Deciphering interactions of the aminoglycoside phosphotransferase(3′)-IIIa with its ligands

Biopolymers

Volumn 91, Issue 9, 2009, Pages 801-809

  Wu, Lingzhi ^a,b   Serpersu, Engin H ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b NANJING UNIVERSITY   (China)

Author keywords

Aminoglycosides; Antibiotic resistance; Enzyme ligand interactions; Phosphoryl transfer reaction; Thermodynamics

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTICS; AMINOGLYCOSIDES; ANTIBIOTIC RESISTANCE; APO-ENZYMES; BINDING AFFINITIES; CATALYTIC RATES; DISSOCIATION CONSTANT; DIVALENT CATION; ELECTRON PARAMAGNETIC RESONANCE; ENZYME-LIGAND INTERACTIONS; ENZYME-SUBSTRATE COMPLEXES; HIGH AFFINITY; METAL BINDING; METAL BINDING SITES; PHOSPHORYL TRANSFER REACTION; PHOSPHOTRANSFERASES; SUBSTRATE RANGE; SUBSTRATE SELECTIVITY; THERMODYNAMIC CHARACTERIZATION; PHOSPHORYL TRANSFER;

ANTIBIOTICS; BINDING ENERGY; BINDING SITES; DISSOCIATION; ENZYMES; FLUORESCENCE SPECTROSCOPY; LIGANDS; MAGNESIUM; MANGANESE; NUCLEOTIDES; PARAMAGNETIC RESONANCE; PARAMAGNETISM; POSITIVE IONS; SULFUR COMPOUNDS; THERMODYNAMICS;

SUBSTRATES;

ADENOSINE TRIPHOSPHATE; AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMINOGLYCOSIDE PHOSPHOTRANSFERASE IIIA; APOENZYME; BUTIROSIN; DIVALENT CATION; KANAMYCIN A; MAGNESIUM; MANGANESE; NEOMYCIN; PHOSPHOTRANSFERASE; SISOMICIN; UNCLASSIFIED DRUG; AMINOGLYCOSIDE; ISOENZYME; KANAMYCIN KINASE; LIGAND; METAL; NUCLEOTIDE; AMINOGLYCOSIDE DERIVATIVE; AMINOGLYCOSIDE PHOSPHOTRANSFERASE(3') IIIA;

ARTICLE; BINDING AFFINITY; BINDING SITE; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; ELECTRON SPIN RESONANCE; ENZYME BINDING; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE SPECTROSCOPY; METAL BINDING; THERMODYNAMICS; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; ANTIBIOTIC RESISTANCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; LIGAND BINDING; NUCLEOTIDE BINDING SITE; PROTEIN PROTEIN INTERACTION; STOICHIOMETRY;

AMINOGLYCOSIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; ISOENZYMES; KANAMYCIN KINASE; LIGANDS; METALS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEOTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS;

EID: 70149116332     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.21251     Document Type: Article

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