Enzyme-substrate interactions with an antibiotic resistance enzyme: Aminoglycoside nucleotidyltransferase(2″)-Ia characterized by kinetic and thermodynamic methods

Biochemistry

Volumn 44, Issue 34, 2005, Pages 11581-11591

  Wright, Edward ^a   Serpersu, Engin H ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; BIOCHEMISTRY; CATALYSIS; ENTHALPY; ENTROPY; PARAMAGNETIC RESONANCE; TEMPERATURE DISTRIBUTION;

DIVALENT CATIONS; NEUCLEOTIDE; TEMPERATURE DEPENDENCE; TITRATION CALORIMETRY;

ENZYME KINETICS;

ADENOSINE TRIPHOSPHATE; AMIDE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE(2''); DIVALENT CATION; HYDROXYL GROUP; KANAMYCIN A; MAGNESIUM; MANGANESE; METAL; NUCLEOTIDE; NUCLEOTIDYLTRANSFERASE; TOBRAMYCIN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANTIBIOTIC RESISTANCE; ARTICLE; COMPLEX FORMATION; DISSOCIATION CONSTANT; ELECTRON SPIN RESONANCE; ENERGY; ENTHALPY; ENTROPY; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE SPECTROSCOPY; ISOTHERMAL TITRATION CALORIMETRY; METAL BINDING; PREVALENCE; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE; THERMODYNAMICS;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE; KINETICS; MAGNESIUM; MANGANESE; NUCLEOTIDYLTRANSFERASES; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 23944495538     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi050797c     Document Type: Article

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