Structural basis for dual nucleotide selectivity of aminoglycoside 2″-phosphotransferase IVa provides insight on determinants of nucleotide specificity of aminoglycoside kinases

Journal of Biological Chemistry

Volumn 287, Issue 16, 2012, Pages 13094-13102

  Shi, Kun ^a   Berghuis, Albert M ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTICS; AMINOGLYCOSIDES; CASEIN KINASE 2; DIFFERENT SUBSTRATES; ENZYMATIC PHOSPHORYLATION; GUANOSINES; INTER-DOMAIN; KEY ELEMENTS; PATHOGENIC STRAINS; PHOSPHOTRANSFERASES; SEQUENCE SIMILARITY; STEADY-STATE KINETICS; STRUCTURAL BASIS; STRUCTURAL COMPARISON; STRUCTURAL HOMOLOGY; WILD-TYPE ENZYMES;

AMINO ACIDS; NUCLEOTIDES; PHOSPHORYLATION;

ENZYMES;

ADENOSINE; AMINOGLYCOSIDE 2'' PHOSPHOTRANSFERASE IVA; AMINOGLYCOSIDE KINASE; CASEIN KINASE II; GUANOSINE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STEADY STATE; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS;

ADENOSINE; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; AMINOGLYCOSIDES; BACTERIAL PROTEINS; BINDING SITES; CASEIN KINASE II; DRUG RESISTANCE, BACTERIAL; GUANINE; GUANOSINE TRIPHOSPHATE; HUMANS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EUKARYOTA; IVA;

EID: 84859739752     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.349670     Document Type: Article

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