TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 52, 2014, Pages 18619-18624

  Qin, Haina ^a   Lim, Liang Zhong ^a   Wei, Yuanyuan ^a   Song, Jianxing ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Amyotrophic lateral sclerosis; FTLD TDP; NMR spectroscopy; TDP 43; Ubiquitin like fold

Indexed keywords

NUCLEIC ACID; RIBONUCLEOPROTEIN; SINGLE STRANDED DNA; TAR DNA BINDING PROTEIN; UBIQUITIN; DNA BINDING PROTEIN; PROTEIN BINDING; PROTEIN TDP-43;

AMINO TERMINAL SEQUENCE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CIRCULAR DICHROISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; FRONTOTEMPORAL DEMENTIA; HETERONUCLEAR SINGLE QUANTUM COHERENCE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN UNFOLDING; SEQUENCE HOMOLOGY; CHEMISTRY; GENETICS; HUMAN; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PROTEIN TERTIARY STRUCTURE; PROTEINOSIS;

AMYOTROPHIC LATERAL SCLEROSIS; CIRCULAR DICHROISM; DNA, SINGLE-STRANDED; DNA-BINDING PROTEINS; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN UNFOLDING;

EID: 84924325934     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1413994112     Document Type: Article

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