Activation of endothelial and epithelial KCa2.3 calcium-activated potassium channels by NS309 relaxes human small pulmonary arteries and bronchioles

British Journal of Pharmacology

Volumn 167, Issue 1, 2012, Pages 37-47

  Kroigaard, Christel ^a   Dalsgaard, Thomas ^a   Nielsen, Gorm ^b   Laursen, Britt E ^a   Pilegaard, Hans ^c   Köhler, Ralf ^b,d   Simonsen, Ulf ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d HOSPITAL UNIVERSITARIO MIGUEL SERVET   (Spain)

Author keywords

bronchioles; calcium activated potassium channels; K Ca3.1; KCa2.3; NS309; pulmonary arteries

Indexed keywords

1 [(2 CHLOROPHENYL)DIPHENYLMETHYL] 1H PYRAZOLE; 6,12,19,20,25,26 HEXAHYDROPYRAZOLE; 6,7 DICHLORO 1H INDOLE 2,3 DIONE 3 OXIME; APAMIN; CHARYBDOTOXIN; HISTAMINE; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KCA2; POTASSIUM CHANNEL KCA2.3; POTASSIUM CHANNEL KCA3.1; POTASSIUM CHANNEL STIMULATING AGENT; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ARTERY CONSTRICTION; ARTERY DIAMETER; ARTERY ENDOTHELIUM; ARTERY EPITHELIUM; ARTICLE; BRONCHIOLE; BRONCHODILATATION; BRONCHUS ENDOTHELIUM; BRONCHUS MUCOSA; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM; EPITHELIUM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREACTIVITY; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PULMONARY ARTERY; VASODILATATION; WHOLE CELL;

AGED; BRONCHIOLES; CELLS, CULTURED; ENDOTHELIUM; EPITHELIAL CELLS; HUMANS; INDOLES; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MIDDLE AGED; OXIMES; PULMONARY ARTERY; RESPIRATORY MUCOSA; RNA, MESSENGER; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS;

EID: 84864654094     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01986.x     Document Type: Article

References (33)

1. th Edition. Br J Pharmacol 164 (Suppl. 1): S1-S324.
2. Bardou O, Trinh NT, Brochiero E, (2009). Molecular diversity and function of K+ channels in airway and alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 296: L145-L155.
3. Benoit C, Renaudon B, Salvail D, Rousseau E, (2001). EETs relax airway smooth muscle via an EpDHF effect: BK(Ca) channel activation and hyperpolarization. Am J Physiol Lung Cell Mol Physiol 280: L965-L973.
4. Bradding P, Wulff H, (2009). The K+ channels K(Ca)3.1 and K(v)1.3 as novel targets for asthma therapy. Br J Pharmacol 157: 1330-1339.
5. Brahler S, Kaistha A, Schmidt VJ, Wolfle SE, Busch C, Kaistha BP, et al,. (2009). Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension. Circulation 119: 2323-2332.
6. Buus NH, Simonsen U, Pilegaard HK, Mulvany MJ, (2000). Nitric oxide, prostanoid and non-NO, non-prostanoid involvement in acetylcholine relaxation of isolated human small arteries. Br J Pharmacol 129: 184-192.
7. Chadha PS, Liu L, Rikard-Bell M, Senadheera S, Howitt L, Bertrand RL, et al,. (2011). Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated k+ channel and nitric oxide. J Pharmacol Exp Ther 336: 701-708.
8. Dalsgaard T, Kroigaard C, Bek T, Simonsen U, (2009). Role of calcium-activated potassium channels with small conductance in bradykinin-induced vasodilation of porcine retinal arterioles. Invest Ophthalmol Vis Sci 50: 3819-3825.
9. Duffy SM, Lawley WJ, Conley EC, Bradding P, (2001). Resting and activation-dependent ion channels in human mast cells. J Immunol 167: 4261-4270.
10. Duffy SM, Cruse G, Lawley WJ, Bradding P, (2005). Beta2-Adrenoceptor regulation of the K+ channel iKCa1 in human mast cells. FASEB J 19: 1006-1008.
11. Edwards G, Dora KA, Gardener MJ, Garland CJ, Weston AH, (1998). K+ is an endothelium-derived hyperpolarizing factor in rat arteries. Nature 396: 269-272.
12. Feletou M, Girard V, Canet E, (1995). Different involvement of nitric oxide in endothelium-dependent relaxation of porcine pulmonary artery and vein: influence of hypoxia. J Cardiovasc Pharmacol 25: 665-673.
13. Flavahan NA, Aarhus LL, Rimele TJ, Vanhoutte PM, (1985). Respiratory epithelium inhibits bronchial smooth muscle tone. J Appl Physiol 58: 834-838.
14. Folkerts G, Nijkamp FP, (1998). Airway epithelium: more than just a barrier! Trends Pharmacol Sci 19: 334-341.
15. Frantz E, Soifer SJ, Clyman RI, Heymann MA, (1989). Bradykinin produces pulmonary vasodilation in fetal lambs: role of prostaglandin production. J Appl Physiol 67: 1512-1517.
16. Grgic I, Kaistha BP, Hoyer J, Kohler R, (2009). Endothelial Ca+-activated K+ channels in normal and impaired EDHF-dilator responses-relevance to cardiovascular pathologies and drug discovery. Br J Pharmacol 157: 509-526.
17. Griffin TJ, Gygi SP, Ideker T, Rist B, Eng J, Hood L, et al,. (2002). Complementary profiling of gene expression at the transcriptome and proteome levels in saccharomyces cerevisiae. Mol Cell Proteomics 1: 323-333.
18. Hernandez M, Elmedal B, Mulvany MJ, Simonsen U, (1998). Mechanisms of relaxations of bovine isolated bronchioles by the nitric oxide donor, GEA 3175. Br J Pharmacol 123: 895-905.
19. Ignarro LJ, Byrns RE, Buga GM, Wood KS, (1987). Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Circ Res 61: 866-879.
20. Jensen BS, Strobaek D, Olesen SP, Christophersen P, (2001). The Ca2+-activated K+ channel of intermediate conductance: a molecular target for novel treatments? Curr Drug Targets 2: 401-422.
21. Kohler R, Degenhardt C, Kuhn M, Runkel N, Paul M, Hoyer J, (2000). Expression and function of endothelial Ca2+-activated K+ channels in human mesenteric artery: a single-cell reverse transcriptase-polymerase chain reaction and electrophysiological study in situ. Circ Res 87: 496-503.
22. Kroigaard C, Dalsgaard T, Simonsen U, (2010). Mechanisms underlying epithelium-dependent relaxation in rat bronchioles: analogy to EDHF-type relaxation in rat pulmonary arteries. Am J Physiol Lung Cell Mol Physiol 298: L531-L542.
23. MaoXiang C, Gorman A, Bill B, Kuljit S, Paul H, Michel C, et al,. (2004). Small and intermediate conductance Ca 2+-activated K + channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum. Naunyn Schmiedebergs Arch Pharmacol V369: 602-615.
24. Minagawa H, Honda M, Miyazaki K, Tabuse Y, Teramoto R, Yamashita T, et al,. (2008). Comparative proteomic and transcriptomic profiling of the human hepatocellular carcinoma. Biochem Biophys Res Commun 366: 186-192.
25. Morimura K, Yamamura H, Ohya S, Imaizumi Y, (2006). Voltage-dependent Ca2+-channel block by openers of intermediate and small conductance Ca2+-activated K+ channels in urinary bladder smooth muscle cells. J Pharmacol Sci 100: 237-241.
26. Morrison KJ, Gao Y, Vanhoutte PM, (1990). Epithelial modulation of airway smooth muscle. Am J Physiol 258: L254-L262.
27. Sankaranarayanan A, Raman G, Busch C, Schultz T, Zimin PI, Hoyer J, et al,. (2009). Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol 75: 281-295.
28. Shepherd MC, Duffy SM, Harris T, Cruse G, Schuliga M, Brightling CE, et al,. (2007). KCa3.1 Ca2+activated K+ channels regulate human airway smooth muscle proliferation. Am J Respir Cell Mol Biol 37: 525-531.
29. Strobaek D, Teuber L, Jorgensen TD, Ahring PK, Kjaer K, Hansen RS, et al,. (2004). Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim Biophys Acta 1665: 1-5.
30. Stuart-Smith K, Vanhoutte PM, (1987). Heterogeneity in the effects of epithelium removal in the canine bronchial tree. J Appl Physiol 63: 2510-2515.
31. Stuart-Smith K, Vanhoutte PM, (1988). Airway epithelium modulates the responsiveness of porcine bronchial smooth muscle. J Appl Physiol 65: 721-727.
32. Vanhoutte PM, (1987). Airway epithelium and bronchial reactivity. Can J Physiol Pharmacol 65: 448-450.
33. Zhang RZ, Yang Q, Yim APC, Huang Y, He GW, (2006). Role of NO and EDHF-mediated endothelial function in the porcine pulmonary circulation: comparison between pulmonary artery and vein. Vascul Pharmacol 44: 183-191.