Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

Molecular Cell

Volumn 61, Issue 3, 2016, Pages 449-460

  Zimmer, Jutta ^a   Tacconi, Eliana M C ^a   Folio, Cecilia ^a   Badie, Sophie ^a   Porru, Manuela ^b   Klare, Kerstin ^a,g   Tumiati, Manuela ^c   Markkanen, Enni ^a,h   Halder, Swagata ^a   Ryan, Anderson ^a   Jackson, Stephen P ^d,e   Ramadan, Kristijan ^a   Kuznetsov, Sergey G ^c   Biroccio, Annamaria ^b   Sale, Julian E ^f   Tarsounas, Madalena ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c UNIVERSITY OF HELSINKI   (Finland)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^f MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^g MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^h UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BRCA1 PROTEIN; BRCA2 PROTEIN; GUANINE QUADRUPLEX; HISTONE H2AX; OLAPARIB; PROTEIN; PROTEIN 53BP1; PROTEIN REV7; PYRIDOSTATIN; RAD51 PROTEIN; REPLICATION FACTOR A; RHPS 4; UNCLASSIFIED DRUG; AMINOQUINOLINE DERIVATIVE; BRCA1 PROTEIN, HUMAN; BRCA2 PROTEIN, HUMAN; MAD2L2 PROTEIN, HUMAN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PICOLINIC ACID DERIVATIVE; PROTEIN MAD2; SIGNAL PEPTIDE; TP53BP1 PROTEIN, HUMAN; TUMOR MARKER; TUMOR SUPPRESSOR P53 BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL VIABILITY; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; DRUG SENSITIVITY; DRUG SENSITIZATION; EMBRYO; G2 PHASE CELL CYCLE CHECKPOINT; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; TELOMERE; ANIMAL; CELL PROLIFERATION; DEFICIENCY; DOSE RESPONSE; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; MALE; METABOLISM; MOLECULARLY TARGETED THERAPY; NEOPLASMS; NUDE MOUSE; PATHOLOGY; RNA INTERFERENCE; TIME FACTOR; TUMOR VOLUME;

AMINOQUINOLINES; ANIMALS; ANTINEOPLASTIC AGENTS; BIOMARKERS, TUMOR; BRCA1 PROTEIN; BRCA2 PROTEIN; CELL PROLIFERATION; DNA BREAKS, DOUBLE-STRANDED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; G-QUADRUPLEXES; G2 PHASE CELL CYCLE CHECKPOINTS; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAD2 PROTEINS; MALE; MICE, NUDE; MOLECULAR TARGETED THERAPY; NEOPLASMS; PICOLINIC ACIDS; POLY(ADP-RIBOSE) POLYMERASE INHIBITORS; RNA INTERFERENCE; TELOMERE; TIME FACTORS; TRANSFECTION; TUMOR BURDEN; TUMOR SUPPRESSOR P53-BINDING PROTEIN 1; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84957429074     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.12.004     Document Type: Article

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