Transient kinetics of aminoglycoside phosphotransferase(3′)-IIIa reveals a potential drug target in the antibiotic resistance mechanism

FEBS Letters

Volumn 586, Issue 23, 2012, Pages 4223-4227

  Lallemand, Perrine ^a   Leban, Nadia ^a   Kunzelmann, Simone ^b   Chaloin, Laurent ^a   Serpersu, Engin H ^c   Webb, Martin R ^b   Barman, Tom ^d   Lionne, Corinne ^a  

^a University of Montpellier I and II   (France)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c UNIVERSITY OF TENNESSEE   (United States)

^d Volunteer   (France)

Author keywords

Abortive complex; Dead end product; Pre steady state kinetics; Quench flow; Stopped flow; Uncompetitive inhibition

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINOGLYCOSIDE PHOSPHOTRANSFERASE(3') IIIA; APOENZYME; BACTERIAL ENZYME; KANAMYCIN A; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG INACTIVATION; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; NONHUMAN; PRIORITY JOURNAL; STEADY STATE;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MICROBIAL; KANAMYCIN; KANAMYCIN KINASE; KINETICS;

BACTERIA (MICROORGANISMS);

EID: 84869507340     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.10.027     Document Type: Article

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