Obesity Early in Adulthood Increases Risk but Does Not Affect Outcomes of Hepatocellular Carcinoma

Gastroenterology

Volumn 149, Issue 1, 2015, Pages 119-129

  Hassan, Manal M ^a   Abdel Wahab, Reham ^a,b   Kaseb, Ahmed ^a   Shalaby, Ahmed ^a   Phan, Alexandria T ^c   El Serag, Hashem B ^d   Hawk, Ernest ^a   Morris, Jeff ^a   Singh Raghav, Kanwal Pratap ^a   Lee, Ju Seog ^a   Vauthey, Jean Nicolas ^a   Bortus, Gehan ^a   Torres, Harrys A ^a   Amos, Christopher I ^e   Wolff, Robert A ^a   Li, Donghui ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b ASSIUT UNIVERSITY   (Egypt)

^c HOUSTON METHODIST HOSPITAL   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Case Control; HCC; Obesity; Risk Factor

Indexed keywords

ADULT; ADULTHOOD; AGE; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CANCER RISK; CANCER SURVIVAL; CASE CONTROL STUDY; CONTROLLED STUDY; DIABETES MELLITUS; FAMILY HISTORY; FEMALE; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; OBESITY; ONSET AGE; OVERALL SURVIVAL; PRIORITY JOURNAL; SMOKING; AGED; AGING; CARCINOMA, HEPATOCELLULAR; LIVER NEOPLASMS; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; RISK FACTOR; YOUNG ADULT;

ADULT; AGE OF ONSET; AGED; AGING; BODY MASS INDEX; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; OBESITY; RISK FACTORS; YOUNG ADULT;

EID: 84931295870     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.03.044     Document Type: Article

References (62)

1. M. Ng, T. Fleming, and M. Robinson Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013 Lancet 384 2014 766 781
2. S. Wild, G. Roglic, and A. Green Global prevalence of diabetes: estimates for the year 2000 and projections for 2030 Diabetes Care 27 2004 1047 1053
3. A.P. Venook, C. Papandreou, and J. Furuse The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective Oncologist 15 Suppl 4 2010 5 13
4. S.F. Altekruse, K.A. McGlynn, and M.E. Reichman Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005 J Clin Oncol 27 2009 1485 1491
5. L. Alhyas, A. McKay, and A. Balasanthiran Prevalences of overweight, obesity, hyperglycaemia, hypertension and dyslipidaemia in the Gulf: systematic review JRSM Short Rep 2 2011 55
6. A.G. Ramirez, E. Munoz, and A.E. Holden Incidence of hepatocellular carcinoma in Texas Latinos, 1995-2010: an update PLoS One 9 2014 e99365
7. A.G. Renehan, M. Tyson, and M. Egger Body mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies Lancet 371 2008 569 578
8. D. Saunders, D. Seidel, and M. Allison Systematic review: the association between obesity and hepatocellular carcinoma-epidemiological evidence Aliment Pharmacol Ther 31 2010 1051 1063
9. S.C. Larsson, and A. Wolk Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies Br J Cancer 97 2007 1005 1008
10. F. Donato, A. Tagger, and U. Gelatti Alcohol and hepatocellular carcinoma: the effect of lifetime intake and hepatitis virus infections in men and women Am J Epidemiol 155 2002 323 331
11. M.M. Hassan, A. Kaseb, and C.J. Etzel Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: risk and prognosis prediction Mol Carcinog 52 Suppl 1 2013 E139 E147
12. A.O. Kaseb, J.S. Morris, and M.M. Hassan Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma J Clin Oncol 29 2011 3892 3899
13. A.O. Kaseb, L. Xiao, and M.M. Hassan Development and validation of insulin-like growth factor-1 score to assess hepatic reserve in hepatocellular carcinoma J Natl Cancer Inst 106 2014 5
14. K.J. Rothman, S. Greenland, and A.M. Walker Concepts of interaction Am J Epidemiol 112 1980 467 470
15. K.J. Rothman The estimation of synergy or antagonism Am J Epidemiol 103 1976 506 511
16. M.M. Hassan, M.R. Spitz, and M.B. Thomas Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women: case-control study Int J Cancer 123 2008 1883 1891
17. M.M. Hassan, S.A. Curley, and D. Li Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma Cancer 116 2010 1938 1946
18. M.M. Hassan, M.R. Spitz, and M.B. Thomas The association of family history of liver cancer with hepatocellular carcinoma: a case-control study in the United States J Hepatol 50 2009 334 341
19. M.M. Hassan, L.Y. Hwang, and C.J. Hatten Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus Hepatology 36 2002 1206 1213
20. C.R. Marrero, and J.A. Marrero Viral hepatitis and hepatocellular carcinoma Arch Med Res 38 2007 612 620
21. H.B. El-Serag, H. Hampel, and F. Javadi The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence Clin Gastroenterol Hepatol 4 2006 369 380
22. M.C. Yu, J.M. Yuan, and S.C. Lu Alcohol, cofactors and the genetics of hepatocellular carcinoma J Gastroenterol Hepatol 23 Suppl 1 2008 S92 S97
23. E.C. Persson, L.M. Schwartz, and Y. Park Alcohol consumption, folate intake, hepatocellular carcinoma, and liver disease mortality Cancer Epidemiol Biomarkers Prev 22 2013 415 421
24. C. Bosetti, F. Turati, and V.C. La Hepatocellular carcinoma epidemiology Best Pract Res Clin Gastroenterol 28 2014 753 770
25. T.M. Welzel, B.I. Graubard, and S. Quraishi Population-attributable fractions of risk factors for hepatocellular carcinoma in the United States Am J Gastroenterol 108 2013 1314 1321
26. T. Ohki, R. Tateishi, and T. Sato Obesity is an independent risk factor for hepatocellular carcinoma development in chronic hepatitis C patients Clin Gastroenterol Hepatol 6 2008 459 464
27. C.L. Chen, H.I. Yang, and W.S. Yang Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan Gastroenterology 135 2008 111 121
28. S. Nair, A. Mason, and J. Eason Is obesity an independent risk factor for hepatocellular carcinoma in cirrhosis? Hepatology 36 2002 150 155
29. A.J. Czaja, H.A. Carpenter, and P.J. Santrach Host- and disease-specific factors affecting steatosis in chronic hepatitis C J Hepatol 29 1998 198 206
30. M.J. Khandekar, P. Cohen, and B.M. Spiegelman Molecular mechanisms of cancer development in obesity Nat Rev Cancer 11 2011 886 895
31. K.S. Polonsky Dynamics of insulin secretion in obesity and diabetes Int J Obes Relat Metab Disord 24 Suppl 2 2000 S29 S31
32. M.R. Meyer, D.J. Clegg, and E.R. Prossnitz Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors Acta Physiol (Oxf) 203 2011 259 269
33. Y. Qian, and J.G. Fan Obesity, fatty liver and liver cancer Hepatobiliary Pancreat Dis Int 4 2005 173 177
34. P.A. Wood Connecting the dots: obesity, fatty acids and cancer Lab Invest 89 2009 1192 1194
35. L. Xu, C. Han, and K. Lim Cross-talk between peroxisome proliferator-activated receptor delta and cytosolic phospholipase A(2)alpha/cyclooxygenase-2/prostaglandin E(2) signaling pathways in human hepatocellular carcinoma cells Cancer Res 66 2006 11859 11868
36. J. Frystyk, C. Skjaerbaek, and E. Vestbo Circulating levels of free insulin-like growth factors in obese subjects: the impact of type 2 diabetes Diabetes Metab Res Rev 15 1999 314 322
37. T. Sohda, S. Kamimura, and K. Iwata Immunohistochemical evidence of insulin-like growth factor II in human small hepatocellular carcinoma with hepatitis C virus infection: relationship to fatty change in carcinoma cells J Gastroenterol Hepatol 12 1997 224 228
38. D. Li, J.S. Morris, and J. Liu Body mass index and risk, age of onset, and survival in patients with pancreatic cancer JAMA 301 2009 2553 2562
39. T. Utsunomiya, M. Okamoto, and T. Kameyama Impact of obesity on the surgical outcome following repeat hepatic resection in Japanese patients with recurrent hepatocellular carcinoma World J Gastroenterol 14 2008 1553 1558
40. A.K. Mathur, A.A. Ghaferi, and N.H. Osborne Body mass index and adverse perioperative outcomes following hepatic resection J Gastrointest Surg 14 2010 1285 1291
41. S. Tanaka, Y. Iimuro, and T. Hirano Safety of hepatic resection for hepatocellular carcinoma in obese patients with cirrhosis Surg Today 43 2013 1290 1297
42. S. Balzan, G. Nagarajan, and O. Farges Safety of liver resections in obese and overweight patients World J Surg 34 2010 2960 2968
43. R. Tateishi, T. Okanoue, and N. Fujiwara Clinical characteristics, treatment, and prognosis of non-B, non-C hepatocellular carcinoma: a large retrospective multicenter cohort study J Gastroenterol 50 2015 350 360
44. M. Haluzik, J. Parizkova, and M.M. Haluzik Adiponectin and its role in the obesity-induced insulin resistance and related complications Physiol Res 53 2004 123 129
45. E. Shin, Y.D. Yu, and D.S. Kim Adiponectin receptor expression predicts favorable prognosis in cases of hepatocellular carcinoma Pathol Oncol Res 20 2014 667 675
46. X.F. Duan, P. Tang, and Q. Li Obesity, adipokines and hepatocellular carcinoma Int J Cancer 133 2013 1776 1783
47. S.N. Wang, K.T. Lee, and C.G. Ker Leptin in hepatocellular carcinoma World J Gastroenterol 16 2010 5801 5809
48. A.B. Siegel, S. Wang, and J.S. Jacobson Obesity and microvascular invasion in hepatocellular carcinoma Cancer Invest 28 2010 1063 1069
49. Y. Kawaguchi, and T. Mizuta Interaction between hepatitis C virus and metabolic factors World J Gastroenterol 20 2014 2888 2901
50. R. Loomba, H.I. Yang, and J. Su Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study Am J Epidemiol 177 2013 333 342
51. J.M. Llovet, A. Burroughs, and J. Bruix Hepatocellular carcinoma Lancet 362 2003 1907 1917
52. J. Bruix, and J.M. Llovet Prognostic prediction and treatment strategy in hepatocellular carcinoma Hepatology 35 2002 519 524
53. J.M. Llovet, S. Ricci, and V. Mazzaferro Sorafenib in advanced hepatocellular carcinoma N Engl J Med 359 2008 378 390
54. M.B. Thomas Systemic therapy for hepatocellular carcinoma Cancer J 14 2008 123 127
55. C.F. Simpson, C.M. Boyd, and M.C. Carlson Agreement between self-report of disease diagnoses and medical record validation in disabled older women: factors that modify agreement J Am Geriatr Soc 52 2004 123 127
56. T.L. Bush, S.R. Miller, and A.L. Golden Self-report and medical record report agreement of selected medical conditions in the elderly Am J Public Health 79 1989 1554 1556
57. K.L. Cavanaugh, S.S. Merkin, and L.C. Plantinga Accuracy of patients' reports of comorbid disease and their association with mortality in ESRD Am J Kidney Dis 52 2008 118 127
58. D.K. Houston, J. Ding, and B.J. Nicklas The association between weight history and physical performance in the Health, Aging and Body Composition study Int J Obes (Lond) 31 2007 1680 1687
59. V.A. Casey, J.T. Dwyer, and C.S. Berkey Long-term memory of body weight and past weight satisfaction: a longitudinal follow-up study Am J Clin Nutr 53 1991 1493 1498
60. J. Stevens, J.E. Keil, and L.R. Waid Accuracy of current, 4-year, and 28-year self-reported body weight in an elderly population Am J Epidemiol 132 1990 1156 1163
61. M.F. Kuczmarski, R.J. Kuczmarski, and M. Najjar Effects of age on validity of self-reported height, weight, and body mass index: findings from the Third National Health and Nutrition Examination Survey, 1988-1994 J Am Diet Assoc 101 2001 28 34
62. D. Gunnell, L. Berney, and P. Holland How accurately are height, weight and leg length reported by the elderly, and how closely are they related to measurements recorded in childhood? Int J Epidemiol 29 2000 456 464