A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain

Bioconjugate Chemistry

Volumn 20, Issue 3, 2009, Pages 500-510

  Stern, Liron ^a   Perry, Rotem ^a   Ofek, Paula ^a   Many, Ariel ^b   Shabat, Doron ^a   Satchi Fainaro, Ronit ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b LIS MATERNITY HOSPITAL   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOBENZYLOXYALANYLALANYLASPARAGINYLAMINO 4 METHYLCOUMARIN; CARBOBENZYLOXYALANYLALANYLASPARAGINYLETHYLENEDIAMINE ETOPOSIDE; ETOPOSIDE; LEGUMAIN; PRODRUG; PROTEINASE; RECOMBINANT HUMAN LEGUMAIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CYSTEINE PROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER TRANSPLANTATION; CELL PROLIFERATION; CELL STRAIN HEK293; CELL STRAIN PC3; CONTROLLED STUDY; DRUG DEGRADATION; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PH; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CHEMISTRY; DRUG EFFECTS; GENETICS; MALE; METABOLISM; TUMOR CELL LINE; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CYSTEINE ENDOPEPTIDASES; ETOPOSIDE; HUMANS; MALE; MICE; MICE, INBRED BALB C; PRODRUGS; UP-REGULATION;

EID: 63749126402     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc800448u     Document Type: Article

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