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Volumn 20, Issue 3, 2014, Pages 540-547

Molecular pathways: How can BRCA-mutated tumors become resistant to PARP inhibitors?

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENTS; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; FEMALE; HUMANS; OVARIAN NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES;

EID: 84893517261     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-0225     Document Type: Article
Times cited : (133)

References (66)
  • 1
    • 84866358168 scopus 로고    scopus 로고
    • The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance
    • Bouwman P, Jonkers J. The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance. Nat Rev Cancer 2012;12:587-98.
    • (2012) Nat Rev Cancer , vol.12 , pp. 587-598
    • Bouwman, P.1    Jonkers, J.2
  • 2
    • 79959733228 scopus 로고    scopus 로고
    • An aCGHclassifier derived fromBRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients
    • Vollebergh MA, Lips EH, Nederlof PM, Wessels LFA, Schmidt MK, van Beers EH, et al. An aCGHclassifier derived fromBRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients. Ann Oncol 2011;22:1561-70.
    • (2011) Ann Oncol , vol.22 , pp. 1561-1570
    • Vollebergh, M.A.1    Lips, E.H.2    Nederlof, P.M.3    Wessels, L.F.A.4    Schmidt, M.K.5    Van Beers, E.H.6
  • 3
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009;361:123-34.
    • (2009) N Engl J Med , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3    Tutt, A.4    Wu, P.5    Mergui-Roelvink, M.6
  • 4
    • 84880777712 scopus 로고    scopus 로고
    • The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: A phase 1 dose-escalation trial
    • Sandhu SK, Schelman WR, Wilding G, Moreno V, Baird RD, Miranda S, et al. The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial. Lancet Oncol 2013;14:882-92.
    • (2013) Lancet Oncol , vol.14 , pp. 882-892
    • Sandhu, S.K.1    Schelman, W.R.2    Wilding, G.3    Moreno, V.4    Baird, R.D.5    Miranda, S.6
  • 5
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
    • Tutt A, Robson M, Garber JE, Domchek SM, Audeh MW, Weitzel JN, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet 2010;376:235-44.
    • (2010) Lancet , vol.376 , pp. 235-244
    • Tutt, A.1    Robson, M.2    Garber, J.E.3    Domchek, S.M.4    Audeh, M.W.5    Weitzel, J.N.6
  • 6
    • 77955039099 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
    • Audeh MW, Carmichael J, Penson RT, Friedlander M, Powell B, Bell- McGuinn KM, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet 2010;376:245-51.
    • (2010) Lancet , vol.376 , pp. 245-251
    • Audeh, M.W.1    Carmichael, J.2    Penson, R.T.3    Friedlander, M.4    Powell, B.5    Bell- McGuinn, K.M.6
  • 7
    • 80052389761 scopus 로고    scopus 로고
    • Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: A phase 2, multicentre, open-label, non-randomised study
    • Gelmon KA, Tischkowitz M, Mackay H, Swenerton K, Robidoux A, Tonkin K, et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. Lancet Oncol 2011;12:852-61.
    • (2011) Lancet Oncol , vol.12 , pp. 852-861
    • Gelmon, K.A.1    Tischkowitz, M.2    Mackay, H.3    Swenerton, K.4    Robidoux, A.5    Tonkin, K.6
  • 9
    • 84862758175 scopus 로고    scopus 로고
    • New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs
    • Gibson BA, Kraus WL. New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. Nat Rev Mol Cell Biol 2012;13:411-24.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 411-424
    • Gibson, B.A.1    Kraus, W.L.2
  • 11
    • 0038219534 scopus 로고    scopus 로고
    • Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse
    • Ménissier de Murcia J, Ricoul M, Tartier L, Niedergang C, Huber A, Dantzer F, et al. Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse. EMBO J 2003;22:2255-63.
    • (2003) EMBO J , vol.22 , pp. 2255-2263
    • Ménissier De Murcia, J.1    Ricoul, M.2    Tartier, L.3    Niedergang, C.4    Huber, A.5    Dantzer, F.6
  • 12
    • 66049143898 scopus 로고    scopus 로고
    • Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination
    • Robert I, Dantzer F, Reina-San-Martin B. Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination. J Exp Med 2009;206: 1047-56.
    • (2009) J Exp Med , vol.206 , pp. 1047-1056
    • Robert, I.1    Dantzer, F.2    Reina-San-Martin, B.3
  • 13
    • 79955588797 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate
    • Ström CE, Johansson F, Uhlén M, Szigyarto CA-K, Erixon K, Helleday T. Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate. Nucleic Acids Res 2011;39:3166-75.
    • (2011) Nucleic Acids Res , vol.39 , pp. 3166-3175
    • Ström, C.E.1    Johansson, F.2    Uhlén, M.3    Ca-K, S.4    Erixon, K.5    Helleday, T.6
  • 14
    • 33845657443 scopus 로고    scopus 로고
    • PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
    • Wang M, Wu W, Wu W, Rosidi B, Zhang L, Wang H, et al. PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res 2006;34:6170-82.
    • (2006) Nucleic Acids Res , vol.34 , pp. 6170-6182
    • Wang, M.1    Wu, W.2    Wu, W.3    Rosidi, B.4    Zhang, L.5    Wang, H.6
  • 15
    • 79952747328 scopus 로고    scopus 로고
    • Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality inhomologous recombination-deficient cells
    • Patel AG, Sarkaria JN, Kaufmann SH. Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality inhomologous recombination-deficient cells. Proc Natl Acad Sci U S A 2011;108:3406-11.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3406-3411
    • Patel, A.G.1    Sarkaria, J.N.2    Kaufmann, S.H.3
  • 16
    • 78049446968 scopus 로고    scopus 로고
    • The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies
    • Mansour WY, Rhein T, Dahm-Daphi J. The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies. Nucleic Acids Res 2010;38: 6065-77.
    • (2010) Nucleic Acids Res , vol.38 , pp. 6065-6077
    • Mansour, W.Y.1    Rhein, T.2    Dahm-Daphi, J.3
  • 17
    • 0344875495 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination
    • Schultz N, Lopez E, Saleh-Gohari N, Helleday T. Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids Res 2003;31:4959-64.
    • (2003) Nucleic Acids Res , vol.31 , pp. 4959-4964
    • Schultz, N.1    Lopez, E.2    Saleh-Gohari, N.3    Helleday, T.4
  • 18
    • 34547225606 scopus 로고    scopus 로고
    • Poly(ADPribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase
    • Fisher AEO, Hochegger H, Takeda S, Caldecott KW. Poly(ADPribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase. Mol Cell Biol 2007;27:5597-605.
    • (2007) Mol Cell Biol , vol.27 , pp. 5597-5605
    • Fisher, A.E.O.1    Hochegger, H.2    Takeda, S.3    Caldecott, K.W.4
  • 19
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP-ribose) polymerase
    • Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP-ribose) polymerase. Nature 2005;434:913-7.
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3    Parker, K.M.4    Flower, D.5    Lopez, E.6
  • 21
    • 55949092708 scopus 로고    scopus 로고
    • High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
    • Rottenberg S, Jaspers JE, Kersbergen A, van der Burg E, Nygren AOH, Zander SAL, et al. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci U S A 2008;105:17079-84.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 17079-17084
    • Rottenberg, S.1    Jaspers, J.E.2    Kersbergen, A.3    Van Der Burg, E.4    Nygren, A.O.H.5    Zander, S.A.L.6
  • 22
    • 84870855799 scopus 로고    scopus 로고
    • Tankyrase-targeted therapeutics: Expanding opportunities in the PARP family
    • Riffell JL, Lord CJ, Ashworth A. Tankyrase-targeted therapeutics: expanding opportunities in the PARP family. Nat Rev Drug Discov 2012;11:923-36.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 923-936
    • Riffell, J.L.1    Lord, C.J.2    Ashworth, A.3
  • 24
    • 84884576079 scopus 로고    scopus 로고
    • BMN673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency
    • Shen Y, Rehman FL, Feng Y, Boshuizen J, Bajrami I, Elliott R, et al. BMN673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency. Clin Cancer Res 2013;19:5003-15.
    • (2013) Clin Cancer Res , vol.19 , pp. 5003-5015
    • Shen, Y.1    Rehman, F.L.2    Feng, Y.3    Boshuizen, J.4    Bajrami, I.5    Elliott, R.6
  • 29
    • 84863116161 scopus 로고    scopus 로고
    • PTEN deletion in prostate cancer cells does not associate with loss of RAD51 function: Implications for radiotherapy and chemotherapy
    • Fraser M, Zhao H, Luoto KR, Lundin C, Coackley C, Chan N, et al. PTEN deletion in prostate cancer cells does not associate with loss of RAD51 function: implications for radiotherapy and chemotherapy. Clin Cancer Res 2012;18:1015-27.
    • (2012) Clin Cancer Res , vol.18 , pp. 1015-1027
    • Fraser, M.1    Zhao, H.2    Luoto, K.R.3    Lundin, C.4    Coackley, C.5    Chan, N.6
  • 30
    • 84866681744 scopus 로고    scopus 로고
    • PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition
    • Ibrahim YH, García-García C, Serra V, He L, Torres-Lockhart K, Prat A, et al. PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition. Cancer Discov 2012;2:1036-47.
    • (2012) Cancer Discov , vol.2 , pp. 1036-1047
    • Ibrahim, Y.H.1    García-García, C.2    Serra, V.3    He, L.4    Torres-Lockhart, K.5    Prat, A.6
  • 32
    • 80055092789 scopus 로고    scopus 로고
    • BRCA1 tumor suppression depends onBRCTphosphoprotein binding, but not its E3 ligase activity
    • Shakya R, Reid LJ, Reczek CR, Cole F, Egli D, Lin C-S, et al. BRCA1 tumor suppression depends onBRCTphosphoprotein binding, but not its E3 ligase activity. Science 2011;334:525-8.
    • (2011) Science , vol.334 , pp. 525-528
    • Shakya, R.1    Reid, L.J.2    Reczek, C.R.3    Cole, F.4    Egli, D.5    Lin, C.-S.6
  • 33
    • 83455229693 scopus 로고    scopus 로고
    • BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance
    • Drost R, Bouwman P, Rottenberg S, Boon U, Schut E, Klarenbeek S, et al. BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance. Cancer Cell 2011;20: 797-809.
    • (2011) Cancer Cell , vol.20 , pp. 797-809
    • Drost, R.1    Bouwman, P.2    Rottenberg, S.3    Boon, U.4    Schut, E.5    Klarenbeek, S.6
  • 34
    • 57349169242 scopus 로고    scopus 로고
    • Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80
    • Wei L, Lan L, Hong Z, Yasui A, Ishioka C, Chiba N. Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80. Mol Cell Biol 2008;28:7380-93.
    • (2008) Mol Cell Biol , vol.28 , pp. 7380-7393
    • Wei, L.1    Lan, L.2    Hong, Z.3    Yasui, A.4    Ishioka, C.5    Chiba, N.6
  • 35
    • 84877823968 scopus 로고    scopus 로고
    • Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation
    • Li M, Yu X. Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation. Cancer Cell 2013;23:693-704.
    • (2013) Cancer Cell , vol.23 , pp. 693-704
    • Li, M.1    Yu, X.2
  • 37
    • 77958045536 scopus 로고    scopus 로고
    • A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer
    • Graeser M, McCarthy A, Lord CJ, Savage K, Hills M, Salter J, et al. A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer. Clin Cancer Res 2010;16:6159-68.
    • (2010) Clin Cancer Res , vol.16 , pp. 6159-6168
    • Graeser, M.1    McCarthy, A.2    Lord, C.J.3    Savage, K.4    Hills, M.5    Salter, J.6
  • 38
    • 77950974130 scopus 로고    scopus 로고
    • Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors
    • Mukhopadhyay A, Elattar A, Cerbinskaite A, Wilkinson SJ, Drew Y, Kyle S, et al. Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors. Clin Cancer Res 2010;16:2344-51.
    • (2010) Clin Cancer Res , vol.16 , pp. 2344-2351
    • Mukhopadhyay, A.1    Elattar, A.2    Cerbinskaite, A.3    Wilkinson, S.J.4    Drew, Y.5    Kyle, S.6
  • 39
    • 84869210797 scopus 로고    scopus 로고
    • Clinicopathological features of homologous recombination-deficient epithelial ovarian cancers: Sensitivity to PARP inhibitors, platinum, and survival
    • Mukhopadhyay A, Plummer ER, Elattar A, Soohoo S, Uzir B, Quinn JE, et al. Clinicopathological features of homologous recombination-deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum, and survival. Cancer Res 2012;72:5675-82.
    • (2012) Cancer Res , vol.72 , pp. 5675-5682
    • Mukhopadhyay, A.1    Plummer, E.R.2    Elattar, A.3    Soohoo, S.4    Uzir, B.5    Quinn, J.E.6
  • 41
    • 84874598091 scopus 로고    scopus 로고
    • Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo
    • Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, et al. Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun 2013;4:1504.
    • (2013) Nat Commun , vol.4 , pp. 1504
    • Thurber, G.M.1    Yang, K.S.2    Reiner, T.3    Kohler, R.H.4    Sorger, P.5    Mitchison, T.6
  • 42
    • 79959391542 scopus 로고    scopus 로고
    • Disposition and drugdrug interaction potential of veliparib (ABT-888), a novel and potent inhibitor of poly(ADP-ribose) polymerase
    • Li X, Delzer J, Voorman R, de Morais SM, Lao Y. Disposition and drugdrug interaction potential of veliparib (ABT-888), a novel and potent inhibitor of poly(ADP-ribose) polymerase. Drug Metab Dispos 2011;39:1161-9.
    • (2011) Drug Metab Dispos , vol.39 , pp. 1161-1169
    • Li, X.1    Delzer, J.2    Voorman, R.3    De Morais, S.M.4    Lao, Y.5
  • 44
    • 77950958141 scopus 로고    scopus 로고
    • 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
    • Bunting SF, Callén E, Wong N, Chen H-T, Polato F, Gunn A, et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 2010;141:243-54.
    • (2010) Cell , vol.141 , pp. 243-254
    • Bunting, S.F.1    Callén, E.2    Wong, N.3    Chen, H.-T.4    Polato, F.5    Gunn, A.6
  • 45
    • 77953291328 scopus 로고    scopus 로고
    • 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
    • Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H, et al. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol 2010;17:688-95.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 688-695
    • Bouwman, P.1    Aly, A.2    Escandell, J.M.3    Pieterse, M.4    Bartkova, J.5    Van Der Gulden, H.6
  • 46
    • 84862776819 scopus 로고    scopus 로고
    • BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair
    • Bunting SF, Callén E, Kozak ML, Kim JM, Wong N, López-Contreras AJ, et al. BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair. Mol Cell 2012;46:125-35.
    • (2012) Mol Cell , vol.46 , pp. 125-135
    • Bunting, S.F.1    Callén, E.2    Kozak, M.L.3    Kim, J.M.4    Wong, N.5    López-Contreras, A.J.6
  • 47
    • 84873726399 scopus 로고    scopus 로고
    • 53BP1 expression in sporadic and inherited ovarian carcinoma: Relationship to genetic status and clinical outcomes
    • Pennington KP, Wickramanayake A, Norquist BM, Pennil CC, Garcia RL, Agnew KJ, et al. 53BP1 expression in sporadic and inherited ovarian carcinoma: relationship to genetic status and clinical outcomes. Gynecol Oncol 2013;128:493-9.
    • (2013) Gynecol Oncol , vol.128 , pp. 493-499
    • Pennington, K.P.1    Wickramanayake, A.2    Norquist, B.M.3    Pennil, C.C.4    Garcia, R.L.5    Agnew, K.J.6
  • 48
    • 84876855215 scopus 로고    scopus 로고
    • RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection
    • Chapman JR, Barral P, Vannier J-B, Borel V, Steger M, Tomas-Loba A, et al. RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol Cell 2013;49:858-71.
    • (2013) Mol Cell , vol.49 , pp. 858-871
    • Chapman, J.R.1    Barral, P.2    Vannier, J.-B.3    Borel, V.4    Steger, M.5    Tomas-Loba, A.6
  • 49
    • 84873526612 scopus 로고    scopus 로고
    • Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching
    • Di Virgilio M, Callen E, Yamane A, Zhang W, Jankovic M, Gitlin AD, et al. Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science 2013;339:711-5.
    • (2013) Science , vol.339 , pp. 711-715
    • Di Virgilio, M.1    Callen, E.2    Yamane, A.3    Zhang, W.4    Jankovic, M.5    Gitlin, A.D.6
  • 50
    • 84876527317 scopus 로고    scopus 로고
    • RIF1 counteracts BRCA1-mediated end resection during DNA repair
    • Feng L, Fong K-W, Wang J, Wang W, Chen J. RIF1 counteracts BRCA1-mediated end resection during DNA repair. J Biol Chem 2013;288:11135-43.
    • (2013) J Biol Chem , vol.288 , pp. 11135-11143
    • Feng, L.1    Fong, K.-W.2    Wang, J.3    Wang, W.4    Chen, J.5
  • 51
    • 84876877091 scopus 로고    scopus 로고
    • A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
    • Escribano-Díaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JTF, Tkáć J, et al. A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol Cell 2013;49:872-83.
    • (2013) Mol Cell , vol.49 , pp. 872-883
    • Escribano-Díaz, C.1    Orthwein, A.2    Fradet-Turcotte, A.3    Xing, M.4    Young, J.T.F.5    Tkáć, J.6
  • 53
    • 84878893538 scopus 로고    scopus 로고
    • 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions
    • Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen H-T, et al. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell 2013;153:1266-80.
    • (2013) Cell , vol.153 , pp. 1266-1280
    • Callen, E.1    Di Virgilio, M.2    Kruhlak, M.J.3    Nieto-Soler, M.4    Wong, N.5    Chen, H.-T.6
  • 54
    • 0037842201 scopus 로고    scopus 로고
    • Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2
    • Ikeda H, Matsushita M, Waisfisz Q, Kinoshita A, Oostra AB, Nieuwint AWM, et al. Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2. Cancer Res 2003;63:2688-94.
    • (2003) Cancer Res , vol.63 , pp. 2688-2694
    • Ikeda, H.1    Matsushita, M.2    Waisfisz, Q.3    Kinoshita, A.4    Oostra, A.B.5    Nieuwint, A.W.M.6
  • 56
    • 39849106300 scopus 로고    scopus 로고
    • Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
    • Sakai W, Swisher EM, Karlan BY, Agarwal MK, Higgins J, Friedman C, et al. Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers. Nature 2008;451:1116-20.
    • (2008) Nature , vol.451 , pp. 1116-1120
    • Sakai, W.1    Swisher, E.M.2    Karlan, B.Y.3    Agarwal, M.K.4    Higgins, J.5    Friedman, C.6
  • 57
    • 69249100461 scopus 로고    scopus 로고
    • Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma
    • Sakai W, Swisher EM, Jacquemont C, Chandramohan KV, Couch FJ, Langdon SP, et al. Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma. Cancer Res 2009;69:6381-6.
    • (2009) Cancer Res , vol.69 , pp. 6381-6386
    • Sakai, W.1    Swisher, E.M.2    Jacquemont, C.3    Chandramohan, K.V.4    Couch, F.J.5    Langdon, S.P.6
  • 58
    • 80051642095 scopus 로고    scopus 로고
    • Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas
    • Norquist B, Wurz KA, Pennil CC, Garcia R, Gross J, Sakai W, et al. Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas. J Clin Oncol 2011;29: 3008-15.
    • (2011) J Clin Oncol , vol.29 , pp. 3008-3015
    • Norquist, B.1    Wurz, K.A.2    Pennil, C.C.3    Garcia, R.4    Gross, J.5    Sakai, W.6
  • 59
    • 42349096328 scopus 로고    scopus 로고
    • Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance
    • Swisher EM, Sakai W, Karlan BY, Wurz K, Urban N, Taniguchi T. Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance. Cancer Res 2008;68:2581-6.
    • (2008) Cancer Res , vol.68 , pp. 2581-2586
    • Swisher, E.M.1    Sakai, W.2    Karlan, B.Y.3    Wurz, K.4    Urban, N.5    Taniguchi, T.6
  • 60
    • 84872971914 scopus 로고    scopus 로고
    • Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor
    • Barber LJ, Sandhu S, Chen L, Campbell J, Kozarewa I, Fenwick K, et al. Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor. J Pathol 2013;229:422-9.
    • (2013) J Pathol , vol.229 , pp. 422-429
    • Barber, L.J.1    Sandhu, S.2    Chen, L.3    Campbell, J.4    Kozarewa, I.5    Fenwick, K.6
  • 61
    • 84886399807 scopus 로고    scopus 로고
    • Efficacy of chemotherapy in BRCA1/2 mutation carrier ovarian cancer in the setting of PARP inhibitor resistance: A multiinstitutional study
    • Ang JE, Gourley C, Powell CB, High H, Shapira-Frommer R, Castonguay V, et al. Efficacy of chemotherapy in BRCA1/2 mutation carrier ovarian cancer in the setting of PARP inhibitor resistance: a multiinstitutional study. Clin Cancer Res 2013;19:5485-93.
    • (2013) Clin Cancer Res , vol.19 , pp. 5485-5493
    • Ang, J.E.1    Gourley, C.2    Powell, C.B.3    High, H.4    Shapira-Frommer, R.5    Castonguay, V.6
  • 62
    • 84859864115 scopus 로고    scopus 로고
    • A phase i combination study of olaparib with cisplatin and gemcitabine in adults with solid tumors
    • Rajan A, Carter CA, Kelly RJ, Gutierrez M, Kummar S, Szabo E, et al. A phase I combination study of olaparib with cisplatin and gemcitabine in adults with solid tumors. Clin Cancer Res 2012; 18:2344-51.
    • (2012) Clin Cancer Res , vol.18 , pp. 2344-2351
    • Rajan, A.1    Carter, C.A.2    Kelly, R.J.3    Gutierrez, M.4    Kummar, S.5    Szabo, E.6
  • 63
    • 80052238687 scopus 로고    scopus 로고
    • Phase i study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas
    • Kummar S, Chen A, Ji J, Zhang Y, Reid JM, Ames M, et al. Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas. Cancer Res 2011;71: 5626-34.
    • (2011) Cancer Res , vol.71 , pp. 5626-5634
    • Kummar, S.1    Chen, A.2    Ji, J.3    Zhang, Y.4    Reid, J.M.5    Ames, M.6
  • 65
    • 78751520563 scopus 로고    scopus 로고
    • CCT241533 is a potent and selective inhibitor ofCHK2 that potentiates the cytotoxicity of PARP inhibitors
    • Anderson VE, Walton MI, Eve PD, Boxall KJ, Antoni L, Caldwell JJ, et al. CCT241533 is a potent and selective inhibitor ofCHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res 2011;71:463-72.
    • (2011) Cancer Res , vol.71 , pp. 463-472
    • Anderson, V.E.1    Walton, M.I.2    Eve, P.D.3    Boxall, K.J.4    Antoni, L.5    Caldwell, J.J.6
  • 66
    • 84867085097 scopus 로고    scopus 로고
    • Synthetic lethality of PARP and NAMPT inhibition in triplenegative breast cancer cells
    • Bajrami I, Kigozi A, Van Weverwijk A, Brough R, Frankum J, Lord CJ, et al. Synthetic lethality of PARP and NAMPT inhibition in triplenegative breast cancer cells. EMBO Mol Med 2012;4:1087-96.
    • (2012) EMBO Mol Med , vol.4 , pp. 1087-1096
    • Bajrami, I.1    Kigozi, A.2    Van Weverwijk, A.3    Brough, R.4    Frankum, J.5    Lord, C.J.6


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