , pp. 281-286
    • Mejos, K.K.1    Kim, H.W.2    Lim, E.M.3    Chang, N.4
  • 53
    • 0019947863 scopus 로고
    • Effect of experimental folate deficiency on lipid metabolism in liver and brain
    • Akesson B, Fehling C, Jagerstad M, Stenram U. Effect of experimental folate deficiency on lipid metabolism in liver and brain. Br J Nutr. 1982;47:505-520.
    • (1982) Br J Nutr , vol.47 , pp. 505-520
    • Akesson, B.1    Fehling, C.2    Jagerstad, M.3    Stenram, U.4
  • 54
    • 84857124389 scopus 로고    scopus 로고
    • Folate depletion changes gene expression of fatty acid metabolism, DNA synthesis, and circadian cycle in male mice
    • Champier J, Claustrat F, Nazaret N, Fevre Montange M, Claustrat B. Folate depletion changes gene expression of fatty acid metabolism, DNA synthesis, and circadian cycle in male mice. Nutr Res. 2012;32:124-132.
    • (2012) Nutr Res , vol.32 , pp. 124-132
    • Champier, J.1    Claustrat, F.2    Nazaret, N.3    Fevre Montange, M.4    Claustrat, B.5
  • 55
    • 38049152517 scopus 로고    scopus 로고
    • Disruption of lipid metabolism in the liver of the pregnant rat fed folate-deficient and methyl donor-deficient diets
    • McNeil CJ, Hay SM, Rucklidge GJ, et al. Disruption of lipid metabolism in the liver of the pregnant rat fed folate-deficient and methyl donor-deficient diets. Br J Nutr. 2008;99:262-271.
    • (2008) Br J Nutr , vol.99 , pp. 262-271
    • McNeil, C.J.1    Hay, S.M.2    Rucklidge, G.J.3
  • 56
    • 73749086098 scopus 로고    scopus 로고
    • Maternal diets deficient in folic acid and related methyl donors modify mechanisms associated with lipid metabolism in the fetal liver of the rat
    • McNeil CJ, Hay SM, Rucklidge GJ, Reid MD, Duncan GJ, Rees WD. Maternal diets deficient in folic acid and related methyl donors modify mechanisms associated with lipid metabolism in the fetal liver of the rat. Br J Nutr. 2009;102:1445-1452.
    • (2009) Br J Nutr , vol.102 , pp. 1445-1452
    • McNeil, C.J.1    Hay, S.M.2    Rucklidge, G.J.3    Reid, M.D.4    Duncan, G.J.5    Rees, W.D.6
  • 57
    • 84901378366 scopus 로고    scopus 로고
    • A central role for GRB10 in regulation of islet function in man
    • Prokopenko I, Poon W, Magi R, et al. A central role for GRB10 in regulation of islet function in man.PLoSGenet. 2014;10:e1004235.
    • (2014) PLoS Genet , vol.10 , pp. e1004235
    • Prokopenko, I.1    Poon, W.2    Magi, R.3
  • 58
    • 84870319843 scopus 로고    scopus 로고
    • Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes
    • Nitert MD, Dayeh T, Volkov P, et al. Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes. Diabetes. 2012;61:3322-3332.
    • (2012) Diabetes , vol.61 , pp. 3322-3332
    • Nitert, M.D.1    Dayeh, T.2    Volkov, P.3
  • 59
    • 84912105627 scopus 로고    scopus 로고
    • Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets
    • Olsson AH, Volkov P, Bacos K, et al. Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets. PLoS Genet. 2014;10:e1004735.
    • (2014) PLoS Genet , vol.10 , pp. e1004735
    • Olsson, A.H.1    Volkov, P.2    Bacos, K.3
  • 60
    • 20544460666 scopus 로고    scopus 로고
    • Grb10 and Grb14: Enigmatic regulators of insulin action-and more?
    • Holt LJ, Siddle K. Grb10 and Grb14: enigmatic regulators of insulin action-and more? Biochem J. 2005;388:393-406.
    • (2005) Biochem J , vol.388 , pp. 393-406
    • Holt, L.J.1    Siddle, K.2
  • 61
    • 84895453068 scopus 로고    scopus 로고
    • Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup
    • Cowley M, Garfield AS, Madon-Simon M, et al. Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup. PLoS Biol. 2014;12:e1001799.
    • (2014) PLoS Biol , vol.12 , pp. e1001799
    • Cowley, M.1    Garfield, A.S.2    Madon-Simon, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.