Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling

Journal of Autoimmunity

Volumn 67, Issue , 2016, Pages 46-56

  Limbach, Maia ^a   Saare, Mario ^a   Tserel, Liina ^a   Kisand, Kai ^a   Eglit, Triin ^b,c   Sauer, Sascha ^d   Axelsson, Tomas ^e   Syvänen, Ann Christine ^e   Metspalu, Andres ^f   Milani, Lili ^f   Peterson, Pärt ^a  

^a Institute of Biomedical and Translational Medicine   (Estonia)

^b UNIVERSITY OF TARTU   (Estonia)

^c TARTU UNIVERSITY HOSPITAL   (Estonia)

^d MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^e UPPSALA UNIVERSITY   (Sweden)

^f UNIVERSITY OF TARTU   (Estonia)

Author keywords

DNA methylation; Epigenetics; Graves' disease; T cell signaling; TSHR

Indexed keywords

CD247 PROTEIN; CD3 ANTIGEN; CD3D PROTEIN; CD3E PROTEIN; CD3G PROTEIN; CD8ALPHA ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DNA; HISTONE H3; HLA DRB1 ANTIGEN; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; T LYMPHOCYTE RECEPTOR; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1; UNCLASSIFIED DRUG; CHROMATIN; HISTONE; LYMPHOCYTE ANTIGEN RECEPTOR; THYROTROPIN RECEPTOR;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; ENHANCER REGION; EPIGENETICS; GENE EXPRESSION PROFILING; GENE ONTOLOGY; GENETIC ASSOCIATION; GRAVES DISEASE; HISTONE METHYLATION; HUMAN; HUMAN CELL; IMMUNOGENETICS; MULTIGENE FAMILY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; TRANSCRIPTION INITIATION SITE; BIOLOGY; CASE CONTROL STUDY; CHROMATIN; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGY; METABOLISM; PROCEDURES;

CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHROMATIN; COMPUTATIONAL BIOLOGY; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; EPIGENOMICS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE ONTOLOGY; GRAVES DISEASE; HISTONES; HUMANS; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, THYROTROPIN; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS;

EID: 84957434897     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2015.09.006     Document Type: Article

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