메뉴 건너뛰기




Volumn 61, Issue 5, 2015, Pages 1555-1564

The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective, randomized, controlled trial

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOKERATIN 18; FERRITIN; GLUCOSE; HEMOGLOBIN A1C; INSULIN; ISOPROSTANE DERIVATIVE;

EID: 84928205060     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27662     Document Type: Article
Times cited : (96)

References (46)
  • 2
    • 79251532050 scopus 로고    scopus 로고
    • Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease
    • Nelson JE, Wilson L, Brunt EM, Yeh MM, Kleiner DE, Unalp-Arida A, Kowdley KV. Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease. Hepatology 2011;53:448-457.
    • (2011) Hepatology , vol.53 , pp. 448-457
    • Nelson, J.E.1    Wilson, L.2    Brunt, E.M.3    Yeh, M.M.4    Kleiner, D.E.5    Unalp-Arida, A.6    Kowdley, K.V.7
  • 3
    • 80052940689 scopus 로고    scopus 로고
    • Iron in fatty liver and in the metabolic syndrome: a promising therapeutic target
    • Dongiovanni P, Fracanzani AL, Fargion S, Valenti L. Iron in fatty liver and in the metabolic syndrome: a promising therapeutic target. J Hepatol 2011;55:920-932.
    • (2011) J Hepatol , vol.55 , pp. 920-932
    • Dongiovanni, P.1    Fracanzani, A.L.2    Fargion, S.3    Valenti, L.4
  • 4
    • 77249139227 scopus 로고    scopus 로고
    • HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease
    • Valenti L, Fracanzani AL, Bugianesi E, Dongiovanni P, Galmozzi E, Vanni E, et al. HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease. Gastroenterology 2010;138:905-912.
    • (2010) Gastroenterology , vol.138 , pp. 905-912
    • Valenti, L.1    Fracanzani, A.L.2    Bugianesi, E.3    Dongiovanni, P.4    Galmozzi, E.5    Vanni, E.6
  • 5
    • 35748974840 scopus 로고    scopus 로고
    • Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death
    • Imeryuz N, Tahan V, Sonsuz A, Eren F, Uraz S, Yuksel M, et al. Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death. J Hepatol 2007;47:851-859.
    • (2007) J Hepatol , vol.47 , pp. 851-859
    • Imeryuz, N.1    Tahan, V.2    Sonsuz, A.3    Eren, F.4    Uraz, S.5    Yuksel, M.6
  • 6
    • 33751020540 scopus 로고    scopus 로고
    • Effects of iron overload in a rat nutritional model of non-alcoholic fatty liver disease
    • Kirsch R, Sijtsema HP, Tlali M, Marais AD, Hall Pde L. Effects of iron overload in a rat nutritional model of non-alcoholic fatty liver disease. Liver Int 2006;26:1258-1267.
    • (2006) Liver Int , vol.26 , pp. 1258-1267
    • Kirsch, R.1    Sijtsema, H.P.2    Tlali, M.3    Marais, A.D.4    Hall Pde, L.5
  • 7
    • 84155188801 scopus 로고    scopus 로고
    • Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease
    • Kowdley KV, Belt P, Wilson LA, Yeh MM, Neuschwander-Tetri BA, Chalasani N, et al. Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease. Hepatology 2012;55:77-85.
    • (2012) Hepatology , vol.55 , pp. 77-85
    • Kowdley, K.V.1    Belt, P.2    Wilson, L.A.3    Yeh, M.M.4    Neuschwander-Tetri, B.A.5    Chalasani, N.6
  • 8
    • 0036291809 scopus 로고    scopus 로고
    • HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity
    • Chitturi S, Weltman M, Farrell GC, McDonald D, Kench J, Liddle C, et al. HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity. Hepatology 2002;36:142-149.
    • (2002) Hepatology , vol.36 , pp. 142-149
    • Chitturi, S.1    Weltman, M.2    Farrell, G.C.3    McDonald, D.4    Kench, J.5    Liddle, C.6
  • 9
    • 84876726206 scopus 로고    scopus 로고
    • Hepatic reticuloendothelial system cell iron deposition is associated with increased apoptosis in nonalcoholic fatty liver disease
    • Maliken BD, Nelson JE, Klintworth HM, Beauchamp M, Yeh MM, Kowdley KV. Hepatic reticuloendothelial system cell iron deposition is associated with increased apoptosis in nonalcoholic fatty liver disease. Hepatology 2013;57:1806-1813.
    • (2013) Hepatology , vol.57 , pp. 1806-1813
    • Maliken, B.D.1    Nelson, J.E.2    Klintworth, H.M.3    Beauchamp, M.4    Yeh, M.M.5    Kowdley, K.V.6
  • 10
    • 1442281989 scopus 로고    scopus 로고
    • Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver
    • Bugianesi E, Manzini P, D'Antico S, Vanni E, Longo F, Leone N, et al. Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver. Hepatology 2004;39:179-187.
    • (2004) Hepatology , vol.39 , pp. 179-187
    • Bugianesi, E.1    Manzini, P.2    D'Antico, S.3    Vanni, E.4    Longo, F.5    Leone, N.6
  • 11
    • 79960847840 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment
    • Smith BW, Adams LA. Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment. Nat Rev Endocrinol 2011;7:456-465.
    • (2011) Nat Rev Endocrinol , vol.7 , pp. 456-465
    • Smith, B.W.1    Adams, L.A.2
  • 12
    • 84881559017 scopus 로고    scopus 로고
    • Effects of excess dietary iron and fat on glucose and lipid metabolism
    • Choi JS, Koh IU, Lee HJ, Kim WH, Song J. Effects of excess dietary iron and fat on glucose and lipid metabolism. J Nutr Biochem 2013;24:1634-1644.
    • (2013) J Nutr Biochem , vol.24 , pp. 1634-1644
    • Choi, J.S.1    Koh, I.U.2    Lee, H.J.3    Kim, W.H.4    Song, J.5
  • 15
    • 33745812430 scopus 로고    scopus 로고
    • Transferrin and iron induce insulin resistance of glucose transport in adipocytes
    • Green A, Basile R, Rumberger JM. Transferrin and iron induce insulin resistance of glucose transport in adipocytes. Metabolism 2006;55:1042-1045.
    • (2006) Metabolism , vol.55 , pp. 1042-1045
    • Green, A.1    Basile, R.2    Rumberger, J.M.3
  • 16
    • 0029189324 scopus 로고
    • Regulation of glucose transport and GLUT-1 expression by iron chelators in muscle cells in culture
    • Potashnik R, Kozlovsky N, Ben-Ezra S, Rudich A, Bashan N. Regulation of glucose transport and GLUT-1 expression by iron chelators in muscle cells in culture. Am J physiol 1995;269:E1052-E1058.
    • (1995) Am J physiol , vol.269 , pp. E1052-E1058
    • Potashnik, R.1    Kozlovsky, N.2    Ben-Ezra, S.3    Rudich, A.4    Bashan, N.5
  • 18
    • 33749827999 scopus 로고    scopus 로고
    • Increased insulin secretory capacity but decreased insulin sensitivity after correction of iron overload by phlebotomy in hereditary haemochromatosis
    • Abraham D, Rogers J, Gault P, Kushner JP, McClain DA. Increased insulin secretory capacity but decreased insulin sensitivity after correction of iron overload by phlebotomy in hereditary haemochromatosis. Diabetologia 2006;49:2546-2551.
    • (2006) Diabetologia , vol.49 , pp. 2546-2551
    • Abraham, D.1    Rogers, J.2    Gault, P.3    Kushner, J.P.4    McClain, D.A.5
  • 19
    • 84867216460 scopus 로고    scopus 로고
    • Dietary iron intake, body iron stores, and the risk of type 2 diabetes: a systematic review and meta-analysis
    • Bao W, Rong Y, Rong S, Liu L. Dietary iron intake, body iron stores, and the risk of type 2 diabetes: a systematic review and meta-analysis. BMC Med 2012;10:119.
    • (2012) BMC Med , vol.10 , pp. 119
    • Bao, W.1    Rong, Y.2    Rong, S.3    Liu, L.4
  • 20
    • 78751690311 scopus 로고    scopus 로고
    • Venesection for non-alcoholic fatty liver disease unresponsive to lifestyle counselling-a propensity score-adjusted observational study
    • Valenti L, Moscatiello S, Vanni E, Fracanzani AL, Bugianesi E, Fargion S, Marchesini G. Venesection for non-alcoholic fatty liver disease unresponsive to lifestyle counselling-a propensity score-adjusted observational study. QJM 2011;104:141-149.
    • (2011) QJM , vol.104 , pp. 141-149
    • Valenti, L.1    Moscatiello, S.2    Vanni, E.3    Fracanzani, A.L.4    Bugianesi, E.5    Fargion, S.6    Marchesini, G.7
  • 21
    • 0031738536 scopus 로고    scopus 로고
    • Effect of phlebotomy on plasma glucose and insulin concentrations
    • Facchini FS. Effect of phlebotomy on plasma glucose and insulin concentrations. Diabetes Care 1998;21:2190.
    • (1998) Diabetes Care , vol.21 , pp. 2190
    • Facchini, F.S.1
  • 22
    • 0034757885 scopus 로고    scopus 로고
    • Low iron status and enhanced insulin sensitivity in lacto-ovo vegetarians
    • Hua NW, Stoohs RA, Facchini FS. Low iron status and enhanced insulin sensitivity in lacto-ovo vegetarians. Br J Nutr 2001;86:515-519.
    • (2001) Br J Nutr , vol.86 , pp. 515-519
    • Hua, N.W.1    Stoohs, R.A.2    Facchini, F.S.3
  • 23
    • 34249098685 scopus 로고    scopus 로고
    • Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study
    • Valenti L, Fracanzani AL, Dongiovanni P, Bugianesi E, Marchesini G, Manzini P, et al. Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study. Am J Gastroenterol 2007;102:1251-1258.
    • (2007) Am J Gastroenterol , vol.102 , pp. 1251-1258
    • Valenti, L.1    Fracanzani, A.L.2    Dongiovanni, P.3    Bugianesi, E.4    Marchesini, G.5    Manzini, P.6
  • 24
    • 77952529040 scopus 로고    scopus 로고
    • A position statement on NAFLD/NASH based on the EASL 2009 special conference
    • Ratziu V, Bellentani S, Cortez-Pinto H, Day C, Marchesini G. A position statement on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol 2010;53:372-384.
    • (2010) J Hepatol , vol.53 , pp. 372-384
    • Ratziu, V.1    Bellentani, S.2    Cortez-Pinto, H.3    Day, C.4    Marchesini, G.5
  • 25
    • 55149115873 scopus 로고    scopus 로고
    • Placebo in nonalcoholic steatohepatitis: insight into natural history and implications for future clinical trials
    • Loomba R, Wesley R, Pucino F, Liang TJ, Kleiner DE, Lavine JE. Placebo in nonalcoholic steatohepatitis: insight into natural history and implications for future clinical trials. Clin Gastroenterol Hepatol 2008;6:1243-1248.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 1243-1248
    • Loomba, R.1    Wesley, R.2    Pucino, F.3    Liang, T.J.4    Kleiner, D.E.5    Lavine, J.E.6
  • 26
    • 84875363403 scopus 로고    scopus 로고
    • Diagnostic performance of a rapid magnetic resonance imaging method of measuring hepatic steatosis
    • House MJ, Gan EK, Adams LA, Ayonrinde OT, Bangma SJ, Bhathal PS, et al. Diagnostic performance of a rapid magnetic resonance imaging method of measuring hepatic steatosis. PloS One 2013;8:e59287.
    • (2013) PloS One , vol.8
    • House, M.J.1    Gan, E.K.2    Adams, L.A.3    Ayonrinde, O.T.4    Bangma, S.J.5    Bhathal, P.S.6
  • 27
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp
    • Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999;22:1462-1470.
    • (1999) Diabetes Care , vol.22 , pp. 1462-1470
    • Matsuda, M.1    DeFronzo, R.A.2
  • 28
    • 84892764858 scopus 로고    scopus 로고
    • Minimizing artifactual elevation of lipid peroxidation products (F2-isoprostanes) in plasma during collection and storage
    • Barden AE, Mas E, Croft KD, Phillips M, Mori TA. Minimizing artifactual elevation of lipid peroxidation products (F2-isoprostanes) in plasma during collection and storage. Anal Biochem 2014;449:129-131.
    • (2014) Anal Biochem , vol.449 , pp. 129-131
    • Barden, A.E.1    Mas, E.2    Croft, K.D.3    Phillips, M.4    Mori, T.A.5
  • 29
    • 84875363403 scopus 로고    scopus 로고
    • Diagnostic performance of a rapid magnetic resonance imaging method of measuring hepatic steatosis
    • House M, Gan E, Adams LA, Ayonrinde OT, Bangma S, Bhathal P, et al. Diagnostic performance of a rapid magnetic resonance imaging method of measuring hepatic steatosis. PloS One 2013;8(3):e59287.
    • (2013) PloS One , vol.8 , Issue.3
    • House, M.1    Gan, E.2    Adams, L.A.3    Ayonrinde, O.T.4    Bangma, S.5    Bhathal, P.6
  • 30
    • 11244355277 scopus 로고    scopus 로고
    • Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance
    • St. Pierre TG, Clark PR, Chua-anusorn W, Fleming AJ, Jeffrey GP, Olynyk JK, et al. Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood 2005;105:855-861.
    • (2005) Blood , vol.105 , pp. 855-861
    • St Pierre, T.G.1    Clark, P.R.2    Chua-anusorn, W.3    Fleming, A.J.4    Jeffrey, G.P.5    Olynyk, J.K.6
  • 31
    • 17144443590 scopus 로고    scopus 로고
    • Chronic hepatitis C virus infection causes a significant reduction in quality of life in the absence of cirrhosis
    • Foster GR, Goldin RD, Thomas HC. Chronic hepatitis C virus infection causes a significant reduction in quality of life in the absence of cirrhosis. Hepatology 1998;27:209-212.
    • (1998) Hepatology , vol.27 , pp. 209-212
    • Foster, G.R.1    Goldin, R.D.2    Thomas, H.C.3
  • 32
    • 84355162927 scopus 로고    scopus 로고
    • Validation of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in older black and white women
    • Beaudreau SA, Spira AP, Stewart A, Kezirian EJ, Lui LY, Ensrud K, et al. Validation of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in older black and white women. Sleep Med 2012;13:36-42.
    • (2012) Sleep Med , vol.13 , pp. 36-42
    • Beaudreau, S.A.1    Spira, A.P.2    Stewart, A.3    Kezirian, E.J.4    Lui, L.Y.5    Ensrud, K.6
  • 33
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006;355:2297-2307.
    • (2006) N Engl J Med , vol.355 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3    Darland, C.4    Finch, J.5    Hardies, J.6
  • 34
    • 79959547265 scopus 로고    scopus 로고
    • Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases
    • Bacon BR, Adams PC, Kowdley KV, Powell LW, Tavill AS. Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology 2011;54:328-343.
    • (2011) Hepatology , vol.54 , pp. 328-343
    • Bacon, B.R.1    Adams, P.C.2    Kowdley, K.V.3    Powell, L.W.4    Tavill, A.S.5
  • 35
    • 43549087627 scopus 로고    scopus 로고
    • Pathways underlying iron accumulation in human nonalcoholic fatty liver disease
    • Aigner E, Theurl I, Theurl M, Lederer D, Haufe H, Dietze O, et al. Pathways underlying iron accumulation in human nonalcoholic fatty liver disease. Am J Clin Nutr 2008;87:1374-1383.
    • (2008) Am J Clin Nutr , vol.87 , pp. 1374-1383
    • Aigner, E.1    Theurl, I.2    Theurl, M.3    Lederer, D.4    Haufe, H.5    Dietze, O.6
  • 36
    • 0036211032 scopus 로고    scopus 로고
    • Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease
    • Facchini FS, Hua NW, Stoohs RA. Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease. Gastroenterology 2002;122:931-939.
    • (2002) Gastroenterology , vol.122 , pp. 931-939
    • Facchini, F.S.1    Hua, N.W.2    Stoohs, R.A.3
  • 38
    • 1542515099 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial
    • Lindor KD, Kowdley KV, Heathcote EJ, Harrison ME, Jorgensen R, Angulo P, et al. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial. Hepatology 2004;39:770-778.
    • (2004) Hepatology , vol.39 , pp. 770-778
    • Lindor, K.D.1    Kowdley, K.V.2    Heathcote, E.J.3    Harrison, M.E.4    Jorgensen, R.5    Angulo, P.6
  • 39
    • 84896470468 scopus 로고    scopus 로고
    • A randomized trial of iron depletion in patients with nonalcoholic fatty liver disease and hyperferritinemia
    • Valenti L, Fracanzani AL, Dongiovanni P, Rovida S, Rametta R, Fatta E, et al. A randomized trial of iron depletion in patients with nonalcoholic fatty liver disease and hyperferritinemia. World J Gastroenterol 2014;20:3002-3010.
    • (2014) World J Gastroenterol , vol.20 , pp. 3002-3010
    • Valenti, L.1    Fracanzani, A.L.2    Dongiovanni, P.3    Rovida, S.4    Rametta, R.5    Fatta, E.6
  • 41
    • 40449095940 scopus 로고    scopus 로고
    • Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL
    • Kim H, Taksali SE, Dufour S, Befroy D, Goodman TR, Petersen KF, et al. Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL. Magn Reson Med 2008;59:521-527.
    • (2008) Magn Reson Med , vol.59 , pp. 521-527
    • Kim, H.1    Taksali, S.E.2    Dufour, S.3    Befroy, D.4    Goodman, T.R.5    Petersen, K.F.6
  • 42
    • 67650882236 scopus 로고    scopus 로고
    • Noninvasive quantitation of human liver steatosis using magnetic resonance and bioassay methods
    • d'Assignies G, Ruel M, Khiat A, Lepanto L, Chagnon M, Kauffmann C, et al. Noninvasive quantitation of human liver steatosis using magnetic resonance and bioassay methods. Eur Radiol 2009;19:2033-2040.
    • (2009) Eur Radiol , vol.19 , pp. 2033-2040
    • d'Assignies, G.1    Ruel, M.2    Khiat, A.3    Lepanto, L.4    Chagnon, M.5    Kauffmann, C.6
  • 43
    • 84861092311 scopus 로고    scopus 로고
    • Hepatic fat quantification: a prospective comparison of magnetic resonance spectroscopy and analysis methods for chemical-shift gradient echo magnetic resonance imaging with histologic assessment as the reference standard
    • Kang BK, Yu ES, Lee SS, Lee Y, Kim N, Sirlin CB, et al. Hepatic fat quantification: a prospective comparison of magnetic resonance spectroscopy and analysis methods for chemical-shift gradient echo magnetic resonance imaging with histologic assessment as the reference standard. Invest Radiol 2012;47:368-375.
    • (2012) Invest Radiol , vol.47 , pp. 368-375
    • Kang, B.K.1    Yu, E.S.2    Lee, S.S.3    Lee, Y.4    Kim, N.5    Sirlin, C.B.6
  • 44
    • 73449116035 scopus 로고    scopus 로고
    • Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
    • Promrat K, Kleiner DE, Niemeier HM, Jackvony E, Kearns M, Wands JR, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 2010;51:121-129.
    • (2010) Hepatology , vol.51 , pp. 121-129
    • Promrat, K.1    Kleiner, D.E.2    Niemeier, H.M.3    Jackvony, E.4    Kearns, M.5    Wands, J.R.6
  • 45
    • 73149092115 scopus 로고    scopus 로고
    • Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
    • Abdelmalek MF, Sanderson SO, Angulo P, Soldevila-Pico C, Liu C, Peter J, et al. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepatology 2009;50:1818-1826.
    • (2009) Hepatology , vol.50 , pp. 1818-1826
    • Abdelmalek, M.F.1    Sanderson, S.O.2    Angulo, P.3    Soldevila-Pico, C.4    Liu, C.5    Peter, J.6
  • 46


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.