-
1
-
-
0036302814
-
Protease degradomics: a new challenge for proteomics
-
Lopez-Otin C., Overall C.M. Protease degradomics: a new challenge for proteomics. Nat. Rev. Mol. Cell Biol. 2002, 3(7):509-519.
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, Issue.7
, pp. 509-519
-
-
Lopez-Otin, C.1
Overall, C.M.2
-
2
-
-
0024284183
-
Endogenous tissue renin-angiotensin systems. From molecular biology to therapy
-
Jin M., et al. Endogenous tissue renin-angiotensin systems. From molecular biology to therapy. Am. J. Med. 1988, 84(3 A):28-36.
-
(1988)
Am. J. Med.
, vol.84
, Issue.3
, pp. 28-36
-
-
Jin, M.1
-
4
-
-
0037192458
-
Matrix metalloproteinase inhibitors and cancer: trials and tribulations
-
Coussens L.M., Fingleton B., Matrisian L.M. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 2002, 295(5564):2387-2392.
-
(2002)
Science
, vol.295
, Issue.5564
, pp. 2387-2392
-
-
Coussens, L.M.1
Fingleton, B.2
Matrisian, L.M.3
-
5
-
-
84927177593
-
Is there new hope for therapeutic matrix metalloproteinase inhibition?
-
Vandenbroucke R.E., Libert C. Is there new hope for therapeutic matrix metalloproteinase inhibition?. Nat. Rev. Drug Discov. 2014, 13(12):904-927.
-
(2014)
Nat. Rev. Drug Discov.
, vol.13
, Issue.12
, pp. 904-927
-
-
Vandenbroucke, R.E.1
Libert, C.2
-
6
-
-
0036512208
-
New functions for the matrix metalloproteinases in cancer progression
-
Egeblad M., Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer 2002, 2(3):161-174.
-
(2002)
Nat. Rev. Cancer
, vol.2
, Issue.3
, pp. 161-174
-
-
Egeblad, M.1
Werb, Z.2
-
7
-
-
77950931419
-
Matrix metalloproteinases: regulators of the tumor microenvironment
-
Kessenbrock K., Plaks V., Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 2010, 141(1):52-67.
-
(2010)
Cell
, vol.141
, Issue.1
, pp. 52-67
-
-
Kessenbrock, K.1
Plaks, V.2
Werb, Z.3
-
8
-
-
9444290419
-
Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP
-
Sabeh F., et al. Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. J. Cell Biol. 2004, 167(4):769-781.
-
(2004)
J. Cell Biol.
, vol.167
, Issue.4
, pp. 769-781
-
-
Sabeh, F.1
-
9
-
-
34648815810
-
Emerging roles of proteases in tumour suppression
-
Lopez-Otin C., Matrisian L.M. Emerging roles of proteases in tumour suppression. Nat. Rev. Cancer 2007, 7(10):800-808.
-
(2007)
Nat. Rev. Cancer
, vol.7
, Issue.10
, pp. 800-808
-
-
Lopez-Otin, C.1
Matrisian, L.M.2
-
10
-
-
79957651592
-
Matrix metalloproteinases: protective roles in cancer
-
Decock J., et al. Matrix metalloproteinases: protective roles in cancer. J. Cell. Mol. Med. 2011, 15(6):1254-1265.
-
(2011)
J. Cell. Mol. Med.
, vol.15
, Issue.6
, pp. 1254-1265
-
-
Decock, J.1
-
11
-
-
84866143444
-
New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment
-
Noel A., et al. New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment. Front. Pharmacol. 2012, 3:140.
-
(2012)
Front. Pharmacol.
, vol.3
, pp. 140
-
-
Noel, A.1
-
12
-
-
42349115927
-
Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion
-
Gutierrez-Fernandez A., et al. Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion. Cancer Res. 2008, 68(8):2755-2763.
-
(2008)
Cancer Res.
, vol.68
, Issue.8
, pp. 2755-2763
-
-
Gutierrez-Fernandez, A.1
-
13
-
-
84928110094
-
Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice
-
Decock J., et al. Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice. Breast Cancer Res. 2015, 17:38.
-
(2015)
Breast Cancer Res.
, vol.17
, pp. 38
-
-
Decock, J.1
-
14
-
-
33646576168
-
Degradomics: systems biology of the protease web. Pleiotropic roles of MMPs in cancer
-
Overall C.M., Dean R.A. Degradomics: systems biology of the protease web. Pleiotropic roles of MMPs in cancer. Cancer Metastasis Rev. 2006, 25(1):69-75.
-
(2006)
Cancer Metastasis Rev.
, vol.25
, Issue.1
, pp. 69-75
-
-
Overall, C.M.1
Dean, R.A.2
-
15
-
-
84901418451
-
Network analyses reveal pervasive functional regulation between proteases in the human protease web
-
Fortelny N., et al. Network analyses reveal pervasive functional regulation between proteases in the human protease web. PLoS Biol. 2014, 12(5).
-
(2014)
PLoS Biol.
, vol.12
, Issue.5
-
-
Fortelny, N.1
-
16
-
-
77249129690
-
Avoiding spam in the proteolytic internet: future strategies for anti-metastatic MMP inhibition
-
Kruger A., Kates R.E., Edwards D.R. Avoiding spam in the proteolytic internet: future strategies for anti-metastatic MMP inhibition. Biochim. Biophys. Acta 2010, 1803(1):95-102.
-
(2010)
Biochim. Biophys. Acta
, vol.1803
, Issue.1
, pp. 95-102
-
-
Kruger, A.1
Kates, R.E.2
Edwards, D.R.3
-
17
-
-
84940956193
-
Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity
-
Maeda H. Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity. Adv. Drug Deliv. Rev. 2015, 91:3-6.
-
(2015)
Adv. Drug Deliv. Rev.
, vol.91
, pp. 3-6
-
-
Maeda, H.1
-
18
-
-
77956279673
-
Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases
-
Atkinson J.M., et al. Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases. Cancer Res. 2010, 70(17):6902-6912.
-
(2010)
Cancer Res.
, vol.70
, Issue.17
, pp. 6902-6912
-
-
Atkinson, J.M.1
-
19
-
-
84893463349
-
Development of novel tumor-targeted theranostic nanoparticles activated by membrane-type matrix metalloproteinases for combined cancer magnetic resonance imaging and therapy
-
(417)
-
Ansari C., et al. Development of novel tumor-targeted theranostic nanoparticles activated by membrane-type matrix metalloproteinases for combined cancer magnetic resonance imaging and therapy. Small 2014, 10(3):566-575. (417).
-
(2014)
Small
, vol.10
, Issue.3
, pp. 566-575
-
-
Ansari, C.1
-
20
-
-
84898001922
-
Tumor-targeted prodrug ICT2588 demonstrates therapeutic activity against solid tumors and reduced potential for cardiovascular toxicity
-
Gill J.H., et al. Tumor-targeted prodrug ICT2588 demonstrates therapeutic activity against solid tumors and reduced potential for cardiovascular toxicity. Mol. Pharm. 2014, 11(4):1294-1300.
-
(2014)
Mol. Pharm.
, vol.11
, Issue.4
, pp. 1294-1300
-
-
Gill, J.H.1
-
21
-
-
0042025174
-
Directed evolution of retroviruses activatable by tumour-associated matrix metalloproteases
-
Schneider R.M., et al. Directed evolution of retroviruses activatable by tumour-associated matrix metalloproteases. Gene Ther. 2003, 10(16):1370-1380.
-
(2003)
Gene Ther.
, vol.10
, Issue.16
, pp. 1370-1380
-
-
Schneider, R.M.1
-
22
-
-
0031787970
-
In vivo selection of protease cleavage sites from retrovirus display libraries
-
Buchholz C.J., et al. In vivo selection of protease cleavage sites from retrovirus display libraries. Nat. Biotechnol. 1998, 16(10):951-954.
-
(1998)
Nat. Biotechnol.
, vol.16
, Issue.10
, pp. 951-954
-
-
Buchholz, C.J.1
-
23
-
-
0032846999
-
Selective transduction of protease-rich tumors by matrix-metalloproteinase-targeted retroviral vectors
-
Peng K.W., et al. Selective transduction of protease-rich tumors by matrix-metalloproteinase-targeted retroviral vectors. Gene Ther. 1999, 6(9):1552-1557.
-
(1999)
Gene Ther.
, vol.6
, Issue.9
, pp. 1552-1557
-
-
Peng, K.W.1
-
24
-
-
84914163554
-
New approaches to selectively target cancer-associated matrix metalloproteinase activity
-
Tauro M., McGuire J., Lynch C.C. New approaches to selectively target cancer-associated matrix metalloproteinase activity. Cancer Metastasis Rev. 2014, 33(4):1043-1057.
-
(2014)
Cancer Metastasis Rev.
, vol.33
, Issue.4
, pp. 1043-1057
-
-
Tauro, M.1
McGuire, J.2
Lynch, C.C.3
-
25
-
-
84930759404
-
Moving targets: emerging roles for MMPs in cancer progression and metastasis
-
Shay G., Lynch C.C., Fingleton B. Moving targets: emerging roles for MMPs in cancer progression and metastasis. Matrix Biol. 2015, 44-46:200-206.
-
(2015)
Matrix Biol.
, pp. 200-206
-
-
Shay, G.1
Lynch, C.C.2
Fingleton, B.3
-
26
-
-
64349083804
-
New enzyme-activated solubility-switchable contrast agent for magnetic resonance imaging: from synthesis to in vivo imaging
-
Jastrzebska B., et al. New enzyme-activated solubility-switchable contrast agent for magnetic resonance imaging: from synthesis to in vivo imaging. J. Med. Chem. 2009, 52(6):1576-1581.
-
(2009)
J. Med. Chem.
, vol.52
, Issue.6
, pp. 1576-1581
-
-
Jastrzebska, B.1
-
27
-
-
77957356444
-
Liver cancer protease activity profiles support therapeutic options with matrix metalloproteinase-activatable oncolytic measles virus
-
Muhlebach M.D., et al. Liver cancer protease activity profiles support therapeutic options with matrix metalloproteinase-activatable oncolytic measles virus. Cancer Res. 2010, 70(19):7620-7629.
-
(2010)
Cancer Res.
, vol.70
, Issue.19
, pp. 7620-7629
-
-
Muhlebach, M.D.1
-
28
-
-
77949741829
-
Intracellular transduction using cell-penetrating peptides
-
Sawant R., Torchilin V. Intracellular transduction using cell-penetrating peptides. Mol. BioSyst. 2010, 6(4):628-640.
-
(2010)
Mol. BioSyst.
, vol.6
, Issue.4
, pp. 628-640
-
-
Sawant, R.1
Torchilin, V.2
-
29
-
-
77749335904
-
Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides
-
Aguilera T.A., et al. Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides. Integr. Biol. (Camb.) 2009, 1(5-6):371-381.
-
(2009)
Integr. Biol. (Camb.)
, vol.1
, Issue.5-6
, pp. 371-381
-
-
Aguilera, T.A.1
-
30
-
-
0001199533
-
Chemical aspects of selective toxicity
-
Albert A. Chemical aspects of selective toxicity. Nature 1958, 182(4633):421-422.
-
(1958)
Nature
, vol.182
, Issue.4633
, pp. 421-422
-
-
Albert, A.1
-
31
-
-
84864572139
-
Protease-activated drug development
-
Choi K.Y., et al. Protease-activated drug development. Theranostics 2012, 2(2):156-178.
-
(2012)
Theranostics
, vol.2
, Issue.2
, pp. 156-178
-
-
Choi, K.Y.1
-
32
-
-
78049512700
-
Prodrugs: some thoughts and current issues
-
Stella V.J. Prodrugs: some thoughts and current issues. J. Pharm. Sci. 2010, 99(12):4755-4765.
-
(2010)
J. Pharm. Sci.
, vol.99
, Issue.12
, pp. 4755-4765
-
-
Stella, V.J.1
-
33
-
-
40149088986
-
Prodrugs: design and clinical applications
-
Rautio J., et al. Prodrugs: design and clinical applications. Nat. Rev. Drug Discov. 2008, 7(3):255-270.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, Issue.3
, pp. 255-270
-
-
Rautio, J.1
-
34
-
-
77149171184
-
Structural and functional bases for allosteric control of MMP activities: can it pave the path for selective inhibition?
-
Sela-Passwell N., et al. Structural and functional bases for allosteric control of MMP activities: can it pave the path for selective inhibition?. Biochim. Biophys. Acta 2010, 1803(1):29-38.
-
(2010)
Biochim. Biophys. Acta
, vol.1803
, Issue.1
, pp. 29-38
-
-
Sela-Passwell, N.1
-
35
-
-
16244401957
-
Simulation of evolution-selected propeptide by high-throughput selection of a peptidomimetic inhibitor on a capillary DNA sequencer platform
-
Hu J., et al. Simulation of evolution-selected propeptide by high-throughput selection of a peptidomimetic inhibitor on a capillary DNA sequencer platform. Anal. Chem. 2005, 77(7):2116-2124.
-
(2005)
Anal. Chem.
, vol.77
, Issue.7
, pp. 2116-2124
-
-
Hu, J.1
-
36
-
-
70450216507
-
"Reverse degradomics", monitoring of proteolytic trimming by multi-CE and confocal detection of fluorescent substrates and reaction products
-
Piccard H., et al. "Reverse degradomics", monitoring of proteolytic trimming by multi-CE and confocal detection of fluorescent substrates and reaction products. Electrophoresis 2009, 30(13):2366-2377.
-
(2009)
Electrophoresis
, vol.30
, Issue.13
, pp. 2366-2377
-
-
Piccard, H.1
-
37
-
-
84874626363
-
Zymography methods for visualizing hydrolytic enzymes
-
Vandooren J., et al. Zymography methods for visualizing hydrolytic enzymes. Nat. Methods 2013, 10(3):211-220.
-
(2013)
Nat. Methods
, vol.10
, Issue.3
, pp. 211-220
-
-
Vandooren, J.1
-
38
-
-
0030759096
-
UPA, uPAR, PAI-1: key intersection of proteolytic, adhesive and chemotactic highways?
-
Blasi F. uPA, uPAR, PAI-1: key intersection of proteolytic, adhesive and chemotactic highways?. Immunol. Today 1997, 18(9):415-417.
-
(1997)
Immunol. Today
, vol.18
, Issue.9
, pp. 415-417
-
-
Blasi, F.1
-
39
-
-
0038059516
-
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)
-
Van den Steen P.E., et al. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit. Rev. Biochem. Mol. Biol. 2002, 37(6):375-536.
-
(2002)
Crit. Rev. Biochem. Mol. Biol.
, vol.37
, Issue.6
, pp. 375-536
-
-
Van den Steen, P.E.1
-
40
-
-
3042743709
-
The urokinase receptor as a potential target in cancer therapy
-
Romer J., Nielsen B.S., Ploug M. The urokinase receptor as a potential target in cancer therapy. Curr. Pharm. Des. 2004, 10(19):2359-2376.
-
(2004)
Curr. Pharm. Des.
, vol.10
, Issue.19
, pp. 2359-2376
-
-
Romer, J.1
Nielsen, B.S.2
Ploug, M.3
-
41
-
-
84893135057
-
Protease-activated delivery and imaging systems
-
Springer, D.R. Edwards, G. Hoyer-Hansen, F. Blasi, B.F. Sloane (Eds.)
-
Fields G.B. Protease-activated delivery and imaging systems. The Cancer Degradome 2008, Springer. D.R. Edwards, G. Hoyer-Hansen, F. Blasi, B.F. Sloane (Eds.).
-
(2008)
The Cancer Degradome
-
-
Fields, G.B.1
-
42
-
-
0033678680
-
A peptide-doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo
-
DeFeo-Jones D., et al. A peptide-doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo. Nat. Med. 2000, 6(11):1248-1252.
-
(2000)
Nat. Med.
, vol.6
, Issue.11
, pp. 1248-1252
-
-
DeFeo-Jones, D.1
-
43
-
-
0035935668
-
The synthesis of a prodrug of doxorubicin designed to provide reduced systemic toxicity and greater target efficacy
-
Garsky V.M., et al. The synthesis of a prodrug of doxorubicin designed to provide reduced systemic toxicity and greater target efficacy. J. Med. Chem. 2001, 44(24):4216-4224.
-
(2001)
J. Med. Chem.
, vol.44
, Issue.24
, pp. 4216-4224
-
-
Garsky, V.M.1
-
44
-
-
18844470751
-
A prostate-specific antigen (PSA)-activated vinblastine prodrug selectively kills PSA-secreting cells in vivo
-
DeFeo-Jones D., et al. A prostate-specific antigen (PSA)-activated vinblastine prodrug selectively kills PSA-secreting cells in vivo. Mol. Cancer Ther. 2002, 1(7):451-459.
-
(2002)
Mol. Cancer Ther.
, vol.1
, Issue.7
, pp. 451-459
-
-
DeFeo-Jones, D.1
-
45
-
-
0033843895
-
In vivo activity of a PSA-activated doxorubicin prodrug against PSA-producing human prostate cancer xenografts
-
Khan S.R., Denmeade S.R. In vivo activity of a PSA-activated doxorubicin prodrug against PSA-producing human prostate cancer xenografts. Prostate 2000, 45(1):80-83.
-
(2000)
Prostate
, vol.45
, Issue.1
, pp. 80-83
-
-
Khan, S.R.1
Denmeade, S.R.2
-
46
-
-
0032526152
-
Enzymatic activation of a doxorubicin-peptide prodrug by prostate-specific antigen
-
Denmeade S.R., et al. Enzymatic activation of a doxorubicin-peptide prodrug by prostate-specific antigen. Cancer Res. 1998, 58(12):2537-2540.
-
(1998)
Cancer Res.
, vol.58
, Issue.12
, pp. 2537-2540
-
-
Denmeade, S.R.1
-
47
-
-
0042308774
-
Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer
-
Denmeade S.R., et al. Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer. J. Natl. Cancer Inst. 2003, 95(13):990-1000.
-
(2003)
J. Natl. Cancer Inst.
, vol.95
, Issue.13
, pp. 990-1000
-
-
Denmeade, S.R.1
-
48
-
-
0029952542
-
Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator
-
Bugge T.H., et al. Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator. Proc. Natl. Acad. Sci. U. S. A. 1996, 93(12):5899-5904.
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, Issue.12
, pp. 5899-5904
-
-
Bugge, T.H.1
-
49
-
-
84881562785
-
Development of tumour-selective and endoprotease-activated anticancer therapeutics
-
Springer, D.R. Edwards, G. Hoyer-Hansen, F. Blasi, B.F. Sloane (Eds.)
-
Gill J.H.a.L., P.M. Development of tumour-selective and endoprotease-activated anticancer therapeutics. The Cancer Degradome 2008, 853-876. Springer. D.R. Edwards, G. Hoyer-Hansen, F. Blasi, B.F. Sloane (Eds.).
-
(2008)
The Cancer Degradome
, pp. 853-876
-
-
Gill, J.H.A.L.1
-
50
-
-
84901472324
-
Proteases as activators for cytotoxic prodrugs in antitumor therapy
-
Weidle U.H., Tiefenthaler G., Georges G. Proteases as activators for cytotoxic prodrugs in antitumor therapy. Cancer Genomics Proteomics 2014, 11(2):67-79.
-
(2014)
Cancer Genomics Proteomics
, vol.11
, Issue.2
, pp. 67-79
-
-
Weidle, U.H.1
Tiefenthaler, G.2
Georges, G.3
-
51
-
-
0020644940
-
Plasmin-activated prodrugs for cancer chemotherapy. 2. Synthesis and biological activity of peptidyl derivatives of doxorubicin
-
Chakravarty P.K., et al. Plasmin-activated prodrugs for cancer chemotherapy. 2. Synthesis and biological activity of peptidyl derivatives of doxorubicin. J. Med. Chem. 1983, 26(5):638-644.
-
(1983)
J. Med. Chem.
, vol.26
, Issue.5
, pp. 638-644
-
-
Chakravarty, P.K.1
-
52
-
-
2442715459
-
Plasmin-activated doxorubicin prodrugs containing a spacer reduce tumor growth and angiogenesis without systemic toxicity
-
Devy L., et al. Plasmin-activated doxorubicin prodrugs containing a spacer reduce tumor growth and angiogenesis without systemic toxicity. FASEB J. 2004, 18(3):565-567.
-
(2004)
FASEB J.
, vol.18
, Issue.3
, pp. 565-567
-
-
Devy, L.1
-
53
-
-
84864251276
-
Synthesis and biological characterization of protease-activated prodrugs of doxazolidine
-
Barthel B.L., et al. Synthesis and biological characterization of protease-activated prodrugs of doxazolidine. J. Med. Chem. 2012, 55(14):6595-6607.
-
(2012)
J. Med. Chem.
, vol.55
, Issue.14
, pp. 6595-6607
-
-
Barthel, B.L.1
-
54
-
-
0042170124
-
Anthrax toxin: structures, functions and tumour targeting
-
Liu S., et al. Anthrax toxin: structures, functions and tumour targeting. Expert. Opin. Biol. Ther. 2003, 3(5):843-853.
-
(2003)
Expert. Opin. Biol. Ther.
, vol.3
, Issue.5
, pp. 843-853
-
-
Liu, S.1
-
55
-
-
0037457895
-
Potent antitumor activity of a urokinase-activated engineered anthrax toxin
-
Liu S., et al. Potent antitumor activity of a urokinase-activated engineered anthrax toxin. Proc. Natl. Acad. Sci. U. S. A. 2003, 100(2):657-662.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, Issue.2
, pp. 657-662
-
-
Liu, S.1
-
56
-
-
24944464206
-
Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin
-
Liu S., et al. Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin. Nat. Biotechnol. 2005, 23(6):725-730.
-
(2005)
Nat. Biotechnol.
, vol.23
, Issue.6
, pp. 725-730
-
-
Liu, S.1
-
57
-
-
34248229594
-
Systematic urokinase-activated anthrax toxin therapy produces regressions of subcutaneous human non-small cell lung tumor in athymic nude mice
-
Su Y., et al. Systematic urokinase-activated anthrax toxin therapy produces regressions of subcutaneous human non-small cell lung tumor in athymic nude mice. Cancer Res. 2007, 67(7):3329-3336.
-
(2007)
Cancer Res.
, vol.67
, Issue.7
, pp. 3329-3336
-
-
Su, Y.1
-
58
-
-
84904254826
-
Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities
-
Peters D.E., et al. Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities. Toxicol. Appl. Pharmacol. 2014, 279(2):220-229.
-
(2014)
Toxicol. Appl. Pharmacol.
, vol.279
, Issue.2
, pp. 220-229
-
-
Peters, D.E.1
-
59
-
-
84875994652
-
Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors
-
Phillips D.D., et al. Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors. J. Biol. Chem. 2013, 288(13):9058-9065.
-
(2013)
J. Biol. Chem.
, vol.288
, Issue.13
, pp. 9058-9065
-
-
Phillips, D.D.1
-
60
-
-
4644221124
-
A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts
-
Abi-Habib R.J., et al. A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts. Blood 2004, 104(7):2143-2148.
-
(2004)
Blood
, vol.104
, Issue.7
, pp. 2143-2148
-
-
Abi-Habib, R.J.1
-
61
-
-
33947276326
-
Molecular markers for prostate cancer
-
Reynolds M.A., et al. Molecular markers for prostate cancer. Cancer Lett. 2007, 249(1):5-13.
-
(2007)
Cancer Lett.
, vol.249
, Issue.1
, pp. 5-13
-
-
Reynolds, M.A.1
-
62
-
-
0037009238
-
A 5-fluorodeoxyuridine prodrug as targeted therapy for prostate cancer
-
Mhaka A., et al. A 5-fluorodeoxyuridine prodrug as targeted therapy for prostate cancer. Bioorg. Med. Chem. Lett. 2002, 12(17):2459-2461.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, Issue.17
, pp. 2459-2461
-
-
Mhaka, A.1
-
63
-
-
34249690674
-
Modulating paclitaxel bioavailability for targeting prostate cancer
-
Kumar S.K., et al. Modulating paclitaxel bioavailability for targeting prostate cancer. Bioorg. Med. Chem. 2007, 15(14):4973-4984.
-
(2007)
Bioorg. Med. Chem.
, vol.15
, Issue.14
, pp. 4973-4984
-
-
Kumar, S.K.1
-
64
-
-
36749064493
-
A prostate-specific antigen activated N-(2-hydroxypropyl) methacrylamide copolymer prodrug as dual-targeted therapy for prostate cancer
-
Chandran S.S., et al. A prostate-specific antigen activated N-(2-hydroxypropyl) methacrylamide copolymer prodrug as dual-targeted therapy for prostate cancer. Mol. Cancer Ther. 2007, 6(11):2928-2937.
-
(2007)
Mol. Cancer Ther.
, vol.6
, Issue.11
, pp. 2928-2937
-
-
Chandran, S.S.1
-
65
-
-
84929710977
-
Targeting thapsigargin towards tumors
-
Doan N.T., et al. Targeting thapsigargin towards tumors. Steroids 2015, 97:2-7.
-
(2015)
Steroids
, vol.97
, pp. 2-7
-
-
Doan, N.T.1
-
66
-
-
84952883254
-
Thapsigargin, origin, chemistry, structure-activity relationships and prodrug development
-
Doan N.T., Christensen S.B. Thapsigargin, origin, chemistry, structure-activity relationships and prodrug development. Curr Pharm Des 2015.
-
(2015)
Curr Pharm Des
-
-
Doan, N.T.1
Christensen, S.B.2
-
67
-
-
84969508985
-
Cysteine cathepsins: their role in tumor progression and recent trends in the development of imaging probes
-
Loser R., Pietzsch J. Cysteine cathepsins: their role in tumor progression and recent trends in the development of imaging probes. Front. Chem. 2015, 3:37.
-
(2015)
Front. Chem.
, vol.3
, pp. 37
-
-
Loser, R.1
Pietzsch, J.2
-
68
-
-
84889256327
-
Selective cancer targeting with prodrugs activated by histone deacetylases and a tumour-associated protease
-
Ueki N., et al. Selective cancer targeting with prodrugs activated by histone deacetylases and a tumour-associated protease. Nat. Commun. 2013, 4:2735.
-
(2013)
Nat. Commun.
, vol.4
, pp. 2735
-
-
Ueki, N.1
-
69
-
-
84920856252
-
Cathepsin B-sensitive cholesteryl hemisuccinate-gemcitabine prodrug nanoparticles: enhanced cellular uptake and intracellular drug controlled release
-
Xu Y.Y., et al. Cathepsin B-sensitive cholesteryl hemisuccinate-gemcitabine prodrug nanoparticles: enhanced cellular uptake and intracellular drug controlled release. RSC Adv. 2015, 5(9):6985-6992.
-
(2015)
RSC Adv.
, vol.5
, Issue.9
, pp. 6985-6992
-
-
Xu, Y.Y.1
-
70
-
-
84860247215
-
The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme
-
Tsume Y., Amidon G.L. The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme. Molecules 2012, 17(4):3672-3689.
-
(2012)
Molecules
, vol.17
, Issue.4
, pp. 3672-3689
-
-
Tsume, Y.1
Amidon, G.L.2
-
71
-
-
84874931140
-
Pancreatic cancer-associated cathepsin E as a drug activator
-
Abd-Elgaliel W.R., et al. Pancreatic cancer-associated cathepsin E as a drug activator. J. Control. Release 2013, 167(3):221-227.
-
(2013)
J. Control. Release
, vol.167
, Issue.3
, pp. 221-227
-
-
Abd-Elgaliel, W.R.1
-
72
-
-
0032402354
-
Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin
-
Dubowchik G.M., Firestone R.A. Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin. Bioorg. Med. Chem. Lett. 1998, 8(23):3341-3346.
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, Issue.23
, pp. 3341-3346
-
-
Dubowchik, G.M.1
Firestone, R.A.2
-
73
-
-
84882433049
-
Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study
-
Wang Q., et al. Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study. J. Transl. Med. 2013, 11:192.
-
(2013)
J. Transl. Med.
, vol.11
, pp. 192
-
-
Wang, Q.1
-
74
-
-
84873664097
-
Cathepsin B-cleavable doxorubicin prodrugs for targeted cancer therapy (review)
-
Zhong Y.J., Shao L.H., Li Y. Cathepsin B-cleavable doxorubicin prodrugs for targeted cancer therapy (review). Int. J. Oncol. 2013, 42(2):373-383.
-
(2013)
Int. J. Oncol.
, vol.42
, Issue.2
, pp. 373-383
-
-
Zhong, Y.J.1
Shao, L.H.2
Li, Y.3
-
75
-
-
84905014950
-
Prodrug-inspired probes selective to cathepsin B over other cysteine cathepsins
-
Chowdhury M.A., et al. Prodrug-inspired probes selective to cathepsin B over other cysteine cathepsins. J. Med. Chem. 2014, 57(14):6092-6104.
-
(2014)
J. Med. Chem.
, vol.57
, Issue.14
, pp. 6092-6104
-
-
Chowdhury, M.A.1
-
76
-
-
75549088309
-
Cathepsin L, target in cancer treatment?
-
Lankelma J.M., et al. Cathepsin L, target in cancer treatment?. Life Sci. 2010, 86(7-8):225-233.
-
(2010)
Life Sci.
, vol.86
, Issue.7-8
, pp. 225-233
-
-
Lankelma, J.M.1
-
77
-
-
84903543514
-
Cysteine cathepsins and extracellular matrix degradation
-
Fonovic M., Turk B. Cysteine cathepsins and extracellular matrix degradation. Biochim. Biophys. Acta 2014, 1840(8):2560-2570.
-
(2014)
Biochim. Biophys. Acta
, vol.1840
, Issue.8
, pp. 2560-2570
-
-
Fonovic, M.1
Turk, B.2
-
78
-
-
33847172239
-
Legumain expression as a prognostic factor in breast cancer patients
-
Gawenda J., et al. Legumain expression as a prognostic factor in breast cancer patients. Breast Cancer Res. Treat. 2007, 102(1):1-6.
-
(2007)
Breast Cancer Res. Treat.
, vol.102
, Issue.1
, pp. 1-6
-
-
Gawenda, J.1
-
79
-
-
84862521462
-
Legumain: a biomarker for diagnosis and prognosis of human ovarian cancer
-
Wang L., et al. Legumain: a biomarker for diagnosis and prognosis of human ovarian cancer. J. Cell. Biochem. 2012, 113(8):2679-2686.
-
(2012)
J. Cell. Biochem.
, vol.113
, Issue.8
, pp. 2679-2686
-
-
Wang, L.1
-
80
-
-
84925238784
-
High expression of the cysteine proteinase legumain in colorectal cancer - implications for therapeutic targeting
-
Haugen M.H., et al. High expression of the cysteine proteinase legumain in colorectal cancer - implications for therapeutic targeting. Eur. J. Cancer 2015, 51(1):9-17.
-
(2015)
Eur. J. Cancer
, vol.51
, Issue.1
, pp. 9-17
-
-
Haugen, M.H.1
-
81
-
-
0038243036
-
Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy
-
Liu C., et al. Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy. Cancer Res. 2003, 63(11):2957-2964.
-
(2003)
Cancer Res.
, vol.63
, Issue.11
, pp. 2957-2964
-
-
Liu, C.1
-
82
-
-
0028673279
-
Legumain: asparaginyl endopeptidase
-
Ishii S. Legumain: asparaginyl endopeptidase. Methods Enzymol. 1994, 244:604-615.
-
(1994)
Methods Enzymol.
, vol.244
, pp. 604-615
-
-
Ishii, S.1
-
83
-
-
84855427940
-
Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug
-
Liu Y., et al. Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug. Mol. Pharm. 2012, 9(1):168-175.
-
(2012)
Mol. Pharm.
, vol.9
, Issue.1
, pp. 168-175
-
-
Liu, Y.1
-
84
-
-
31544445218
-
Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms
-
Wu W., et al. Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms. Cancer Res. 2006, 66(2):970-980.
-
(2006)
Cancer Res.
, vol.66
, Issue.2
, pp. 970-980
-
-
Wu, W.1
-
85
-
-
78650532605
-
The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity
-
Bajjuri K.M., et al. The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity. ChemMedChem 2011, 6(1):54-59.
-
(2011)
ChemMedChem
, vol.6
, Issue.1
, pp. 54-59
-
-
Bajjuri, K.M.1
-
86
-
-
84883448249
-
Selective ablation of tumor-associated macrophages suppresses metastasis and angiogenesis
-
Lin Y., et al. Selective ablation of tumor-associated macrophages suppresses metastasis and angiogenesis. Cancer Sci. 2013, 104(9):1217-1225.
-
(2013)
Cancer Sci.
, vol.104
, Issue.9
, pp. 1217-1225
-
-
Lin, Y.1
-
87
-
-
33746718151
-
Targeting tumor-associated macrophages as a novel strategy against breast cancer
-
Luo Y., et al. Targeting tumor-associated macrophages as a novel strategy against breast cancer. J. Clin. Invest. 2006, 116(8):2132-2141.
-
(2006)
J. Clin. Invest.
, vol.116
, Issue.8
, pp. 2132-2141
-
-
Luo, Y.1
-
88
-
-
84901939834
-
Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity
-
Smith R.L., et al. Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity. Bioorg. Med. Chem. 2014, 22(13):3309-3315.
-
(2014)
Bioorg. Med. Chem.
, vol.22
, Issue.13
, pp. 3309-3315
-
-
Smith, R.L.1
-
89
-
-
63749126402
-
A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain
-
Stern L., et al. A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain. Bioconjug. Chem. 2009, 20(3):500-510.
-
(2009)
Bioconjug. Chem.
, vol.20
, Issue.3
, pp. 500-510
-
-
Stern, L.1
-
90
-
-
84859426282
-
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors
-
(Database issue)
-
Rawlings N.D., Barrett A.J., Bateman A. MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Res. 2012, 40:D343-D350. (Database issue).
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. D343-D350
-
-
Rawlings, N.D.1
Barrett, A.J.2
Bateman, A.3
-
91
-
-
84930752348
-
Metalloproteinases: a parade of functions in matrix biology and an outlook for the future
-
Apte S.S., Parks W.C. Metalloproteinases: a parade of functions in matrix biology and an outlook for the future. Matrix Biol. 2015, 44-46:1-6.
-
(2015)
Matrix Biol.
, pp. 1-6
-
-
Apte, S.S.1
Parks, W.C.2
-
92
-
-
84878446393
-
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade
-
Vandooren J., Van den Steen P.E., Opdenakker G. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade. Crit. Rev. Biochem. Mol. Biol. 2013, 48(3):222-272.
-
(2013)
Crit. Rev. Biochem. Mol. Biol.
, vol.48
, Issue.3
, pp. 222-272
-
-
Vandooren, J.1
Van den Steen, P.E.2
Opdenakker, G.3
-
93
-
-
77956784544
-
Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases
-
Cauwe B., Opdenakker G. Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases. Crit. Rev. Biochem. Mol. Biol. 2010, 45(5):351-423.
-
(2010)
Crit. Rev. Biochem. Mol. Biol.
, vol.45
, Issue.5
, pp. 351-423
-
-
Cauwe, B.1
Opdenakker, G.2
-
94
-
-
34250312341
-
The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases
-
Cauwe B., Van den Steen P.E., Opdenakker G. The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases. Crit. Rev. Biochem. Mol. Biol. 2007, 42(3):113-185.
-
(2007)
Crit. Rev. Biochem. Mol. Biol.
, vol.42
, Issue.3
, pp. 113-185
-
-
Cauwe, B.1
Van den Steen, P.E.2
Opdenakker, G.3
-
95
-
-
76249124026
-
Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain
-
Redondo-Munoz J., et al. Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain. Cancer Cell 2010, 17(2):160-172.
-
(2010)
Cancer Cell
, vol.17
, Issue.2
, pp. 160-172
-
-
Redondo-Munoz, J.1
-
96
-
-
1542379675
-
Matrix metalloproteinase 1 interacts with neuronal integrins and stimulates dephosphorylation of Akt
-
Conant K., et al. Matrix metalloproteinase 1 interacts with neuronal integrins and stimulates dephosphorylation of Akt. J. Biol. Chem. 2004, 279(9):8056-8062.
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.9
, pp. 8056-8062
-
-
Conant, K.1
-
97
-
-
84969409468
-
Nonproteolytic functions of matrix metalloproteinases in pathology and insights for the development of novel therapeutic inhibitors
-
Garcia-Pardo A., Opdenakker G. Nonproteolytic functions of matrix metalloproteinases in pathology and insights for the development of novel therapeutic inhibitors. Metalloproteinases in Medicine 2015, 2:19-28.
-
(2015)
Metalloproteinases in Medicine
, vol.2
, pp. 19-28
-
-
Garcia-Pardo, A.1
Opdenakker, G.2
-
98
-
-
41149162565
-
Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene
-
Eguchi T., et al. Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene. Mol. Cell. Biol. 2008, 28(7):2391-2413.
-
(2008)
Mol. Cell. Biol.
, vol.28
, Issue.7
, pp. 2391-2413
-
-
Eguchi, T.1
-
99
-
-
84902964671
-
A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity
-
Marchant D.J., et al. A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nat. Med. 2014, 20(5):493-502.
-
(2014)
Nat. Med.
, vol.20
, Issue.5
, pp. 493-502
-
-
Marchant, D.J.1
-
100
-
-
0029903248
-
Matrix metalloproteinases and tumor invasion: from correlation and causality to the clinic
-
Stetler-Stevenson W.G., Hewitt R., Corcoran M. Matrix metalloproteinases and tumor invasion: from correlation and causality to the clinic. Semin. Cancer Biol. 1996, 7(3):147-154.
-
(1996)
Semin. Cancer Biol.
, vol.7
, Issue.3
, pp. 147-154
-
-
Stetler-Stevenson, W.G.1
Hewitt, R.2
Corcoran, M.3
-
101
-
-
33646576169
-
Matrix metalloproteinases and tumor metastasis
-
Deryugina E.I., Quigley J.P. Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev. 2006, 25(1):9-34.
-
(2006)
Cancer Metastasis Rev.
, vol.25
, Issue.1
, pp. 9-34
-
-
Deryugina, E.I.1
Quigley, J.P.2
-
102
-
-
0034326255
-
Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin
-
Liu S., et al. Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin. Cancer Res. 2000, 60(21):6061-6067.
-
(2000)
Cancer Res.
, vol.60
, Issue.21
, pp. 6061-6067
-
-
Liu, S.1
-
103
-
-
84928720100
-
Thapsigargin-from Thapsia L. to mipsagargin
-
Andersen T.B., et al. Thapsigargin-from Thapsia L. to mipsagargin. Molecules 2015, 20(4):6113-6127.
-
(2015)
Molecules
, vol.20
, Issue.4
, pp. 6113-6127
-
-
Andersen, T.B.1
-
104
-
-
84864130855
-
Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy
-
(p. 140ra86)
-
Denmeade S.R., et al. Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy. Sci. Transl. Med. 2012, 4(140). (p. 140ra86).
-
(2012)
Sci. Transl. Med.
, vol.4
, Issue.140
-
-
Denmeade, S.R.1
-
105
-
-
84957799033
-
Protease-activated pore-forming peptides for the treatment and imaging of prostate cancer
-
LeBeau A.M., Denmeade S.R. Protease-activated pore-forming peptides for the treatment and imaging of prostate cancer. Mol. Cancer Ther. 2015, 14(3):659-668.
-
(2015)
Mol. Cancer Ther.
, vol.14
, Issue.3
, pp. 659-668
-
-
LeBeau, A.M.1
Denmeade, S.R.2
-
106
-
-
51049090204
-
Nanoparticle therapeutics: an emerging treatment modality for cancer
-
Davis M.E., Chen Z.G., Shin D.M. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat. Rev. Drug Discov. 2008, 7(9):771-782.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, Issue.9
, pp. 771-782
-
-
Davis, M.E.1
Chen, Z.G.2
Shin, D.M.3
-
107
-
-
84890341671
-
Intradermal air pouch leukocytosis as an in vivo test for nanoparticles
-
Vandooren J., et al. Intradermal air pouch leukocytosis as an in vivo test for nanoparticles. Int. J. Nanomedicine 2013, 8:4745-4756.
-
(2013)
Int. J. Nanomedicine
, vol.8
, pp. 4745-4756
-
-
Vandooren, J.1
-
108
-
-
79955084359
-
Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid
-
Hatakeyama H., et al. Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid. Biomaterials 2011, 32(18):4306-4316.
-
(2011)
Biomaterials
, vol.32
, Issue.18
, pp. 4306-4316
-
-
Hatakeyama, H.1
-
109
-
-
0029150245
-
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size
-
Yuan F., et al. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res. 1995, 55(17):3752-3756.
-
(1995)
Cancer Res.
, vol.55
, Issue.17
, pp. 3752-3756
-
-
Yuan, F.1
-
110
-
-
0032516078
-
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment
-
Hobbs S.K., et al. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(8):4607-4612.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, Issue.8
, pp. 4607-4612
-
-
Hobbs, S.K.1
-
111
-
-
36849067019
-
Nanocarriers as an emerging platform for cancer therapy
-
Peer D., et al. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol. 2007, 2(12):751-760.
-
(2007)
Nat. Nanotechnol.
, vol.2
, Issue.12
, pp. 751-760
-
-
Peer, D.1
-
112
-
-
84897076970
-
Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs
-
Accardo A., et al. Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs. Int. J. Nanomedicine 2014, 9:1537-1557.
-
(2014)
Int. J. Nanomedicine
, vol.9
, pp. 1537-1557
-
-
Accardo, A.1
-
113
-
-
43749121851
-
Function and expression of somatostatin receptors of the endocrine pancreas
-
Strowski M.Z., Blake A.D. Function and expression of somatostatin receptors of the endocrine pancreas. Mol. Cell. Endocrinol. 2008, 286(1-2):169-179.
-
(2008)
Mol. Cell. Endocrinol.
, vol.286
, Issue.1-2
, pp. 169-179
-
-
Strowski, M.Z.1
Blake, A.D.2
-
114
-
-
52649169324
-
Protease-triggered unveiling of bioactive nanoparticles
-
Harris T.J., et al. Protease-triggered unveiling of bioactive nanoparticles. Small 2008, 4(9):1307-1312.
-
(2008)
Small
, vol.4
, Issue.9
, pp. 1307-1312
-
-
Harris, T.J.1
-
115
-
-
33750503424
-
Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery
-
Cheng J., et al. Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials 2007, 28(5):869-876.
-
(2007)
Biomaterials
, vol.28
, Issue.5
, pp. 869-876
-
-
Cheng, J.1
-
116
-
-
77953138176
-
Controlled release of PEG chain from gold nanorods: targeted delivery to tumor
-
Niidome T., et al. Controlled release of PEG chain from gold nanorods: targeted delivery to tumor. Bioorg. Med. Chem. 2010, 18(12):4453-4458.
-
(2010)
Bioorg. Med. Chem.
, vol.18
, Issue.12
, pp. 4453-4458
-
-
Niidome, T.1
-
117
-
-
33645234124
-
Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipid containing galactosylated liposomes for hepatocellular carcinoma-selective targeting
-
Terada T., et al. Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipid containing galactosylated liposomes for hepatocellular carcinoma-selective targeting. J. Control. Release 2006, 111(3):333-342.
-
(2006)
J. Control. Release
, vol.111
, Issue.3
, pp. 333-342
-
-
Terada, T.1
-
118
-
-
84879795014
-
Polydopamine-based surface modification for the development of peritumorally activatable nanoparticles
-
Gullotti E., Park J., Yeo Y. Polydopamine-based surface modification for the development of peritumorally activatable nanoparticles. Pharm. Res. 2013, 30(8):1956-1967.
-
(2013)
Pharm. Res.
, vol.30
, Issue.8
, pp. 1956-1967
-
-
Gullotti, E.1
Park, J.2
Yeo, Y.3
-
119
-
-
84868121994
-
PEG-co-PCL nanoparticles modified with MMP-2/9 activatable low molecular weight protamine for enhanced targeted glioblastoma therapy
-
Gu G., et al. PEG-co-PCL nanoparticles modified with MMP-2/9 activatable low molecular weight protamine for enhanced targeted glioblastoma therapy. Biomaterials 2013, 34(1):196-208.
-
(2013)
Biomaterials
, vol.34
, Issue.1
, pp. 196-208
-
-
Gu, G.1
-
120
-
-
84925688271
-
Protease-mediated release of chemotherapeutics from mesoporous silica nanoparticles to ex vivo human and mouse lung tumors
-
van Rijt S.H., et al. Protease-mediated release of chemotherapeutics from mesoporous silica nanoparticles to ex vivo human and mouse lung tumors. ACS Nano 2015, 9(3):2377-2389.
-
(2015)
ACS Nano
, vol.9
, Issue.3
, pp. 2377-2389
-
-
van Rijt, S.H.1
-
121
-
-
34249036719
-
Nanoparticle self-assembly gated by logical proteolytic triggers
-
von Maltzahn G., et al. Nanoparticle self-assembly gated by logical proteolytic triggers. J. Am. Chem. Soc. 2007, 129(19):6064-6065.
-
(2007)
J. Am. Chem. Soc.
, vol.129
, Issue.19
, pp. 6064-6065
-
-
von Maltzahn, G.1
-
122
-
-
84882815878
-
Therapeutic nanomedicine based on dual-intelligent functionalized gold nanoparticles for cancer imaging and therapy in vivo
-
Chen W.H., et al. Therapeutic nanomedicine based on dual-intelligent functionalized gold nanoparticles for cancer imaging and therapy in vivo. Biomaterials 2013, 34(34):8798-8807.
-
(2013)
Biomaterials
, vol.34
, Issue.34
, pp. 8798-8807
-
-
Chen, W.H.1
-
123
-
-
84893458872
-
Theranostic GO-based nanohybrid for tumor induced imaging and potential combinational tumor therapy
-
Qin S.Y., et al. Theranostic GO-based nanohybrid for tumor induced imaging and potential combinational tumor therapy. Small 2014, 10(3):599-608.
-
(2014)
Small
, vol.10
, Issue.3
, pp. 599-608
-
-
Qin, S.Y.1
-
124
-
-
0033576644
-
Synthesis and biological evaluation of novel prodrugs of anthracyclines for selective activation by the tumor-associated protease plasmin
-
de Groot F.M., et al. Synthesis and biological evaluation of novel prodrugs of anthracyclines for selective activation by the tumor-associated protease plasmin. J. Med. Chem. 1999, 42(25):5277-5283.
-
(1999)
J. Med. Chem.
, vol.42
, Issue.25
, pp. 5277-5283
-
-
de Groot, F.M.1
-
125
-
-
0032032363
-
Inverse targeting of retroviral vectors: selective gene transfer in a mixed population of hematopoietic and nonhematopoietic cells
-
Fielding A.K., et al. Inverse targeting of retroviral vectors: selective gene transfer in a mixed population of hematopoietic and nonhematopoietic cells. Blood 1998, 91(5):1802-1809.
-
(1998)
Blood
, vol.91
, Issue.5
, pp. 1802-1809
-
-
Fielding, A.K.1
-
126
-
-
42249084437
-
A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination
-
Lee S., et al. A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination. Angew. Chem. Int. Ed. Engl. 2008, 47(15):2804-2807.
-
(2008)
Angew. Chem. Int. Ed. Engl.
, vol.47
, Issue.15
, pp. 2804-2807
-
-
Lee, S.1
-
127
-
-
75949098347
-
In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer
-
Olson E.S., et al. In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. Integr. Biol. (Camb.) 2009, 1(5-6):382-393.
-
(2009)
Integr. Biol. (Camb.)
, vol.1
, Issue.5-6
, pp. 382-393
-
-
Olson, E.S.1
-
128
-
-
3242762259
-
Synthesis and characterization of dextran-peptide-methotrexate conjugates for tumor targeting via mediation by matrix metalloproteinase II and matrix metalloproteinase IX
-
Chau Y., Tan F.E., Langer R. Synthesis and characterization of dextran-peptide-methotrexate conjugates for tumor targeting via mediation by matrix metalloproteinase II and matrix metalloproteinase IX. Bioconjug. Chem. 2004, 15(4):931-941.
-
(2004)
Bioconjug. Chem.
, vol.15
, Issue.4
, pp. 931-941
-
-
Chau, Y.1
Tan, F.E.2
Langer, R.3
-
129
-
-
33645328042
-
Investigation of targeting mechanism of new dextran-peptide-methotrexate conjugates using biodistribution study in matrix-metalloproteinase-overexpressing tumor xenograft model
-
Chau Y., et al. Investigation of targeting mechanism of new dextran-peptide-methotrexate conjugates using biodistribution study in matrix-metalloproteinase-overexpressing tumor xenograft model. J. Pharm. Sci. 2006, 95(3):542-551.
-
(2006)
J. Pharm. Sci.
, vol.95
, Issue.3
, pp. 542-551
-
-
Chau, Y.1
-
130
-
-
33644500132
-
Antitumor efficacy of a novel polymer-peptide-drug conjugate in human tumor xenograft models
-
Chau Y., et al. Antitumor efficacy of a novel polymer-peptide-drug conjugate in human tumor xenograft models. Int. J. Cancer 2006, 118(6):1519-1526.
-
(2006)
Int. J. Cancer
, vol.118
, Issue.6
, pp. 1519-1526
-
-
Chau, Y.1
-
131
-
-
58149096269
-
Protease-specific nanosensors for magnetic resonance imaging
-
Schellenberger E., et al. Protease-specific nanosensors for magnetic resonance imaging. Bioconjug. Chem. 2008, 19(12):2440-2445.
-
(2008)
Bioconjug. Chem.
, vol.19
, Issue.12
, pp. 2440-2445
-
-
Schellenberger, E.1
-
132
-
-
61549102484
-
PEGylated and MMP-2 specifically dePEGylated quantum dots: comparative evaluation of cellular uptake
-
Mok H., et al. PEGylated and MMP-2 specifically dePEGylated quantum dots: comparative evaluation of cellular uptake. Langmuir 2009, 25(3):1645-1650.
-
(2009)
Langmuir
, vol.25
, Issue.3
, pp. 1645-1650
-
-
Mok, H.1
|