Twins as a tool for evaluating the influence of genetic susceptibility in thyroid autoimmunity;Les jumeaux: un outil d'évaluation de l'influence de la susceptibilité génétique à l'auto-immunité antithyroïdienne

Annales d'Endocrinologie

Volumn 72, Issue 2, 2011, Pages 103-107

  Brix, T H ^a   Hegedus L ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Autoimmune thyroid disease; Epigenetic; Twins; X chromosome inactivation

Indexed keywords

AUTOANTIBODY; THYROGLOBULIN ANTIBODY; THYROID PEROXIDASE ANTIBODY;

ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CASE CONTROL STUDY; CHROMOSOME INACTIVATION; DIZYGOTIC TWINS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; EPIGENETICS; EUTHYROIDISM; GENE FUNCTION; GENE INTERACTION; GENE LOCATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GRAVES DISEASE; HASHIMOTO DISEASE; HEREDITY; HERITABILITY; HUMAN; MONOZYGOTIC TWINS; PHENOTYPE; THYROID DISEASE;

AUTOIMMUNITY; DISEASES IN TWINS; EPIGENOMICS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; SEX FACTORS; THYROIDITIS, AUTOIMMUNE; TWINS; X CHROMOSOME INACTIVATION;

EID: 79955713602     PISSN: 00034266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ando.2011.03.013     Document Type: Article

References (29)

1. Vanderpump M.P.J., Tunbridge W.M.G., French J.M., Appleton D., Bates D., Clark F., et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham survey. Clin Endocrinol 1995, 43:55-68.
2. Knudsen N., Jørgensen T., Rasmussen S., Christiansen E., Perrild H. The prevalence of thyroid dysfunction in a population with borderline iodine deficiency. Clin Endocrinol 1999, 51:361-367.
3. Tomer Y., Davies T.F. Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene function. Endocr Rev 2003, 24:694-717.
4. Taylor J.C., Gough S.C., Hunt P.J., Brix T.H., Chatterjee K., Connell J.M., et al. A genome-wide screen in 1119 relative pairs with autoimmune thyroid disease. J Clin Endocrinol Metab 2006, 91:646-653.
5. Weetman A.P. Graves' disease. N Engl J Med 2000, 343:1236-1248.
6. Prummel M.F., Strieder T.G.A., Wiersinga W.M. The environment and autoimmune thyroid diseases. Eur J Endocrinol 2004, 150:605-618.
7. Brix T.H., Hegedus L. Environmental factors in the pathogenesis of Graves' disease. Thyroid eye disease, diagnosis and treatment 2002, 127-138. Marcel Dekker, New York. J.J. Dutton, B.G. Haik (Eds.).
8. MacGregor A.J., Snieder H., Schork N.J., Spector T.D. Twins. Novel uses to study complex traits and genetic diseases. Trends Genet 2000, 16:131-134.
9. Martin N., Boomsma D., Machin G. A twin-pronged attack on complex traits. Nat Genet 1997, 17:387-392.
10. Kyvik K.O. Nature versus nurture in common diseases. Genetics of common diseases: future therapeutic and diagnostic possibilities 1997, 19-32. BIOS Scientific Publishers Ltd, Oxford. 1st ed. I.N.M. Day, S.E. Humphries (Eds.).
11. Rijsdijk F.J., Sham P.C. Analytic approaches to twin data using structural equation models. Briefings in Bioinformatics 2002, 3:119-133.
12. Bryan E.M. The role of twins in epidemiological studies. Paediatr Perinat Epidemiol 1992, 6:460-464.
13. Phillips D.I.W. Twin studies in medical research: can they tell us whether diseases are genetically determined?. Lancet 1993, 341:1008-1009.
14. Hrubec Z., Robinette C.D. The study of human twins in medical research. N Engl J Med 1984, 310:435-441.
15. Brix T.H., Christensen K., Holm N.V., Harvald B., Hegedüs L. A population based study of Graves' disease in Danish twins. Clin Endocrinol 1998, 48:397-400.
16. Brix T.H., Kyvik K.O., Christensen K., Hegedüs L. Evidence for a major role of heredity in Graves' disease - a population based study of two Danish twin cohorts. J Clin Endocrinol Metab 2001, 86:930-934.
17. Ringold D.A., Nicoloff J.T., Kesler M., Davis H., Hamilton A., Mack T. Further evidence for a strong genetic influence on the development of autoimmune thyroid disease: the California Twin Study. Thyroid 2002, 12:647-653.
18. Brix T.H., Kyvik K.O., Hegedüs L. A population based study of chronic autoimmune hypothyroidism in Danish twins. J Clin Endocrinol Metab 2000, 85:536-539.
19. Phillips D.I., Osmond C., Baird J., Huckle A., Rees-Smith B. Is birthweight associated with thyroid autoimmunity? A study in twins. Thyroid 2002, 12:377-380.
20. Hansen P.S., Brix T.H., Iachine I.A., Kyvik K.O., Hegedüs L. The relative importance of genetic and environmental effects for the early stages of thyroid autoimmunity. A study of healthy Danish twins. Eur J Endocrinol 2006, 154:29-38.
21. Brix T.H., Heged X., Gardas A., Banga J.P., Nielsen C.H. Monozygotic twin pairs discordant for Hashimoto's thyroiditis share a high proportion of thyroid peroxidase autoantibodies to the immunodominant region A. Further evidence for genetic transmission of epitopic "fingerprints" Autoimmunity 2010, [Epub ahead of print]. 10.3109/08916934.2010.518575.
22. Wang C., Crapo L.M. The epidemiology of thyroid disease and implications for screening. Endocrinol Metab Clin N Am 1997, 26:189-218.
23. Brix T.H., Hansen P.S., Kyvik K.O., Hegedüs L. Cigarette smoking and risk of clinically overt thyroid disease: a population based twin case-control study. Arch Intern Med 2000, 160:661-666.
24. Brix T.H., Kyvik K.O., Hegedüs L. Low birth weight is not associated with clinically overt thyroid disease: a population based twin case-control study. Clin Endocrinol 2000, 53:171-176.
25. Brix T.H., Hansen P.S., Rudbeck A.B., Hansen J.B., Skytthe A., Kyvik K.O., et al. Low birth weight is not associated with thyroid autoimmunity. A population based twin study. J Clin Endocrinol Metab 2006, 91:3499-3502.
26. Hansen P.S., Wenzel B.E., Brix T.H., Hegedüs L. Yersinia enterocolitica infection does not confer an increased risk of thyroid antibodies: evidence from a Danish Twin Study. Clin Exp Immunol 2006, 146:32-38.
27. Brix T.H., Hansen P.S., Hegedüs L., Wenzel B.E. Too early to dismiss Yersinia enterocolitica infection in the aetiology of Graves' disease: evidence from a twin case-control study. Clin Endocrinol 2008, 69:491-496.
28. Brix T.H., Knudsen G.P., Kristiansen M., Kyvik K.O., Ørstavik K.H., Hegedüs L. High frequency of skewed X chromosome inactivation in females with autoimmune thyroid disease: a possible explanation for the female predisposition to thyroid autoimmunity. J Clin Endocrinol Metab 2005, 90:5949-5953.
29. Brix T.H., Hansen P.S., Kyvik K.O., Hegedus L. Preliminary evidence of a noncausal association between the X-chromosome inactivation pattern and thyroid autoimmunity: a twin study. Eur J Hum Genet 2010, 18:254-257.