Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermodynamic, structural and kinetic study

Biochimica et Biophysica Acta - General Subjects

Volumn 1860, Issue 4, 2016, Pages 802-813

  Kaplan, Elise ^a   Guichou, Jean François ^b   Chaloin, Laurent ^a   Kunzelmann, Simone ^c   Leban, Nadia ^a,e   Serpersu, Engin H ^d,f   Lionne, Corinne ^a  

^a UNIV MONTPELLIER   (France)

^b CENTRE DE BIOCHIMIE STRUCTURALE   (France)

^c THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^d UNIVERSITY OF TENNESSEE   (United States)

^e UNIVERSITY OF MONASTIR   (Tunisia)

^f NATIONAL SCIENCE FOUNDATION   (United States)

Author keywords

Aminoglycoside modifying enzymes; Electrostatic potential calculations; Isothermal titration calorimetry; Molecular dynamics simulations; Transient kinetics; X ray crystallography

Indexed keywords

AMINOGLYCOSIDE; AMINOGLYCOSIDE 2'' PHOSPHOTRANSFERASE IVA; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; AMINOGLYCOSIDE 2''-PHOSPHOTRANSFERASE; BACTERIAL PROTEIN; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; PRIORITY JOURNAL; STATIC ELECTRICITY; STEADY STATE; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY; CHEMISTRY; ENTEROCOCCUS; ENZYMOLOGY; KINETICS; METABOLISM;

AMINOGLYCOSIDES; BACTERIAL PROTEINS; ENTEROCOCCUS; KINETICS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; STATIC ELECTRICITY;

EID: 84957547818     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2016.01.016     Document Type: Article

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