High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma

Molecular Carcinogenesis

Volumn 35, Issue 2, 2002, Pages 85-92

  Zhang, Yu Jing ^a   Ahsan, Habibul ^a   Chen, Yu ^a   Lunn, Ruth M ^b   Wang, Li Yu ^c   Chen, Shu Yuan ^d   Lee, Po Huang ^e   Chen, Chien Jen ^f   Santella, Regina M ^a,g  

^a Mailman School of Public Health of Columbia University ^*  (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c TZU CHI UNIVERSITY   (Taiwan)

^d NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^f NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^g NewYork Presbyterian Hospital   (United States)

Author keywords

Aflatoxin B1; CpG island; Epigenetic changes; Gene expression; Hepatocellular carcinoma; Hypermethylation

Indexed keywords

AFLATOXIN B1; CARCINOGEN;

ARTICLE; CANCER GENETICS; CELL STRAIN HEPG2; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; CPG ISLAND; DNA ADDUCT; DNA DAMAGE; DNA METHYLATION; ENVIRONMENTAL EXPOSURE; FEMALE; GENE; GENE EXPRESSION; GENE INACTIVATION; GENE LOCUS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MOLECULAR CLONING; MULTIGENE FAMILY; P16 GENE; PRIORITY JOURNAL; PROMOTER REGION; RASSF1A GENE; STATISTICAL SIGNIFICANCE;

AFLATOXIN B1; ALTERNATIVE SPLICING; CARCINOMA, HEPATOCELLULAR; CHROMOSOMES, HUMAN, PAIR 3; CPG ISLANDS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA ADDUCTS; DNA METHYLATION; FEMALE; GENES, TUMOR SUPPRESSOR; HELA CELLS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN ISOFORMS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0036789450     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.10076     Document Type: Article

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