Pharmacological characterization of adenosine receptors on isolated human bronchi

American Journal of Respiratory Cell and Molecular Biology

Volumn 45, Issue 6, 2011, Pages 1222-1231

  Calzetta, Luigino ^a,b   Spina, Domenico ^b   Cazzola, Mario ^a,c   Page, Clive P ^b   Facciolo, Francesco ^d   Rendina, Erino A ^e   Matera, Maria G ^f  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c Istituto di Ricovero e Cura A Carattere Scientifico   (Italy)

^d REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Adenosine; Airway smooth muscle contraction; Human bronchi

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 6 N CYCLOPENTYLADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 CHLORO 2 (2 FURYL) 5 PHENYLACETYLAMINO 1,2,4 TRIAZOLO[1,5 C]QUINAZOLINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE PHOSPHATE; ADENOSINE RECEPTOR STIMULATING AGENT; ATROPINE; CAPSAICIN; CYSTEINE; EPINASTINE; HISTAMINE; LEUKOTRIENE; MUSCARINIC RECEPTOR; N (4 CYANOPHENYL) 2 [4 (2,3,6,7 TETRAHYDRO 2,6 DIOXO 1,3 DIPROPYL 1H PURIN 8 YL)PHENOXY]ACETAMIDE; PROTEINASE;

AIRWAY; ARTICLE; ASTHMA; ATOPY; BRONCHUS; BRONCHUS TONE; CLINICAL ARTICLE; CONTROLLED STUDY; DESENSITIZATION; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; LUNG ALVEOLUS EPITHELIUM; LUNG CARCINOMA; LUNG PARENCHYMA; PROTEIN FUNCTION; SENSITIZATION; SENSORY NERVE; SMOOTH MUSCLE CONTRACTILITY; STIMULATION;

EID: 84856404019     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2011-0056OC     Document Type: Article

References (54)

1. Polosa R, Holgate ST. Adenosine bronchoprovocation: a promising marker of allergic inflammation in asthma? Thorax 1997;52:919-923. (Pubitemid 27473938)
2. Brown RA, Spina D, Page CP. Adenosine receptors and asthma. Br J Pharmacol 2008;153:S446-S456. (Pubitemid 351341018)
3. 1 receptor in bronchial biopsy specimens from asthmatic subjects. Eur Respir J 2008;31:311-319.
4. Spicuzza L, Bonfiglio C, Polosa R. Research applications and implications of adenosine in diseased airways. Trends Pharmacol Sci 2003;24:409-413. (Pubitemid 36952557)
5. Spicuzza L, Di Maria G, Polosa R. Adenosine in the airways: implications and applications. Eur J Pharmacol 2006;533:77-88. (Pubitemid 43340006)
6. Olah ME, Stiles GL. The role of receptor structure in determining adenosine receptor activity. Pharmacol Ther 2000;85:55-75. (Pubitemid 30069477)
7. Cronstein BN, Van de Stouwe M, Druska L, Levin RI, Weissmann G. Nonsteroidal antiinflammatory agents inhibit stimulated neutrophil adhesion to endothelium: adenosine dependent and independent mechanisms. Inflammation 1994;18:323-335. (Pubitemid 24232684)
8. Blackburn MR. Too much of a good thing: adenosine overload in adenosine-deaminase-deficient mice. Trends Pharmacol Sci 2003;24:66-70. (Pubitemid 36135878)
9. Blackburn MR, Lee CG, Young HW, Zhu Z, Chunn JL, Kang MJ, Banerjee SK, Elias JA. Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. J Clin Invest 2003;112:332-344. (Pubitemid 38063762)
10. 1 receptor mediated protection of the globally ischemic isolated rat heart. J Mol Cell Cardiol 1990;22:39-47.
11. Linden J. Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection. Annu Rev Pharmacol Toxicol 2001;41:775-787. (Pubitemid 32385906)
12. Rudolphi KA, Schubert P, Parkinson FE, Fredholm BB. Neuroprotective role of adenosine in cerebral ischaemia. Trends Pharmacol Sci 1992;13:439-445.
13. Pauwels RA, Van der Straeten ME. An animal model for adenosine-induced bronchoconstriction. Am Rev Respir Dis 1987;136:374-378. (Pubitemid 18018537)
14. Hannon JP, Tigani B, Schuurman HJ, Fozard JR. Suppression of adenosine A(3) receptor-mediated hypotension and mast cell degranulation in the rat by dexamethasone. J Pharmacol Exp Ther 2002;302:725-730. (Pubitemid 34787241)
15. Hannon JP, Tigani B, Wolber C, Williams I, Mazzoni L, Howes C, Fozard JR. Evidence for an atypical receptor mediating the augmented bronchoconstrictor response to adenosine induced by allergen challenge in actively sensitized brown norway rats. Br J Pharmacol 2002;135:685-696. (Pubitemid 34177646)
16. Thorne JR, Danahay H, Broadley KJ. Analysis of the bronchoconstrictor responses to adenosine receptor agonists in sensitized guineapig lungs and trachea. Eur J Pharmacol 1996;316:263-271. (Pubitemid 27008160)
17. 2b receptors: a novel therapeutic target in asthma? Trends Pharmacol Sci 1998;19:148-153.
18. Björck T, Gustafsson LE, Dahlen SE. Isolated bronchi from asthmatics are hyperresponsive to adenosine, which apparently acts indirectly by liberation of leukotrienes and histamine. Am Rev Respir Dis 1992;145:1087-1091.
19. Rajakulasingam K, Polosa R, Church MK, Howarth PH, Holgate ST. Effect of inhaled frusemide on responses of airways to bradykinin and adenosine 5′-monophosphate in asthma. Thorax 1994;49:485-491. (Pubitemid 24170402)
20. 2b receptor as a novel therapeutic target in asthma. Br J Pharmacol 2005;145:1009-1015.
21. Polosa R, Santonocito G, Magri S, Paolino G, Armato F, Pagano C, Crimi N. Neutral endopeptidase inhibition with inhaled phosphoramidon: no effect on bronchial responsiveness to adenosine 5′-monophosphate (AMP) in asthma. Eur Respir J 1997;10:2460-2464. (Pubitemid 28048616)
22. Kraan J, Vink-Klooster H, Postma DS. The NK-2 receptor antagonist SR 48968c does not improve adenosine hyperresponsiveness and airway obstruction in allergic asthma. Clin Exp Allergy 2001;31:274-278. (Pubitemid 32232996)
23. Polosa R, Phillips GD, Rajakulasingam K, Holgate ST. The effect of inhaled ipratropium bromide alone and in combination with oral terfenadine on bronchoconstriction provoked by adenosine 5′-monophosphate and histamine in asthma. J Allergy Clin Immunol 1991;87:939-947.
24. Rorke S, Jennison S, Jeffs JA, Sampson AP, Arshad H, Holgate ST. Role of cysteinyl leukotrienes in adenosine 5′-monophosphate induced bronchoconstriction in asthma. Thorax 2002;57:323-327. (Pubitemid 34298929)
25. O'Connor BJ, Chung KF, Chen-Worsdell YM, Fuller RW, Barnes PJ. Effect of inhaled furosemide and bumetanide on adenosine 5′-monophosphate- and sodium metabisulfite-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis 1991;143:1329-1333.
26. Polosa R, Rorke S, Holgate ST. Evolving concepts on the value of adenosine hyperresponsiveness in asthma and chronic obstructive pulmonary disease. Thorax 2002;57:649-654. (Pubitemid 34761770)
27. Manzini S, Ballati L. 2-Chloroadenosine induction of vagally-mediated and atropine-resistant bronchomotor responses in anaesthetized guinea-pigs. Br J Pharmacol 1990;100:251-256. (Pubitemid 20170638)
28. Rabe KF. Mechanisms of immune sensitization of human bronchus. Am J Respir Crit Care Med 1998;158:S161-S170. (Pubitemid 28536585)
29. Watson N, Bodtke K, Coleman RA, Dent G, Morton BE, Ruhlmann E, Magnussen H, Rabe KF. Role of IgE in hyperresponsiveness induced by passive sensitization of human airways. Am J Respir Crit Care Med 1997;155:839-844. (Pubitemid 27133391)
30. Goodman LS, Gilman A, Brunton LL, editors. Goodman & Gilman's manual of pharmacology and therapeutics. New York: McGraw Hill Medical; 2008.
31. Motulsky H, Christopoulos A. Fitting models to biological data using linear and nonlinear regression: a practical guide to curve fitting. Oxford: Oxford University Press; 2004.
32. Kenakin TP. The Schild regression in the process of receptor classification. Can J Physiol Pharmacol 1982;60:249-265. (Pubitemid 12144825)
33. Klotz KN. Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch Pharmacol 2000;362:382-391.
34. Cordeaux Y, Briddon SJ, Megson AE, McDonnell J, Dickenson JM, Hill SJ. Influence of receptor number on functional responses elicited by agonists acting at the human adenosine A(1) receptor: evidence for signaling pathway-dependent changes in agonist potency and relative intrinsic activity. Mol Pharmacol 2000;58:1075-1084.
35. Cooper J, Hill SJ, Alexander SP. An endogenous A2b adenosine receptor coupled to cyclic AMP generation in human embryonic kidney (HEK 293) cells. Br J Pharmacol 1997;122:546-550. (Pubitemid 27429731)
36. Crimi N, Palermo F, Oliveri R, Polosa R, Vancheri C, Palermo B, Mistretta A. Tachyphylaxis to repeated challenges with inhaled adenosine in asthmatic subjects. Ann Allergy 1990;65:134-138. (Pubitemid 20259593)
37. Daxun Z, Rafferty P, Richards R, Summerell S, Holgate ST. Airway refractoriness to adenosine 59-monophosphate after repeated inhalation. J Allergy Clin Immunol 1989;83:152-158. (Pubitemid 19054138)
38. Torphy TJ, Rinard GA, Rietow MG, Mayer SE. Functional antagonism in canine tracheal smooth muscle: inhibition by methacholine of the mechanical and biochemical responses to isoproterenol. J Pharmacol Exp Ther 1983;227:694-699. (Pubitemid 14215055)
39. von der Leyen H, Schmitz W, Scholz H, Scholz J, Lohse MJ, Schwabe U. Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guineapig atrial and ventricular cardiac preparations. Naunyn Schmiedebergs Arch Pharmacol 1989;340:204-209. (Pubitemid 19203274)
40. Kenakin T, Jenkinson S, Watson C. Determining the potency and molecular mechanism of action of insurmountable antagonists. J Pharmacol Exp Ther 2006;319:710-723.
41. Black JW, Jenkinson DH, Kenakin TP. Antagonism of an indirectly acting agonist: block by propranolol and sotalol of the action of tyramine on rat heart. Eur J Pharmacol 1980;65:1-10. (Pubitemid 10034859)
42. Reynolds SM, Docherty R, Robbins J, Spina D, Page CP. Adenosine induces a cholinergic tracheal reflex contraction in guinea pigs in vivo via an adenosine A1 receptor-dependent mechanism. J Appl Physiol 2008;105:187-196.
43. Hua X, Erikson CJ, Chason KD, Rosebrock CN, Deshpande DA, Penn RB, Tilley SL. Involvement of A1 adenosine receptors and neural pathways in adenosine-induced bronchoconstriction in mice. Am J Physiol Lung Cell Mol Physiol 2007;293:L25-L32. (Pubitemid 47080711)
44. Polosa R, Rajakulasingam K, Prosperini G, Church MK, Holgate ST. Relative potencies and time course of changes in adenosine 5′-monophosphate airway responsiveness with inhaled furosemide and bumetanide in asthma. J Allergy Clin Immunol 1993;92:288-297. (Pubitemid 23254117)
45. Dixon AK, Gubitz AK, Sirinathsinghji DJ, Richardson PJ, Freeman TC. Tissue distribution of adenosine receptor mRNAs in the rat. Br J Pharmacol 1996;118:1461-1468. (Pubitemid 26248800)
46. Kummer W, Lips KS, Pfeil U. The epithelial cholinergic system of the airways. Histochem Cell Biol 2008;130:219-234.
47. McNamara N, Gallup M, Khong A, Sucher A, Maltseva I, Fahy J, Basbaum C. Adenosine up-regulation of the mucin gene, MUC2, in asthma. FASEB J 2004;18:1770-1772. (Pubitemid 39561679)
48. Keir S, Boswell-Smith V, Spina D, Page C. Mechanism of adenosine-induced airways obstruction in allergic guinea pigs. Br J Pharmacol 2006;147:720-728.
49. Smith N, Broadley KJ. Adenosine receptor subtypes in airways responses of sensitized guinea-pigs to inhaled ovalbumin. Pulm Pharmacol Ther 2010;23:355-364.
50. Wilson CN. Adenosine receptors and asthma in humans. Br J Pharmacol 2008;155:475-486.
51. Polosa R, Blackburn MR. Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease. Trends Pharmacol Sci 2009;30:528-535.
52. Schmidt D, Rabe KF. Immune mechanisms of smooth muscle hyperreactivity in asthma. J Allergy Clin Immunol 2000;105:673-682. (Pubitemid 30226439)
53. Williams CM, Galli SJ. The diverse potential effector and immunoregulatory roles of mast cells in allergic disease. J Allergy Clin Immunol 2000;105:847-859. (Pubitemid 30324391)
54. Ikeda RK, Miller M, Nayar J, Walker L, Cho JY, McElwain K, McElwain S, Raz E, Broide DH. Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: modulation by immunostimulatory DNA sequences. J Immunol 2003;171:4860-4867. (Pubitemid 37310608)