Activity-dependent FUS dysregulation disrupts

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 44, 2014, Pages E4769-E4778

  Sephtona, Chantelle F ^a,b   Tangc, Amy A ^c   Kulkarnia, Ashwinikumar ^a,d   Westa, James ^a   Brooksa, Mieu ^a   Stubblefielda, Jeremy J ^a   Liua, Yun ^a   Zhangd, Michael Q ^d,e   Greena, Carla B ^a   Hubera, Kimberly M ^a   Huangc, Eric J ^c   Herza, Joachim ^a   Yua, Gang ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITÉ LAVAL   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

^e TSINGHUA UNIVERSITY   (China)

Author keywords

Amyotrophic lateral sclerosis; Frontotemporal lobar degeneration; FUS; Metabotropic glutamate receptors; Synaptic homeostasis

Indexed keywords

CRE RECOMBINASE; FUSED IN SARCOMA PROTEIN; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; RNA BINDING PROTEIN;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY MASS; CELL LYSATE; COGNITION; CONTROLLED STUDY; DENDRITIC SPINE; DENERVATION; DNA SEQUENCE; FEMALE; FOOD INTAKE; FRONTOTEMPORAL DEMENTIA; GAIT; GENE OVEREXPRESSION; GERM LINE; GRIP STRENGTH; HINDLIMB; HOMEOSTASIS; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; LETHALITY; LOCOMOTION; LOXP SITE; MALE; MISSENSE MUTATION; MOTONEURON; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROMUSCULAR SYNAPSE; NONHUMAN; PHENOTYPE; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RNA SEQUENCE; SENSORIMOTOR CORTEX; SMELLING; SOCIAL INTERACTION; STEROL SYNTHESIS; AMINO ACID SUBSTITUTION; ANIMAL; DENDRITE; GENETICS; METABOLISM; MOTOR ACTIVITY; PATHOLOGY; SPINE; TRANSGENIC MOUSE;

MUS; MUS MUSCULUS;

AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DENDRITES; FRONTOTEMPORAL LOBAR DEGENERATION; HUMANS; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; MUTATION, MISSENSE; NEUROMUSCULAR JUNCTION; RNA-BINDING PROTEIN FUS; SPINE;

EID: 84914696708     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1406162111     Document Type: Article

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