-
1
-
-
0345052314
-
Mechanism of streptomycin action on bacteria: Unitary hypothesis
-
Spotts, C. R. and Stanier, R. Y. (1961) Mechanism of Streptomycin Action on Bacteria: Unitary Hypothesis Nature 192, 633-637
-
(1961)
Nature
, vol.192
, pp. 633-637
-
-
Spotts, C.R.1
Stanier, R.Y.2
-
2
-
-
0023238983
-
Interaction of Antibiotics with Functional Sites in 16s Ribosomal-RNA
-
Moazed, D. and Noller, H. F. (1987) Interaction of Antibiotics with Functional Sites in 16s Ribosomal-RNA Nature 327, 389-394
-
(1987)
Nature
, vol.327
, pp. 389-394
-
-
Moazed, D.1
Noller, H.F.2
-
3
-
-
0027478123
-
Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes
-
Shaw, K. J., Rather, P. N., Hare, R. S., and Miller, G. H. (1993) Molecular Genetics of Aminoglycoside Resistance Genes and Familial Relationships of the Aminoglycoside-Modifying Enzymes Microbiol. Rev. 57, 138-163
-
(1993)
Microbiol. Rev.
, vol.57
, pp. 138-163
-
-
Shaw, K.J.1
Rather, P.N.2
Hare, R.S.3
Miller, G.H.4
-
4
-
-
67650532852
-
NMR Detected Hydrogen-Deuterium Exchange Reveals Differential Dynamics of Antibiotic- and Nucleotide-Bound Aminoglycoside Phosphotransferase 3′-IIIa
-
Norris, A. L. and Serpersu, E. H. (2009) NMR Detected Hydrogen-Deuterium Exchange Reveals Differential Dynamics of Antibiotic- and Nucleotide-Bound Aminoglycoside Phosphotransferase 3′-IIIa J. Am. Chem. Soc. 131, 8587-8594
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 8587-8594
-
-
Norris, A.L.1
Serpersu, E.H.2
-
5
-
-
33845227846
-
Dissection of aminoglycoside-enzyme interactions: A calorimetric and NMR study of neomycin B binding to the aminoglycoside phosphotransferase(3′)- IIIa
-
Ozen, C., Malek, J. M., and Serpersu, E. H. (2006) Dissection of aminoglycoside-enzyme interactions: A calorimetric and NMR study of neomycin B binding to the aminoglycoside phosphotransferase(3′)-IIIa J. Am. Chem. Soc. 128, 15248-15254
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 15248-15254
-
-
Ozen, C.1
Malek, J.M.2
Serpersu, E.H.3
-
6
-
-
37849019274
-
Detection of specific solvent rearrangement regions of an enzyme: NMR and ITC studies with aminoglycoside phosphotransferase(3′)-IIIa
-
Ozen, C., Norris, A. L., Land, M. L., Tjioe, E., and Serpersu, E. H. (2008) Detection of specific solvent rearrangement regions of an enzyme: NMR and ITC studies with aminoglycoside phosphotransferase(3′)-IIIa Biochemistry 47, 40-49
-
(2008)
Biochemistry
, vol.47
, pp. 40-49
-
-
Ozen, C.1
Norris, A.L.2
Land, M.L.3
Tjioe, E.4
Serpersu, E.H.5
-
7
-
-
8744252619
-
Thermodynamics of aminoglycoside binding to aminoglycoside-3′- phosphotransferase IIIa studied by isothermal titration calorimetry
-
Ozen, C. and Serpersu, E. H. (2004) Thermodynamics of aminoglycoside binding to aminoglycoside-3′-phosphotransferase IIIa studied by isothermal titration calorimetry Biochemistry 43, 14667-14675
-
(2004)
Biochemistry
, vol.43
, pp. 14667-14675
-
-
Ozen, C.1
Serpersu, E.H.2
-
8
-
-
23944495538
-
Enzyme-Substrate Interactions with an Antibiotic Resistance Enzyme: Aminoglycoside Nucleotidyltransferase(2′)-Ia Characterized by Kinetic and Thermodynamic Methods
-
Wright, E. and Serpersu, E. H. (2005) Enzyme-Substrate Interactions with an Antibiotic Resistance Enzyme: Aminoglycoside Nucleotidyltransferase(2′) -Ia Characterized by Kinetic and Thermodynamic Methods Biochemistry 44, 11581-11591
-
(2005)
Biochemistry
, vol.44
, pp. 11581-11591
-
-
Wright, E.1
Serpersu, E.H.2
-
9
-
-
33748670057
-
Molecular determinants of affinity for aminoglycoside binding to the aminoglycoside nucleotidyltransferase(2′)-Ia
-
Wright, E. and Serpersu, E. H. (2006) Molecular Determinants of Affinity for Aminoglycoside Binding to the Aminoglycoside Nucleotidyltransferase(2′ )-Ia Biochemistry 45, 10243-10250
-
(2006)
Biochemistry
, vol.45
, pp. 10243-10250
-
-
Wright, E.1
Serpersu, E.H.2
-
10
-
-
0002881670
-
Aminoglycoside-aminocyclitol antibiotics and their modifying enzymes
-
(Ed.) 4th ed., Lippincott Williams & Wilkins, Baltimore.
-
Davies, J. E. (1991) Aminoglycoside-Aminocyclitol Antibiotics and Their Modifying Enzymes. In Antibiotics in Laboratory Medicine (Lorian, V., Ed.) 4th ed., p 1283, Lippincott Williams & Wilkins, Baltimore.
-
(1991)
Antibiotics in Laboratory Medicine
, pp. 1283
-
-
Davies, J.E.1
Lorian, V.2
-
11
-
-
0037015158
-
Cloning, overexpression, and purification of aminoglycoside antibiotic 3-acetyltransferase-IIIb: Conformational studies with bound substrates
-
Owston, M. A. and Serpersu, E. H. (2002) Cloning, overexpression, and purification of aminoglycoside antibiotic 3-acetyltransferase-IIIb: Conformational studies with bound substrates Biochemistry 41, 10764-10770
-
(2002)
Biochemistry
, vol.41
, pp. 10764-10770
-
-
Owston, M.A.1
Serpersu, E.H.2
-
12
-
-
70149116332
-
Deciphering Interactions of the Aminoglycoside Phosphotransferase(3′)-IIIa with its Ligands
-
Wu, L. Z. and Serpersu, E. H. (2009) Deciphering Interactions of the Aminoglycoside Phosphotransferase(3′)-IIIa with its Ligands Biopolymers 91, 801-809
-
(2009)
Biopolymers
, vol.91
, pp. 801-809
-
-
Wu, L.Z.1
Serpersu, E.H.2
-
13
-
-
0016154360
-
Calorimetric determination of the heat of oxygenation of human hemoglobin as a function of pH and the extent of reaction
-
Atha, D. H. and Ackers, G. K. (1974) Calorimetric determination of the heat of oxygenation of human hemoglobin as a function of pH and the extent of reaction Biochemistry 13, 376-23822
-
(1974)
Biochemistry
, vol.13
, pp. 376-23822
-
-
Atha, D.H.1
Ackers, G.K.2
-
14
-
-
0018133513
-
Kinetic Mechanisms of Gentamicin Acetyltransferase-I - Antibiotic-Dependent Shift from Rapid to Nonrapid Equilibrium Random Mechanisms
-
Williams, J. W. and Northrop, D. B. (1978) Kinetic Mechanisms of Gentamicin Acetyltransferase-I-Antibiotic-Dependent Shift from Rapid to Nonrapid Equilibrium Random Mechanisms J. Biol. Chem. 253, 5902-5907
-
(1978)
J. Biol. Chem.
, vol.253
, pp. 5902-5907
-
-
Williams, J.W.1
Northrop, D.B.2
-
15
-
-
0036740806
-
ESyPred3D: Prediction of proteins 3D structures
-
Lambert, C., Leonard, N., De Bolle, X., and Depiereux, E. (2002) ESyPred3D: Prediction of proteins 3D structures Bioinformatics 18, 1250-1256
-
(2002)
Bioinformatics
, vol.18
, pp. 1250-1256
-
-
Lambert, C.1
Leonard, N.2
De Bolle, X.3
Depiereux, E.4
-
16
-
-
32144432437
-
The SWISS-MODEL workspace: A web-based environment for protein structure homology modelling
-
Arnold, K., Bordoli, L., Kopp, J., and Schwede, T. (2006) The SWISS-MODEL workspace: A web-based environment for protein structure homology modelling Bioinformatics 22, 195-201
-
(2006)
Bioinformatics
, vol.22
, pp. 195-201
-
-
Arnold, K.1
Bordoli, L.2
Kopp, J.3
Schwede, T.4
-
17
-
-
58149193233
-
The SWISS-MODEL Repository and associated resources
-
Kiefer, F., Arnold, K., Künzli, M., Bordoli, L., and Schwede, T. (2009) The SWISS-MODEL Repository and associated resources Nucleic Acids Res. 37, D387-D392
-
(2009)
Nucleic Acids Res.
, vol.37
-
-
Kiefer, F.1
Arnold, K.2
Künzli, M.3
Bordoli, L.4
Schwede, T.5
-
18
-
-
0029004590
-
Protein modeling by E-mail
-
Peitsch, M. C. (1995) Protein Modeling by E-mail Nat. Biotechnol. 13, 658-660
-
(1995)
Nat. Biotechnol.
, vol.13
, pp. 658-660
-
-
Peitsch, M.C.1
-
19
-
-
0036172167
-
Geno3D: Automatic comparative molecular modelling of protein
-
Combet, C., Jambon, M., Deleage, G., and Geourjon, C. (2002) Geno3D: Automatic comparative molecular modelling of protein Bioinformatics 18, 213-214
-
(2002)
Bioinformatics
, vol.18
, pp. 213-214
-
-
Combet, C.1
Jambon, M.2
Deleage, G.3
Geourjon, C.4
-
20
-
-
0004313709
-
-
Chemical Computing Group Inc., Montreal.
-
Molecular Operating Environment, Chemical Computing Group Inc., Montreal (http://www.chemcomp.com).
-
Molecular Operating Environment
-
-
-
21
-
-
33745853833
-
Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3′)-Ii/AAC(6′)-IId from Serratia marcescens
-
Kim, C., Hesek, D., Zajicek, J., Vakulenko, S. B., and Mobashery, S. (2006) Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3′)-Ii/AAC(6′)-IId from Serratia marcescens Biochemistry 45, 8368-8377
-
(2006)
Biochemistry
, vol.45
, pp. 8368-8377
-
-
Kim, C.1
Hesek, D.2
Zajicek, J.3
Vakulenko, S.B.4
Mobashery, S.5
-
22
-
-
34248147112
-
Kinetic mechanism of enterococcal aminoglycoside phosphotransferase 2′-Ib
-
Toth, M., Zajicek, J., Kim, C., Chow, J. W., Smith, C., Mobashery, S., and Vakulenko, S. (2007) Kinetic mechanism of enterococcal aminoglycoside phosphotransferase 2′-Ib Biochemistry 46, 5570-5578
-
(2007)
Biochemistry
, vol.46
, pp. 5570-5578
-
-
Toth, M.1
Zajicek, J.2
Kim, C.3
Chow, J.W.4
Smith, C.5
Mobashery, S.6
Vakulenko, S.7
-
23
-
-
28944432885
-
The kinetic mechanism of AAC(3)-IV aminoglycoside acetyltransferase from Escherichia coli
-
Magalhaes, M. L. B. and Blanchard, J. S. (2005) The kinetic mechanism of AAC(3)-IV aminoglycoside acetyltransferase from Escherichia coli Biochemistry 44, 16275-16283
-
(2005)
Biochemistry
, vol.44
, pp. 16275-16283
-
-
Magalhaes, M.L.B.1
Blanchard, J.S.2
-
24
-
-
0038728733
-
Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6)-Ii from Enterococcus faecium: Evidence of dimer subunit cooperativity
-
Draker, K. A., Northrop, D. B., and Wright, G. D. (2003) Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6)-Ii from Enterococcus faecium: Evidence of dimer subunit cooperativity Biochemistry 42, 6565-6574
-
(2003)
Biochemistry
, vol.42
, pp. 6565-6574
-
-
Draker, K.A.1
Northrop, D.B.2
Wright, G.D.3
-
25
-
-
43149084149
-
Aminoglycoside 2′-phosphotransferase type IIIa from Enterococcus
-
Badarau, A., Shi, Q., Chow, J. W., Zajicek, J., Mobashery, S., and Vakulenko, S. (2008) Aminoglycoside 2′-phosphotransferase type IIIa from Enterococcus J. Biol. Chem. 283, 7638-7647
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 7638-7647
-
-
Badarau, A.1
Shi, Q.2
Chow, J.W.3
Zajicek, J.4
Mobashery, S.5
Vakulenko, S.6
-
26
-
-
0028358078
-
Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: Overexpression, purification and substrate specificity
-
McKay, G. A., Thompson, P. R., and Wright, G. D. (1994) Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: Overexpression, purification and substrate specificity Biochemistry 33, 6936-6944
-
(1994)
Biochemistry
, vol.33
, pp. 6936-6944
-
-
McKay, G.A.1
Thompson, P.R.2
Wright, G.D.3
-
27
-
-
0037062602
-
Thermodynamics of aminoglycoside and acyl-coenzyme A binding to the Salmonella enterica AAC(6′)-Iy aminoglycoside N-acetyltransferase
-
Hedge, S. S., Dam, T. K., Brewer, C. F., and Blanchard, J. S. (2002) Thermodynamics of aminoglycoside and acyl-coenzyme A binding to the Salmonella enterica AAC(6′)-Iy aminoglycoside N-acetyltransferase Biochemistry 41, 7519-7527
-
(2002)
Biochemistry
, vol.41
, pp. 7519-7527
-
-
Hedge, S.S.1
Dam, T.K.2
Brewer, C.F.3
Blanchard, J.S.4
-
28
-
-
0032579377
-
Kinetic analysis of the catalytic mechanism of serotonin N-acetyltransferase (EC 2.3.1.87)
-
De Angelis, J., Gastel, J., Klein, D. C., and Cole, P. A. (1998) Kinetic analysis of the catalytic mechanism of serotonin N-acetyltransferase (EC 2.3.1.87) J. Biol. Chem. 273, 3045-3050
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 3045-3050
-
-
De Angelis, J.1
Gastel, J.2
Klein, D.C.3
Cole, P.A.4
-
29
-
-
0031017444
-
Biologically important conformations of aminoglycoside antibiotics bound to an aminoglycoside 3′-phosphotransferase as determined by transferred nuclear Overhauser effect spectroscopy
-
Cox, J. R. and Serpersu, E. H. (1997) Biologically important conformations of aminoglycoside antibiotics bound to an aminoglycoside 3′-phosphotransferase as determined by transferred nuclear Overhauser effect spectroscopy Biochemistry 36, 2353-2359
-
(1997)
Biochemistry
, vol.36
, pp. 2353-2359
-
-
Cox, J.R.1
Serpersu, E.H.2
-
30
-
-
0032539959
-
Solution studies of isepamicin and conformational comparisons between isepamicin and butirosin a when bound to an aminoglycoside 6'-N- acetyltransferase determined by NMR spectroscopy
-
DOI 10.1021/bi972778b
-
DiGiammarino, E. L., Draker, K., Wright, G. D., and Serpersu, E. H. (1998) Solution studies of isepamicin and conformational comparisons between isepamicin and butirosin A when bound to an aminoglycoside 6′-N- acetyltransferase determined by NMR spectroscopy Biochemistry 37, 3638-3644 (Pubitemid 28162918)
-
(1998)
Biochemistry
, vol.37
, Issue.11
, pp. 3638-3644
-
-
DiGiammarino, E.L.1
Draker, K.-A.2
Wright, G.D.3
Serpersu, E.H.4
-
31
-
-
0035912790
-
Cloning, overexpression, and purification of aminoglycoside antibiotic nucleotidyltransferase (2′)-Ia: Conformational studies with bound substrates
-
Ekman, D. R., DiGiammarino, E. L., Wright, E., Witter, E. D., and Serpersu, E. H. (2001) Cloning, overexpression, and purification of aminoglycoside antibiotic nucleotidyltransferase (2′)-Ia: Conformational studies with bound substrates Biochemistry 40, 7017-7024
-
(2001)
Biochemistry
, vol.40
, pp. 7017-7024
-
-
Ekman, D.R.1
Digiammarino, E.L.2
Wright, E.3
Witter, E.D.4
Serpersu, E.H.5
-
32
-
-
0034573469
-
Conformations of antibiotics in active sites of aminoglycoside- detoxifyiing enzymes
-
Serpersu, E. H., Cox, J. R., DiGiammarino, E. L., Mohler, M. L., Ekman, D. R., Akal-Strader, A., and Owston, M. (2000) Conformations of antibiotics in active sites of aminoglycoside-detoxifyiing enzymes Cell Biochem. Biophys. 33, 309-321
-
(2000)
Cell Biochem. Biophys.
, vol.33
, pp. 309-321
-
-
Serpersu, E.H.1
Cox, J.R.2
Digiammarino, E.L.3
Mohler, M.L.4
Ekman, D.R.5
Akal-Strader, A.6
Owston, M.7
-
33
-
-
0028879950
-
Loss of Individual Electrostatic Interactions between Aminoglycoside Antibiotics and Resistance Enzymes as an Effective Means to Overcoming Bacterial Drug Resistance
-
Roestamadji, J., Grapsas, I., and Mobashery, S. (1995) Loss of Individual Electrostatic Interactions between Aminoglycoside Antibiotics and Resistance Enzymes as an Effective Means to Overcoming Bacterial Drug Resistance J. Am. Chem. Soc. 117, 11060-11069
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 11060-11069
-
-
Roestamadji, J.1
Grapsas, I.2
Mobashery, S.3
-
34
-
-
0029926515
-
Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3′-phosphotransferase type IIIa: Role of substrate amino groups
-
McKay, G. A., Roestamadji, J., Mobashery, S., and Wright, G. D. (1996) Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3′-phosphotransferase type IIIa: Role of substrate amino groups Antimicrob. Agents Chemother. 40, 2648-2650
-
(1996)
Antimicrob. Agents Chemother.
, vol.40
, pp. 2648-2650
-
-
McKay, G.A.1
Roestamadji, J.2
Mobashery, S.3
Wright, G.D.4
-
35
-
-
0023937023
-
Substrate specificities and structure activity relationships for the nucleotidylation of antibiotics catalyzed by aminoglycoside nucleotidyltransferase-2′-I
-
Gates, C. A. and Northrop, D. B. (1988) Substrate Specificities and Structure Activity Relationships for the Nucleotidylation of Antibiotics Catalyzed by Aminoglycoside Nucleotidyltransferase-2′-I Biochemistry 27, 3820-3825
-
(1988)
Biochemistry
, vol.27
, pp. 3820-3825
-
-
Gates, C.A.1
Northrop, D.B.2
-
36
-
-
0033877252
-
GCN5-related N-acetyltransferases: A structural overview
-
Dyda, F., Klein, D. C., and Hickman, A. B. (2000) GCN5-related N-acetyltransferases: A structural overview Annu. Rev. Biophys. Biomol. Struct. 29, 81-103
-
(2000)
Annu. Rev. Biophys. Biomol. Struct.
, vol.29
, pp. 81-103
-
-
Dyda, F.1
Klein, D.C.2
Hickman, A.B.3
-
37
-
-
0025183708
-
Basic local alignment search tool
-
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. (1990) Basic Local Alignment Search Tool J. Mol. Biol. 215, 403-410
-
(1990)
J. Mol. Biol.
, vol.215
, pp. 403-410
-
-
Altschul, S.F.1
Gish, W.2
Miller, W.3
Myers, E.W.4
Lipman, D.J.5
-
38
-
-
34249857539
-
COBALT: Constraint-based alignment tool for multiple protein sequences
-
Papadopoulos, J. S. and Agarwala, R. (2007) COBALT: Constraint-based alignment tool for multiple protein sequences Bioinformatics 23, 1073-1079
-
(2007)
Bioinformatics
, vol.23
, pp. 1073-1079
-
-
Papadopoulos, J.S.1
Agarwala, R.2
-
39
-
-
0033042935
-
Estimation of the number of α-helical and β-strand segments in proteins using circular dichroism spectroscopy
-
Sreerama, N., Venyaminov, S. Y., and Woody, R. W. (1999) Estimation of the number of α-helical and β-strand segments in proteins using circular dichroism spectroscopy Protein Sci. 8, 370-380
-
(1999)
Protein Sci.
, vol.8
, pp. 370-380
-
-
Sreerama, N.1
Venyaminov, S.Y.2
Woody, R.W.3
|