Prevalidation of the ex-vivo model PCLS for prediction of respiratory toxicity

Toxicology in Vitro

Volumn 32, Issue , 2016, Pages 347-361

  Hess, A ^a   Wang Lauenstein, L ^b,c   Braun, A ^b,c   Kolle, S N ^a   Landsiedel, R ^a   Liebsch, M ^e   Ma Hock, L ^a   Pirow, R ^e   Schneider, X ^d   Steinfath, M ^e   Vogel, S ^a   Martin, C ^d   Sewald, K ^b,c  

^a BASF SE   (Germany)

^b FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^c Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH)   (Germany)

^d RWTH AACHEN UNIVERSITY   (Germany)

^e FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

Author keywords

Acute inhalation toxicity; Industrial chemicals; Precision cut lung slices; Prevalidation; Reproducibility; Respiratory toxicity; Submersed culture conditions; Transferability; Two group classification model

Indexed keywords

ACETIC ANHYDRIDE; ACETONE; ALCOHOL; AMMONIUM DERIVATIVE; AMMONIUM HEXACHLOROPLATINATE; ANILINE; CHLORIDE; DODECYL SULFATE SODIUM; FORMALDEHYDE; GLUTARALDEHYDE; HALOACID; INTERLEUKIN 1ALPHA; ISOPHORONE; ISOPHORONE DIISOCYANATE; LACTATE DEHYDROGENASE; LACTOSE; METHACRYLIC ACID METHYL ESTER; N HEXYLCHLOROFORMATE; N,N DIMETHYLFORMAMIDE; OCTANOYLCHLORIDE; PARACETAMOL; PARAQUAT; TOLUENE DIISOCYANATE; TRIMELLITIC ANHYDRIDE; TRITON X 100; UNCLASSIFIED DRUG; ZINC OXIDE; 2-(4-IODOPHENYL)-3-(4-NITROPHENYL)-5-(2,4-DISULFOPHENYL)-2H-TETRAZOLIUM; TETRAZOLIUM;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE TECHNIQUE; EX VIVO STUDY; FEMALE; IC50; LABORATORY; LC50; LUNG SLICE; LUNG TOXICITY; MITOCHONDRION; NONHUMAN; PRECISION CUT LUNG SLICE; PREDICTION; RAT; STATISTICAL MODEL; TOXICITY TESTING; VALIDATION PROCESS; WST-1 ASSAY; ANIMAL; ANIMAL TESTING ALTERNATIVE; BIOLOGICAL MODEL; CELL SURVIVAL; IN VITRO STUDY; LUNG; METABOLISM; REPRODUCIBILITY; WISTAR RAT;

ANIMAL TESTING ALTERNATIVES; ANIMALS; CELL SURVIVAL; FEMALE; IN VITRO TECHNIQUES; INTERLEUKIN-1ALPHA; L-LACTATE DEHYDROGENASE; LABORATORIES; LUNG; MODELS, BIOLOGICAL; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; TETRAZOLIUM SALTS; TOXICITY TESTS;

EID: 84958520800     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2016.01.006     Document Type: Article

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