메뉴 건너뛰기




Volumn 14, Issue SUPPL.3, 2012, Pages 1-11

Chromatin structure, epigenetic mechanisms and long-range interactions in the human insulin locus

Author keywords

Chromatin conformation capture (3C); Histones; Synaptotagmin 8 (SYT8)

Indexed keywords

GLUCOSE; INSULIN; UNTRANSLATED RNA;

EID: 84865605602     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2012.01645.x     Document Type: Review
Times cited : (17)

References (64)
  • 1
    • 80052000538 scopus 로고    scopus 로고
    • Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism
    • Voss TC, Schiltz RL, Sung MH et al. Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism. Cell 2011; 146: 544-554.
    • (2011) Cell , vol.146 , pp. 544-554
    • Voss, T.C.1    Schiltz, R.L.2    Sung, M.H.3
  • 2
    • 33847334699 scopus 로고    scopus 로고
    • Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
    • Heintzman ND, Stuart RK, Hon G et al. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet 2007; 39: 311-318.
    • (2007) Nat Genet , vol.39 , pp. 311-318
    • Heintzman, N.D.1    Stuart, R.K.2    Hon, G.3
  • 3
    • 0024506821 scopus 로고
    • A dominant control region from the human beta-globin locus conferring integration site-independent gene expression
    • Talbot D, Collis P, Antoniou M et al. A dominant control region from the human beta-globin locus conferring integration site-independent gene expression. Nature 1989; 338: 352-355.
    • (1989) Nature , vol.338 , pp. 352-355
    • Talbot, D.1    Collis, P.2    Antoniou, M.3
  • 4
    • 0023550898 scopus 로고
    • Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids
    • Forrester WC, Takegawa S, Papayannopoulou T, Stamatoyannopoulos G, Groudine M. Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids. Nucleic Acids Res 1987; 15: 10159-10177.
    • (1987) Nucleic Acids Res , vol.15 , pp. 10159-10177
    • Forrester, W.C.1    Takegawa, S.2    Papayannopoulou, T.3    Stamatoyannopoulos, G.4    Groudine, M.5
  • 7
    • 0027254748 scopus 로고
    • A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila
    • Chung JH, Whiteley M, Felsenfeld G. A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 1993; 74: 505-514.
    • (1993) Cell , vol.74 , pp. 505-514
    • Chung, J.H.1    Whiteley, M.2    Felsenfeld, G.3
  • 8
    • 0033529654 scopus 로고    scopus 로고
    • The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
    • Bell AC, West AG, Felsenfeld G. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell 1999; 98: 387-396.
    • (1999) Cell , vol.98 , pp. 387-396
    • Bell, A.C.1    West, A.G.2    Felsenfeld, G.3
  • 9
    • 67549119096 scopus 로고    scopus 로고
    • Ctcf: master weaver of the genome
    • Phillips JE, Corces VG. Ctcf: master weaver of the genome. Cell 2009; 137: 1194-1211.
    • (2009) Cell , vol.137 , pp. 1194-1211
    • Phillips, J.E.1    Corces, V.G.2
  • 10
    • 0842310349 scopus 로고    scopus 로고
    • CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species
    • Yusufzai TM, Tagami H, Nakatani Y, Felsenfeld G. CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species. Mol Cell 2004; 13: 291-298.
    • (2004) Mol Cell , vol.13 , pp. 291-298
    • Yusufzai, T.M.1    Tagami, H.2    Nakatani, Y.3    Felsenfeld, G.4
  • 11
    • 0034713375 scopus 로고    scopus 로고
    • Methylation of a CTCF-dependent boundary controls imprinted expression of the igf2 gene
    • Bell AC, Felsenfeld G. Methylation of a CTCF-dependent boundary controls imprinted expression of the igf2 gene. Nature 2000; 405: 482-485.
    • (2000) Nature , vol.405 , pp. 482-485
    • Bell, A.C.1    Felsenfeld, G.2
  • 12
    • 0034644120 scopus 로고    scopus 로고
    • Functional association of CTCF with the insulator upstream of the h19 gene is parent of origin-specific and methylation-sensitive
    • Kanduri C, Pant V, Loukinov D et al. Functional association of CTCF with the insulator upstream of the h19 gene is parent of origin-specific and methylation-sensitive. Curr Biol 2000; 10: 853-856.
    • (2000) Curr Biol , vol.10 , pp. 853-856
    • Kanduri, C.1    Pant, V.2    Loukinov, D.3
  • 13
    • 33746063711 scopus 로고    scopus 로고
    • CTCF binding at the h19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to igf2
    • Kurukuti S, Tiwari VK, Tavoosidana G et al. CTCF binding at the h19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to igf2. Proc Natl Acad Sci USA 2006; 103: 10684-10689.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 10684-10689
    • Kurukuti, S.1    Tiwari, V.K.2    Tavoosidana, G.3
  • 14
    • 33645820241 scopus 로고    scopus 로고
    • Imprinting of IGF2 p0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human
    • Monk D, Sanches R, Arnaud P et al. Imprinting of IGF2 p0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human. Hum Mol Genet 2006; 15: 1259-1269.
    • (2006) Hum Mol Genet , vol.15 , pp. 1259-1269
    • Monk, D.1    Sanches, R.2    Arnaud, P.3
  • 15
    • 70350453755 scopus 로고    scopus 로고
    • The human insulin gene is part of a large open chromatin domain specific for human islets
    • Mutskov V, Felsenfeld G. The human insulin gene is part of a large open chromatin domain specific for human islets. Proc Natl Acad Sci USA 2009; 106: 17419-17424.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 17419-17424
    • Mutskov, V.1    Felsenfeld, G.2
  • 16
    • 78049446282 scopus 로고    scopus 로고
    • Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci
    • Stitzel ML, Sethupathy P, Pearson DS et al. Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab 2010; 12: 443-455.
    • (2010) Cell Metab , vol.12 , pp. 443-455
    • Stitzel, M.L.1    Sethupathy, P.2    Pearson, D.S.3
  • 17
    • 79957840356 scopus 로고    scopus 로고
    • Long noncoding RNAs and human disease
    • Wapinski O, Chang HY. Long noncoding RNAs and human disease. Trends Cell Biol 2011; 21: 354-361.
    • (2011) Trends Cell Biol , vol.21 , pp. 354-361
    • Wapinski, O.1    Chang, H.Y.2
  • 18
    • 70349462799 scopus 로고    scopus 로고
    • An engineered zinc finger protein reveals a role for the insulin VNTR in the regulation of the insulin and adjacent IGF2 genes
    • Ferguson LA, Docherty HM, MacKenzie AE, Docherty K. An engineered zinc finger protein reveals a role for the insulin VNTR in the regulation of the insulin and adjacent IGF2 genes. FEBS Lett 2009; 583: 3181-3186.
    • (2009) FEBS Lett , vol.583 , pp. 3181-3186
    • Ferguson, L.A.1    Docherty, H.M.2    MacKenzie, A.E.3    Docherty, K.4
  • 19
    • 0034507714 scopus 로고    scopus 로고
    • Regulation of insulin gene transcription
    • Ohneda K, Ee H, German M. Regulation of insulin gene transcription. Semin Cell Dev Biol 2000; 11: 227-233.
    • (2000) Semin Cell Dev Biol , vol.11 , pp. 227-233
    • Ohneda, K.1    Ee, H.2    German, M.3
  • 21
    • 33750212321 scopus 로고    scopus 로고
    • Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4c)
    • Simonis M, Klous P, Splinter E et al. Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4c). Nat Genet 2006; 38: 1348-1354.
    • (2006) Nat Genet , vol.38 , pp. 1348-1354
    • Simonis, M.1    Klous, P.2    Splinter, E.3
  • 22
    • 33750203582 scopus 로고    scopus 로고
    • Circular chromosome conformation capture (4c) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions
    • Zhao Z, Tavoosidana G, Sjolinder M et al. Circular chromosome conformation capture (4c) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Nat Genet 2006; 38: 1341-1347.
    • (2006) Nat Genet , vol.38 , pp. 1341-1347
    • Zhao, Z.1    Tavoosidana, G.2    Sjolinder, M.3
  • 23
    • 79952360420 scopus 로고    scopus 로고
    • Mapping of ins promoter interactions reveals its role in long-range regulation of syt8 transcription
    • Xu Z, Wei G, Chepelev I, Zhao K, Felsenfeld G. Mapping of ins promoter interactions reveals its role in long-range regulation of syt8 transcription. Nat Struct Mol Biol 2011; 18: 372-378.
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 372-378
    • Xu, Z.1    Wei, G.2    Chepelev, I.3    Zhao, K.4    Felsenfeld, G.5
  • 24
    • 33749400168 scopus 로고    scopus 로고
    • Chromosome conformation capture carbon copy (5c): a massively parallel solution for mapping interactions between genomic elements
    • Dostie J, Richmond TA, Arnaout RA et al. Chromosome conformation capture carbon copy (5c): a massively parallel solution for mapping interactions between genomic elements. Genome Res 2006; 16: 1299-1309.
    • (2006) Genome Res , vol.16 , pp. 1299-1309
    • Dostie, J.1    Richmond, T.A.2    Arnaout, R.A.3
  • 25
    • 70349873824 scopus 로고    scopus 로고
    • Comprehensive mapping of long-range interactions reveals folding principles of the human genome
    • Lieberman-Aiden E, van Berkum NL, Williams L et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 2009; 326: 289-293.
    • (2009) Science , vol.326 , pp. 289-293
    • Lieberman-Aiden, E.1    van Berkum, N.L.2    Williams, L.3
  • 26
    • 11244328520 scopus 로고    scopus 로고
    • Loss of silent-chromatin looping and impaired imprinting of dlx5 in rett syndrome
    • Horike S, Cai S, Miyano M, Cheng JF, Kohwi-Shigematsu T. Loss of silent-chromatin looping and impaired imprinting of dlx5 in rett syndrome. Nat Genet 2005; 37: 31-40.
    • (2005) Nat Genet , vol.37 , pp. 31-40
    • Horike, S.1    Cai, S.2    Miyano, M.3    Cheng, J.F.4    Kohwi-Shigematsu, T.5
  • 27
    • 70449103609 scopus 로고    scopus 로고
    • An oestrogen-receptor-alpha-bound human chromatin interactome
    • Fullwood MJ, Liu MH, Pan YF et al. An oestrogen-receptor-alpha-bound human chromatin interactome. Nature 2009; 462: 58-64.
    • (2009) Nature , vol.462 , pp. 58-64
    • Fullwood, M.J.1    Liu, M.H.2    Pan, Y.F.3
  • 28
    • 0024457316 scopus 로고
    • Hyperinsulinemia in transgenic mice carrying multiple copies of the human insulin gene
    • Marban SL, DeLoia JA, Gearhart JD. Hyperinsulinemia in transgenic mice carrying multiple copies of the human insulin gene. Dev Genet 1989; 10: 356-364.
    • (1989) Dev Genet , vol.10 , pp. 356-364
    • Marban, S.L.1    DeLoia, J.A.2    Gearhart, J.D.3
  • 29
    • 34249817566 scopus 로고    scopus 로고
    • Transgenic expression of human ins gene in ins1/ins2 double knockout mice leads to insulin underproduction and diabetes in some male mice
    • Karaca M, Durel B, Languille L et al. Transgenic expression of human ins gene in ins1/ins2 double knockout mice leads to insulin underproduction and diabetes in some male mice. Front Biosci 2007; 12: 1586-1593.
    • (2007) Front Biosci , vol.12 , pp. 1586-1593
    • Karaca, M.1    Durel, B.2    Languille, L.3
  • 32
    • 16944366697 scopus 로고    scopus 로고
    • Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group
    • Bennett ST, Wilson AJ, Esposito L et al. Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group. Nat Genet 1997; 17: 350-352.
    • (1997) Nat Genet , vol.17 , pp. 350-352
    • Bennett, S.T.1    Wilson, A.J.2    Esposito, L.3
  • 33
    • 0031914019 scopus 로고    scopus 로고
    • Imprinting at the mouse ins2 locus: evidence for cis- and trans-allelic interactions
    • Duvillie B, Bucchini D, Tang T, Jami J, Paldi A. Imprinting at the mouse ins2 locus: evidence for cis- and trans-allelic interactions. Genomics 1998; 47: 52-57.
    • (1998) Genomics , vol.47 , pp. 52-57
    • Duvillie, B.1    Bucchini, D.2    Tang, T.3    Jami, J.4    Paldi, A.5
  • 34
    • 33745319337 scopus 로고    scopus 로고
    • RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse
    • Rassoulzadegan M, Grandjean V, Gounon P et al. RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse. Nature 2006; 441: 469-474.
    • (2006) Nature , vol.441 , pp. 469-474
    • Rassoulzadegan, M.1    Grandjean, V.2    Gounon, P.3
  • 35
    • 0033665147 scopus 로고    scopus 로고
    • Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain
    • Onyango P, Miller W, Lehoczky J et al. Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain. Genome Res 2000; 10: 1697-1710.
    • (2000) Genome Res , vol.10 , pp. 1697-1710
    • Onyango, P.1    Miller, W.2    Lehoczky, J.3
  • 36
    • 0035654182 scopus 로고    scopus 로고
    • P57(kip2) expression in normal islet cells and in hyperinsulinism of infancy
    • Kassem SA, Ariel I, Thornton PS et al. P57(kip2) expression in normal islet cells and in hyperinsulinism of infancy. Diabetes 2001; 50: 2763-2769.
    • (2001) Diabetes , vol.50 , pp. 2763-2769
    • Kassem, S.A.1    Ariel, I.2    Thornton, P.S.3
  • 37
    • 0037341243 scopus 로고    scopus 로고
    • The focal form of persistent hyperinsulinemic hypoglycemia of infancy: morphological and molecular studies show structural and functional differences with insulinoma
    • Sempoux C, Guiot Y, Dahan K et al. The focal form of persistent hyperinsulinemic hypoglycemia of infancy: morphological and molecular studies show structural and functional differences with insulinoma. Diabetes 2003; 52: 784-794.
    • (2003) Diabetes , vol.52 , pp. 784-794
    • Sempoux, C.1    Guiot, Y.2    Dahan, K.3
  • 38
    • 41649086377 scopus 로고    scopus 로고
    • Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice
    • Gustavsson N, Lao Y, Maximov A et al. Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. Proc Natl Acad Sci USA 2008; 105: 3992-3997.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3992-3997
    • Gustavsson, N.1    Lao, Y.2    Maximov, A.3
  • 40
    • 43749099640 scopus 로고    scopus 로고
    • Pdx1 and beta2/neurod1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene
    • Babu DA, Chakrabarti SK, Garmey JC, Mirmira RG. Pdx1 and beta2/neurod1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene. J Biol Chem 2008; 283: 8164-8172.
    • (2008) J Biol Chem , vol.283 , pp. 8164-8172
    • Babu, D.A.1    Chakrabarti, S.K.2    Garmey, J.C.3    Mirmira, R.G.4
  • 41
    • 0026742624 scopus 로고
    • Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin i gene
    • Emens LA, Landers DW, Moss LG. Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin i gene. Proc Natl Acad Sci USA 1992; 89: 7300-7304.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7300-7304
    • Emens, L.A.1    Landers, D.W.2    Moss, L.G.3
  • 42
    • 33947394493 scopus 로고    scopus 로고
    • Regulation of human insulin, IGF-i, and multidrug resistance protein 2 promoter activity by hepatocyte nuclear factor (hnf)-1beta and hnf-1alpha and the abnormality of HNF-1beta mutants
    • Kitanaka S, Sato U, Igarashi T. Regulation of human insulin, IGF-i, and multidrug resistance protein 2 promoter activity by hepatocyte nuclear factor (hnf)-1beta and hnf-1alpha and the abnormality of HNF-1beta mutants. J Endocrinol 2007; 192: 141-147.
    • (2007) J Endocrinol , vol.192 , pp. 141-147
    • Kitanaka, S.1    Sato, U.2    Igarashi, T.3
  • 43
    • 0037135622 scopus 로고    scopus 로고
    • Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha
    • Bartoov-Shifman R, Hertz R, Wang H et al. Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha. J Biol Chem 2002; 277: 25914-25919.
    • (2002) J Biol Chem , vol.277 , pp. 25914-25919
    • Bartoov-Shifman, R.1    Hertz, R.2    Wang, H.3
  • 44
    • 70450193472 scopus 로고    scopus 로고
    • Human genetics illuminates the paths to metabolic disease
    • O'Rahilly S. Human genetics illuminates the paths to metabolic disease. Nature 2009; 462: 307-314.
    • (2009) Nature , vol.462 , pp. 307-314
    • O'Rahilly, S.1
  • 45
    • 57349177198 scopus 로고    scopus 로고
    • Severe intrauterine growth retardation and atypical diabetes associated with a translocation breakpoint disrupting regulation of the insulin-like growth factor 2 gene
    • Murphy R, Baptista J, Holly J et al. Severe intrauterine growth retardation and atypical diabetes associated with a translocation breakpoint disrupting regulation of the insulin-like growth factor 2 gene. J Clin Endocrinol Metab 2008; 93: 4373-4380.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4373-4380
    • Murphy, R.1    Baptista, J.2    Holly, J.3
  • 46
    • 77950525321 scopus 로고    scopus 로고
    • Loss of IGF2 imprinting is associated with abrogation of long-range intrachromosomal interactions in human cancer cells
    • Vu TH, Nguyen AH, Hoffman AR. Loss of IGF2 imprinting is associated with abrogation of long-range intrachromosomal interactions in human cancer cells. Hum Mol Genet 2010; 19: 901-919.
    • (2010) Hum Mol Genet , vol.19 , pp. 901-919
    • Vu, T.H.1    Nguyen, A.H.2    Hoffman, A.R.3
  • 47
    • 84857066786 scopus 로고    scopus 로고
    • Modular regulatory principles of large non-coding RNAs
    • Guttman M, Rinn JL. Modular regulatory principles of large non-coding RNAs. Nature 2010; 482: 339-346.
    • (2010) Nature , vol.482 , pp. 339-346
    • Guttman, M.1    Rinn, J.L.2
  • 48
    • 80053045739 scopus 로고    scopus 로고
    • Molecular mechanisms of long noncoding RNAs
    • Wang KC, Chang HY. Molecular mechanisms of long noncoding RNAs. Mol Cell 2011; 43: 904-914.
    • (2011) Mol Cell , vol.43 , pp. 904-914
    • Wang, K.C.1    Chang, H.Y.2
  • 49
    • 80052815461 scopus 로고    scopus 로고
    • Noncoding RNAs and enhancers: complications of a long-distance relationship
    • Orom UA, Shiekhattar R. Noncoding RNAs and enhancers: complications of a long-distance relationship. Trends Genet 2011; 27: 433-439.
    • (2011) Trends Genet , vol.27 , pp. 433-439
    • Orom, U.A.1    Shiekhattar, R.2
  • 50
    • 79957552432 scopus 로고    scopus 로고
    • Kcnq1ot1: a chromatin regulatory RNA
    • Kanduri C. Kcnq1ot1: a chromatin regulatory RNA. Semin Cell Dev Biol 2011; 22: 343-350.
    • (2011) Semin Cell Dev Biol , vol.22 , pp. 343-350
    • Kanduri, C.1
  • 51
    • 77955757309 scopus 로고    scopus 로고
    • Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1
    • Mohammad F, Mondal T, Guseva N, Pandey GK, Kanduri C. Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Development 2010; 137: 2493-2499.
    • (2010) Development , vol.137 , pp. 2493-2499
    • Mohammad, F.1    Mondal, T.2    Guseva, N.3    Pandey, G.K.4    Kanduri, C.5
  • 52
    • 54049138948 scopus 로고    scopus 로고
    • Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation
    • Pandey RR, Mondal T, Mohammad F et al. Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation. Mol Cell 2008; 32: 232-246.
    • (2008) Mol Cell , vol.32 , pp. 232-246
    • Pandey, R.R.1    Mondal, T.2    Mohammad, F.3
  • 53
    • 79960357962 scopus 로고    scopus 로고
    • An extended domain of kcnq1ot1 silencing revealed by an imprinted fluorescent reporter
    • Jones MJ, Bogutz AB, Lefebvre L. An extended domain of kcnq1ot1 silencing revealed by an imprinted fluorescent reporter. Mol Cell Biol 2011; 31: 2827-2837.
    • (2011) Mol Cell Biol , vol.31 , pp. 2827-2837
    • Jones, M.J.1    Bogutz, A.B.2    Lefebvre, L.3
  • 55
    • 33746972820 scopus 로고    scopus 로고
    • A maternal hypomethylation syndrome presenting as transient neonatal diabetes mellitus
    • Mackay DJ, Boonen SE, Clayton-Smith J et al. A maternal hypomethylation syndrome presenting as transient neonatal diabetes mellitus. Hum Genet 2006; 120: 262-269.
    • (2006) Hum Genet , vol.120 , pp. 262-269
    • Mackay, D.J.1    Boonen, S.E.2    Clayton-Smith, J.3
  • 56
    • 18744406710 scopus 로고    scopus 로고
    • Zac, lit1 (kcnq1ot1) and p57kip2 (cdkn1c) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome
    • Arima T, Kamikihara T, Hayashida T et al. Zac, lit1 (kcnq1ot1) and p57kip2 (cdkn1c) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome. Nucleic Acids Res 2005; 33: 2650-2660.
    • (2005) Nucleic Acids Res , vol.33 , pp. 2650-2660
    • Arima, T.1    Kamikihara, T.2    Hayashida, T.3
  • 57
    • 33644513754 scopus 로고    scopus 로고
    • Epimutation of the TNDM locus and the beckwith-wiedemann syndrome centromeric locus in individuals with transient neonatal diabetes mellitus
    • Mackay DJ, Hahnemann JM, Boonen SE et al. Epimutation of the TNDM locus and the beckwith-wiedemann syndrome centromeric locus in individuals with transient neonatal diabetes mellitus. Hum Genet 2006; 119: 179-184.
    • (2006) Hum Genet , vol.119 , pp. 179-184
    • Mackay, D.J.1    Hahnemann, J.M.2    Boonen, S.E.3
  • 58
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    • Scott LJ, Mohlke KL, Bonnycastle LL et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007; 316: 1341-1345.
    • (2007) Science , vol.316 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3
  • 59
    • 77949775636 scopus 로고    scopus 로고
    • Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice
    • Visel A, Zhu Y, May D et al. Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature 2010; 464: 409-412.
    • (2010) Nature , vol.464 , pp. 409-412
    • Visel, A.1    Zhu, Y.2    May, D.3
  • 60
    • 80053428353 scopus 로고    scopus 로고
    • Single-stranded noncoding rnas mediate local epigenetic alterations at gene promoters in rat cell lines
    • Tomikawa J, Shimokawa H, Uesaka M et al. Single-stranded noncoding rnas mediate local epigenetic alterations at gene promoters in rat cell lines. J Biol Chem 2011; 286: 34788-34799.
    • (2011) J Biol Chem , vol.286 , pp. 34788-34799
    • Tomikawa, J.1    Shimokawa, H.2    Uesaka, M.3
  • 61
    • 84862908850 scopus 로고    scopus 로고
    • Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation
    • Li G, Ruan X, Auerbach RK et al. Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell 2012; 148: 84-98.
    • (2012) Cell , vol.148 , pp. 84-98
    • Li, G.1    Ruan, X.2    Auerbach, R.K.3
  • 62
    • 72449122779 scopus 로고    scopus 로고
    • Parental origin of sequence variants associated with complex diseases
    • Kong A, Steinthorsdottir V, Masson G et al. Parental origin of sequence variants associated with complex diseases. Nature 2009; 462: 868-874.
    • (2009) Nature , vol.462 , pp. 868-874
    • Kong, A.1    Steinthorsdottir, V.2    Masson, G.3
  • 63
    • 50449085998 scopus 로고    scopus 로고
    • Variants in kcnq1 are associated with susceptibility to type 2 diabetes mellitus
    • Yasuda K, Miyake K, Horikawa Y et al. Variants in kcnq1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 2008; 40: 1092-1097.
    • (2008) Nat Genet , vol.40 , pp. 1092-1097
    • Yasuda, K.1    Miyake, K.2    Horikawa, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.