Chemoenzymatic synthesis of (S)-duloxetine using carbonyl reductase from Rhodosporidium toruloides

Bioorganic Chemistry

Volumn 65, Issue , 2016, Pages 82-89

  Chen, Xiang ^a   Liu, Zhi Qiang ^a   Lin, Chao Ping ^a   Zheng, Yu Guo ^a  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

(S) 3 (dimethylamino) 1 (2 thienyl) 1 propanol; Asymmetric synthesis; Carbonyl reductases; Chemoenzymatic; Duloxetine

Indexed keywords

CARBONYL REDUCTASE; DULOXETINE; GLUCOSE DEHYDROGENASE; ALCOHOL DEHYDROGENASE; RECOMBINANT PROTEIN;

ARTICLE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; ESCHERICHIA COLI; FUNGUS ISOLATION; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; RHODOSPORIDIUM TORULOIDES; SUBSTRATE CONCENTRATION; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; RHODOSPIRILLUM; STEREOISOMERISM;

ALCOHOL OXIDOREDUCTASES; DULOXETINE HYDROCHLORIDE; ESCHERICHIA COLI; MOLECULAR STRUCTURE; RECOMBINANT PROTEINS; RHODOSPIRILLUM; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 84958161089     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2016.02.002     Document Type: Article

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