ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function

Nature Communications

Volumn 7, Issue , 2016, Pages

  Sharma, Aarti ^a   Lyashchenko, Alexander K ^a   Lu, Lei ^a   Nasrabady, Sara Ebrahimi ^b   Elmaleh, Margot ^a   Mendelsohn, Monica ^b   Nemes, Adriana ^a   Tapia, Juan Carlos ^a   Mentis, George Z ^b   Shneider, Neil A ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUSED IN SARCOMA PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; PROTEIN; SYNAPTIC VESICLE PROTEIN 2; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; FUS PROTEIN, HUMAN; RNA BINDING PROTEIN FUS;

JUVENILE; MUTATION; NEUROLOGY; PATHOGEN; PHENOTYPE; RODENT; SURVIVAL;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; DENERVATION; EMBRYO; EVOKED MUSCLE RESPONSE; GAIN OF FUNCTION MUTATION; GENE FUNCTION; GENE STRUCTURE; HUMAN; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; MOTONEURON; MOUSE; MUSCLE INNERVATION; NERVE CELL DEGENERATION; NERVE ENDING; NEUROFILAMENT; NEUROMUSCULAR SYNAPSE; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; OCULOMOTOR NUCLEUS; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SPINAL CORD VENTRAL HORN; TRANSGENIC MOUSE; WESTERN BLOTTING; ANIMAL; CONFOCAL MICROSCOPY; DISEASE MODEL; ELECTRON MICROSCOPY; GENETICS; INNERVATION; KNOCKOUT MOUSE; METABOLISM; MUTATION; NERVE DEGENERATION; NEUROMUSCULAR JUNCTION; PATHOLOGY; SKELETAL MUSCLE; SPINAL CORD;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL SURVIVAL; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MOTOR NEURONS; MUSCLE, SKELETAL; MUTATION; NERVE DEGENERATION; NEUROMUSCULAR JUNCTION; PHENOTYPE; RNA-BINDING PROTEIN FUS; SPINAL CORD;

EID: 84957593035     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10465     Document Type: Article

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