Maternal diets deficient in folic acid and related methyl donors modify mechanisms associated with lipid metabolism in the fetal liver of the rat

British Journal of Nutrition

Volumn 102, Issue 10, 2009, Pages 1445-1452

  McNeil, Christopher J ^a   Hay, Susan M ^a   Rucklidge, Garry J ^a   Reid, Martin D ^a   Duncan, Gary J ^a   Rees, William D ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Choline; Endoplasmic reticulum; Folic acid; Methionine; Pregnancy

Indexed keywords

2,4 DIENOYL COENZYME A REDUCTASE (NADPH); ACETYL COENZYME A CARBOXYLASE; ADENOSYLHOMOCYSTEINASE; ALDEHYDE DEHYDROGENASE; ALPHA ENOLASE; CARNITINE PALMITOYLTRANSFERASE; CATHEPSIN B; CD36 ANTIGEN; CHOLINE; CYTOSOL AMINOPEPTIDASE; FOLIC ACID; GAMMA BUTYROBETAINE DIOXYGENASE; GERANYLTRANSFERASE; HEPATOCYTE NUCLEAR FACTOR 1; INITIATION FACTOR 4A; ISOCITRATE DEHYDROGENASE; MALATE DEHYDROGENASE; MESSENGER RNA; METHIONINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHENYLALANINE TRANSFER RNA LIGASE; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEASOME; PROTEIN DEXTRO ASPARTATE METHYLTRANSFERASE; PTERIN DERIVATIVE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UBIQUITIN; UROCANATE HYDRATASE;

ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSKELETON; DOWN REGULATION; ENDOPLASMIC RETICULUM; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FEMALE; FETUS; FETUS DEVELOPMENT; FOLIC ACID DEFICIENCY; FOOD INTAKE; GESTATION PERIOD; LIPID METABOLISM; LIQUID CHROMATOGRAPHY; MATERNAL NUTRITION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PREGNANCY; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMAL FEED; ANIMALS; DIET; FEMALE; FETUS; FOLIC ACID; FOLIC ACID DEFICIENCY; GENE EXPRESSION REGULATION; LIPID METABOLISM; LIVER; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; PREGNANCY; RATS; RNA, MESSENGER;

RATTUS;

EID: 73749086098     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114509990389     Document Type: Article

References (31)

1. De Wals P, Tairou F, Van Allen MI, et al. (2007) Reduction in neural-tube defects after folic acid fortification in Canada. N Engl J Med 357, 135-142.
2. Relton CL, Pearce MS & Parker L (2005) The influence of erythrocyte folate and serum vitamin B12 status on birth weight. Br J Nutr 93, 593-599.
3. Anna E & Beaudin P (2007) Folate-mediated one-carbon metabolism and neural tube defects: balancing genome synthesis and gene expression. Birth Defects Res C Embryo Today 81, 183-203.
4. Dunlevy LP, Burren KA, Mills K, et al. (2006) Integrity of the methylation cycle is essential for mammalian neural tube closure. Birth Defects Res A Clin Mol Teratol 76, 544-552.
5. Burdge GC, Hanson MA, Slater-Jefferies JL, et al. (2007) Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life? Br J Nutr 97, 1036-1046.
6. Lillycrop KA, Phillips ES, Jackson AA, et al. (2005) Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 135, 1382-1386.
7. Torrens C, Brawley L, Anthony FW, et al. (2006) Folate supplementation during pregnancy improves offspring cardiovascular dysfunction induced by protein restriction. Hypertension 47, 982-987.
8. Jackson AA, Dunn RL, Marchand MC, et al. (2002) Increased systolic blood pressure in rats induced by a maternal lowprotein diet is reversed by dietary supplementation with glycine. Clin Sci (Lond) 103, 633-639.
9. Maloney CA, Hay SM & Rees WD (2009) The effects of feeding rats diets deficient in folic acid and related methyl donors on the blood pressure and glucose tolerance of the offspring. Br J Nutr 101, 1333-1340.
10. Maloney CA, Hay SM & Rees WD (2007) Folate deficiency during pregnancy impacts on methyl metabolism without affecting global DNA methylation in the rat fetus. Br J Nutr 97, 1090-1098.
11. McNeil CJ, Hay SM, Rucklidge G, et al. (2008) Disruption of lipid metabolism in the liver of the pregnant rat fed folate deficient and methyl donor deficient diets. Br J Nutr 99, 262-271.
12. Higuchi N, Kato M, Shundo Y, et al. (2008) Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. Hepatol Res 38, 1122-1129.
13. American Institute of Nutrition (1977) Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. J Nutr 107, 340-348.
14. Maloney CA, Lilley C, Cruickshank M, et al. (2005) The expression of growth-arrest genes in the liver and kidney of the protein-restricted rat fetus. Br J Nutr 94, 12-18.
15. Chanson A, Sayd T, Rock E, et al. (2005) Proteomic analysis reveals changes in the liver protein pattern of rats exposed to dietary folate deficiency. J Nutr 135, 2524-2529.
16. Meneses-Lorente G, Watt A, Salim K, et al. (2006) Identification of early proteomic markers for hepatic steatosis. Chem Res Toxicol 19, 986-998.
17. Marten NW, Hsiang CH, Yu L, et al. (1999) Functional activity of hepatocyte nuclear factor-1 is specifically decreased in amino acid-limited hepatoma cells. Biochim Biophys Acta 1447, 160-174.
18. Vabulas RM & Hartl FU (2005) Protein synthesis upon acute nutrient restriction relies on proteasome function. Science 310, 1960-1963.
19. Fleming JV, Hay SM, Harries DN, et al. (1998) Effects of nutrient deprivation and differentiation on the expression of growth-arrest genes (gas and gadd) in F9 embryonal carcinoma cells. Biochem J 330, 573-579.
20. Schlessinger J (2000) Cell signaling by receptor tyrosine kinases. Cell 103, 211-225.
21. Maurer A, Wieland T, Meissl F, et al. (2005) The b-subunit of G proteins is a substrate of protein histidine phosphatase. Biochem Biophys Res Commun 334, 1115-1120.
22. Dovas A & Couchman JR (2005) RhoGDI: multiple functions in the regulation of Rho family GTPase activities. Biochem J 390, 1-9.
23. McNeil CJ, Hay SM, Rucklidge G, et al. (2009) Gene and protein expression profiles in the foetal liver of the pregnant rat fed a low protein diet. Gene Nutr (epublication ahead of print version 30 May 2009).
24. Bischoff FR, Krebber H, Kempf T, et al. (1995) Human RanGTPase- activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. Proc Natl Acad Sci U S A 92, 1749-1753.
25. Fisher EA & Ginsberg HN (2002) Complexity in the secretory pathway: the assembly and secretion of apolipoprotein b-containing lipoproteins. J Biol Chem 277, 17377-17380.
26. Qiu W, Kohen-Avramoglu R, Rashid-Kolvear F, et al. (2004) Overexpression of the endoplasmic reticulum 60 protein ER-60 downregulates ApoB100 secretion by inducing its intracellular degradation via a nonproteasomal pathway: evidence for an ER-60-mediated and pCMB-sensitive intracellular degradative pathway. Biochemistry 43, 4819-4831.
27. Gerke V & Moss SE (2002) Annexins: from structure to function. Physiol Rev 82, 331-371.
28. Preiss D & Sattar N (2008) Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations. Clin Sci 115, 141-150.
29. Ravnskjaer K, Boergesen M, Rubi B, et al. (2005) Peroxisome proliferator-activated receptor a (PPARa) potentiates, whereas PPARg attenuates, glucose-stimulated insulin secretion in pancreatic b-cells. Endocrinology 146, 3266-3276.
30. Sandberg MB, Bloksgaard M, Duran-Sandoval D, et al. (2005) The gene encoding acyl-CoA-binding protein is subject to metabolic regulation by both sterol regulatory element-binding protein and peroxisome proliferator-activated receptor a in hepatocytes. J Biol Chem 280, 5258-5266.
31. Ameen C, Linden D, Larsson BM, et al. (2004) Effects of gender and GH secretory pattern on sterol regulatory elementbinding protein-1c and its target genes in rat liver. Am J Physiol Endocrinol Metab 287, E1039-E1048.