Resolution of 3-(methylamino)-1-(2-thienyl)propan-1-ol, a new key intermediate for duloxetine, with (S)-mandelic acid

Tetrahedron Asymmetry

Volumn 14, Issue 12, 2003, Pages 1631-1636

  Sakai, Kenichi ^a   Sakurai, Rumiko ^a   Yuzawa, Atsushi ^a   Kobayashi, Yuka ^b   Saigo, Kazuhiko ^b  

^a Yamakawa Chemical Industry Co Ltd   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 BUTANOL; 3 (METHYLAMINO) 1 (2 THIENYL)PROPAN 1 OL; DULOXETINE; MANDELIC ACID; PROPRANOLOL DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CRYSTALLIZATION; DIASTEREOISOMER; PRIORITY JOURNAL; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

EID: 0038544136     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(03)00315-X     Document Type: Article

References (14)

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9. Diastereomeric purity (% d.p.)=|A-B|×100/(A+B), where A and B are both diastereomers.
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