메뉴 건너뛰기




Volumn 65, Issue 8, 2016, Pages 1151-1160

Nonalcoholic fatty liver disease and hepatocellular carcinoma

Author keywords

Carcinogenesis; Fatty liver; Hepatoma; Metabolic liver disease; Primary liver tumor

Indexed keywords

IRON;

EID: 84958580773     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2016.01.010     Document Type: Article
Times cited : (142)

References (89)
  • 1
    • 79956222876 scopus 로고    scopus 로고
    • Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease
    • [1] Tannapfel, A., Denk, H., Dienes, H.P., Langner, C., Schirmacher, P., Trauner, M., et al. Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease. Virchows Arch 458 (2011), 511–523.
    • (2011) Virchows Arch , vol.458 , pp. 511-523
    • Tannapfel, A.1    Denk, H.2    Dienes, H.P.3    Langner, C.4    Schirmacher, P.5    Trauner, M.6
  • 2
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease
    • [2] Ludwig, J., Viggiano, T.R., McGill, D.B., Oh, B.J., Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 55 (1980), 434–438.
    • (1980) Mayo Clin Proc , vol.55 , pp. 434-438
    • Ludwig, J.1    Viggiano, T.R.2    McGill, D.B.3    Oh, B.J.4
  • 3
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years
    • [3] Powell, E.E., Cooksley, W.G., Hanson, R., Searle, J., Halliday, J.W., Powell, L.W., The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 11 (1990), 74–80.
    • (1990) Hepatology , vol.11 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.2    Hanson, R.3    Searle, J.4    Halliday, J.W.5    Powell, L.W.6
  • 4
    • 0028932680 scopus 로고
    • Two cases from the spectrum of nonalcoholic steatohepatitis
    • [4] Abdelmalek, M., Ludwig, J., Lindor, K.D., Two cases from the spectrum of nonalcoholic steatohepatitis. J Clin Gastroenterol 20 (1995), 127–130.
    • (1995) J Clin Gastroenterol , vol.20 , pp. 127-130
    • Abdelmalek, M.1    Ludwig, J.2    Lindor, K.D.3
  • 5
    • 0028875908 scopus 로고
    • The natural history of nonalcoholic fatty liver: a follow-up study
    • [5] Teli, M.R., James, O.F., Burt, A.D., Bennett, M.K., Day, C.P., The natural history of nonalcoholic fatty liver: a follow-up study. Hepatology 22 (1995), 1714–1719.
    • (1995) Hepatology , vol.22 , pp. 1714-1719
    • Teli, M.R.1    James, O.F.2    Burt, A.D.3    Bennett, M.K.4    Day, C.P.5
  • 6
    • 84861591910 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology
    • [6] Chalasani, N., Younossi, Z., Lavine, J.E., Diehl, A.M., Brunt, E.M., Cusi, K., et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 142 (2012), 1592–1609.
    • (2012) Gastroenterology , vol.142 , pp. 1592-1609
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3    Diehl, A.M.4    Brunt, E.M.5    Cusi, K.6
  • 7
    • 84927796763 scopus 로고    scopus 로고
    • Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management
    • [7] McPherson, S., Hardy, T., Henderson, E., Burt, A.D., Day, C.P., Anstee, Q.M., Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management. J Hepatol 62 (2015), 1148–1155.
    • (2015) J Hepatol , vol.62 , pp. 1148-1155
    • McPherson, S.1    Hardy, T.2    Henderson, E.3    Burt, A.D.4    Day, C.P.5    Anstee, Q.M.6
  • 8
    • 55549106451 scopus 로고    scopus 로고
    • Does nonalcoholic fatty liver disease predispose patients to hepatocellular carcinoma in the absence of cirrhosis?
    • [8] Guzman, G., Brunt, E.M., Petrovic, L.M., Chejfec, G., Layden, T.J., Cotler, S.J., Does nonalcoholic fatty liver disease predispose patients to hepatocellular carcinoma in the absence of cirrhosis?. Arch Pathol Lab Med 132 (2008), 1761–1766.
    • (2008) Arch Pathol Lab Med , vol.132 , pp. 1761-1766
    • Guzman, G.1    Brunt, E.M.2    Petrovic, L.M.3    Chejfec, G.4    Layden, T.J.5    Cotler, S.J.6
  • 9
    • 84921795197 scopus 로고    scopus 로고
    • Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease
    • [9] Leung, C., Yeoh, S.W., Patrick, D., Ket, S., Marion, K., Gow, P., et al. Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease. World J Gastroenterol 21 (2015), 1189–1196.
    • (2015) World J Gastroenterol , vol.21 , pp. 1189-1196
    • Leung, C.1    Yeoh, S.W.2    Patrick, D.3    Ket, S.4    Marion, K.5    Gow, P.6
  • 10
    • 84869436442 scopus 로고    scopus 로고
    • Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review
    • [10] White, D.L., Kanwal, F., El-Serag, H.B., Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review. Clin Gastroenterol Hepatol 10 (2012), 1342–1359.e2.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 1342-1359.e2
    • White, D.L.1    Kanwal, F.2    El-Serag, H.B.3
  • 11
    • 18544365700 scopus 로고    scopus 로고
    • Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis
    • [11] Ratziu, V., Bonyhay, L., Di Martino, V., Charlotte, F., Cavallaro, L., Sayegh-Tainturier, M.H., et al. Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis. Hepatology 35 (2002), 1485–1493.
    • (2002) Hepatology , vol.35 , pp. 1485-1493
    • Ratziu, V.1    Bonyhay, L.2    Di Martino, V.3    Charlotte, F.4    Cavallaro, L.5    Sayegh-Tainturier, M.H.6
  • 12
    • 0043268063 scopus 로고    scopus 로고
    • Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C
    • [12] Hui, J.M., Kench, J.G., Chitturi, S., Sud, A., Farrell, G.C., Byth, K., et al. Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C. Hepatology 38 (2003), 420–427.
    • (2003) Hepatology , vol.38 , pp. 420-427
    • Hui, J.M.1    Kench, J.G.2    Chitturi, S.3    Sud, A.4    Farrell, G.C.5    Byth, K.6
  • 13
    • 79960549297 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study
    • [13] Bhala, N., Angulo, P., van der Poorten, D., Lee, E., Hui, J.M., Saracco, G., et al. The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study. Hepatology 54 (2011), 1208–1216.
    • (2011) Hepatology , vol.54 , pp. 1208-1216
    • Bhala, N.1    Angulo, P.2    van der Poorten, D.3    Lee, E.4    Hui, J.M.5    Saracco, G.6
  • 14
    • 58849132440 scopus 로고    scopus 로고
    • Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C
    • [14] Yatsuji, S., Hashimoto, E., Tobari, M., Taniai, M., Tokushige, K., Shiratori, K., Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C. J Gastroenterol Hepatol 24 (2009), 248–254.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 248-254
    • Yatsuji, S.1    Hashimoto, E.2    Tobari, M.3    Taniai, M.4    Tokushige, K.5    Shiratori, K.6
  • 15
    • 77951456114 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection
    • [15] Starley, B.Q., Calcagno, C.J., Harrison, S.A., Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepatology 51 (2010), 1820–1832.
    • (2010) Hepatology , vol.51 , pp. 1820-1832
    • Starley, B.Q.1    Calcagno, C.J.2    Harrison, S.A.3
  • 16
    • 84872671526 scopus 로고    scopus 로고
    • Liver and diabetes. A vicious circle
    • [16] Loria, P., Lonardo, A., Anania, F., Liver and diabetes. A vicious circle. Hepatol Res 43 (2013), 51–64.
    • (2013) Hepatol Res , vol.43 , pp. 51-64
    • Loria, P.1    Lonardo, A.2    Anania, F.3
  • 17
    • 58149280387 scopus 로고    scopus 로고
    • Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis
    • [17] Sorrentino, P., D'Angelo, S., Ferbo, U., Micheli, P., Bracigliano, A., Vecchione, R., Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis. J Hepatol 50 (2009), 351–357.
    • (2009) J Hepatol , vol.50 , pp. 351-357
    • Sorrentino, P.1    D'Angelo, S.2    Ferbo, U.3    Micheli, P.4    Bracigliano, A.5    Vecchione, R.6
  • 18
    • 77952730428 scopus 로고    scopus 로고
    • The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
    • [18] Ascha, M.S., Hanouneh, I.A., Lopez, R., Tamimi, T.A., Feldstein, A.F., Zein, N.N., The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology 51 (2010), 1972–1978.
    • (2010) Hepatology , vol.51 , pp. 1972-1978
    • Ascha, M.S.1    Hanouneh, I.A.2    Lopez, R.3    Tamimi, T.A.4    Feldstein, A.F.5    Zein, N.N.6
  • 19
    • 79955033727 scopus 로고    scopus 로고
    • Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma
    • [quiz e50]
    • [19] Yasui, K., Hashimoto, E., Komorizono, Y., Koike, K., Arii, S., Imai, Y., et al. Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma. Clin Gastroenterol Hepatol 9 (2011), 428–433 [quiz e50].
    • (2011) Clin Gastroenterol Hepatol , vol.9 , pp. 428-433
    • Yasui, K.1    Hashimoto, E.2    Komorizono, Y.3    Koike, K.4    Arii, S.5    Imai, Y.6
  • 20
    • 77950803622 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis-associated hepatocellular carcinoma: our case series and literature review
    • [20] Takuma, Y., Nouso, K., Nonalcoholic steatohepatitis-associated hepatocellular carcinoma: our case series and literature review. World J Gastroenterol 16 (2010), 1436–1441.
    • (2010) World J Gastroenterol , vol.16 , pp. 1436-1441
    • Takuma, Y.1    Nouso, K.2
  • 21
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • [21] Calle, E.E., Rodriguez, C., Walker-Thurmond, K., Thun, M.J., Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348 (2003), 1625–1638.
    • (2003) N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 22
    • 84931295870 scopus 로고    scopus 로고
    • Obesity Early in Adulthood Increases Risk but Does Not Affect Outcomes of Hepatocellular Carcinoma
    • [22] Hassan, M.M., Abdel-Wahab, R., Kaseb, A., Shalaby, A., Phan, A.T., El-Serag, H.B., et al. Obesity Early in Adulthood Increases Risk but Does Not Affect Outcomes of Hepatocellular Carcinoma. Gastroenterology 149 (2015), 119–129.
    • (2015) Gastroenterology , vol.149 , pp. 119-129
    • Hassan, M.M.1    Abdel-Wahab, R.2    Kaseb, A.3    Shalaby, A.4    Phan, A.T.5    El-Serag, H.B.6
  • 23
    • 77951222429 scopus 로고    scopus 로고
    • Systematic review: the association between obesity and hepatocellular carcinoma - epidemiological evidence
    • [23] Saunders, D., Seidel, D., Allison, M., Lyratzopoulos, G., Systematic review: the association between obesity and hepatocellular carcinoma - epidemiological evidence. Aliment Pharmacol Ther 31 (2010), 1051–1063.
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 1051-1063
    • Saunders, D.1    Seidel, D.2    Allison, M.3    Lyratzopoulos, G.4
  • 24
    • 84899447215 scopus 로고    scopus 로고
    • Obesity-associated mechanisms of hepatocarcinogenesis
    • [24] Karagozian, R., Derdak, Z., Baffy, G., Obesity-associated mechanisms of hepatocarcinogenesis. Metabolism 63 (2014), 607–617.
    • (2014) Metabolism , vol.63 , pp. 607-617
    • Karagozian, R.1    Derdak, Z.2    Baffy, G.3
  • 25
    • 0029821203 scopus 로고    scopus 로고
    • Excess risk of primary liver cancer in patients with diabetes mellitus
    • [25] Adami, H.O., Chow, W.H., Nyren, O., Berne, C., Linet, M.S., Ekbom, A., et al. Excess risk of primary liver cancer in patients with diabetes mellitus. J Natl Cancer Inst 88 (1996), 1472–1477.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1472-1477
    • Adami, H.O.1    Chow, W.H.2    Nyren, O.3    Berne, C.4    Linet, M.S.5    Ekbom, A.6
  • 26
    • 0030774675 scopus 로고    scopus 로고
    • Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark
    • [26] Wideroff, L., Gridley, G., Mellemkjaer, L., Chow, W.H., Linet, M., Keehn, S., et al. Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst 89 (1997), 1360–1365.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1360-1365
    • Wideroff, L.1    Gridley, G.2    Mellemkjaer, L.3    Chow, W.H.4    Linet, M.5    Keehn, S.6
  • 28
    • 70349634197 scopus 로고    scopus 로고
    • Glycemic load in relation to hepatocellular carcinoma among patients with chronic hepatitis infection
    • [28] Lagiou, P., Rossi, M., Tzonou, A., Georgila, C., Trichopoulos, D., La Vecchia, C., Glycemic load in relation to hepatocellular carcinoma among patients with chronic hepatitis infection. Ann Oncol 20 (2009), 1741–1745.
    • (2009) Ann Oncol , vol.20 , pp. 1741-1745
    • Lagiou, P.1    Rossi, M.2    Tzonou, A.3    Georgila, C.4    Trichopoulos, D.5    La Vecchia, C.6
  • 29
    • 84909643580 scopus 로고    scopus 로고
    • Risk factors for combined hepatocellular-cholangiocarcinoma: a hospital-based case-control study
    • [29] Zhou, Y.M., Zhang, X.F., Wu, L.P., Sui, C.J., Yang, J.M., Risk factors for combined hepatocellular-cholangiocarcinoma: a hospital-based case-control study. World J Gastroenterol 20 (2014), 12615–12620.
    • (2014) World J Gastroenterol , vol.20 , pp. 12615-12620
    • Zhou, Y.M.1    Zhang, X.F.2    Wu, L.P.3    Sui, C.J.4    Yang, J.M.5
  • 30
    • 79251532050 scopus 로고    scopus 로고
    • Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease
    • [30] Nelson, J.E., Wilson, L., Brunt, E.M., Yeh, M.M., Kleiner, D.E., Unalp-Arida, A., et al. Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease. Hepatology 53 (2011), 448–457.
    • (2011) Hepatology , vol.53 , pp. 448-457
    • Nelson, J.E.1    Wilson, L.2    Brunt, E.M.3    Yeh, M.M.4    Kleiner, D.E.5    Unalp-Arida, A.6
  • 31
  • 32
    • 84929129284 scopus 로고    scopus 로고
    • Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
    • [32] Schulze, K., Imbeaud, S., Letouze, E., Alexandrov, L.B., Calderaro, J., Rebouissou, S., et al. Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. Nat Genet 47 (2015), 505–511.
    • (2015) Nat Genet , vol.47 , pp. 505-511
    • Schulze, K.1    Imbeaud, S.2    Letouze, E.3    Alexandrov, L.B.4    Calderaro, J.5    Rebouissou, S.6
  • 33
    • 84899755032 scopus 로고    scopus 로고
    • Genome-wide analysis of copy number variation identifies candidate gene loci associated with the progression of non-alcoholic fatty liver disease
    • [33] Zain, S.M., Mohamed, R., Cooper, D.N., Razali, R., Rampal, S., Mahadeva, S., et al. Genome-wide analysis of copy number variation identifies candidate gene loci associated with the progression of non-alcoholic fatty liver disease. PLoS One, 9, 2014, e95604.
    • (2014) PLoS One , vol.9 , pp. e95604
    • Zain, S.M.1    Mohamed, R.2    Cooper, D.N.3    Razali, R.4    Rampal, S.5    Mahadeva, S.6
  • 34
    • 0034663939 scopus 로고    scopus 로고
    • Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes
    • [34] Lipowsky, G., Bischoff, F.R., Schwarzmaier, P., Kraft, R., Kostka, S., Hartmann, E., et al. Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes. EMBO J 19 (2000), 4362–4371.
    • (2000) EMBO J , vol.19 , pp. 4362-4371
    • Lipowsky, G.1    Bischoff, F.R.2    Schwarzmaier, P.3    Kraft, R.4    Kostka, S.5    Hartmann, E.6
  • 35
    • 79951592100 scopus 로고    scopus 로고
    • Decreased expression of XPO4 is associated with poor prognosis in hepatocellular carcinoma
    • [35] Liang, X.T., Pan, K., Chen, M.S., Li, J.J., Wang, H., Zhao, J.J., et al. Decreased expression of XPO4 is associated with poor prognosis in hepatocellular carcinoma. J Gastroenterol Hepatol 26 (2011), 544–549.
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 544-549
    • Liang, X.T.1    Pan, K.2    Chen, M.S.3    Li, J.J.4    Wang, H.5    Zhao, J.J.6
  • 36
    • 84869485418 scopus 로고    scopus 로고
    • Evaluation of TGFbeta, XPO4, elF5A2 and ANGPTL4 as biomarkers in HCC
    • [36] Zhang, H., Wei, S., Ning, S., Jie, Y., Ru, Y., Gu, Y., Evaluation of TGFbeta, XPO4, elF5A2 and ANGPTL4 as biomarkers in HCC. Exp Ther Med 5 (2013), 119–127.
    • (2013) Exp Ther Med , vol.5 , pp. 119-127
    • Zhang, H.1    Wei, S.2    Ning, S.3    Jie, Y.4    Ru, Y.5    Gu, Y.6
  • 37
    • 2342547678 scopus 로고    scopus 로고
    • Integrative analysis of multiple gene expression profiles applied to liver cancer study
    • [37] Choi, J.K., Choi, J.Y., Kim, D.G., Choi, D.W., Kim, B.Y., Lee, K.H., et al. Integrative analysis of multiple gene expression profiles applied to liver cancer study. FEBS Lett 565 (2004), 93–100.
    • (2004) FEBS Lett , vol.565 , pp. 93-100
    • Choi, J.K.1    Choi, J.Y.2    Kim, D.G.3    Choi, D.W.4    Kim, B.Y.5    Lee, K.H.6
  • 38
    • 77957361278 scopus 로고    scopus 로고
    • Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors
    • [38] Hernandez-Vargas, H., Lambert, M.P., Le Calvez-Kelm, F., Gouysse, G., McKay-Chopin, S., Tavtigian, S.V., et al. Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors. PLoS One, 5, 2010, e9749.
    • (2010) PLoS One , vol.5 , pp. e9749
    • Hernandez-Vargas, H.1    Lambert, M.P.2    Le Calvez-Kelm, F.3    Gouysse, G.4    McKay-Chopin, S.5    Tavtigian, S.V.6
  • 39
    • 84943153918 scopus 로고    scopus 로고
    • Association of APC, GSTP1 and SOCS1 promoter methylation with the risk of hepatocellular carcinoma: a meta-analysis
    • [39] Liu, M., Cui, L.H., Li, C.C., Zhang, L., Association of APC, GSTP1 and SOCS1 promoter methylation with the risk of hepatocellular carcinoma: a meta-analysis. Eur J Cancer Prev, 2015.
    • (2015) Eur J Cancer Prev
    • Liu, M.1    Cui, L.H.2    Li, C.C.3    Zhang, L.4
  • 40
    • 84880506510 scopus 로고    scopus 로고
    • MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways
    • [40] Bao, L., Yan, Y., Xu, C., Ji, W., Shen, S., Xu, G., et al. MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways. Cancer Lett 337 (2013), 226–236.
    • (2013) Cancer Lett , vol.337 , pp. 226-236
    • Bao, L.1    Yan, Y.2    Xu, C.3    Ji, W.4    Shen, S.5    Xu, G.6
  • 41
    • 84870610975 scopus 로고    scopus 로고
    • YAP mediates crosstalk between the Hippo and PI(3)K-TOR pathways by suppressing PTEN via miR-29
    • [41] Tumaneng, K., Schlegelmilch, K., Russell, R.C., Yimlamai, D., Basnet, H., Mahadevan, N., et al. YAP mediates crosstalk between the Hippo and PI(3)K-TOR pathways by suppressing PTEN via miR-29. Nat Cell Biol 14 (2012), 1322–1329.
    • (2012) Nat Cell Biol , vol.14 , pp. 1322-1329
    • Tumaneng, K.1    Schlegelmilch, K.2    Russell, R.C.3    Yimlamai, D.4    Basnet, H.5    Mahadevan, N.6
  • 42
    • 84911031215 scopus 로고    scopus 로고
    • Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis
    • [42] Takaki, Y., Saito, Y., Takasugi, A., Toshimitsu, K., Yamada, S., Muramatsu, T., et al. Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis. Cancer Sci 105 (2014), 1254–1260.
    • (2014) Cancer Sci , vol.105 , pp. 1254-1260
    • Takaki, Y.1    Saito, Y.2    Takasugi, A.3    Toshimitsu, K.4    Yamada, S.5    Muramatsu, T.6
  • 44
    • 0026605216 scopus 로고
    • Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma
    • [44] Nishiyama, M., Wands, J.R., Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma. Biochem Biophys Res Commun 183 (1992), 280–285.
    • (1992) Biochem Biophys Res Commun , vol.183 , pp. 280-285
    • Nishiyama, M.1    Wands, J.R.2
  • 45
    • 0023897684 scopus 로고
    • Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
    • [45] Whitman, M., Downes, C.P., Keeler, M., Keller, T., Cantley, L., Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 332 (1988), 644–646.
    • (1988) Nature , vol.332 , pp. 644-646
    • Whitman, M.1    Downes, C.P.2    Keeler, M.3    Keller, T.4    Cantley, L.5
  • 46
    • 84893249799 scopus 로고    scopus 로고
    • PI3K and cancer: lessons, challenges and opportunities
    • [46] Fruman, D.A., Rommel, C., PI3K and cancer: lessons, challenges and opportunities. Nat Rev Drug Discov 13 (2014), 140–156.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 140-156
    • Fruman, D.A.1    Rommel, C.2
  • 47
    • 81355127657 scopus 로고    scopus 로고
    • Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway
    • [47] Kudo, Y., Tanaka, Y., Tateishi, K., Yamamoto, K., Yamamoto, S., Mohri, D., et al. Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway. J Hepatol 55 (2011), 1400–1408.
    • (2011) J Hepatol , vol.55 , pp. 1400-1408
    • Kudo, Y.1    Tanaka, Y.2    Tateishi, K.3    Yamamoto, K.4    Yamamoto, S.5    Mohri, D.6
  • 48
    • 29144509972 scopus 로고    scopus 로고
    • Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma
    • [48] Watanabe, S., Horie, Y., Suzuki, A., Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma. Hepatol Res 33 (2005), 161–166.
    • (2005) Hepatol Res , vol.33 , pp. 161-166
    • Watanabe, S.1    Horie, Y.2    Suzuki, A.3
  • 49
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • [49] Vivanco, I., Sawyers, C.L., The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2 (2002), 489–501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 50
    • 35848951652 scopus 로고    scopus 로고
    • Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation
    • [50] Kitisin, K., Ganesan, N., Tang, Y., Jogunoori, W., Volpe, E.A., Kim, S.S., et al. Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation. Oncogene 26 (2007), 7103–7110.
    • (2007) Oncogene , vol.26 , pp. 7103-7110
    • Kitisin, K.1    Ganesan, N.2    Tang, Y.3    Jogunoori, W.4    Volpe, E.A.5    Kim, S.S.6
  • 52
    • 0032546929 scopus 로고    scopus 로고
    • Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism
    • [52] Fan, C.Y., Pan, J., Usuda, N., Yeldandi, A.V., Rao, M.S., Reddy, J.K., Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism. J Biol Chem 273 (1998), 15639–15645.
    • (1998) J Biol Chem , vol.273 , pp. 15639-15645
    • Fan, C.Y.1    Pan, J.2    Usuda, N.3    Yeldandi, A.V.4    Rao, M.S.5    Reddy, J.K.6
  • 53
    • 80052459616 scopus 로고    scopus 로고
    • Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice
    • [53] Huang, J., Viswakarma, N., Yu, S., Jia, Y., Bai, L., Vluggens, A., et al. Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice. Am J Pathol 179 (2011), 703–713.
    • (2011) Am J Pathol , vol.179 , pp. 703-713
    • Huang, J.1    Viswakarma, N.2    Yu, S.3    Jia, Y.4    Bai, L.5    Vluggens, A.6
  • 54
    • 84907976095 scopus 로고    scopus 로고
    • Metabolic activation of intrahepatic CD8 + T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes
    • [54] Wolf, M.J., Adili, A., Piotrowitz, K., Abdullah, Z., Boege, Y., Stemmer, K., et al. Metabolic activation of intrahepatic CD8 + T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell 26 (2014), 549–564.
    • (2014) Cancer Cell , vol.26 , pp. 549-564
    • Wolf, M.J.1    Adili, A.2    Piotrowitz, K.3    Abdullah, Z.4    Boege, Y.5    Stemmer, K.6
  • 55
    • 79957480596 scopus 로고    scopus 로고
    • Mouse models of hepatocarcinogenesis: what can we learn for the prevention of human hepatocellular carcinoma?
    • [55] Vucur, M., Roderburg, C., Bettermann, K., Tacke, F., Heikenwalder, M., Trautwein, C., et al. Mouse models of hepatocarcinogenesis: what can we learn for the prevention of human hepatocellular carcinoma?. Oncotarget 1 (2010), 373–378.
    • (2010) Oncotarget , vol.1 , pp. 373-378
    • Vucur, M.1    Roderburg, C.2    Bettermann, K.3    Tacke, F.4    Heikenwalder, M.5    Trautwein, C.6
  • 56
    • 84872223447 scopus 로고    scopus 로고
    • NF-kappaB1 deficiency stimulates the progression of non-alcoholic steatohepatitis (NASH) in mice by promoting NKT-cell-mediated responses
    • [56] Locatelli, I., Sutti, S., Vacchiano, M., Bozzola, C., Albano, E., NF-kappaB1 deficiency stimulates the progression of non-alcoholic steatohepatitis (NASH) in mice by promoting NKT-cell-mediated responses. Clin Sci (Lond) 124 (2013), 279–287.
    • (2013) Clin Sci (Lond) , vol.124 , pp. 279-287
    • Locatelli, I.1    Sutti, S.2    Vacchiano, M.3    Bozzola, C.4    Albano, E.5
  • 57
    • 21244472975 scopus 로고    scopus 로고
    • IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • [57] Maeda, S., Kamata, H., Luo, J.L., Leffert, H., Karin, M., IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121 (2005), 977–990.
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 58
    • 4644324186 scopus 로고    scopus 로고
    • NF-kappaB functions as a tumour promoter in inflammation-associated cancer
    • [58] Pikarsky, E., Porat, R.M., Stein, I., Abramovitch, R., Amit, S., Kasem, S., et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431 (2004), 461–466.
    • (2004) Nature , vol.431 , pp. 461-466
    • Pikarsky, E.1    Porat, R.M.2    Stein, I.3    Abramovitch, R.4    Amit, S.5    Kasem, S.6
  • 59
    • 77953859606 scopus 로고    scopus 로고
    • NF-kappaB as a critical link between inflammation and cancer
    • [59] Karin, M., NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol, 1, 2009, a000141.
    • (2009) Cold Spring Harb Perspect Biol , vol.1 , pp. a000141
    • Karin, M.1
  • 61
    • 0035870293 scopus 로고    scopus 로고
    • Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin
    • [61] Cadoret, A., Ovejero, C., Saadi-Kheddouci, S., Souil, E., Fabre, M., Romagnolo, B., et al. Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin. Cancer Res 61 (2001), 3245–3249.
    • (2001) Cancer Res , vol.61 , pp. 3245-3249
    • Cadoret, A.1    Ovejero, C.2    Saadi-Kheddouci, S.3    Souil, E.4    Fabre, M.5    Romagnolo, B.6
  • 62
    • 0036531817 scopus 로고    scopus 로고
    • Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin
    • [62] Harada, N., Miyoshi, H., Murai, N., Oshima, H., Tamai, Y., Oshima, M., et al. Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin. Cancer Res 62 (2002), 1971–1977.
    • (2002) Cancer Res , vol.62 , pp. 1971-1977
    • Harada, N.1    Miyoshi, H.2    Murai, N.3    Oshima, H.4    Tamai, Y.5    Oshima, M.6
  • 63
    • 77951487860 scopus 로고    scopus 로고
    • Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine-45 mutant beta-catenin
    • [63] Nejak-Bowen, K.N., Thompson, M.D., Singh, S., Bowen, W.C. Jr., Dar, M.J., Khillan, J., et al. Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine-45 mutant beta-catenin. Hepatology 51 (2010), 1603–1613.
    • (2010) Hepatology , vol.51 , pp. 1603-1613
    • Nejak-Bowen, K.N.1    Thompson, M.D.2    Singh, S.3    Bowen, W.C.4    Dar, M.J.5    Khillan, J.6
  • 64
    • 22344435816 scopus 로고    scopus 로고
    • Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver
    • [64] Tan, X., Apte, U., Micsenyi, A., Kotsagrelos, E., Luo, J.H., Ranganathan, S., et al. Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver. Gastroenterology 129 (2005), 285–302.
    • (2005) Gastroenterology , vol.129 , pp. 285-302
    • Tan, X.1    Apte, U.2    Micsenyi, A.3    Kotsagrelos, E.4    Luo, J.H.5    Ranganathan, S.6
  • 66
    • 84902688337 scopus 로고    scopus 로고
    • Carriage of the PNPLA3 rs738409 C > G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma
    • [66] Liu, Y.L., Patman, G.L., Leathart, J.B., Piguet, A.C., Burt, A.D., Dufour, J.F., et al. Carriage of the PNPLA3 rs738409 C > G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma. J Hepatol 61 (2014), 75–81.
    • (2014) J Hepatol , vol.61 , pp. 75-81
    • Liu, Y.L.1    Patman, G.L.2    Leathart, J.B.3    Piguet, A.C.4    Burt, A.D.5    Dufour, J.F.6
  • 67
    • 84903708160 scopus 로고    scopus 로고
    • TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
    • [67] Liu, Y.L., Reeves, H.L., Burt, A.D., Tiniakos, D., McPherson, S., Leathart, J.B., et al. TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease. Nat Commun, 5, 2014, 4309.
    • (2014) Nat Commun , vol.5 , pp. 4309
    • Liu, Y.L.1    Reeves, H.L.2    Burt, A.D.3    Tiniakos, D.4    McPherson, S.5    Leathart, J.B.6
  • 69
    • 84859812538 scopus 로고    scopus 로고
    • Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
    • [69] Dapito, D.H., Mencin, A., Gwak, G.Y., Pradere, J.P., Jang, M.K., Mederacke, I., et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 21 (2012), 504–516.
    • (2012) Cancer Cell , vol.21 , pp. 504-516
    • Dapito, D.H.1    Mencin, A.2    Gwak, G.Y.3    Pradere, J.P.4    Jang, M.K.5    Mederacke, I.6
  • 70
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • [70] Yoshimoto, S., Loo, T.M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 499 (2013), 97–101.
    • (2013) Nature , vol.499 , pp. 97-101
    • Yoshimoto, S.1    Loo, T.M.2    Atarashi, K.3    Kanda, H.4    Sato, S.5    Oyadomari, S.6
  • 71
    • 84874660234 scopus 로고    scopus 로고
    • Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies
    • [71] Chen, H.P., Shieh, J.J., Chang, C.C., Chen, T.T., Lin, J.T., Wu, M.S., et al. Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies. Gut 62 (2013), 606–615.
    • (2013) Gut , vol.62 , pp. 606-615
    • Chen, H.P.1    Shieh, J.J.2    Chang, C.C.3    Chen, T.T.4    Lin, J.T.5    Wu, M.S.6
  • 72
    • 84928205060 scopus 로고    scopus 로고
    • The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective, randomized, controlled trial
    • [72] Adams, L.A., Crawford, D.H., Stuart, K., House MJ, St Pierre, T.G., Webb, M., et al. The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective, randomized, controlled trial. Hepatology 61 (2015), 1555–1564.
    • (2015) Hepatology , vol.61 , pp. 1555-1564
    • Adams, L.A.1    Crawford, D.H.2    Stuart, K.3    House MJ4    St Pierre, T.G.5    Webb, M.6
  • 73
    • 33645963121 scopus 로고    scopus 로고
    • Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
    • [73] Sanyal, A.J., Banas, C., Sargeant, C., Luketic, V.A., Sterling, R.K., Stravitz, R.T., et al. Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. Hepatology 43 (2006), 682–689.
    • (2006) Hepatology , vol.43 , pp. 682-689
    • Sanyal, A.J.1    Banas, C.2    Sargeant, C.3    Luketic, V.A.4    Sterling, R.K.5    Stravitz, R.T.6
  • 74
    • 0036302288 scopus 로고    scopus 로고
    • Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma
    • [74] Bugianesi, E., Leone, N., Vanni, E., Marchesini, G., Brunello, F., Carucci, P., et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 123 (2002), 134–140.
    • (2002) Gastroenterology , vol.123 , pp. 134-140
    • Bugianesi, E.1    Leone, N.2    Vanni, E.3    Marchesini, G.4    Brunello, F.5    Carucci, P.6
  • 75
    • 0031550247 scopus 로고    scopus 로고
    • Identification of a mouse homolog for the human hereditary haemochromatosis candidate gene
    • [75] Hashimoto, K., Hirai, M., Kurosawa, Y., Identification of a mouse homolog for the human hereditary haemochromatosis candidate gene. Biochem Biophys Res Commun 230 (1997), 35–39.
    • (1997) Biochem Biophys Res Commun , vol.230 , pp. 35-39
    • Hashimoto, K.1    Hirai, M.2    Kurosawa, Y.3
  • 76
    • 33645274921 scopus 로고    scopus 로고
    • Hepatocellular carcinoma arising from nonalcoholic steatohepatitis: report of two cases
    • [76] Hai, S., Kubo, S., Shuto, T., Tanaka, H., Takemura, S., Yamamoto, T., et al. Hepatocellular carcinoma arising from nonalcoholic steatohepatitis: report of two cases. Surg Today 36 (2006), 390–394.
    • (2006) Surg Today , vol.36 , pp. 390-394
    • Hai, S.1    Kubo, S.2    Shuto, T.3    Tanaka, H.4    Takemura, S.5    Yamamoto, T.6
  • 77
    • 58149394927 scopus 로고    scopus 로고
    • Surgically resected hepatocellular carcinomas in patients with non-alcoholic steatohepatitis
    • [77] Maeda, T., Hashimoto, K., Kihara, Y., Ikegami, T., Ishida, T., Aimitsu, S., et al. Surgically resected hepatocellular carcinomas in patients with non-alcoholic steatohepatitis. Hepatogastroenterology 55 (2008), 1404–1406.
    • (2008) Hepatogastroenterology , vol.55 , pp. 1404-1406
    • Maeda, T.1    Hashimoto, K.2    Kihara, Y.3    Ikegami, T.4    Ishida, T.5    Aimitsu, S.6
  • 78
    • 73449130477 scopus 로고    scopus 로고
    • Hepatocellular carcinoma arising from non-cirrhotic nonalcoholic steatohepatitis
    • [78] Kawada, N., Imanaka, K., Kawaguchi, T., Tamai, C., Ishihara, R., Matsunaga, T., et al. Hepatocellular carcinoma arising from non-cirrhotic nonalcoholic steatohepatitis. J Gastroenterol 44 (2009), 1190–1194.
    • (2009) J Gastroenterol , vol.44 , pp. 1190-1194
    • Kawada, N.1    Imanaka, K.2    Kawaguchi, T.3    Tamai, C.4    Ishihara, R.5    Matsunaga, T.6
  • 79
    • 67649313330 scopus 로고    scopus 로고
    • Liver transplantation in patients with nonalcoholic steatohepatitis-related hepatocellular carcinoma
    • [79] Malik, S.M., Gupte, P.A., de Vera, M.E., Ahmad, J., Liver transplantation in patients with nonalcoholic steatohepatitis-related hepatocellular carcinoma. Clin Gastroenterol Hepatol 7 (2009), 800–806.
    • (2009) Clin Gastroenterol Hepatol , vol.7 , pp. 800-806
    • Malik, S.M.1    Gupte, P.A.2    de Vera, M.E.3    Ahmad, J.4
  • 80
    • 71049127867 scopus 로고    scopus 로고
    • Does hepatocellular carcinoma in non-alcoholic steatohepatitis exist in cirrhotic and non-cirrhotic patients?
    • [80] Chagas, A.L., Kikuchi, L.O., Oliveira, C.P., Vezozzo, D.C., Mello, E.S., Oliveira, A.C., et al. Does hepatocellular carcinoma in non-alcoholic steatohepatitis exist in cirrhotic and non-cirrhotic patients?. Braz J Med Biol Res 42 (2009), 958–962.
    • (2009) Braz J Med Biol Res , vol.42 , pp. 958-962
    • Chagas, A.L.1    Kikuchi, L.O.2    Oliveira, C.P.3    Vezozzo, D.C.4    Mello, E.S.5    Oliveira, A.C.6
  • 81
    • 0035056507 scopus 로고    scopus 로고
    • Detection of hypermethylation of the p16(INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus
    • [81] Kaneto, H., Sasaki, S., Yamamoto, H., Itoh, F., Toyota, M., Suzuki, H., et al. Detection of hypermethylation of the p16(INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus. Gut 48 (2001), 372–377.
    • (2001) Gut , vol.48 , pp. 372-377
    • Kaneto, H.1    Sasaki, S.2    Yamamoto, H.3    Itoh, F.4    Toyota, M.5    Suzuki, H.6
  • 82
    • 84930592195 scopus 로고    scopus 로고
    • Identification of hepatocellular carcinoma-associated hub genes and pathways by integrated microarray analysis
    • [82] Liu, F., Li, H., Chang, H., Wang, J., Lu, J., Identification of hepatocellular carcinoma-associated hub genes and pathways by integrated microarray analysis. Tumori 101 (2015), 206–214.
    • (2015) Tumori , vol.101 , pp. 206-214
    • Liu, F.1    Li, H.2    Chang, H.3    Wang, J.4    Lu, J.5
  • 83
    • 0036789450 scopus 로고    scopus 로고
    • High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma
    • [83] Zhang, Y.J., Ahsan, H., Chen, Y., Lunn, R.M., Wang, L.Y., Chen, S.Y., et al. High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma. Mol Carcinog 35 (2002), 85–92.
    • (2002) Mol Carcinog , vol.35 , pp. 85-92
    • Zhang, Y.J.1    Ahsan, H.2    Chen, Y.3    Lunn, R.M.4    Wang, L.Y.5    Chen, S.Y.6
  • 84
    • 77950628676 scopus 로고    scopus 로고
    • DNA methylation changes in normal liver tissues and hepatocellular carcinoma with different viral infection
    • [84] Feng, Q., Stern, J.E., Hawes, S.E., Lu, H., Jiang, M., Kiviat, N.B., DNA methylation changes in normal liver tissues and hepatocellular carcinoma with different viral infection. Exp Mol Pathol 88 (2010), 287–292.
    • (2010) Exp Mol Pathol , vol.88 , pp. 287-292
    • Feng, Q.1    Stern, J.E.2    Hawes, S.E.3    Lu, H.4    Jiang, M.5    Kiviat, N.B.6
  • 85
    • 84865543987 scopus 로고    scopus 로고
    • Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma
    • [85] Nishida, N., Kudo, M., Nagasaka, T., Ikai, I., Goel, A., Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma. Hepatology 56 (2012), 994–1003.
    • (2012) Hepatology , vol.56 , pp. 994-1003
    • Nishida, N.1    Kudo, M.2    Nagasaka, T.3    Ikai, I.4    Goel, A.5
  • 86
    • 77953971188 scopus 로고    scopus 로고
    • Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years
    • [86] Wong, V.W., Wong, G.L., Choi, P.C., Chan, A.W., Li, M.K., Chan, H.Y., et al. Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years. Gut 59 (2010), 969–974.
    • (2010) Gut , vol.59 , pp. 969-974
    • Wong, V.W.1    Wong, G.L.2    Choi, P.C.3    Chan, A.W.4    Li, M.K.5    Chan, H.Y.6
  • 87
    • 84882906611 scopus 로고    scopus 로고
    • A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver
    • [87] Pais, R., Charlotte, F., Fedchuk, L., Bedossa, P., Lebray, P., Poynard, T., et al. A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver. J Hepatol 59 (2013), 550–556.
    • (2013) J Hepatol , vol.59 , pp. 550-556
    • Pais, R.1    Charlotte, F.2    Fedchuk, L.3    Bedossa, P.4    Lebray, P.5    Poynard, T.6
  • 88
    • 84924938800 scopus 로고    scopus 로고
    • Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies
    • [quiz e39-40]
    • [88] Singh, S., Allen, A.M., Wang, Z., Prokop, L.J., Murad, M.H., Loomba, R., Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol 13 (2015), 643–654 [quiz e39-40].
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 643-654
    • Singh, S.1    Allen, A.M.2    Wang, Z.3    Prokop, L.J.4    Murad, M.H.5    Loomba, R.6
  • 89
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • [89] Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation. Cell 144 (2011), 646–674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.