Molecular determinants of affinity for aminoglycoside binding to the aminoglycoside nucleotidyltransferase(2″)-Ia

Biochemistry

Volumn 45, Issue 34, 2006, Pages 10243-10250

  Wright, Edward ^a   Serpersu, Engin H ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CALORIMETRY; ENTROPY; MOLECULAR DYNAMICS; OSMOSIS;

AMINOGLYCOSIDES STUDIED; ISOTHERMAL TITRATION CALORIMETRY (ITC); MOLECULAR DETERMINANTS; TOBRAMYCIN;

ENZYMES;

ADENOSINE TRIPHOSPHATE; AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; FRAMYCETIN; KANAMYCIN A; KANAMYCIN B; MAGNESIUM CHLORIDE; NUCLEOTIDYLTRANSFERASE; PAROMOMYCIN; SISOMICIN; TOBRAMYCIN;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; DRUG PROTEIN BINDING; ENTHALPY; ENTROPY; ENZYME KINETICS; ISOTHERMAL TITRATION CALORIMETRY; PRIORITY JOURNAL; PROTEIN DETERMINATION; THERMODYNAMICS;

AMINOGLYCOSIDES; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; NUCLEOTIDYLTRANSFERASES; PROTEIN BINDING; THERMODYNAMICS; WATER;

EID: 33748670057     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060935d     Document Type: Article

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