Combining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography

Acta Crystallographica Section D: Biological Crystallography

Volumn 71, Issue , 2015, Pages 1777-1787

  Gelin, Muriel ^a,b   Delfosse, Vanessa ^a,b   Allemand, Frédéric ^a,b   Hoh, François ^a,b   Sallaz Damaz, Yoann ^c,d   Pirocchi, Michel ^c,d   Bourguet, William ^a,b   Ferrer, Jean Luc ^c,d   Labesse, Gilles ^a,b   Guichou, Jean François ^a,b  

^a UNIV MONTPELLIER   (France)

^b CENTRE DE BIOCHIMIE STRUCTURALE   (France)

^c INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^d CEA GRENOBLE   (France)

Author keywords

Drug design; Fragment library screening; In situ X ray diffraction; Ligand screening; Therapeutic targets

Indexed keywords

CYCLOPHILIN; CYCLOPHILIN D; HEN EGG LYSOZYME; LIGAND; LYSOZYME; MITOGEN ACTIVATED PROTEIN KINASE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN;

ANIMAL; CHEMISTRY; CHICKEN; CRYSTALLIZATION; DRUG DEVELOPMENT; HUMAN; METABOLISM; PROCEDURES; RAT; X RAY CRYSTALLOGRAPHY;

ANIMALS; CHICKENS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CYCLOPHILINS; DRUG DISCOVERY; HUMANS; LIGANDS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MURAMIDASE; PPAR GAMMA; PROTEINS; RATS;

EID: 84938858384     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S1399004715010342     Document Type: Article

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