메뉴 건너뛰기




Volumn 173, Issue 4, 2016, Pages 716-728

Immunoinflammatory diseases of the central nervous system - The tale of two cytokines

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; INTERLEUKIN 6; ANTIINFLAMMATORY AGENT;

EID: 84957546102     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13175     Document Type: Review
Times cited : (33)

References (152)
  • 1
    • 10944263734 scopus 로고    scopus 로고
    • Aicardi-Goutieres syndrome: Special type early-onset encephalopathy
    • Aicardi J, (2002). Aicardi-Goutieres syndrome: special type early-onset encephalopathy. Eur J Paediatr Neurol 6 (Suppl. A): A1-A7.
    • (2002) Eur J Paediatr Neurol , vol.6 , Issue.SUPPL. A , pp. A1-A7
    • Aicardi, J.1
  • 2
    • 0021336060 scopus 로고
    • A progressive familial encephalopathy in infancy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosis
    • Aicardi J, Goutieres F, (1984). A progressive familial encephalopathy in infancy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosis. Ann Neurol 15: 49-54.
    • (1984) Ann Neurol , vol.15 , pp. 49-54
    • Aicardi, J.1    Goutieres, F.2
  • 3
    • 46849113681 scopus 로고    scopus 로고
    • Promoter polymorphisms in the IRF3 gene confer protection against systemic lupus erythematosus
    • Akahoshi M, Nakashima H, Sadanaga A, Miyake K, Obara K, Tamari M, et al. (2008). Promoter polymorphisms in the IRF3 gene confer protection against systemic lupus erythematosus. Lupus 17: 568-574.
    • (2008) Lupus , vol.17 , pp. 568-574
    • Akahoshi, M.1    Nakashima, H.2    Sadanaga, A.3    Miyake, K.4    Obara, K.5    Tamari, M.6
  • 4
    • 0032211097 scopus 로고    scopus 로고
    • Transgenic expression of IFN-a in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration
    • Akwa Y, Hassett DE, Eloranta ML, Sandberg K, Masliah E, Powell H, et al. (1998). Transgenic expression of IFN-a in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration. J Immunol 161: 5016-5026.
    • (1998) J Immunol , vol.161 , pp. 5016-5026
    • Akwa, Y.1    Hassett, D.E.2    Eloranta, M.L.3    Sandberg, K.4    Masliah, E.5    Powell, H.6
  • 8
    • 84880844455 scopus 로고    scopus 로고
    • Clinical improvement in a patient with neuromyelitis optica following therapy with the anti-IL-6 receptor monoclonal antibody tocilizumab
    • Araki M, Aranami T, Matsuoka T, Nakamura M, Miyake S, Yamamura T, (2013). Clinical improvement in a patient with neuromyelitis optica following therapy with the anti-IL-6 receptor monoclonal antibody tocilizumab. Mod Rheumatol 23: 827-831.
    • (2013) Mod Rheumatol , vol.23 , pp. 827-831
    • Araki, M.1    Aranami, T.2    Matsuoka, T.3    Nakamura, M.4    Miyake, S.5    Yamamura, T.6
  • 9
    • 84902096246 scopus 로고    scopus 로고
    • Efficacy of the anti-IL-6 receptor antibody tocilizumab in neuromyelitis optica: A pilot study
    • Araki M, Matsuoka T, Miyamoto K, Kusunoki S, Okamoto T, Murata M, et al. (2014). Efficacy of the anti-IL-6 receptor antibody tocilizumab in neuromyelitis optica: a pilot study. Neurology 82: 1302-1306.
    • (2014) Neurology , vol.82 , pp. 1302-1306
    • Araki, M.1    Matsuoka, T.2    Miyamoto, K.3    Kusunoki, S.4    Okamoto, T.5    Murata, M.6
  • 10
    • 84874904135 scopus 로고    scopus 로고
    • Interleukin 6 receptor blockade in patients with neuromyelitis optica nonresponsive to anti-CD20 therapy
    • Ayzenberg I, Kleiter I, Schroder A, Hellwig K, Chan A, Yamamura T, et al. (2013). Interleukin 6 receptor blockade in patients with neuromyelitis optica nonresponsive to anti-CD20 therapy. JAMA Neurol 70: 394-397.
    • (2013) JAMA Neurol , vol.70 , pp. 394-397
    • Ayzenberg, I.1    Kleiter, I.2    Schroder, A.3    Hellwig, K.4    Chan, A.5    Yamamura, T.6
  • 11
    • 84860779782 scopus 로고    scopus 로고
    • Neuromyelitis optica: Not a multiple sclerosis variant
    • Barnett MH, Sutton I, (2012). Neuromyelitis optica: not a multiple sclerosis variant. Curr Opin Neurol 25: 215-220.
    • (2012) Curr Opin Neurol , vol.25 , pp. 215-220
    • Barnett, M.H.1    Sutton, I.2
  • 12
    • 0030268026 scopus 로고    scopus 로고
    • Chronic complement C3 gene expression in the CNS of transgenic mice with astrocyte-targeted interleukin-6 expression
    • Barnum SR, Jones JL, Muller-Ladner U, Samimi A, Campbell IL, (1996). Chronic complement C3 gene expression in the CNS of transgenic mice with astrocyte-targeted interleukin-6 expression. Glia 18: 107-117.
    • (1996) Glia , vol.18 , pp. 107-117
    • Barnum, S.R.1    Jones, J.L.2    Muller-Ladner, U.3    Samimi, A.4    Campbell, I.L.5
  • 13
    • 0028843876 scopus 로고
    • Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6
    • Bellinger FP, Madamba SG, Campbell IL, Siggins G, (1995). Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6. Neurosci Letts 198: 95-98.
    • (1995) Neurosci Letts , vol.198 , pp. 95-98
    • Bellinger, F.P.1    Madamba, S.G.2    Campbell, I.L.3    Siggins, G.4
  • 14
    • 0022534982 scopus 로고
    • Calcification of the basal ganglia in infants and children with acquired immunodeficiency syndrome
    • Belman AL, Lantos G, Horoupian D, Novick BE, Ultmann MH, Dickson DW, et al. (1986). Calcification of the basal ganglia in infants and children with acquired immunodeficiency syndrome. Neurology 36: 1192-1199.
    • (1986) Neurology , vol.36 , pp. 1192-1199
    • Belman, A.L.1    Lantos, G.2    Horoupian, D.3    Novick, B.E.4    Ultmann, M.H.5    Dickson, D.W.6
  • 17
    • 0035900481 scopus 로고    scopus 로고
    • Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus
    • Blanco P, Palucka AK, Gill M, Pascual V, Banchereau J, (2001). Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science 294: 1540-1543.
    • (2001) Science , vol.294 , pp. 1540-1543
    • Blanco, P.1    Palucka, A.K.2    Gill, M.3    Pascual, V.4    Banchereau, J.5
  • 18
    • 84866748115 scopus 로고    scopus 로고
    • Mycobacterial disease and impaired IFN-gamma immunity in humans with inherited ISG15 deficiency
    • Bogunovic D, Byun M, Durfee LA, Abhyankar A, Sanal O, Mansouri D, et al. (2012). Mycobacterial disease and impaired IFN-gamma immunity in humans with inherited ISG15 deficiency. Science 337: 1684-1688.
    • (2012) Science , vol.337 , pp. 1684-1688
    • Bogunovic, D.1    Byun, M.2    Durfee, L.A.3    Abhyankar, A.4    Sanal, O.5    Mansouri, D.6
  • 19
    • 33748450379 scopus 로고    scopus 로고
    • Complex modulation of cell type-specific signaling in response to type I interferons
    • van Boxel-Dezaire AH, Rani MR, Stark GR, (2006). Complex modulation of cell type-specific signaling in response to type I interferons. Immunity 25: 361-372.
    • (2006) Immunity , vol.25 , pp. 361-372
    • Van Boxel-Dezaire, A.H.1    Rani, M.R.2    Stark, G.R.3
  • 20
    • 0028866623 scopus 로고
    • Evolution of neuropathologic abnormalities associated with blood-brain barrier breakdown in transgenic mice expressing interleukin-6 in astrocytes
    • Brett FM, Mizisin AP, Powell HC, Campbell IL, (1995). Evolution of neuropathologic abnormalities associated with blood-brain barrier breakdown in transgenic mice expressing interleukin-6 in astrocytes. J Neuropathol Exp Neurol 54: 766-775.
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 766-775
    • Brett, F.M.1    Mizisin, A.P.2    Powell, H.C.3    Campbell, I.L.4
  • 22
    • 79956055051 scopus 로고    scopus 로고
    • Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior
    • Burton MD, Sparkman NL, Johnson RW, (2011). Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior. J Neuroinflammation 8: 54.
    • (2011) J Neuroinflammation , vol.8 , pp. 54
    • Burton, M.D.1    Sparkman, N.L.2    Johnson, R.W.3
  • 23
    • 84876858460 scopus 로고    scopus 로고
    • Central inhibition of interleukin-6 trans-signaling during peripheral infection reduced neuroinflammation and sickness in aged mice
    • Burton MD, Rytych JL, Freund GG, Johnson RW, (2013). Central inhibition of interleukin-6 trans-signaling during peripheral infection reduced neuroinflammation and sickness in aged mice. Brain Behav Immun 30: 66-72.
    • (2013) Brain Behav Immun , vol.30 , pp. 66-72
    • Burton, M.D.1    Rytych, J.L.2    Freund, G.G.3    Johnson, R.W.4
  • 24
    • 84920285641 scopus 로고    scopus 로고
    • IL-6 biology: Implications for clinical targeting in rheumatic disease
    • Calabrese LH, Rose-John S, (2014). IL-6 biology: implications for clinical targeting in rheumatic disease. Nat Rev Rheumatol 10: 720-727.
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 720-727
    • Calabrese, L.H.1    Rose-John, S.2
  • 26
    • 0033578192 scopus 로고    scopus 로고
    • Structural and functional neuropathology in transgenic mice with CNS expression of IFN-a
    • Campbell IL, Krucker T, Steffensen S, Akwa Y, Powell HC, Lane T, et al. (1999). Structural and functional neuropathology in transgenic mice with CNS expression of IFN-a. Brain Res 835: 46-61.
    • (1999) Brain Res , vol.835 , pp. 46-61
    • Campbell, I.L.1    Krucker, T.2    Steffensen, S.3    Akwa, Y.4    Powell, H.C.5    Lane, T.6
  • 27
    • 77956094385 scopus 로고    scopus 로고
    • Transgenic models for cytokine-induced neurological disease
    • Campbell IL, Hofer MJ, Pagenstecher A, (2010). Transgenic models for cytokine-induced neurological disease. Biochim Biophys Acta 1802: 903-917.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 903-917
    • Campbell, I.L.1    Hofer, M.J.2    Pagenstecher, A.3
  • 28
    • 84893676729 scopus 로고    scopus 로고
    • Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain
    • Campbell IL, Erta M, Lim SL, Frausto R, May U, Rose-John S, et al. (2014). Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain. J Neurosci 34: 2503-2513.
    • (2014) J Neurosci , vol.34 , pp. 2503-2513
    • Campbell, I.L.1    Erta, M.2    Lim, S.L.3    Frausto, R.4    May, U.5    Rose-John, S.6
  • 29
    • 0032192504 scopus 로고    scopus 로고
    • Localization of metallothionein-I and-III expression in the CNS of transgenic mice with astrocyte-targeted expression of interleukin-6
    • Carrasco J, Hernandez J, Campbell IL, Hidalgo J, (1998). Localization of metallothionein-I and-III expression in the CNS of transgenic mice with astrocyte-targeted expression of interleukin-6. Exp Neurol 153: 184-194.
    • (1998) Exp Neurol , vol.153 , pp. 184-194
    • Carrasco, J.1    Hernandez, J.2    Campbell, I.L.3    Hidalgo, J.4
  • 30
    • 84859585345 scopus 로고    scopus 로고
    • Aicardi-Goutieres syndrome: from patients to genes and beyond
    • Chahwan C, Chahwan R, (2012). Aicardi-Goutieres syndrome: from patients to genes and beyond. Clin Genet 81: 413-420.
    • (2012) Clin Genet , vol.81 , pp. 413-420
    • Chahwan, C.1    Chahwan, R.2
  • 31
    • 0028598750 scopus 로고
    • Reactive gliosis as a consequence of interleukin-6 expression in the brain. Studies in transgenic mice
    • Chiang C-S, Stalder A, Samimi A, Campbell IL, (1994). Reactive gliosis as a consequence of interleukin-6 expression in the brain. Studies in transgenic mice. Dev Neurosci 16: 212-221.
    • (1994) Dev Neurosci , vol.16 , pp. 212-221
    • Chiang, C.-S.1    Stalder, A.2    Samimi, A.3    Campbell, I.L.4
  • 32
    • 79952762854 scopus 로고    scopus 로고
    • Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica
    • Chihara N, Aranami T, Sato W, Miyazaki Y, Miyake S, Okamoto T, et al. (2011). Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. Proc Natl Acad Sci U S A 108: 3701-3706.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3701-3706
    • Chihara, N.1    Aranami, T.2    Sato, W.3    Miyazaki, Y.4    Miyake, S.5    Okamoto, T.6
  • 33
    • 33750458329 scopus 로고    scopus 로고
    • Neurologic problems
    • Zeichner S. Read J. (eds). Cambridge University Press: New York
    • Civitello L, (2005). Neurologic problems. In:, Zeichner S, Read J, (eds). Textbook of Pediatric HIV Care. Cambridge University Press: New York, pp. 431-444.
    • (2005) Textbook of Pediatric HIV Care , pp. 431-444
    • Civitello, L.1
  • 34
    • 79952393266 scopus 로고    scopus 로고
    • The inflammasomes in health and disease: from genetics to molecular mechanisms of autoinflammation and beyond
    • Conforti-Andreoni C, Ricciardi-Castagnoli P, Mortellaro A, (2011). The inflammasomes in health and disease: from genetics to molecular mechanisms of autoinflammation and beyond. Cell Mol Immunol 8: 135-145.
    • (2011) Cell Mol Immunol , vol.8 , pp. 135-145
    • Conforti-Andreoni, C.1    Ricciardi-Castagnoli, P.2    Mortellaro, A.3
  • 36
    • 82555192885 scopus 로고    scopus 로고
    • Type I interferonopathies: A novel set of inborn errors of immunity
    • Crow YJ, (2011). Type I interferonopathies: a novel set of inborn errors of immunity. Ann N Y Acad Sci 1238: 91-98.
    • (2011) Ann N y Acad Sci , vol.1238 , pp. 91-98
    • Crow, Y.J.1
  • 37
    • 43949144252 scopus 로고    scopus 로고
    • Aicardi-Goutieres syndrome: An important Mendelian mimic of congenital infection
    • Crow YJ, Livingston JH, (2008). Aicardi-Goutieres syndrome: an important Mendelian mimic of congenital infection. Dev Med Child Neurol 50: 410-416.
    • (2008) Dev Med Child Neurol , vol.50 , pp. 410-416
    • Crow, Y.J.1    Livingston, J.H.2
  • 38
    • 0033625515 scopus 로고    scopus 로고
    • Aicardi-Goutieres syndrome displays genetic heterogeneity with one locus (AGS1) on chromosome 3p21
    • Crow YJ, Jackson AP, Roberts E, van Beusekom E, Barth P, Corry P, et al. (2000). Aicardi-Goutieres syndrome displays genetic heterogeneity with one locus (AGS1) on chromosome 3p21. Am J Hum Genet 67: 213-221.
    • (2000) Am J Hum Genet , vol.67 , pp. 213-221
    • Crow, Y.J.1    Jackson, A.P.2    Roberts, E.3    Van Beusekom, E.4    Barth, P.5    Corry, P.6
  • 39
    • 0037338578 scopus 로고    scopus 로고
    • Cree encephalitis is allelic with Aicardi-Goutieres syndrome: Implications for the pathogenesis of disorders of interferon alpha metabolism
    • Crow YJ, Black DN, Ali M, Bond J, Jackson AP, Lefson M, et al. (2003). Cree encephalitis is allelic with Aicardi-Goutieres syndrome: implications for the pathogenesis of disorders of interferon alpha metabolism. J Med Genet 40: 183-187.
    • (2003) J Med Genet , vol.40 , pp. 183-187
    • Crow, Y.J.1    Black, D.N.2    Ali, M.3    Bond, J.4    Jackson, A.P.5    Lefson, M.6
  • 40
    • 33746581694 scopus 로고    scopus 로고
    • Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus
    • Crow YJ, Hayward BE, Parmar R, Robins P, Leitch A, Ali M, et al. (2006a). Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus. Nat Genet 38: 917-920.
    • (2006) Nat Genet , vol.38 , pp. 917-920
    • Crow, Y.J.1    Hayward, B.E.2    Parmar, R.3    Robins, P.4    Leitch, A.5    Ali, M.6
  • 41
    • 33746522835 scopus 로고    scopus 로고
    • Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection
    • Crow YJ, Leitch A, Hayward BE, Garner A, Parmar R, Griffith E, et al. (2006b). Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection. Nat Genet 38: 910-916.
    • (2006) Nat Genet , vol.38 , pp. 910-916
    • Crow, Y.J.1    Leitch, A.2    Hayward, B.E.3    Garner, A.4    Parmar, R.5    Griffith, E.6
  • 42
    • 31544481206 scopus 로고    scopus 로고
    • Phenotypic overlap between infantile systemic lupus erythematosus and Aicardi-Goutieres syndrome
    • De Laet C, Goyens P, Christophe C, Ferster A, Mascart F, Dan B, (2005). Phenotypic overlap between infantile systemic lupus erythematosus and Aicardi-Goutieres syndrome. Neuropediatrics 36: 399-402.
    • (2005) Neuropediatrics , vol.36 , pp. 399-402
    • De Laet, C.1    Goyens, P.2    Christophe, C.3    Ferster, A.4    Mascart, F.5    Dan, B.6
  • 43
    • 78649830454 scopus 로고    scopus 로고
    • Genetic susceptibility to systemic lupus erythematosus in the genomic era
    • Deng Y, Tsao BP, (2010). Genetic susceptibility to systemic lupus erythematosus in the genomic era. Nat Rev Rheumatol 6: 683-692.
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 683-692
    • Deng, Y.1    Tsao, B.P.2
  • 44
    • 0021852049 scopus 로고
    • Intrathecal synthesis of different alpha-interferons in patients with various neurological diseases
    • Dussaix E, Lebon P, Ponsot G, Huault G, Tardieu M, (1985). Intrathecal synthesis of different alpha-interferons in patients with various neurological diseases. Acta Neurol Scand 7: 504-509.
    • (1985) Acta Neurol Scand , vol.7 , pp. 504-509
    • Dussaix, E.1    Lebon, P.2    Ponsot, G.3    Huault, G.4    Tardieu, M.5
  • 45
    • 0025911370 scopus 로고
    • Ribonuclease H from K562 human erythroleukemia cells. Purification, characterization, and substrate specificity
    • Eder PS, Walder JA, (1991). Ribonuclease H from K562 human erythroleukemia cells. Purification, characterization, and substrate specificity. J Biol Chem 266: 6472-6479.
    • (1991) J Biol Chem , vol.266 , pp. 6472-6479
    • Eder, P.S.1    Walder, J.A.2
  • 46
    • 70350022338 scopus 로고    scopus 로고
    • Pathogenesis of neuropsychiatric systemic lupus erythematosus and potential biomarkers
    • Efthimiou P, Blanco M, (2009). Pathogenesis of neuropsychiatric systemic lupus erythematosus and potential biomarkers. Mod Rheumatol 19: 457-468.
    • (2009) Mod Rheumatol , vol.19 , pp. 457-468
    • Efthimiou, P.1    Blanco, M.2
  • 47
    • 0346157324 scopus 로고    scopus 로고
    • Acquiring signalling specificity from the cytokine receptor gp130
    • Ernst M, Jenkins BJ, (2004). Acquiring signalling specificity from the cytokine receptor gp130. Trends Genet 20: 23-32.
    • (2004) Trends Genet , vol.20 , pp. 23-32
    • Ernst, M.1    Jenkins, B.J.2
  • 48
    • 84869857934 scopus 로고    scopus 로고
    • Interleukin-6, a major cytokine in the central nervous system
    • Erta M, Quintana A, Hidalgo J, (2012). Interleukin-6, a major cytokine in the central nervous system. Int J Biol Sci 8: 1254-1266.
    • (2012) Int J Biol Sci , vol.8 , pp. 1254-1266
    • Erta, M.1    Quintana, A.2    Hidalgo, J.3
  • 49
    • 79953707345 scopus 로고    scopus 로고
    • Association of a functional IRF7 variant with systemic lupus erythematosus
    • Fu Q, Zhao J, Qian X, Wong JL, Kaufman KM, Yu CY, et al. (2011). Association of a functional IRF7 variant with systemic lupus erythematosus. Arthritis Rheum 63: 749-754.
    • (2011) Arthritis Rheum , vol.63 , pp. 749-754
    • Fu, Q.1    Zhao, J.2    Qian, X.3    Wong, J.L.4    Kaufman, K.M.5    Yu, C.Y.6
  • 50
    • 84894028950 scopus 로고    scopus 로고
    • Autoimmune disorders associated with gain of function of the intracellular sensor MDA5
    • Funabiki M, Kato H, Miyachi Y, Toki H, Motegi H, Inoue M, et al. (2014). Autoimmune disorders associated with gain of function of the intracellular sensor MDA5. Immunity 40: 199-212.
    • (2014) Immunity , vol.40 , pp. 199-212
    • Funabiki, M.1    Kato, H.2    Miyachi, Y.3    Toki, H.4    Motegi, H.5    Inoue, M.6
  • 54
    • 1042278125 scopus 로고    scopus 로고
    • Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1
    • Hartner JC, Schmittwolf C, Kispert A, Muller AM, Higuchi M, Seeburg PH, (2004). Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1. J Biol Chem 279: 4894-4902.
    • (2004) J Biol Chem , vol.279 , pp. 4894-4902
    • Hartner, J.C.1    Schmittwolf, C.2    Kispert, A.3    Muller, A.M.4    Higuchi, M.5    Seeburg, P.H.6
  • 55
    • 57849136005 scopus 로고    scopus 로고
    • ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling
    • Hartner JC, Walkley CR, Lu J, Orkin SH, (2009). ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat Immunol 10: 109-115.
    • (2009) Nat Immunol , vol.10 , pp. 109-115
    • Hartner, J.C.1    Walkley, C.R.2    Lu, J.3    Orkin, S.H.4
  • 56
    • 44949218591 scopus 로고    scopus 로고
    • Astrocytes produce interferon-alpha and CXCL10, but not IL-6 or CXCL8, in Aicardi-Goutieres syndrome
    • van Heteren JT, Rozenberg F, Aronica E, Troost D, Lebon P, Kuijpers TW, (2008). Astrocytes produce interferon-alpha and CXCL10, but not IL-6 or CXCL8, in Aicardi-Goutieres syndrome. Glia 56: 568-578.
    • (2008) Glia , vol.56 , pp. 568-578
    • Van Heteren, J.T.1    Rozenberg, F.2    Aronica, E.3    Troost, D.4    Lebon, P.5    Kuijpers, T.W.6
  • 57
    • 0031028141 scopus 로고    scopus 로고
    • Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain
    • Heyser CJ, Masliah E, Samimi A, Campbell IL, Gold LH, (1997). Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain. Proc Natl Acad Sci USA 94: 1500-1505.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1500-1505
    • Heyser, C.J.1    Masliah, E.2    Samimi, A.3    Campbell, I.L.4    Gold, L.H.5
  • 58
    • 0001004486 scopus 로고
    • Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2)
    • Hirano T, Taga T, Nakano N, Yasukawa K, Kashiwamura S, Shimizu K, et al. (1985). Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc Natl Acad Sci U S A 82: 5490-5494.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 5490-5494
    • Hirano, T.1    Taga, T.2    Nakano, N.3    Yasukawa, K.4    Kashiwamura, S.5    Shimizu, K.6
  • 59
    • 0022499547 scopus 로고
    • Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
    • Hirano T, Yasukawa K, Harada H, Tage T, Watanabe Y, Matsuda T, et al. (1986). Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324: 73-76.
    • (1986) Nature , vol.324 , pp. 73-76
    • Hirano, T.1    Yasukawa, K.2    Harada, H.3    Tage, T.4    Watanabe, Y.5    Matsuda, T.6
  • 60
    • 0025226107 scopus 로고
    • Biological and clinical aspects of interleukin 6
    • Hirano T, Akira S, Taga T, Kishimoto T, (1990). Biological and clinical aspects of interleukin 6. Immunol Today 11: 443-449.
    • (1990) Immunol Today , vol.11 , pp. 443-449
    • Hirano, T.1    Akira, S.2    Taga, T.3    Kishimoto, T.4
  • 61
    • 84881255428 scopus 로고    scopus 로고
    • Type I interferon in neurological disease-the devil from within
    • Hofer MJ, Campbell IL, (2013). Type I interferon in neurological disease-the devil from within. Cytokine Growth Factor Rev 24: 257-267.
    • (2013) Cytokine Growth Factor Rev , vol.24 , pp. 257-267
    • Hofer, M.J.1    Campbell, I.L.2
  • 62
    • 0000520727 scopus 로고
    • Virus interference. 1. The interferon
    • Isaacs A, Lindenmann J, (1957). Virus interference. 1. The interferon. Proc R Soc Lond B 147: 258-267.
    • (1957) Proc R Soc Lond B , vol.147 , pp. 258-267
    • Isaacs, A.1    Lindenmann, J.2
  • 64
    • 69949146813 scopus 로고    scopus 로고
    • Interferon-related transcriptome alterations in the cerebrospinal fluid cells of Aicardi-Goutieres patients
    • Izzotti A, Pulliero A, Orcesi S, Cartiglia C, Longobardi MG, Capra V, et al. (2009). Interferon-related transcriptome alterations in the cerebrospinal fluid cells of Aicardi-Goutieres patients. Brain Pathol 19: 650-660.
    • (2009) Brain Pathol , vol.19 , pp. 650-660
    • Izzotti, A.1    Pulliero, A.2    Orcesi, S.3    Cartiglia, C.4    Longobardi, M.G.5    Capra, V.6
  • 65
    • 0037309385 scopus 로고    scopus 로고
    • Cytokines: Powerful regulators of glial cell activation
    • John GR, Lee SC, Brosnan CF, (2003). Cytokines: powerful regulators of glial cell activation. Neuroscientist 9: 10-22.
    • (2003) Neuroscientist , vol.9 , pp. 10-22
    • John, G.R.1    Lee, S.C.2    Brosnan, C.F.3
  • 66
    • 17744413725 scopus 로고    scopus 로고
    • The heterogeneity of neuropsychiatric systemic lupus erythematosus is reflected in lack of association with cerebrospinal fluid cytokine profiles
    • Jonsen A, Bengtsson AA, Nived O, Ryberg B, Truedsson L, Ronnblom L, et al. (2003). The heterogeneity of neuropsychiatric systemic lupus erythematosus is reflected in lack of association with cerebrospinal fluid cytokine profiles. Lupus 12: 846-850.
    • (2003) Lupus , vol.12 , pp. 846-850
    • Jonsen, A.1    Bengtsson, A.A.2    Nived, O.3    Ryberg, B.4    Truedsson, L.5    Ronnblom, L.6
  • 67
    • 0035160256 scopus 로고    scopus 로고
    • Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
    • Jostock T, Mullberg J, Ozbek S, Atreya R, Blinn G, Voltz N, et al. (2001). Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur J Biochem 268: 160-167.
    • (2001) Eur J Biochem , vol.268 , pp. 160-167
    • Jostock, T.1    Mullberg, J.2    Ozbek, S.3    Atreya, R.4    Blinn, G.5    Voltz, N.6
  • 68
    • 26444619864 scopus 로고    scopus 로고
    • IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis
    • Kaplin AI, Deshpande DM, Scott E, Krishnan C, Carmen JS, Shats I, et al. (2005). IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis. J Clin Invest 115: 2731-2741.
    • (2005) J Clin Invest , vol.115 , pp. 2731-2741
    • Kaplin, A.I.1    Deshpande, D.M.2    Scott, E.3    Krishnan, C.4    Carmen, J.S.5    Shats, I.6
  • 69
    • 0026753990 scopus 로고
    • CT and MR evaluation of intracranial involvement in pediatric HIV infection: A clinical imaging correlation
    • Kauffman WM, Sivit CJ, Fitz CR, Rakusan A, Herzog K, Chandra RS, (1992). CT and MR evaluation of intracranial involvement in pediatric HIV infection: a clinical imaging correlation. Am J Neuroradiol 13: 949-957.
    • (1992) Am J Neuroradiol , vol.13 , pp. 949-957
    • Kauffman, W.M.1    Sivit, C.J.2    Fitz, C.R.3    Rakusan, A.4    Herzog, K.5    Chandra, R.S.6
  • 70
    • 34447518917 scopus 로고    scopus 로고
    • Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection
    • Kenneson A, Cannon MJ, (2007). Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol 17: 253-276.
    • (2007) Rev Med Virol , vol.17 , pp. 253-276
    • Kenneson, A.1    Cannon, M.J.2
  • 71
    • 84874859809 scopus 로고    scopus 로고
    • Disease amelioration with tocilizumab in a treatment-resistant patient with neuromyelitis optica: Implication for cellular immune responses
    • Kieseier BC, Stuve O, Dehmel T, Goebels N, Leussink VI, Mausberg AK, et al. (2013). Disease amelioration with tocilizumab in a treatment-resistant patient with neuromyelitis optica: implication for cellular immune responses. JAMA Neurol 70: 390-393.
    • (2013) JAMA Neurol , vol.70 , pp. 390-393
    • Kieseier, B.C.1    Stuve, O.2    Dehmel, T.3    Goebels, N.4    Leussink, V.I.5    Mausberg, A.K.6
  • 72
    • 84881097754 scopus 로고    scopus 로고
    • Anti-interferon alpha treatment in SLE
    • Kirou KA, Gkrouzman E, (2013). Anti-interferon alpha treatment in SLE. Clin Immunol 148: 303-312.
    • (2013) Clin Immunol , vol.148 , pp. 303-312
    • Kirou, K.A.1    Gkrouzman, E.2
  • 73
    • 17644368573 scopus 로고    scopus 로고
    • Interleukin-6: from basic science to medicine - 40 years in immunology
    • Kishimoto T, (2005). Interleukin-6: from basic science to medicine-40 years in immunology. Annu Rev Immunol 23: 1-21.
    • (2005) Annu Rev Immunol , vol.23 , pp. 1-21
    • Kishimoto, T.1
  • 74
    • 0032881785 scopus 로고    scopus 로고
    • Measuring HIV-1 RNA and interferon-a in the cerebrospinal fluid of AIDS patients: Insights into the pathogenesis of AIDS Dementia Complex
    • Krivine A, Force G, Servan J, Cabee A-E, Rozenberg F, Dighiero L, et al. (1999). Measuring HIV-1 RNA and interferon-a in the cerebrospinal fluid of AIDS patients: insights into the pathogenesis of AIDS Dementia Complex. J Neurovirol 5: 500-506.
    • (1999) J Neurovirol , vol.5 , pp. 500-506
    • Krivine, A.1    Force, G.2    Servan, J.3    Cabee, A.-E.4    Rozenberg, F.5    Dighiero, L.6
  • 75
    • 84898656660 scopus 로고    scopus 로고
    • Treating neuromyelitis optica with the interleukin-6 receptor antagonist tocilizumab
    • Lauenstein AS, Stettner M, Kieseier BC, Lensch E, (2014). Treating neuromyelitis optica with the interleukin-6 receptor antagonist tocilizumab. BMJ Case Rep 2014. doi: 10.1136/bcr-2013-202939
    • (2014) BMJ Case Rep , vol.2014
    • Lauenstein, A.S.1    Stettner, M.2    Kieseier, B.C.3    Lensch, E.4
  • 76
    • 84904898296 scopus 로고    scopus 로고
    • Type I interferon blockade in systemic lupus erythematosus: Where do we stand?
    • Lauwerys BR, Ducreux J, Houssiau FA, (2014). Type I interferon blockade in systemic lupus erythematosus: where do we stand? Rheumatology (Oxford) 53: 1369-1376.
    • (2014) Rheumatology (Oxford) , vol.53 , pp. 1369-1376
    • Lauwerys, B.R.1    Ducreux, J.2    Houssiau, F.A.3
  • 77
    • 0023873028 scopus 로고
    • Intrathecal synthesis of interferon-alpha in infants with progressive familial encephalopathy
    • Lebon P, Badoual J, Ponsot G, Goutieres F, Hemeury-Cukier F, Aicardi J, (1988). Intrathecal synthesis of interferon-alpha in infants with progressive familial encephalopathy. J Neurol Sci 84: 201-208.
    • (1988) J Neurol Sci , vol.84 , pp. 201-208
    • Lebon, P.1    Badoual, J.2    Ponsot, G.3    Goutieres, F.4    Hemeury-Cukier, F.5    Aicardi, J.6
  • 80
    • 23944444890 scopus 로고    scopus 로고
    • IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
    • Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR, (2005). IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 202: 473-477.
    • (2005) J Exp Med , vol.202 , pp. 473-477
    • Lennon, V.A.1    Kryzer, T.J.2    Pittock, S.J.3    Verkman, A.S.4    Hinson, S.R.5
  • 81
    • 70349929184 scopus 로고    scopus 로고
    • Context-dependent IL-6 potentiation of interferon-gamma-induced IL-12 secretion and CD40 expression in murine microglia
    • Lin HW, Levison SW, (2009). Context-dependent IL-6 potentiation of interferon-gamma-induced IL-12 secretion and CD40 expression in murine microglia. J Neurochem 111: 808-818.
    • (2009) J Neurochem , vol.111 , pp. 808-818
    • Lin, H.W.1    Levison, S.W.2
  • 83
    • 84876426161 scopus 로고    scopus 로고
    • The ex vivo production of IL-6 and IL-21 by CD4+ T cells is directly associated with neurological disability in neuromyelitis optica patients
    • Linhares UC, Schiavoni PB, Barros PO, Kasahara TM, Teixeira B, Ferreira TB, et al. (2013). The ex vivo production of IL-6 and IL-21 by CD4+ T cells is directly associated with neurological disability in neuromyelitis optica patients. J Clin Immunol 33: 179-189.
    • (2013) J Clin Immunol , vol.33 , pp. 179-189
    • Linhares, U.C.1    Schiavoni, P.B.2    Barros, P.O.3    Kasahara, T.M.4    Teixeira, B.5    Ferreira, T.B.6
  • 84
    • 84912098781 scopus 로고    scopus 로고
    • The RNA-editing enzyme ADAR1 controls innate immune responses to RNA
    • Mannion NM, Greenwood SM, Young R, Cox S, Brindle J, Read D, et al. (2014). The RNA-editing enzyme ADAR1 controls innate immune responses to RNA. Cell Rep 9: 1482-1494.
    • (2014) Cell Rep , vol.9 , pp. 1482-1494
    • Mannion, N.M.1    Greenwood, S.M.2    Young, R.3    Cox, S.4    Brindle, J.5    Read, D.6
  • 85
    • 0031410622 scopus 로고    scopus 로고
    • Activation of gp130 by IL-6/soluble IL-6 receptor induces neuronal differentiation
    • Marz P, Herget T, Lang E, Otten U, Rose-John S, (1997). Activation of gp130 by IL-6/soluble IL-6 receptor induces neuronal differentiation. Eur J Neurosci 9: 2765-2773.
    • (1997) Eur J Neurosci , vol.9 , pp. 2765-2773
    • Marz, P.1    Herget, T.2    Lang, E.3    Otten, U.4    Rose-John, S.5
  • 86
    • 0345104338 scopus 로고    scopus 로고
    • Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression
    • Marz P, Heese K, Dimitriades-Schmutz B, Rose-John S, Otten U, (1999). Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression. Glia 26: 191-200.
    • (1999) Glia , vol.26 , pp. 191-200
    • Marz, P.1    Heese, K.2    Dimitriades-Schmutz, B.3    Rose-John, S.4    Otten, U.5
  • 87
    • 33751532617 scopus 로고    scopus 로고
    • Increased expression of the beta4 and alpha5 integrin subunits in cerebral blood vessels of transgenic mice chronically producing the pro-inflammatory cytokines IL-6 or IFN-alpha in the central nervous system
    • Milner R, Campbell IL, (2006). Increased expression of the beta4 and alpha5 integrin subunits in cerebral blood vessels of transgenic mice chronically producing the pro-inflammatory cytokines IL-6 or IFN-alpha in the central nervous system. Mol Cell Neurosci 33: 429-440.
    • (2006) Mol Cell Neurosci , vol.33 , pp. 429-440
    • Milner, R.1    Campbell, I.L.2
  • 88
    • 33750433582 scopus 로고    scopus 로고
    • HIV-1 encephalopathy among perinatally infected children: Neuropathogenesis and response to highly active antiretroviral therapy
    • Mitchell CD, (2006). HIV-1 encephalopathy among perinatally infected children: neuropathogenesis and response to highly active antiretroviral therapy. Ment Retard Dev Disabil Res Rev 12: 216-222.
    • (2006) Ment Retard Dev Disabil Res Rev , vol.12 , pp. 216-222
    • Mitchell, C.D.1
  • 89
    • 3242672339 scopus 로고    scopus 로고
    • Gene-targeted mice lacking the Trex1 (DNase III) 3′→5′ DNA exonuclease develop inflammatory myocarditis
    • Morita M, Stamp G, Robins P, Dulic A, Rosewell I, Hrivnak G, et al. (2004). Gene-targeted mice lacking the Trex1 (DNase III) 3′→5′ DNA exonuclease develop inflammatory myocarditis. Mol Cell Biol 24: 6719-6727.
    • (2004) Mol Cell Biol , vol.24 , pp. 6719-6727
    • Morita, M.1    Stamp, G.2    Robins, P.3    Dulic, A.4    Rosewell, I.5    Hrivnak, G.6
  • 90
    • 84863878702 scopus 로고    scopus 로고
    • Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6
    • Nelson TE, Olde Engberink A, Hernandez R, Puro A, Huitron-Resendiz S, Hao C, et al. (2012). Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6. Brain Behav Immun 26: 959-971.
    • (2012) Brain Behav Immun , vol.26 , pp. 959-971
    • Nelson, T.E.1    Olde Engberink, A.2    Hernandez, R.3    Puro, A.4    Huitron-Resendiz, S.5    Hao, C.6
  • 91
  • 93
    • 0042329609 scopus 로고    scopus 로고
    • The central role of dendritic cells and interferon-alpha in SLE
    • Pascual V, Banchereau J, Palucka AK, (2003). The central role of dendritic cells and interferon-alpha in SLE. Curr Opin Rheumatol 15: 548-556.
    • (2003) Curr Opin Rheumatol , vol.15 , pp. 548-556
    • Pascual, V.1    Banchereau, J.2    Palucka, A.K.3
  • 95
    • 84891791940 scopus 로고    scopus 로고
    • The IUPHAR/BPS Guide to PHARMACOLOGY: An expert-driven knowledge base of drug targets and their ligands
    • NC-IUPHAR
    • Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP, et al.; NC-IUPHAR (2014). The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledge base of drug targets and their ligands. Nucl Acids Res 42 (Database Issue): D1098-D1106.
    • (2014) Nucl Acids Res , vol.42 , Issue.DATABASE ISSUE , pp. D1098-D1106
    • Pawson, A.J.1    Sharman, J.L.2    Benson, H.E.3    Faccenda, E.4    Alexander, S.P.5    Buneman, O.P.6
  • 96
    • 0035074521 scopus 로고    scopus 로고
    • Transforming growth factor beta-1 and interferon-alpha in the AIDS dementia complex (ADC): Possible relationship with cerebral viral load?
    • Perrella O, Carreiri PB, Perrella A, Sbreglia C, Gorga F, Guarnaccia D, et al. (2001). Transforming growth factor beta-1 and interferon-alpha in the AIDS dementia complex (ADC): possible relationship with cerebral viral load? Eur Cytokine Netw 12: 51-55.
    • (2001) Eur Cytokine Netw , vol.12 , pp. 51-55
    • Perrella, O.1    Carreiri, P.B.2    Perrella, A.3    Sbreglia, C.4    Gorga, F.5    Guarnaccia, D.6
  • 97
    • 0344405659 scopus 로고    scopus 로고
    • CD4+ and CD8+ cells accumulate in the brains of acquired immunodeficiency syndrome patients with human immunodeficiency virus encephalitis
    • Petito CK, Adkins B, McCarthy M, Roberts B, Khamis I, (2003). CD4+ and CD8+ cells accumulate in the brains of acquired immunodeficiency syndrome patients with human immunodeficiency virus encephalitis. J Neurovirol 9: 36-44.
    • (2003) J Neurovirol , vol.9 , pp. 36-44
    • Petito, C.K.1    Adkins, B.2    McCarthy, M.3    Roberts, B.4    Khamis, I.5
  • 99
    • 68149148572 scopus 로고    scopus 로고
    • Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis
    • Quintana A, Muller M, Frausto RF, Ramos R, Getts DR, Sanz E, et al. (2009). Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis. J Immunol 183: 2079-2088.
    • (2009) J Immunol , vol.183 , pp. 2079-2088
    • Quintana, A.1    Muller, M.2    Frausto, R.F.3    Ramos, R.4    Getts, D.R.5    Sanz, E.6
  • 100
    • 0031439207 scopus 로고    scopus 로고
    • Modulation of hypothalamic-pituitary-adrenal function by transgenic expression of interleukin-6 in the CNS of mice
    • Raber J, O'Shea RD, Bloom FE, Campbell IL, (1997). Modulation of hypothalamic-pituitary-adrenal function by transgenic expression of interleukin-6 in the CNS of mice. J Neurosci 17: 9473-9480.
    • (1997) J Neurosci , vol.17 , pp. 9473-9480
    • Raber, J.1    O'Shea, R.D.2    Bloom, F.E.3    Campbell, I.L.4
  • 101
    • 84925481580 scopus 로고    scopus 로고
    • From physiology to disease and targeted therapy: Interleukin-6 in inflammation and inflammation-associated carcinogenesis
    • Rath T, Billmeier U, Waldner MJ, Atreya R, Neurath MF, (2015). From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis. Arch Toxicol 89: 541-554.
    • (2015) Arch Toxicol , vol.89 , pp. 541-554
    • Rath, T.1    Billmeier, U.2    Waldner, M.J.3    Atreya, R.4    Neurath, M.F.5
  • 102
    • 78650658122 scopus 로고    scopus 로고
    • Autosomal dominant inheritance of a heterozygous mutation in SAMHD1 causing familial chilblain lupus
    • Ravenscroft JC, Suri M, Rice GI, Szynkiewicz M, Crow YJ, (2011). Autosomal dominant inheritance of a heterozygous mutation in SAMHD1 causing familial chilblain lupus. Am J Med Genet A 155A: 235-237.
    • (2011) Am J Med Genet A , vol.155 A , pp. 235-237
    • Ravenscroft, J.C.1    Suri, M.2    Rice, G.I.3    Szynkiewicz, M.4    Crow, Y.J.5
  • 106
    • 67649861901 scopus 로고    scopus 로고
    • Mutations involved in Aicardi-Goutieres syndrome implicate SAMHD1 as regulator of the innate immune response
    • Rice GI, Bond J, Asipu A, Brunette RL, Manfield IW, Carr IM, et al. (2009). Mutations involved in Aicardi-Goutieres syndrome implicate SAMHD1 as regulator of the innate immune response. Nat Genet 41: 829-832.
    • (2009) Nat Genet , vol.41 , pp. 829-832
    • Rice, G.I.1    Bond, J.2    Asipu, A.3    Brunette, R.L.4    Manfield, I.W.5    Carr, I.M.6
  • 107
    • 84868207785 scopus 로고    scopus 로고
    • Mutations in ADAR1 cause Aicardi-Goutieres syndrome associated with a type I interferon signature
    • Rice GI, Kasher PR, Forte GM, Mannion NM, Greenwood SM, Szynkiewicz M, et al. (2012). Mutations in ADAR1 cause Aicardi-Goutieres syndrome associated with a type I interferon signature. Nat Genet 44: 1243-1248.
    • (2012) Nat Genet , vol.44 , pp. 1243-1248
    • Rice, G.I.1    Kasher, P.R.2    Forte, G.M.3    Mannion, N.M.4    Greenwood, S.M.5    Szynkiewicz, M.6
  • 108
    • 84899495767 scopus 로고    scopus 로고
    • Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling
    • Rice GI, Del Toro Duany Y, Jenkinson EM, Forte GM, Anderson BH, Ariaudo G, et al. (2014). Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling. Nat Genet 46: 503-509.
    • (2014) Nat Genet , vol.46 , pp. 503-509
    • Rice, G.I.1    Del Toro Duany, Y.2    Jenkinson, E.M.3    Forte, G.M.4    Anderson, B.H.5    Ariaudo, G.6
  • 109
    • 50249145876 scopus 로고    scopus 로고
    • Nucleic acid-mediated inflammatory diseases
    • Rigby RE, Leitch A, Jackson AP, (2008). Nucleic acid-mediated inflammatory diseases. Bioessays 30: 833-842.
    • (2008) Bioessays , vol.30 , pp. 833-842
    • Rigby, R.E.1    Leitch, A.2    Jackson, A.P.3
  • 110
    • 84867917889 scopus 로고    scopus 로고
    • Interleukin-6: from an inflammatory marker to a target for inflammatory diseases
    • Rincon M, (2012). Interleukin-6: from an inflammatory marker to a target for inflammatory diseases. Trends Immunol 33: 571-577.
    • (2012) Trends Immunol , vol.33 , pp. 571-577
    • Rincon, M.1
  • 111
    • 0025057503 scopus 로고
    • Possible induction of systemic lupus erythematosus by interferon-alpha treatment in a patient with a malignant carcinoid tumour
    • Ronnblom LE, Alm GV, Oberg KE, (1990). Possible induction of systemic lupus erythematosus by interferon-alpha treatment in a patient with a malignant carcinoid tumour. J Intern Med 227: 207-210.
    • (1990) J Intern Med , vol.227 , pp. 207-210
    • Ronnblom, L.E.1    Alm, G.V.2    Oberg, K.E.3
  • 112
    • 0028226196 scopus 로고
    • Soluble receptors for cytokines and growth factors: Generation and biological function
    • Rose-John S, Heinrich PC, (1994). Soluble receptors for cytokines and growth factors: generation and biological function. Biochem J 300 (Pt 2): 281-290.
    • (1994) Biochem J , vol.300 , pp. 281-290
    • Rose-John, S.1    Heinrich, P.C.2
  • 113
    • 33748848714 scopus 로고    scopus 로고
    • Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: Role in inflammation and cancer
    • Rose-John S, Scheller J, Elson G, Jones SA, (2006). Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J Leukoc Biol 80: 227-236.
    • (2006) J Leukoc Biol , vol.80 , pp. 227-236
    • Rose-John, S.1    Scheller, J.2    Elson, G.3    Jones, S.A.4
  • 115
    • 0028869476 scopus 로고
    • Cytokines and the nervous system II: Actions and mechanisms of action
    • Rothwell NJ, Hopkins SJ, (1995). Cytokines and the nervous system II: actions and mechanisms of action. Trends Neurosci 18: 130-136.
    • (1995) Trends Neurosci , vol.18 , pp. 130-136
    • Rothwell, N.J.1    Hopkins, S.J.2
  • 116
    • 0036516741 scopus 로고    scopus 로고
    • Macrophages, chemokines and neuronal injury in HIV-1-associated dementia
    • Ryan LA, Cotter RL, Zink WE 2nd, Gendelman HE, Zheng J, (2002). Macrophages, chemokines and neuronal injury in HIV-1-associated dementia. Cell Mol Biol 48: 137-150.
    • (2002) Cell Mol Biol , vol.48 , pp. 137-150
    • Ryan, L.A.1    Cotter, R.L.2    Zink, W.E.3    Gendelman, H.E.4    Zheng, J.5
  • 117
    • 0037168516 scopus 로고    scopus 로고
    • Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts
    • Rydberg B, Game J, (2002). Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts. Proc Natl Acad Sci U S A 99: 16654-16659.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 16654-16659
    • Rydberg, B.1    Game, J.2
  • 119
    • 0037829339 scopus 로고    scopus 로고
    • Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6
    • Samland H, Huitron-Resendiz S, Masliah E, Criado J, Henriksen SJ, Campbell IL, (2003). Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6. J Neurosci Res 73: 176-187.
    • (2003) J Neurosci Res , vol.73 , pp. 176-187
    • Samland, H.1    Huitron-Resendiz, S.2    Masliah, E.3    Criado, J.4    Henriksen, S.J.5    Campbell, I.L.6
  • 120
    • 37349009752 scopus 로고    scopus 로고
    • Minimal role for STAT1 in interleukin-6 signaling and actions in the murine brain
    • Sanz E, Hofer MJ, Unzeta M, Campbell IL, (2007). Minimal role for STAT1 in interleukin-6 signaling and actions in the murine brain. Glia 56: 190-199.
    • (2007) Glia , vol.56 , pp. 190-199
    • Sanz, E.1    Hofer, M.J.2    Unzeta, M.3    Campbell, I.L.4
  • 121
    • 84896488117 scopus 로고    scopus 로고
    • Interleukin-6: from basic biology to selective blockade of pro-inflammatory activities
    • Scheller J, Garbers C, Rose-John S, (2014). Interleukin-6: from basic biology to selective blockade of pro-inflammatory activities. Semin Immunol 26: 2-12.
    • (2014) Semin Immunol , vol.26 , pp. 2-12
    • Scheller, J.1    Garbers, C.2    Rose-John, S.3
  • 122
    • 77956113383 scopus 로고    scopus 로고
    • Type I interferon modulates the battle of host immune system against viruses
    • Seo YJ, Hahm B, (2010). Type I interferon modulates the battle of host immune system against viruses. Adv Appl Microbiol 73: 83-101.
    • (2010) Adv Appl Microbiol , vol.73 , pp. 83-101
    • Seo, Y.J.1    Hahm, B.2
  • 123
    • 78751615954 scopus 로고    scopus 로고
    • Congenital and perinatal infections: Throwing new light with an old TORCH
    • Shet A, (2011). Congenital and perinatal infections: throwing new light with an old TORCH. Indian J Pediatr 78: 88-95.
    • (2011) Indian J Pediatr , vol.78 , pp. 88-95
    • Shet, A.1
  • 125
    • 13844292408 scopus 로고    scopus 로고
    • Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus
    • Sigurdsson S, Nordmark G, Goring HH, Lindroos K, Wiman AC, Sturfelt G, et al. (2005). Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am J Hum Genet 76: 528-537.
    • (2005) Am J Hum Genet , vol.76 , pp. 528-537
    • Sigurdsson, S.1    Nordmark, G.2    Goring, H.H.3    Lindroos, K.4    Wiman, A.C.5    Sturfelt, G.6
  • 128
    • 0028298627 scopus 로고
    • Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice
    • Steffensen SC, Campbell IL, Henriksen SJ, (1994). Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice. Brain Res 652: 149-153.
    • (1994) Brain Res , vol.652 , pp. 149-153
    • Steffensen, S.C.1    Campbell, I.L.2    Henriksen, S.J.3
  • 129
    • 55849122679 scopus 로고    scopus 로고
    • Nuanced roles of cytokines in three major human brain disorders
    • Steinman L, (2008). Nuanced roles of cytokines in three major human brain disorders. J Clin Invest 118: 3557-3563.
    • (2008) J Clin Invest , vol.118 , pp. 3557-3563
    • Steinman, L.1
  • 130
    • 48549085675 scopus 로고    scopus 로고
    • Aicardi-Goutieres syndrome (AGS)
    • Stephenson JB, (2008). Aicardi-Goutieres syndrome (AGS). Eur J Paediatr Neurol 12: 355-358.
    • (2008) Eur J Paediatr Neurol , vol.12 , pp. 355-358
    • Stephenson, J.B.1
  • 131
    • 49549100511 scopus 로고    scopus 로고
    • Trex1 prevents cell-intrinsic initiation of autoimmunity
    • Stetson DB, Ko JS, Heidmann T, Medzhitov R, (2008). Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 134: 587-598.
    • (2008) Cell , vol.134 , pp. 587-598
    • Stetson, D.B.1    Ko, J.S.2    Heidmann, T.3    Medzhitov, R.4
  • 133
    • 77954982900 scopus 로고    scopus 로고
    • Astrocytic damage is far more severe than demyelination in NMO: A clinical CSF biomarker study
    • Takano R, Misu T, Takahashi T, Sato S, Fujihara K, Itoyama Y, (2010). Astrocytic damage is far more severe than demyelination in NMO: a clinical CSF biomarker study. Neurology 75: 208-216.
    • (2010) Neurology , vol.75 , pp. 208-216
    • Takano, R.1    Misu, T.2    Takahashi, T.3    Sato, S.4    Fujihara, K.5    Itoyama, Y.6
  • 134
    • 84869755800 scopus 로고    scopus 로고
    • Targeting interleukin-6: All the way to treat autoimmune and inflammatory diseases
    • Tanaka T, Kishimoto T, (2012). Targeting interleukin-6: all the way to treat autoimmune and inflammatory diseases. Int J Biol Sci 8: 1227-1236.
    • (2012) Int J Biol Sci , vol.8 , pp. 1227-1236
    • Tanaka, T.1    Kishimoto, T.2
  • 135
    • 80051983083 scopus 로고    scopus 로고
    • Structural linkage between ligand discrimination and receptor activation by type I interferons
    • Thomas C, Moraga I, Levin D, Krutzik PO, Podoplelova Y, Trejo A, et al. (2011). Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell 146: 621-632.
    • (2011) Cell , vol.146 , pp. 621-632
    • Thomas, C.1    Moraga, I.2    Levin, D.3    Krutzik, P.O.4    Podoplelova, Y.5    Trejo, A.6
  • 137
    • 78650092261 scopus 로고    scopus 로고
    • Cytokine and chemokine profiles in neuromyelitis optica: Significance of interleukin-6
    • Uzawa A, Mori M, Arai K, Sato Y, Hayakawa S, Masuda S, et al. (2010). Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6. Mult Scler 16: 1443-1452.
    • (2010) Mult Scler , vol.16 , pp. 1443-1452
    • Uzawa, A.1    Mori, M.2    Arai, K.3    Sato, Y.4    Hayakawa, S.5    Masuda, S.6
  • 138
    • 84876319240 scopus 로고    scopus 로고
    • Cerebrospinal fluid interleukin-6 and glial fibrillary acidic protein levels are increased during initial neuromyelitis optica attacks
    • Uzawa A, Mori M, Sawai S, Masuda S, Muto M, Uchida T, et al. (2013). Cerebrospinal fluid interleukin-6 and glial fibrillary acidic protein levels are increased during initial neuromyelitis optica attacks. Clin Chim Acta 421: 181-183.
    • (2013) Clin Chim Acta , vol.421 , pp. 181-183
    • Uzawa, A.1    Mori, M.2    Sawai, S.3    Masuda, S.4    Muto, M.5    Uchida, T.6
  • 139
    • 84890759137 scopus 로고    scopus 로고
    • Cytokines and chemokines in neuromyelitis optica: Pathogenetic and therapeutic implications
    • Uzawa A, Masahiro M, Kuwabara S, (2014a). Cytokines and chemokines in neuromyelitis optica: pathogenetic and therapeutic implications. Brain Pathol 24: 67-73.
    • (2014) Brain Pathol , vol.24 , pp. 67-73
    • Uzawa, A.1    Masahiro, M.2    Kuwabara, S.3
  • 140
    • 84890565442 scopus 로고    scopus 로고
    • Neuromyelitis optica: Concept, immunology and treatment
    • Uzawa A, Mori M, Kuwabara S, (2014b). Neuromyelitis optica: concept, immunology and treatment. J Clin Neurosci 21: 12-21.
    • (2014) J Clin Neurosci , vol.21 , pp. 12-21
    • Uzawa, A.1    Mori, M.2    Kuwabara, S.3
  • 142
    • 0037079993 scopus 로고    scopus 로고
    • Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6
    • Vallieres L, Campbell IL, Gage FH, Sawchenko PE, (2002). Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. J Neurosci 22: 486-492.
    • (2002) J Neurosci , vol.22 , pp. 486-492
    • Vallieres, L.1    Campbell, I.L.2    Gage, F.H.3    Sawchenko, P.E.4
  • 143
    • 0033168292 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) production by astrocytes: Autocrine regulation by IL-6 and the soluble IL-6 receptor
    • Van Wagoner NJ, Oh JW, Repovic P, Benveniste EN, (1999). Interleukin-6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor. J Neurosci 19: 5236-5244.
    • (1999) J Neurosci , vol.19 , pp. 5236-5244
    • Van Wagoner, N.J.1    Oh, J.W.2    Repovic, P.3    Benveniste, E.N.4
  • 144
    • 1042289736 scopus 로고    scopus 로고
    • Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene
    • Wang Q, Miyakoda M, Yang W, Khillan J, Stachura DL, Weiss MJ, et al. (2004). Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene. J Biol Chem 279: 4952-4961.
    • (2004) J Biol Chem , vol.279 , pp. 4952-4961
    • Wang, Q.1    Miyakoda, M.2    Yang, W.3    Khillan, J.4    Stachura, D.L.5    Weiss, M.J.6
  • 145
    • 84861670735 scopus 로고    scopus 로고
    • The interferons and their receptors - distribution and regulation
    • de Weerd NA, Nguyen T, (2012). The interferons and their receptors-distribution and regulation. Immunol Cell Biol 90: 483-491.
    • (2012) Immunol Cell Biol , vol.90 , pp. 483-491
    • De Weerd, N.A.1    Nguyen, T.2
  • 146
    • 80455164552 scopus 로고    scopus 로고
    • Competition between ADAR and RNAi pathways for an extensive class of RNA targets
    • Wu D, Lamm AT, Fire AZ, (2011). Competition between ADAR and RNAi pathways for an extensive class of RNA targets. Nat Struct Mol Biol 18: 1094-1101.
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 1094-1101
    • Wu, D.1    Lamm, A.T.2    Fire, A.Z.3
  • 147
    • 84862801311 scopus 로고    scopus 로고
    • IRF7, a functional factor associates with systemic lupus erythematosus
    • Xu WD, Zhang YJ, Xu K, Zhai Y, Li BZ, Pan HF, et al. (2012). IRF7, a functional factor associates with systemic lupus erythematosus. Cytokine 58: 317-320.
    • (2012) Cytokine , vol.58 , pp. 317-320
    • Xu, W.D.1    Zhang, Y.J.2    Xu, K.3    Zhai, Y.4    Li, B.Z.5    Pan, H.F.6
  • 148
    • 13544275929 scopus 로고    scopus 로고
    • ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells
    • Yang W, Wang Q, Howell KL, Lee JT, Cho DS, Murray JM, et al. (2005). ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells. J Biol Chem 280: 3946-3953.
    • (2005) J Biol Chem , vol.280 , pp. 3946-3953
    • Yang, W.1    Wang, Q.2    Howell, K.L.3    Lee, J.T.4    Cho, D.S.5    Murray, J.M.6
  • 149
    • 36248988008 scopus 로고    scopus 로고
    • Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
    • Yang YG, Lindahl T, Barnes DE, (2007). Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 131: 873-886.
    • (2007) Cell , vol.131 , pp. 873-886
    • Yang, Y.G.1    Lindahl, T.2    Barnes, D.E.3
  • 150
    • 84922880395 scopus 로고    scopus 로고
    • Human intracellular ISG15 prevents interferon-alpha/beta over-amplification and auto-inflammation
    • Zhang X, Bogunovic D, Payelle-Brogard B, Francois-Newton V, Speer SD, Yuan C, et al. (2014a). Human intracellular ISG15 prevents interferon-alpha/beta over-amplification and auto-inflammation. Nature 517: 89-93.
    • (2014) Nature , vol.517 , pp. 89-93
    • Zhang, X.1    Bogunovic, D.2    Payelle-Brogard, B.3    Francois-Newton, V.4    Speer, S.D.5    Yuan, C.6
  • 151
    • 84906901689 scopus 로고    scopus 로고
    • An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex
    • Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O'Keeffe S, et al. (2014b). An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci 34: 11929-11947.
    • (2014) J Neurosci , vol.34 , pp. 11929-11947
    • Zhang, Y.1    Chen, K.2    Sloan, S.A.3    Bennett, M.L.4    Scholze, A.R.5    O'Keeffe, S.6
  • 152
    • 0035174095 scopus 로고    scopus 로고
    • HIV-1 infected immune competent mononuclear phagocytes influence the pathways to neuronal demise
    • Zheng J, Thylin MR, Persidsky Y, Williams CE, Cotter RL, Zink W, et al. (2001). HIV-1 infected immune competent mononuclear phagocytes influence the pathways to neuronal demise. Neurotox Res 3: 461-484.
    • (2001) Neurotox Res , vol.3 , pp. 461-484
    • Zheng, J.1    Thylin, M.R.2    Persidsky, Y.3    Williams, C.E.4    Cotter, R.L.5    Zink, W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.