Dissection of aminoglycoside-enzyme interactions: A calorimetric and NMR study of neomycin B binding to the aminoglycoside phosphotransferase(3′)- IIIa

Journal of the American Chemical Society

Volumn 128, Issue 47, 2006, Pages 15248-15254

  Özen, Can ^a   Malek, Joseph M ^a   Serpersu, Engin H ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; CALORIMETRY; COMPLEXATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; THERMODYNAMIC PROPERTIES; TITRATION;

AMINOGLYCOSIDES; BINDING LINKED PROTONATION; ISOTHERMAL TITRATION CALORIMETRY; PHOSPHOTRANSFERASE;

ENZYMES;

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMINOGLYCOSIDE PHOSPHOTRANSFERASE IIIA; FRAMYCETIN; NITROGEN 15; PHOSPHOTRANSFERASE;

ARTICLE; DRUG ISOLATION; DRUG PROTEIN BINDING; ENTHALPY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; ISOTHERMAL TITRATION CALORIMETRY; NITROGEN NUCLEAR MAGNETIC RESONANCE; PH; PKA; PROTON TRANSPORT; STREPTOMYCES FRADIAE; THERMODYNAMICS;

CALORIMETRY; CARBOHYDRATE SEQUENCE; FRAMYCETIN; KANAMYCIN KINASE; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; THERMODYNAMICS;

EID: 33845227846     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0643220     Document Type: Article

References (36)

1. Moazed, D.; Noller, H. F. Nature 1987, 327, 389-394.
2. Umezawa, H. Adv. Carbohydr. Chem. Biochem. 1974, 30, 183-225.
3. Benveniste, R.; Davies, J. Proc. Natl. Acad. Sci. U.S.A. 1973, 70 (8), 2276-2280.
4. Davies, J. E. Science 1994, 264, 375-382.
5. Shaw, K. J.; Rather, P. N.; Hare, R. S.; Miller, G. H. Microbiol. Rev. 1993, 57 (1), 138-163.
6. Cox, J. R.; McKay, G. A.; Wright, G. D.; Serpersu, E. H. J. Am. Chem. Soc. 1996, 118 (6), 1295-1301.
7. Cox, J. R.; Serpersu, E. H. Biochemistry 1997, 36 (9), 2353-2359.
8. McKay, G., A.; Thompson, P. R.; Wright, G. D. Biochemistry 1994, 33, 6936-6944.
9. McKay, G. A.; Wright, G. D. J. Biol. Chem. 1995, 270 (42), 24686-24692.
10. Fong, D. H.; Berghuis, A. M. EMBO J. 2002, 21 (10), 2323-2331.
11. Liu, M.; Haddad, J.; Azucena, E.; Kotra, L. P.; Kirzhner, M.; Mobashery, S. J. Org. Chem. 2000, 65 (22), 7422-7431.
12. Boehr, D. D.; Farley, A. R.; Wright, G. D.; Cox, J. R. Chem. Biol. 2002, 9 (11), 1209-1217.
13. Ozen, C.; Serpersu, E. H. Biochemistry 2004, 43 (46), 14667-14675.
14. Burkhalter, N. F.; Dimick, S. M.; Toone, E. J. Protein-Carbohydrate interaction: Fundamental considerations. In Carbohydtrates in Chemistry and Biology, Ernst, B., Hart, G. W., Sinay, P., Eds.; Wiley-VCH: New York, 2000; Vol. 2, pp 863-914.
15. Dam, T. K.; Brewer, F. C. Chem. Rev. 2002, 102, 387-429.
16. Botto, R. E.; Coxon, B. J. Am. Chem. Soc. 1983, 105, 1021-1028.
17. Hedge, S. S.; Dam, T. K.; Brewer, C. F.; Blanchard, J. S. Biochemistry 2002, 41, 7519-7527.
18. Umezawa, H.; Ueda, M.; Maeda, K.; Yagishita, K.; Kondo, S.; Okami, Y.; Utahara, R.; Osato, Y.; Nitta, K.; Takeuchi, T. J. Antibiot., Ser. A 1957, 10 (5), 181-188.
19. Shomura, T.; Ezaki, N.; Tsuruoka, T.; Niwa, T.; Akita, E.; Niida, T. J. Antibiot. 1970, 23 (3), 155.
20. Wiseman, T.; Williston, S.; Brandts, J. F.; Lin, L. N. Anal. Biochem. 1989, 179 (1), 131-137.
21. Dorman, D. E.; Paschal, J. W.; Merkel, K. E. J. Am. Chem. Soc. 1976, 98, 6885-6888.
22. Cox, J. R.; Ekman, D. R.; DiGiammarino, E. L.; Akal-Strader, A.; Serpersu, E. H. Cell Biochem. Biophys. 2000, 33 (3), 297-308.
23. Barbieri, C. M.; Pilch, D. S. Biophys. J. 2006, 90, 1338-1349.
24. Serpersu, E. H.; Cox, J. R.; DiGiammarino, E. L.; Mohler, M. L.; Ekman, D. R.; Akal-Strader, A.; Owston, M. Cell Biochem. Biophys. 2000, 33 (3), 309-321.
25. Owston, M. A.; Serpersu, E. H. Biochemistry 2002, 41 (35), 10764-10770.
26. DeLano, W. L., 2002.
27. Guex, N.; Peitsch, M. C.Electrophoresis 1997, 18 (15), 2714-2723.
28. Welch, K. T.; Virga, K. G.; Brown, C. L.; Wright, E.; Lee R. E.; Serpersu, E. H. Bioorg. Med. Chem. 2005, 13, 6252-6263.
29. Serpersu, E. H.; Shortle, D.; Mildvan, A. S. Biochemistry 1986, 25, 68-77.
30. Serpersu, E. H.; Shortle, D.; Mildvan, A. S. Biochemistry 1987, 26, 1289-1300.
31. Atha, D. H.; Ackers, G. K. Biochemistry 1974, 13, 376-23822.
32. Christensen, T.; Svensson, B.; Sigurskjold, B.W. Biochemistry 1999, 38, (19), 6300-6310.
33. Freire, E. Proc.Natl. Acad. Sci. U.S.A. 1999, 96, 10118-10122.
34. McKay, G. A.; Roestamadji, J.; Mobashery, S.; Wright, G. D. Antimicrob.Agents Chemother. 1996, 40 (11), 2648-2650.
35. Wright, E.;Serpersu, E. H. Biochemistry 2005, 44, 11581-11591.
36. Uncertainties represent curve fitting errors.