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Volumn 98, Issue , 2016, Pages 375-389

Myeloproliferative neoplasms: Current molecular biology and genetics

Author keywords

CALR; JAK2; Myeloproliferative neoplasms; Polycythemia vera

Indexed keywords

ASXL1 PROTEIN; CALRETICULIN; CBL PROTEIN; CD135 ANTIGEN; DNA METHYLTRANSFERASE 3A; HIGH MOBILITY GROUP A2 PROTEIN; IKAROS FAMILY ZINC FINGER PROTEIN 1; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; JANUS KINASE 2; K RAS PROTEIN; PROTEIN P53; SH2B3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; TET2 PROTEIN; THROMBOPOIETIN RECEPTOR; TRANSCRIPTION FACTOR EZH2; TUMOR MARKER; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; CALRETICULIN, HUMAN; CBL PROTEIN, HUMAN; DNA (CYTOSINE 5) METHYLTRANSFERASE; EZH2 PROTEIN, HUMAN; JAK2 PROTEIN, HUMAN;

EID: 84957428955     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2015.11.004     Document Type: Review
Times cited : (43)

References (232)
  • 1
    • 54349105660 scopus 로고    scopus 로고
    • Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias
    • Abbas S., Rotmans G., Lowenberg B., Valk P.J. Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias. Haematologica 2008, 93:1595-1597.
    • (2008) Haematologica , vol.93 , pp. 1595-1597
    • Abbas, S.1    Rotmans, G.2    Lowenberg, B.3    Valk, P.J.4
  • 2
    • 77957192661 scopus 로고    scopus 로고
    • Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value
    • Abbas S., Lugthart S., Kavelaars F.G., Schelen A., Koenders J.E., Zeilemaker A., et al. Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. Blood 2010, 116:2122-2126.
    • (2010) Blood , vol.116 , pp. 2122-2126
    • Abbas, S.1    Lugthart, S.2    Kavelaars, F.G.3    Schelen, A.4    Koenders, J.E.5    Zeilemaker, A.6
  • 3
    • 67651065502 scopus 로고    scopus 로고
    • Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
    • Abdel-Wahab O., Mullally A., Hedvat C., Garcia-Manero G., Patel J., Wadleigh M., et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood 2009, 114:144-147.
    • (2009) Blood , vol.114 , pp. 144-147
    • Abdel-Wahab, O.1    Mullally, A.2    Hedvat, C.3    Garcia-Manero, G.4    Patel, J.5    Wadleigh, M.6
  • 4
    • 76549109434 scopus 로고    scopus 로고
    • Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias
    • Abdel-Wahab O., Manshouri T., Patel J., Harris K., Yao J., Hedvat C., et al. Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer Res. 2010, 70:447-452.
    • (2010) Cancer Res. , vol.70 , pp. 447-452
    • Abdel-Wahab, O.1    Manshouri, T.2    Patel, J.3    Harris, K.4    Yao, J.5    Hedvat, C.6
  • 5
    • 79960248721 scopus 로고    scopus 로고
    • DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms
    • Abdel-Wahab O., Pardanani A., Rampal R., Lasho T.L., Levine R.L., Tefferi A. DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms. Leukemia 2011, 25:1219-1220.
    • (2011) Leukemia , vol.25 , pp. 1219-1220
    • Abdel-Wahab, O.1    Pardanani, A.2    Rampal, R.3    Lasho, T.L.4    Levine, R.L.5    Tefferi, A.6
  • 6
    • 84865152223 scopus 로고    scopus 로고
    • ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
    • Abdel-Wahab O., Adli M., LaFave L.M., Gao J., Hricik T., Shih A.H., et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell 2012, 22:180-193.
    • (2012) Cancer Cell , vol.22 , pp. 180-193
    • Abdel-Wahab, O.1    Adli, M.2    LaFave, L.M.3    Gao, J.4    Hricik, T.5    Shih, A.H.6
  • 7
    • 0036050145 scopus 로고    scopus 로고
    • A novel MPL point mutation resulting in thrombopoietin-independent activation
    • Abe M., Suzuki K., Inagaki O., Sassa S., Shikama H. A novel MPL point mutation resulting in thrombopoietin-independent activation. Leukemia 2002, 16:1500-1506.
    • (2002) Leukemia , vol.16 , pp. 1500-1506
    • Abe, M.1    Suzuki, K.2    Inagaki, O.3    Sassa, S.4    Shikama, H.5
  • 10
    • 79251500335 scopus 로고    scopus 로고
    • FLT3 and NPM1 mutations in myelodysplastic syndromes: frequency and potential value for predicting progression to acute myeloid leukemia
    • Bains A., Luthra R., Medeiros L.J., Zuo Z. FLT3 and NPM1 mutations in myelodysplastic syndromes: frequency and potential value for predicting progression to acute myeloid leukemia. Am. J. Clin. Pathol. 2011, 135:62-69.
    • (2011) Am. J. Clin. Pathol. , vol.135 , pp. 62-69
    • Bains, A.1    Luthra, R.2    Medeiros, L.J.3    Zuo, Z.4
  • 11
    • 67649402606 scopus 로고    scopus 로고
    • Perspectives on thrombosis in essential thrombocythemia and polycythemia vera: is leukocytosis a causative factor?
    • Barbui T., Carobbio A., Rambaldi A., Finazzi G. Perspectives on thrombosis in essential thrombocythemia and polycythemia vera: is leukocytosis a causative factor?. Blood 2009, 114:759-763.
    • (2009) Blood , vol.114 , pp. 759-763
    • Barbui, T.1    Carobbio, A.2    Rambaldi, A.3    Finazzi, G.4
  • 12
    • 79551491928 scopus 로고    scopus 로고
    • Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet
    • Barbui T., Barosi G., Birgegard G., Cervantes F., Finazzi G., Griesshammer M., et al. Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet. J. Clin. Oncol. 2011, 29:761-770.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 761-770
    • Barbui, T.1    Barosi, G.2    Birgegard, G.3    Cervantes, F.4    Finazzi, G.5    Griesshammer, M.6
  • 13
    • 84871501896 scopus 로고    scopus 로고
    • Development and validation of an International Prognostic Score of thrombosis in World Health Organization-essential thrombocythemia (IPSET-thrombosis)
    • quiz 252
    • Barbui T., Finazzi G., Carobbio A., Thiele J., Passamonti F., Rumi E., et al. Development and validation of an International Prognostic Score of thrombosis in World Health Organization-essential thrombocythemia (IPSET-thrombosis). Blood 2012, 120:5128-5133. quiz 252.
    • (2012) Blood , vol.120 , pp. 5128-5133
    • Barbui, T.1    Finazzi, G.2    Carobbio, A.3    Thiele, J.4    Passamonti, F.5    Rumi, E.6
  • 14
    • 37049039725 scopus 로고    scopus 로고
    • JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis
    • Barosi G., Bergamaschi G., Marchetti M., Vannucchi A.M., Guglielmelli P., Antonioli E., et al. JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis. Blood 2007, 110:4030-4036.
    • (2007) Blood , vol.110 , pp. 4030-4036
    • Barosi, G.1    Bergamaschi, G.2    Marchetti, M.3    Vannucchi, A.M.4    Guglielmelli, P.5    Antonioli, E.6
  • 15
    • 84925408151 scopus 로고    scopus 로고
    • Essential thrombocythemia vs. early/prefibrotic myelofibrosis: why does it matter
    • Barosi G. Essential thrombocythemia vs. early/prefibrotic myelofibrosis: why does it matter. Best Pract. Res. Clin. Haematol. 2014, 27:129-140.
    • (2014) Best Pract. Res. Clin. Haematol. , vol.27 , pp. 129-140
    • Barosi, G.1
  • 16
    • 80054909843 scopus 로고    scopus 로고
    • Epigenomic profiling in polycythaemia vera and essential thrombocythaemia shows low levels of aberrant DNA methylation
    • Barrio S., Gallardo M., Albizua E., Jimenez A., Rapado I., Ayala R., et al. Epigenomic profiling in polycythaemia vera and essential thrombocythaemia shows low levels of aberrant DNA methylation. J. Clin. Pathol. 2011, 64:1010-1013.
    • (2011) J. Clin. Pathol. , vol.64 , pp. 1010-1013
    • Barrio, S.1    Gallardo, M.2    Albizua, E.3    Jimenez, A.4    Rapado, I.5    Ayala, R.6
  • 17
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • Baxter E.J., Scott L.M., Campbell P.J., East C., Fourouclas N., Swanton S., et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005, 365:1054-1061.
    • (2005) Lancet , vol.365 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3    East, C.4    Fourouclas, N.5    Swanton, S.6
  • 18
    • 47249092413 scopus 로고    scopus 로고
    • MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort
    • Beer P.A., Campbell P.J., Scott L.M., Bench A.J., Erber W.N., Bareford D., et al. MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort. Blood 2008, 112:141-149.
    • (2008) Blood , vol.112 , pp. 141-149
    • Beer, P.A.1    Campbell, P.J.2    Scott, L.M.3    Bench, A.J.4    Erber, W.N.5    Bareford, D.6
  • 19
    • 77950977381 scopus 로고    scopus 로고
    • Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm
    • Beer P.A., Delhommeau F., LeCouedic J.P., Dawson M.A., Chen E., Bareford D., et al. Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm. Blood 2010, 115:2891-2900.
    • (2010) Blood , vol.115 , pp. 2891-2900
    • Beer, P.A.1    Delhommeau, F.2    LeCouedic, J.P.3    Dawson, M.A.4    Chen, E.5    Bareford, D.6
  • 20
    • 78649854130 scopus 로고    scopus 로고
    • Molecular mechanisms associated with leukemic transformation of MPL-mutant myeloproliferative neoplasms
    • Beer P.A., Ortmann C.A., Stegelmann F., Guglielmelli P., Reilly J.T., Larsen T.S., et al. Molecular mechanisms associated with leukemic transformation of MPL-mutant myeloproliferative neoplasms. Haematologica 2010, 95:2153-2156.
    • (2010) Haematologica , vol.95 , pp. 2153-2156
    • Beer, P.A.1    Ortmann, C.A.2    Stegelmann, F.3    Guglielmelli, P.4    Reilly, J.T.5    Larsen, T.S.6
  • 21
    • 0038820386 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription proteins in leukemias
    • Benekli M., Baer M.R., Baumann H., Wetzler M. Signal transducer and activator of transcription proteins in leukemias. Blood 2003, 101:2940-2954.
    • (2003) Blood , vol.101 , pp. 2940-2954
    • Benekli, M.1    Baer, M.R.2    Baumann, H.3    Wetzler, M.4
  • 22
    • 48749084130 scopus 로고    scopus 로고
    • Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2
    • Bersenev A., Wu C., Balcerek J., Tong W. Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2. J. Clin. Invest. 2008, 118:2832-2844.
    • (2008) J. Clin. Invest. , vol.118 , pp. 2832-2844
    • Bersenev, A.1    Wu, C.2    Balcerek, J.3    Tong, W.4
  • 23
    • 77949810252 scopus 로고    scopus 로고
    • Clinical utility of routine MPL exon 10 analysis in the diagnosis of essential thrombocythaemia and primary myelofibrosis
    • Boyd E.M., Bench A.J., Goday-Fernandez A., Anand S., Vaghela K.J., Beer P., et al. Clinical utility of routine MPL exon 10 analysis in the diagnosis of essential thrombocythaemia and primary myelofibrosis. Br. J. Haematol. 2010, 149:250-257.
    • (2010) Br. J. Haematol. , vol.149 , pp. 250-257
    • Boyd, E.M.1    Bench, A.J.2    Goday-Fernandez, A.3    Anand, S.4    Vaghela, K.J.5    Beer, P.6
  • 25
    • 84861702964 scopus 로고    scopus 로고
    • Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms
    • Brecqueville M., Rey J., Bertucci F., Coppin E., Finetti P., Carbuccia N., et al. Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms. Genes Chromosomes Cancer 2012, 51:743-755.
    • (2012) Genes Chromosomes Cancer , vol.51 , pp. 743-755
    • Brecqueville, M.1    Rey, J.2    Bertucci, F.3    Coppin, E.4    Finetti, P.5    Carbuccia, N.6
  • 26
    • 84919467186 scopus 로고    scopus 로고
    • Presence of calreticulin mutations in JAK2-negative polycythemia vera
    • Broseus J., Park J.H., Carillo S., Hermouet S., Girodon F. Presence of calreticulin mutations in JAK2-negative polycythemia vera. Blood 2014, 124:3964-3966.
    • (2014) Blood , vol.124 , pp. 3964-3966
    • Broseus, J.1    Park, J.H.2    Carillo, S.3    Hermouet, S.4    Girodon, F.5
  • 27
    • 42349112583 scopus 로고    scopus 로고
    • Two novel JAK2 exon 12 mutations in JAK2V617F-negative polycythaemia vera patients
    • Butcher C.M., Hahn U., To L.B., Gecz J., Wilkins E.J., Scott H.S., et al. Two novel JAK2 exon 12 mutations in JAK2V617F-negative polycythaemia vera patients. Leukemia 2008, 22:870-873.
    • (2008) Leukemia , vol.22 , pp. 870-873
    • Butcher, C.M.1    Hahn, U.2    To, L.B.3    Gecz, J.4    Wilkins, E.J.5    Scott, H.S.6
  • 28
    • 34547950568 scopus 로고    scopus 로고
    • Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia
    • Caligiuri M.A., Briesewitz R., Yu J., Wang L., Wei M., Arnoczky K.J., et al. Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia. Blood 2007, 110:1022-1024.
    • (2007) Blood , vol.110 , pp. 1022-1024
    • Caligiuri, M.A.1    Briesewitz, R.2    Yu, J.3    Wang, L.4    Wei, M.5    Arnoczky, K.J.6
  • 29
    • 28244442441 scopus 로고    scopus 로고
    • Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study
    • Campbell P.J., Scott L.M., Buck G., Wheatley K., East C.L., Marsden J.T., et al. Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study. Lancet 2005, 366:1945-1953.
    • (2005) Lancet , vol.366 , pp. 1945-1953
    • Campbell, P.J.1    Scott, L.M.2    Buck, G.3    Wheatley, K.4    East, C.L.5    Marsden, J.T.6
  • 30
    • 33344471678 scopus 로고    scopus 로고
    • V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis
    • Campbell P.J., Griesshammer M., Dohner K., Dohner H., Kusec R., Hasselbalch H.C., et al. V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis. Blood 2006, 107:2098-2100.
    • (2006) Blood , vol.107 , pp. 2098-2100
    • Campbell, P.J.1    Griesshammer, M.2    Dohner, K.3    Dohner, H.4    Kusec, R.5    Hasselbalch, H.C.6
  • 32
    • 42249115029 scopus 로고    scopus 로고
    • Epigenetic inactivation of suppressors of cytokine signalling in Philadelphia-negative chronic myeloproliferative disorders
    • Capello D., Deambrogi C., Rossi D., Lischetti T., Piranda D., Cerri M., et al. Epigenetic inactivation of suppressors of cytokine signalling in Philadelphia-negative chronic myeloproliferative disorders. Br. J. Haematol. 2008, 141:504-511.
    • (2008) Br. J. Haematol. , vol.141 , pp. 504-511
    • Capello, D.1    Deambrogi, C.2    Rossi, D.3    Lischetti, T.4    Piranda, D.5    Cerri, M.6
  • 34
    • 76749084667 scopus 로고    scopus 로고
    • Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias
    • Carbuccia N., Trouplin V., Gelsi-Boyer V., Murati A., Rocquain J., Adelaide J., et al. Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias. Leukemia 2010, 24:469-473.
    • (2010) Leukemia , vol.24 , pp. 469-473
    • Carbuccia, N.1    Trouplin, V.2    Gelsi-Boyer, V.3    Murati, A.4    Rocquain, J.5    Adelaide, J.6
  • 35
    • 33947262701 scopus 로고    scopus 로고
    • Leukocytosis is a risk factor for thrombosis in essential thrombocythemia: interaction with treatment, standard risk factors, and Jak2 mutation status
    • Carobbio A., Finazzi G., Guerini V., Spinelli O., Delaini F., Marchioli R., et al. Leukocytosis is a risk factor for thrombosis in essential thrombocythemia: interaction with treatment, standard risk factors, and Jak2 mutation status. Blood 2007, 109:2310-2313.
    • (2007) Blood , vol.109 , pp. 2310-2313
    • Carobbio, A.1    Finazzi, G.2    Guerini, V.3    Spinelli, O.4    Delaini, F.5    Marchioli, R.6
  • 37
    • 84902589906 scopus 로고    scopus 로고
    • From Janus kinase 2 to calreticulin: the clinically relevant genomic landscape of myeloproliferative neoplasms
    • Cazzola M., Kralovics R. From Janus kinase 2 to calreticulin: the clinically relevant genomic landscape of myeloproliferative neoplasms. Blood 2014, 123:3714-3719.
    • (2014) Blood , vol.123 , pp. 3714-3719
    • Cazzola, M.1    Kralovics, R.2
  • 38
    • 63849328927 scopus 로고    scopus 로고
    • New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment
    • Cervantes F., Dupriez B., Pereira A., Passamonti F., Reilly J.T., Morra E., et al. New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment. Blood 2009, 113:2895-2901.
    • (2009) Blood , vol.113 , pp. 2895-2901
    • Cervantes, F.1    Dupriez, B.2    Pereira, A.3    Passamonti, F.4    Reilly, J.T.5    Morra, E.6
  • 39
    • 49449094277 scopus 로고    scopus 로고
    • New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition
    • Chaligne R., Tonetti C., Besancenot R., Roy L., Marty C., Mossuz P., et al. New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition. Leukemia 2008, 22:1557-1566.
    • (2008) Leukemia , vol.22 , pp. 1557-1566
    • Chaligne, R.1    Tonetti, C.2    Besancenot, R.3    Roy, L.4    Marty, C.5    Mossuz, P.6
  • 41
    • 79954464525 scopus 로고    scopus 로고
    • The thrombopoietin/MPL pathway in hematopoiesis and leukemogenesis
    • Chou F.S., Mulloy J.C. The thrombopoietin/MPL pathway in hematopoiesis and leukemogenesis. J. Cell. Biochem. 2011, 112:1491-1498.
    • (2011) J. Cell. Biochem. , vol.112 , pp. 1491-1498
    • Chou, F.S.1    Mulloy, J.C.2
  • 42
    • 84856353050 scopus 로고    scopus 로고
    • The importance of cytogenetics in polycythemia vera, primary myelofibrosis and essential thrombocythemia
    • Conchon M. The importance of cytogenetics in polycythemia vera, primary myelofibrosis and essential thrombocythemia. Rev. Bras. Hematol. Hemoterapia 2011, 33:401-402.
    • (2011) Rev. Bras. Hematol. Hemoterapia , vol.33 , pp. 401-402
    • Conchon, M.1
  • 43
    • 77956265489 scopus 로고    scopus 로고
    • IDH mutations in glioma and acute myeloid leukemia
    • Dang L., Jin S., Su S.M. IDH mutations in glioma and acute myeloid leukemia. Trends Mol. Med. 2010, 16:387-397.
    • (2010) Trends Mol. Med. , vol.16 , pp. 387-397
    • Dang, L.1    Jin, S.2    Su, S.M.3
  • 45
    • 2542502506 scopus 로고    scopus 로고
    • Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin
    • Ding J., Komatsu H., Wakita A., Kato-Uranishi M., Ito M., Satoh A., et al. Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin. Blood 2004, 103:4198-4200.
    • (2004) Blood , vol.103 , pp. 4198-4200
    • Ding, J.1    Komatsu, H.2    Wakita, A.3    Kato-Uranishi, M.4    Ito, M.5    Satoh, A.6
  • 46
    • 73949129831 scopus 로고    scopus 로고
    • AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms
    • Ding Y., Harada Y., Imagawa J., Kimura A., Harada H. AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms. Blood 2009, 114:5201-5205.
    • (2009) Blood , vol.114 , pp. 5201-5205
    • Ding, Y.1    Harada, Y.2    Imagawa, J.3    Kimura, A.4    Harada, H.5
  • 48
    • 57749114621 scopus 로고    scopus 로고
    • 250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies
    • Dunbar A.J., Gondek L.P., O'Keefe C.L., Makishima H., Rataul M.S., Szpurka H., et al. 250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies. Cancer Res. 2008, 68:10349-10357.
    • (2008) Cancer Res. , vol.68 , pp. 10349-10357
    • Dunbar, A.J.1    Gondek, L.P.2    O'Keefe, C.L.3    Makishima, H.4    Rataul, M.S.5    Szpurka, H.6
  • 49
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • Ernst T., Chase A.J., Score J., Hidalgo-Curtis C.E., Bryant C., Jones A.V., et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat. Genet. 2010, 42:722-726.
    • (2010) Nat. Genet. , vol.42 , pp. 722-726
    • Ernst, T.1    Chase, A.J.2    Score, J.3    Hidalgo-Curtis, C.E.4    Bryant, C.5    Jones, A.V.6
  • 50
    • 34250207360 scopus 로고    scopus 로고
    • Rearrangements involving 12q in myeloproliferative disorders: possible role of HMGA2 and SOCS2 genes
    • Etienne A., Carbuccia N., Adelaide J., Bekhouche I., Remy V., Sohn C., et al. Rearrangements involving 12q in myeloproliferative disorders: possible role of HMGA2 and SOCS2 genes. Cancer Genet. Cytogenet. 2007, 176:80-88.
    • (2007) Cancer Genet. Cytogenet. , vol.176 , pp. 80-88
    • Etienne, A.1    Carbuccia, N.2    Adelaide, J.3    Bekhouche, I.4    Remy, V.5    Sohn, C.6
  • 51
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa M.E., Abdel-Wahab O., Lu C., Ward P.S., Patel J., Shih A., et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010, 18:553-567.
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3    Ward, P.S.4    Patel, J.5    Shih, A.6
  • 52
    • 33846896185 scopus 로고    scopus 로고
    • Risk of thrombosis in patients with essential thrombocythemia and polycythemia vera according to JAK2 V617F mutation status
    • Finazzi G., Rambaldi A., Guerini V., Carobbo A., Barbui T. Risk of thrombosis in patients with essential thrombocythemia and polycythemia vera according to JAK2 V617F mutation status. Haematologica 2007, 92:135-136.
    • (2007) Haematologica , vol.92 , pp. 135-136
    • Finazzi, G.1    Rambaldi, A.2    Guerini, V.3    Carobbo, A.4    Barbui, T.5
  • 54
    • 55549126446 scopus 로고    scopus 로고
    • Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myeloproliferative disorders
    • Fourouclas N., Li J., Gilby D.C., Campbell P.J., Beer P.A., Boyd E.M., et al. Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myeloproliferative disorders. Haematologica 2008, 93:1635-1644.
    • (2008) Haematologica , vol.93 , pp. 1635-1644
    • Fourouclas, N.1    Li, J.2    Gilby, D.C.3    Campbell, P.J.4    Beer, P.A.5    Boyd, E.M.6
  • 55
    • 0037732866 scopus 로고    scopus 로고
    • Identification of CBL, a proto-oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemia
    • Fu J.F., Hsu J.J., Tang T.C., Shih L.Y. Identification of CBL, a proto-oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemia. Genes Chromosomes Cancer 2003, 37:214-219.
    • (2003) Genes Chromosomes Cancer , vol.37 , pp. 214-219
    • Fu, J.F.1    Hsu, J.J.2    Tang, T.C.3    Shih, L.Y.4
  • 56
    • 36448992338 scopus 로고    scopus 로고
    • Roles of HMGA proteins in cancer
    • Fusco A., Fedele M. Roles of HMGA proteins in cancer. Nat. Rev. Cancer 2007, 7:899-910.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 899-910
    • Fusco, A.1    Fedele, M.2
  • 57
    • 33846540216 scopus 로고    scopus 로고
    • Risk stratification for survival and leukemic transformation in essential thrombocythemia: a single institutional study of 605 patients
    • Gangat N., Wolanskyj A.P., McClure R.F., Li C.Y., Schwager S., Wu W., et al. Risk stratification for survival and leukemic transformation in essential thrombocythemia: a single institutional study of 605 patients. Leukemia 2007, 21:270-276.
    • (2007) Leukemia , vol.21 , pp. 270-276
    • Gangat, N.1    Wolanskyj, A.P.2    McClure, R.F.3    Li, C.Y.4    Schwager, S.5    Wu, W.6
  • 58
    • 79952087335 scopus 로고    scopus 로고
    • DIPSS plus: a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status
    • Gangat N., Caramazza D., Vaidya R., George G., Begna K., Schwager S., et al. DIPSS plus: a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status. J. Clin. Oncol. 2011, 29:392-397.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 392-397
    • Gangat, N.1    Caramazza, D.2    Vaidya, R.3    George, G.4    Begna, K.5    Schwager, S.6
  • 59
    • 66849124925 scopus 로고    scopus 로고
    • Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia
    • Gelsi-Boyer V., Trouplin V., Adelaide J., Bonansea J., Cervera N., Carbuccia N., et al. Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia. Br. J. Haematol. 2009, 145:788-800.
    • (2009) Br. J. Haematol. , vol.145 , pp. 788-800
    • Gelsi-Boyer, V.1    Trouplin, V.2    Adelaide, J.3    Bonansea, J.4    Cervera, N.5    Carbuccia, N.6
  • 61
    • 33745596402 scopus 로고    scopus 로고
    • Serial determination of FLT3 mutations in myelodysplastic syndrome patients at diagnosis, follow up or acute myeloid leukaemia transformation: incidence and their prognostic significance
    • Georgiou G., Karali V., Zouvelou C., Kyriakou E., Dimou M., Chrisochoou S., et al. Serial determination of FLT3 mutations in myelodysplastic syndrome patients at diagnosis, follow up or acute myeloid leukaemia transformation: incidence and their prognostic significance. Br. J. Haematol. 2006, 134:302-306.
    • (2006) Br. J. Haematol. , vol.134 , pp. 302-306
    • Georgiou, G.1    Karali, V.2    Zouvelou, C.3    Kyriakou, E.4    Dimou, M.5    Chrisochoou, S.6
  • 62
    • 0036519296 scopus 로고    scopus 로고
    • Haematopoietic cell-fate decisions chromatin regulation and ikaros
    • Georgopoulos K. Haematopoietic cell-fate decisions chromatin regulation and ikaros. Nat. Rev. Immunol. 2002, 2:162-174.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 162-174
    • Georgopoulos, K.1
  • 63
  • 65
    • 67650401377 scopus 로고    scopus 로고
    • Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms
    • Grand F.H., Hidalgo-Curtis C.E., Ernst T., Zoi K., Zoi C., McGuire C., et al. Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. Blood 2009, 113:6182-6192.
    • (2009) Blood , vol.113 , pp. 6182-6192
    • Grand, F.H.1    Hidalgo-Curtis, C.E.2    Ernst, T.3    Zoi, K.4    Zoi, C.5    McGuire, C.6
  • 68
    • 0029049709 scopus 로고
    • Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation
    • Gurney A.L., Wong S.C., Henzel W.J., de Sauvage F.J. Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:5292-5296.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 5292-5296
    • Gurney, A.L.1    Wong, S.C.2    Henzel, W.J.3    de Sauvage, F.J.4
  • 69
    • 84899736426 scopus 로고    scopus 로고
    • Analysis of the ten-eleven translocation 2 (TET2) gene mutation in myeloproliferative neoplasms
    • Ha J.S., Jeon D.S., Kim J.R., Ryoo N.H., Suh J.S. Analysis of the ten-eleven translocation 2 (TET2) gene mutation in myeloproliferative neoplasms. Ann. Clin. Lab. Sci. 2014, 44:173-179.
    • (2014) Ann. Clin. Lab. Sci. , vol.44 , pp. 173-179
    • Ha, J.S.1    Jeon, D.S.2    Kim, J.R.3    Ryoo, N.H.4    Suh, J.S.5
  • 70
    • 1542373639 scopus 로고    scopus 로고
    • High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia
    • Harada H., Harada Y., Niimi H., Kyo T., Kimura A., Inaba T. High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia. Blood 2004, 103:2316-2324.
    • (2004) Blood , vol.103 , pp. 2316-2324
    • Harada, H.1    Harada, Y.2    Niimi, H.3    Kyo, T.4    Kimura, A.5    Inaba, T.6
  • 71
    • 84921418510 scopus 로고    scopus 로고
    • Dysregulation of the MIRLET7/HMGA2 axis with methylation of the CDKN2A promoter in myeloproliferative neoplasms
    • Harada-Shirado K., Ikeda K., Ogawa K., Ohkawara H., Kimura H., Kai T., et al. Dysregulation of the MIRLET7/HMGA2 axis with methylation of the CDKN2A promoter in myeloproliferative neoplasms. Br. J. Haematol. 2014.
    • (2014) Br. J. Haematol.
    • Harada-Shirado, K.1    Ikeda, K.2    Ogawa, K.3    Ohkawara, H.4    Kimura, H.5    Kai, T.6
  • 73
    • 84957446172 scopus 로고    scopus 로고
    • JAK2V617F-positive myeloproliferative neoplasms: KI mouse models
    • Universite Paris Sud, Paris, XI; 2013
    • Hasan S. JAK2V617F-positive myeloproliferative neoplasms: KI mouse models. Interferon- A Therapy and Clonal Architecture 2013, Universite Paris Sud, Paris, XI; 2013.
    • (2013) Interferon- A Therapy and Clonal Architecture
    • Hasan, S.1
  • 74
    • 84928409407 scopus 로고    scopus 로고
    • Incidence of CALR mutations in patients with splanchnic vein thrombosis
    • Haslam K., Langabeer S.E. Incidence of CALR mutations in patients with splanchnic vein thrombosis. Br. J. Haematol. 2014.
    • (2014) Br. J. Haematol.
    • Haslam, K.1    Langabeer, S.E.2
  • 76
    • 64249164411 scopus 로고    scopus 로고
    • Conventional cytogenetics in myelofibrosis: literature review and discussion
    • Hussein K., Van Dyke D.L., Tefferi A. Conventional cytogenetics in myelofibrosis: literature review and discussion. Eur. J. Haematol. 2009, 82:329-338.
    • (2009) Eur. J. Haematol. , vol.82 , pp. 329-338
    • Hussein, K.1    Van Dyke, D.L.2    Tefferi, A.3
  • 77
    • 79958017228 scopus 로고    scopus 로고
    • 3'UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice
    • Ikeda K., Mason P.J., Bessler M. 3'UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice. Blood 2011, 117:5860-5869.
    • (2011) Blood , vol.117 , pp. 5860-5869
    • Ikeda, K.1    Mason, P.J.2    Bessler, M.3
  • 78
    • 84891408394 scopus 로고    scopus 로고
    • The role of HMGA2 in the proliferation and expansion of a hematopoietic cell in myeloproliferative neoplasms
    • Ikeda K., Ogawa K., Takeishi Y. The role of HMGA2 in the proliferation and expansion of a hematopoietic cell in myeloproliferative neoplasms. Fukushima J. Med. Sci. 2012, 58:91-100.
    • (2012) Fukushima J. Med. Sci. , vol.58 , pp. 91-100
    • Ikeda, K.1    Ogawa, K.2    Takeishi, Y.3
  • 79
    • 84908279899 scopus 로고    scopus 로고
    • DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies
    • Im A.P., Sehgal A.R., Carroll M.P., Smith B.D., Tefferi A., Johnson D.E., et al. DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies. Leukemia 2014, 28:1774-1783.
    • (2014) Leukemia , vol.28 , pp. 1774-1783
    • Im, A.P.1    Sehgal, A.R.2    Carroll, M.P.3    Smith, B.D.4    Tefferi, A.5    Johnson, D.E.6
  • 80
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
    • Ito S., D'Alessio A.C., Taranova O.V., Hong K., Sowers L.C., Zhang Y. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 2010, 466:1129-1133.
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1    D'Alessio, A.C.2    Taranova, O.V.3    Hong, K.4    Sowers, L.C.5    Zhang, Y.6
  • 81
    • 78951489053 scopus 로고    scopus 로고
    • Molecular pathogenesis of Philadelphia chromosome negative chronic myeloproliferative neoplasms
    • Jager R., Kralovics R. Molecular pathogenesis of Philadelphia chromosome negative chronic myeloproliferative neoplasms. Curr. Cancer Drug Targets 2011, 11:20-30.
    • (2011) Curr. Cancer Drug Targets , vol.11 , pp. 20-30
    • Jager, R.1    Kralovics, R.2
  • 82
    • 77954661062 scopus 로고    scopus 로고
    • Deletions of the transcription factor Ikaros in myeloproliferative neoplasms
    • Jager R., Gisslinger H., Passamonti F., Rumi E., Berg T., Gisslinger B., et al. Deletions of the transcription factor Ikaros in myeloproliferative neoplasms. Leukemia 2010, 24:1290-1298.
    • (2010) Leukemia , vol.24 , pp. 1290-1298
    • Jager, R.1    Gisslinger, H.2    Passamonti, F.3    Rumi, E.4    Berg, T.5    Gisslinger, B.6
  • 83
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • James C., Ugo V., Le C., ouedic J.P., Staerk J., Delhommeau F., Lacout C., et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 2005, 434:1144-1148.
    • (2005) Nature , vol.434 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le, C.3    ouedic, J.P.4    Staerk, J.5    Delhommeau, F.6    Lacout, C.7
  • 84
    • 33646546386 scopus 로고    scopus 로고
    • The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation
    • Jamieson C.H., Gotlib J., Durocher J.A., Chao M.P., Mariappan M.R., Lay M., et al. The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:6224-6229.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 6224-6229
    • Jamieson, C.H.1    Gotlib, J.2    Durocher, J.A.3    Chao, M.P.4    Mariappan, M.R.5    Lay, M.6
  • 85
    • 67650588639 scopus 로고    scopus 로고
    • Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms
    • Jankowska A.M., Szpurka H., Tiu R.V., Makishima H., Afable M., Huh J., et al. Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms. Blood 2009, 113:6403-6410.
    • (2009) Blood , vol.113 , pp. 6403-6410
    • Jankowska, A.M.1    Szpurka, H.2    Tiu, R.V.3    Makishima, H.4    Afable, M.5    Huh, J.6
  • 86
    • 80053135096 scopus 로고    scopus 로고
    • Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
    • Jankowska A.M., Makishima H., Tiu R.V., Szpurka H., Huang Y., Traina F., et al. Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood 2011, 118:3932-3941.
    • (2011) Blood , vol.118 , pp. 3932-3941
    • Jankowska, A.M.1    Makishima, H.2    Tiu, R.V.3    Szpurka, H.4    Huang, Y.5    Traina, F.6
  • 87
    • 25844447519 scopus 로고    scopus 로고
    • JAK2 mutation 1849G > T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia
    • Jelinek J., Oki Y., Gharibyan V., Bueso-Ramos C., Prchal J.T., Verstovsek S., et al. JAK2 mutation 1849G > T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia. Blood 2005, 106:3370-3373.
    • (2005) Blood , vol.106 , pp. 3370-3373
    • Jelinek, J.1    Oki, Y.2    Gharibyan, V.3    Bueso-Ramos, C.4    Prchal, J.T.5    Verstovsek, S.6
  • 89
    • 63449099560 scopus 로고    scopus 로고
    • JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms
    • Jones A.V., Chase A., Silver R.T., Oscier D., Zoi K., Wang Y.L., et al. JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms. Nat. Genet. 2009, 41:446-449.
    • (2009) Nat. Genet. , vol.41 , pp. 446-449
    • Jones, A.V.1    Chase, A.2    Silver, R.T.3    Oscier, D.4    Zoi, K.5    Wang, Y.L.6
  • 90
    • 33847223121 scopus 로고    scopus 로고
    • Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders
    • Jost E., do O.N., Dahl E., Maintz C.E., Jousten P., Habets L., et al. Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders. Leukemia 2007, 21:505-510.
    • (2007) Leukemia , vol.21 , pp. 505-510
    • Jost, E.1    do, O.N.2    Dahl, E.3    Maintz, C.E.4    Jousten, P.5    Habets, L.6
  • 91
    • 84859440906 scopus 로고    scopus 로고
    • Role of Ikaros in T-cell acute lymphoblastic leukemia
    • Kastner P., Chan S. Role of Ikaros in T-cell acute lymphoblastic leukemia. World J. Biol. Chem. 2011, 2:108-114.
    • (2011) World J. Biol. Chem. , vol.2 , pp. 108-114
    • Kastner, P.1    Chan, S.2
  • 92
    • 84881108886 scopus 로고    scopus 로고
    • Functional and cancer genomics of ASXL family members
    • Katoh M. Functional and cancer genomics of ASXL family members. Br. J. Cancer 2013, 109:299-306.
    • (2013) Br. J. Cancer , vol.109 , pp. 299-306
    • Katoh, M.1
  • 93
    • 63449127583 scopus 로고    scopus 로고
    • A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms
    • Kilpivaara O., Mukherjee S., Schram A.M., Wadleigh M., Mullally A., Ebert B.L., et al. A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms. Nat. Genet. 2009, 41:455-459.
    • (2009) Nat. Genet. , vol.41 , pp. 455-459
    • Kilpivaara, O.1    Mukherjee, S.2    Schram, A.M.3    Wadleigh, M.4    Mullally, A.5    Ebert, B.L.6
  • 94
    • 34249071097 scopus 로고    scopus 로고
    • Clinical correlates of JAK2V617F allele burden in essential thrombocythemia
    • Kittur J., Knudson R.A., Lasho T.L., Finke C.M., Gangat N., Wolanskyj A.P., et al. Clinical correlates of JAK2V617F allele burden in essential thrombocythemia. Cancer 2007, 109:2279-2284.
    • (2007) Cancer , vol.109 , pp. 2279-2284
    • Kittur, J.1    Knudson, R.A.2    Lasho, T.L.3    Finke, C.M.4    Gangat, N.5    Wolanskyj, A.P.6
  • 95
    • 79960145108 scopus 로고    scopus 로고
    • Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression
    • Klampfl T., Harutyunyan A., Berg T., Gisslinger B., Schalling M., Bagienski K., et al. Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression. Blood 2011, 118:167-176.
    • (2011) Blood , vol.118 , pp. 167-176
    • Klampfl, T.1    Harutyunyan, A.2    Berg, T.3    Gisslinger, B.4    Schalling, M.5    Bagienski, K.6
  • 97
    • 70350438115 scopus 로고    scopus 로고
    • TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)
    • Kosmider O., Gelsi-Boyer V., Cheok M., Grabar S., Della-Valle V., Picard F., et al. TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs). Blood 2009, 114:3285-3291.
    • (2009) Blood , vol.114 , pp. 3285-3291
    • Kosmider, O.1    Gelsi-Boyer, V.2    Cheok, M.3    Grabar, S.4    Della-Valle, V.5    Picard, F.6
  • 99
    • 33745721197 scopus 로고    scopus 로고
    • JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis
    • Lacout C., Pisani D.F., Tulliez M., Gachelin F.M., Vainchenker W., Villeval J.L. JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis. Blood 2006, 108:1652-1660.
    • (2006) Blood , vol.108 , pp. 1652-1660
    • Lacout, C.1    Pisani, D.F.2    Tulliez, M.3    Gachelin, F.M.4    Vainchenker, W.5    Villeval, J.L.6
  • 100
    • 84862808429 scopus 로고    scopus 로고
    • A novel mutation in MPL (Y252H) results in increased thrombopoietin sensitivity in essential thrombocythemia
    • Lambert M.P., Jiang J., Batra V., Wu C., Tong W. A novel mutation in MPL (Y252H) results in increased thrombopoietin sensitivity in essential thrombocythemia. Am. J. Hematol. 2012, 87:532-534.
    • (2012) Am. J. Hematol. , vol.87 , pp. 532-534
    • Lambert, M.P.1    Jiang, J.2    Batra, V.3    Wu, C.4    Tong, W.5
  • 102
    • 33750550297 scopus 로고    scopus 로고
    • Concurrent MPL515 and JAK2V617F mutations in myelofibrosis: chronology of clonal emergence and changes in mutant allele burden over time
    • Lasho T.L., Pardanani A., McClure R.F., Mesa R.A., Levine R.L., Gilliland D.G., et al. Concurrent MPL515 and JAK2V617F mutations in myelofibrosis: chronology of clonal emergence and changes in mutant allele burden over time. Br. J. Haematol. 2006, 135:683-687.
    • (2006) Br. J. Haematol. , vol.135 , pp. 683-687
    • Lasho, T.L.1    Pardanani, A.2    McClure, R.F.3    Mesa, R.A.4    Levine, R.L.5    Gilliland, D.G.6
  • 103
    • 77956670899 scopus 로고    scopus 로고
    • LNK mutations in JAK2 mutation-negative erythrocytosis
    • Lasho T.L., Pardanani A., Tefferi A. LNK mutations in JAK2 mutation-negative erythrocytosis. N. Engl. J. Med. 2010, 363:1189-1190.
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1189-1190
    • Lasho, T.L.1    Pardanani, A.2    Tefferi, A.3
  • 104
    • 84969379800 scopus 로고    scopus 로고
    • Calreticulin mutations in myeloproliferative neoplasms
    • Lavi N. Calreticulin mutations in myeloproliferative neoplasms. Rambam Maimonides Med. J. 2014, 5:e0035.
    • (2014) Rambam Maimonides Med. J. , vol.5 , pp. e0035
    • Lavi, N.1
  • 105
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • Levine R.L., Wadleigh M., Cools J., Ebert B.L., Wernig G., Huntly B.J., et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 2005, 7:387-397.
    • (2005) Cancer Cell , vol.7 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3    Ebert, B.L.4    Wernig, G.5    Huntly, B.J.6
  • 106
    • 25844518265 scopus 로고    scopus 로고
    • The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia
    • Levine R.L., Loriaux M., Huntly B.J., Loh M.L., Beran M., Stoffregen E., et al. The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. Blood 2005, 106:3377-3379.
    • (2005) Blood , vol.106 , pp. 3377-3379
    • Levine, R.L.1    Loriaux, M.2    Huntly, B.J.3    Loh, M.L.4    Beran, M.5    Stoffregen, E.6
  • 108
    • 34447273407 scopus 로고    scopus 로고
    • DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells
    • Li O., Li J., Droge P. DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells. FEBS Lett. 2007, 581:3533-3537.
    • (2007) FEBS Lett. , vol.581 , pp. 3533-3537
    • Li, O.1    Li, J.2    Droge, P.3
  • 109
    • 79956096380 scopus 로고    scopus 로고
    • Mouse models of myeloproliferative neoplasms: JAK of all grades
    • Li J., Kent D.G., Chen E., Green A.R. Mouse models of myeloproliferative neoplasms: JAK of all grades. Dis. Models Mech. 2011, 4:311-317.
    • (2011) Dis. Models Mech. , vol.4 , pp. 311-317
    • Li, J.1    Kent, D.G.2    Chen, E.3    Green, A.R.4
  • 111
    • 70349249988 scopus 로고    scopus 로고
    • Mutations in CBL occur frequently in juvenile myelomonocytic leukemia
    • Loh M.L., Sakai D.S., Flotho C., Kang M., Fliegauf M., Archambeault S., et al. Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. Blood 2009, 114:1859-1863.
    • (2009) Blood , vol.114 , pp. 1859-1863
    • Loh, M.L.1    Sakai, D.S.2    Flotho, C.3    Kang, M.4    Fliegauf, M.5    Archambeault, S.6
  • 112
    • 84872808860 scopus 로고    scopus 로고
    • P5 as a target in myeloproliferative neoplasms
    • Lu M., Hoffman R. p5 as a target in myeloproliferative neoplasms. Oncotarget 2012, 3:1052-1053.
    • (2012) Oncotarget , vol.3 , pp. 1052-1053
    • Lu, M.1    Hoffman, R.2
  • 113
    • 84899065964 scopus 로고    scopus 로고
    • Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms
    • Lundberg P., Karow A., Nienhold R., Looser R., Hao-Shen H., Nissen I., et al. Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms. Blood 2014, 123:2220-2228.
    • (2014) Blood , vol.123 , pp. 2220-2228
    • Lundberg, P.1    Karow, A.2    Nienhold, R.3    Looser, R.4    Hao-Shen, H.5    Nissen, I.6
  • 114
    • 84874112079 scopus 로고    scopus 로고
    • The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies
    • Luo B., Lee A.S. The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene 2013, 32:805-818.
    • (2013) Oncogene , vol.32 , pp. 805-818
    • Luo, B.1    Lee, A.S.2
  • 115
    • 0031017533 scopus 로고    scopus 로고
    • Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways
    • Luo H., Rose P., Barber D., Hanratty W.P., Lee S., Roberts T.M., et al. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol. Cell. Biol. 1997, 17:1562-1571.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1562-1571
    • Luo, H.1    Rose, P.2    Barber, D.3    Hanratty, W.P.4    Lee, S.5    Roberts, T.M.6
  • 116
    • 68549116852 scopus 로고    scopus 로고
    • Association of V617F Jak2 mutation with the risk of thrombosis among patients with essential thrombocythaemia or idiopathic myelofibrosis: a systematic review
    • Lussana F., Caberlon S., Pagani C., Kamphuisen P.W., Buller H.R., Cattaneo M. Association of V617F Jak2 mutation with the risk of thrombosis among patients with essential thrombocythaemia or idiopathic myelofibrosis: a systematic review. Thromb. Res. 2009, 124:409-417.
    • (2009) Thromb. Res. , vol.124 , pp. 409-417
    • Lussana, F.1    Caberlon, S.2    Pagani, C.3    Kamphuisen, P.W.4    Buller, H.R.5    Cattaneo, M.6
  • 117
    • 74949108515 scopus 로고    scopus 로고
    • Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies
    • Makishima H., Cazzolli H., Szpurka H., Dunbar A., Tiu R., Huh J., et al. Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies. J. Clin. Oncol. 2009, 27:6109-6116.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 6109-6116
    • Makishima, H.1    Cazzolli, H.2    Szpurka, H.3    Dunbar, A.4    Tiu, R.5    Huh, J.6
  • 118
    • 77957987676 scopus 로고    scopus 로고
    • Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies
    • Makishima H., Jankowska A.M., Tiu R.V., Szpurka H., Sugimoto Y., Hu Z., et al. Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies. Leukemia 2010, 24:1799-1804.
    • (2010) Leukemia , vol.24 , pp. 1799-1804
    • Makishima, H.1    Jankowska, A.M.2    Tiu, R.V.3    Szpurka, H.4    Sugimoto, Y.5    Hu, Z.6
  • 121
    • 84908499749 scopus 로고    scopus 로고
    • JAK2 V617F and CALR mutations are not mutually exclusive; findings from retrospective analysis of a small patient cohort
    • McGaffin G., Harper K., Stirling D., McLintock L. JAK2 V617F and CALR mutations are not mutually exclusive; findings from retrospective analysis of a small patient cohort. Br. J. Haematol. 2014, 167:276-278.
    • (2014) Br. J. Haematol. , vol.167 , pp. 276-278
    • McGaffin, G.1    Harper, K.2    Stirling, D.3    McLintock, L.4
  • 122
    • 33746054198 scopus 로고    scopus 로고
    • JAK2(V617F) and leukemic transformation in myelofibrosis with myeloid metaplasia
    • Mesa R.A., Powell H., Lasho T., Dewald G., McClure R., Tefferi A. JAK2(V617F) and leukemic transformation in myelofibrosis with myeloid metaplasia. Leukemia Res. 2006, 30:1457-1460.
    • (2006) Leukemia Res. , vol.30 , pp. 1457-1460
    • Mesa, R.A.1    Powell, H.2    Lasho, T.3    Dewald, G.4    McClure, R.5    Tefferi, A.6
  • 124
    • 59849120392 scopus 로고    scopus 로고
    • Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum
    • Michalak M., Groenendyk J., Szabo E., Gold L.I., Opas M. Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum. Biochem. J. 2009, 417:651-666.
    • (2009) Biochem. J. , vol.417 , pp. 651-666
    • Michalak, M.1    Groenendyk, J.2    Szabo, E.3    Gold, L.I.4    Opas, M.5
  • 129
  • 131
    • 77953515445 scopus 로고    scopus 로고
    • Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms
    • Ogawa S., Sanada M., Shih L.Y., Suzuki T., Otsu M., Nakauchi H., et al. Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms. Cell Cycle 2010, 9:1051-1056.
    • (2010) Cell Cycle , vol.9 , pp. 1051-1056
    • Ogawa, S.1    Sanada, M.2    Shih, L.Y.3    Suzuki, T.4    Otsu, M.5    Nakauchi, H.6
  • 132
    • 77953485892 scopus 로고    scopus 로고
    • Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
    • Oh S.T., Simonds E.F., Jones C., Hale M.B., Goltsev Y., Gibbs K.D., et al. Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood 2010, 116:988-992.
    • (2010) Blood , vol.116 , pp. 988-992
    • Oh, S.T.1    Simonds, E.F.2    Jones, C.3    Hale, M.B.4    Goltsev, Y.5    Gibbs, K.D.6
  • 134
    • 10744230464 scopus 로고    scopus 로고
    • Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia
    • Ozeki K., Kiyoi H., Hirose Y., Iwai M., Ninomiya M., Kodera Y., et al. Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia. Blood 2004, 103:1901-1908.
    • (2004) Blood , vol.103 , pp. 1901-1908
    • Ozeki, K.1    Kiyoi, H.2    Hirose, Y.3    Iwai, M.4    Ninomiya, M.5    Kodera, Y.6
  • 135
    • 84874138259 scopus 로고    scopus 로고
    • Evaluation of the association between the JAK2 46/1 haplotype and chronic myeloproliferative neoplasms in a Brazilian population
    • Pagliarini-e-Silva S., Santos B.C., Pereira E.M., Ferreira M.E., Baraldi E.C., Sell A.M., et al. Evaluation of the association between the JAK2 46/1 haplotype and chronic myeloproliferative neoplasms in a Brazilian population. Clinics 2013, 68:5-9.
    • (2013) Clinics , vol.68 , pp. 5-9
    • Pagliarini-e-Silva, S.1    Santos, B.C.2    Pereira, E.M.3    Ferreira, M.E.4    Baraldi, E.C.5    Sell, A.M.6
  • 136
    • 52249100940 scopus 로고    scopus 로고
    • A sensitive detection method for MPLW515L or MPLW515K mutation in chronic myeloproliferative disorders with locked nucleic acid-modified probes and real-time polymerase chain reaction
    • Pancrazzi A., Guglielmelli P., Ponziani V., Bergamaschi G., Bosi A., Barosi G., et al. A sensitive detection method for MPLW515L or MPLW515K mutation in chronic myeloproliferative disorders with locked nucleic acid-modified probes and real-time polymerase chain reaction. J. Mol. Diagn. 2008, 10:435-441.
    • (2008) J. Mol. Diagn. , vol.10 , pp. 435-441
    • Pancrazzi, A.1    Guglielmelli, P.2    Ponziani, V.3    Bergamaschi, G.4    Bosi, A.5    Barosi, G.6
  • 137
    • 33750534561 scopus 로고    scopus 로고
    • MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients
    • Pardanani A.D., Levine R.L., Lasho T., Pikman Y., Mesa R.A., Wadleigh M., et al. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood 2006, 108:3472-3476.
    • (2006) Blood , vol.108 , pp. 3472-3476
    • Pardanani, A.D.1    Levine, R.L.2    Lasho, T.3    Pikman, Y.4    Mesa, R.A.5    Wadleigh, M.6
  • 138
    • 34548128326 scopus 로고    scopus 로고
    • Prevalence and clinicopathologic correlates of JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera
    • Pardanani A., Lasho T.L., Finke C., Hanson C.A., Tefferi A. Prevalence and clinicopathologic correlates of JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera. Leukemia 2007, 21:1960-1963.
    • (2007) Leukemia , vol.21 , pp. 1960-1963
    • Pardanani, A.1    Lasho, T.L.2    Finke, C.3    Hanson, C.A.4    Tefferi, A.5
  • 139
    • 41949128334 scopus 로고    scopus 로고
    • Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders
    • Pardanani A., Fridley B.L., Lasho T.L., Gilliland D.G., Tefferi A. Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders. Blood 2008, 111:2785-2789.
    • (2008) Blood , vol.111 , pp. 2785-2789
    • Pardanani, A.1    Fridley, B.L.2    Lasho, T.L.3    Gilliland, D.G.4    Tefferi, A.5
  • 140
    • 77954573304 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms
    • Pardanani A., Lasho T.L., Finke C.M., Mai M., McClure R.F., Tefferi A. IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms. Leukemia 2010, 24:1146-1151.
    • (2010) Leukemia , vol.24 , pp. 1146-1151
    • Pardanani, A.1    Lasho, T.L.2    Finke, C.M.3    Mai, M.4    McClure, R.F.5    Tefferi, A.6
  • 141
    • 77958021645 scopus 로고    scopus 로고
    • LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations
    • Pardanani A., Lasho T., Finke C., Oh S.T., Gotlib J., Tefferi A. LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations. Leukemia 2010, 24:1713-1718.
    • (2010) Leukemia , vol.24 , pp. 1713-1718
    • Pardanani, A.1    Lasho, T.2    Finke, C.3    Oh, S.T.4    Gotlib, J.5    Tefferi, A.6
  • 142
    • 77950352432 scopus 로고    scopus 로고
    • A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)
    • Passamonti F., Cervantes F., Vannucchi A.M., Morra E., Rumi E., Pereira A., et al. A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood 2010, 115:1703-1708.
    • (2010) Blood , vol.115 , pp. 1703-1708
    • Passamonti, F.1    Cervantes, F.2    Vannucchi, A.M.3    Morra, E.4    Rumi, E.5    Pereira, A.6
  • 143
    • 79551607979 scopus 로고    scopus 로고
    • Molecular and clinical features of the myeloproliferative neoplasm associated with JAK2 exon 12 mutations
    • Passamonti F., Elena C., Schnittger S., Skoda R.C., Green A.R., Girodon F., et al. Molecular and clinical features of the myeloproliferative neoplasm associated with JAK2 exon 12 mutations. Blood 2011, 117:2813-2816.
    • (2011) Blood , vol.117 , pp. 2813-2816
    • Passamonti, F.1    Elena, C.2    Schnittger, S.3    Skoda, R.C.4    Green, A.R.5    Girodon, F.6
  • 144
    • 84865187605 scopus 로고    scopus 로고
    • A prognostic model to predict survival in 867 World Health Organization-defined essential thrombocythemia at diagnosis: a study by the International Working Group on Myelofibrosis Research and Treatment
    • Passamonti F., Thiele J., Girodon F., Rumi E., Carobbio A., Gisslinger H., et al. A prognostic model to predict survival in 867 World Health Organization-defined essential thrombocythemia at diagnosis: a study by the International Working Group on Myelofibrosis Research and Treatment. Blood 2012, 120:1197-1201.
    • (2012) Blood , vol.120 , pp. 1197-1201
    • Passamonti, F.1    Thiele, J.2    Girodon, F.3    Rumi, E.4    Carobbio, A.5    Gisslinger, H.6
  • 145
    • 84878740538 scopus 로고    scopus 로고
    • TET2 mutations in Ph-negative myeloproliferative neoplasms: identification of three novel mutations and relationship with clinical and laboratory findings
    • Patriarca A., Colaizzo D., Tiscia G., Spadano R., Di Z., Acomo S., Spadano A., et al. TET2 mutations in Ph-negative myeloproliferative neoplasms: identification of three novel mutations and relationship with clinical and laboratory findings. BioMed Res. Int. 2013, 2013:929840.
    • (2013) BioMed Res. Int. , vol.2013 , pp. 929840
    • Patriarca, A.1    Colaizzo, D.2    Tiscia, G.3    Spadano, R.4    Di, Z.5    Acomo, S.6    Spadano, A.7
  • 146
    • 77952299670 scopus 로고    scopus 로고
    • The idic(X)(q13) in myeloid malignancies: breakpoint clustering in segmental duplications and association with TET2 mutations
    • Paulsson K., Haferlach C., Fonatsch C., Hagemeijer A., Andersen M.K., Slovak M.L., et al. The idic(X)(q13) in myeloid malignancies: breakpoint clustering in segmental duplications and association with TET2 mutations. Hum. Mol. Genet. 2010, 19:1507-1514.
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 1507-1514
    • Paulsson, K.1    Haferlach, C.2    Fonatsch, C.3    Hagemeijer, A.4    Andersen, M.K.5    Slovak, M.L.6
  • 147
    • 37049013530 scopus 로고    scopus 로고
    • The frequency of JAK2 exon 12 mutations in idiopathic erythrocytosis patients with low serum erythropoietin levels
    • Percy M.J., Scott L.M., Erber W.N., Harrison C.N., Reilly J.T., Jones F.G., et al. The frequency of JAK2 exon 12 mutations in idiopathic erythrocytosis patients with low serum erythropoietin levels. Haematologica 2007, 92:1607-1614.
    • (2007) Haematologica , vol.92 , pp. 1607-1614
    • Percy, M.J.1    Scott, L.M.2    Erber, W.N.3    Harrison, C.N.4    Reilly, J.T.5    Jones, F.G.6
  • 148
    • 70349100374 scopus 로고    scopus 로고
    • JAK2V617F activating mutation is associated with the myeloproliferative type of chronic myelomonocytic leukaemia
    • Pich A., Riera L., Sismondi F., Godio L., Davico B., onino L., Marmont F., et al. JAK2V617F activating mutation is associated with the myeloproliferative type of chronic myelomonocytic leukaemia. J. Clin. Pathol. 2009, 62:798-801.
    • (2009) J. Clin. Pathol. , vol.62 , pp. 798-801
    • Pich, A.1    Riera, L.2    Sismondi, F.3    Godio, L.4    Davico, B.5    onino, L.6    Marmont, F.7
  • 149
    • 38949160429 scopus 로고    scopus 로고
    • Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders
    • Pietra D., Li S., Brisci A., Passamonti F., Rumi E., Theocharides A., et al. Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders. Blood 2008, 111:1686-1689.
    • (2008) Blood , vol.111 , pp. 1686-1689
    • Pietra, D.1    Li, S.2    Brisci, A.3    Passamonti, F.4    Rumi, E.5    Theocharides, A.6
  • 150
    • 79953890796 scopus 로고    scopus 로고
    • Deep sequencing reveals double mutations in cis of MPL exon 10 in myeloproliferative neoplasms
    • Pietra D., Brisci A., Rumi E., Boggi S., Elena C., Pietrelli A., et al. Deep sequencing reveals double mutations in cis of MPL exon 10 in myeloproliferative neoplasms. Haematologica 2011, 96:607-611.
    • (2011) Haematologica , vol.96 , pp. 607-611
    • Pietra, D.1    Brisci, A.2    Rumi, E.3    Boggi, S.4    Elena, C.5    Pietrelli, A.6
  • 151
    • 33746437130 scopus 로고    scopus 로고
    • MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
    • Pikman Y., Lee B.H., Mercher T., McDowell E., Ebert B.L., Gozo M., et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006, 3:e270.
    • (2006) PLoS Med. , vol.3 , pp. e270
    • Pikman, Y.1    Lee, B.H.2    Mercher, T.3    McDowell, E.4    Ebert, B.L.5    Gozo, M.6
  • 153
    • 0026456042 scopus 로고
    • Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24
    • Pritchard M.A., Baker E., Callen D.F., Sutherland G.R., Wilks A.F. Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24. Mamm. Genome 1992, 3:36-38.
    • (1992) Mamm. Genome , vol.3 , pp. 36-38
    • Pritchard, M.A.1    Baker, E.2    Callen, D.F.3    Sutherland, G.R.4    Wilks, A.F.5
  • 154
    • 84924759494 scopus 로고    scopus 로고
    • Coexistence of JAK2V617F mutation and BCR-ABL Translocation in a pregnant woman with essential thrombocythemia
    • Qin Y.W., Yang Y.N., Li S., Wang C. Coexistence of JAK2V617F mutation and BCR-ABL Translocation in a pregnant woman with essential thrombocythemia. Indian J. Hematol. Blood Transfus. 2014, 30:331-334.
    • (2014) Indian J. Hematol. Blood Transfus. , vol.30 , pp. 331-334
    • Qin, Y.W.1    Yang, Y.N.2    Li, S.3    Wang, C.4
  • 155
    • 0028206119 scopus 로고
    • JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells
    • Rane S.G., Reddy E.P. JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells. Oncogene 1994, 9:2415-2423.
    • (1994) Oncogene , vol.9 , pp. 2415-2423
    • Rane, S.G.1    Reddy, E.P.2
  • 156
    • 77957965853 scopus 로고    scopus 로고
    • Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling
    • Rathinam C., Thien C.B., Flavell R.A., Langdon W.Y. Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling. Cancer Cell 2010, 18:341-352.
    • (2010) Cancer Cell , vol.18 , pp. 341-352
    • Rathinam, C.1    Thien, C.B.2    Flavell, R.A.3    Langdon, W.Y.4
  • 158
    • 33645312560 scopus 로고    scopus 로고
    • Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML
    • Reindl C., Bagrintseva K., Vempati S., Schnittger S., Ellwart J.W., Wenig K., et al. Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML. Blood 2006, 107:3700-3707.
    • (2006) Blood , vol.107 , pp. 3700-3707
    • Reindl, C.1    Bagrintseva, K.2    Vempati, S.3    Schnittger, S.4    Ellwart, J.W.5    Wenig, K.6
  • 159
    • 33744478891 scopus 로고    scopus 로고
    • Occurrence of the JAK2 V617F mutation in the WHO provisional entity: myelodysplastic/myeloproliferative disease, unclassifiable-refractory anemia with ringed sideroblasts associated with marked thrombocytosis
    • Remacha A.F., Nomdedeu J.F., Puget G., Estivill C., Sarda M.P., Canals C., et al. Occurrence of the JAK2 V617F mutation in the WHO provisional entity: myelodysplastic/myeloproliferative disease, unclassifiable-refractory anemia with ringed sideroblasts associated with marked thrombocytosis. Haematologica 2006, 91:719-720.
    • (2006) Haematologica , vol.91 , pp. 719-720
    • Remacha, A.F.1    Nomdedeu, J.F.2    Puget, G.3    Estivill, C.4    Sarda, M.P.5    Canals, C.6
  • 160
    • 85044550232 scopus 로고    scopus 로고
    • High occurrence of JAK2 V617 mutation in refractory anemia with ringed sideroblasts associated with marked thrombocytosis
    • Renneville A., Quesnel B., Charpentier A., Terriou L., Crinquette A., Lai J.L., et al. High occurrence of JAK2 V617 mutation in refractory anemia with ringed sideroblasts associated with marked thrombocytosis. Leukemia 2006, 20:2067-2070.
    • (2006) Leukemia , vol.20 , pp. 2067-2070
    • Renneville, A.1    Quesnel, B.2    Charpentier, A.3    Terriou, L.4    Crinquette, A.5    Lai, J.L.6
  • 161
    • 0030271712 scopus 로고    scopus 로고
    • Genomic sequence, organization, and chromosomal localization of human JAK3
    • Riedy M.C., Dutra A.S., Blake T.B., Modi W., Lal B.K., Davis J., et al. Genomic sequence, organization, and chromosomal localization of human JAK3. Genomics 1996, 37:57-61.
    • (1996) Genomics , vol.37 , pp. 57-61
    • Riedy, M.C.1    Dutra, A.S.2    Blake, T.B.3    Modi, W.4    Lal, B.K.5    Davis, J.6
  • 162
    • 84897568260 scopus 로고    scopus 로고
    • Impact of calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia
    • Rotunno G., Mannarelli C., Guglielmelli P., Pacilli A., Pancrazzi A., Pieri L., et al. Impact of calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia. Blood 2014, 123:1552-1555.
    • (2014) Blood , vol.123 , pp. 1552-1555
    • Rotunno, G.1    Mannarelli, C.2    Guglielmelli, P.3    Pacilli, A.4    Pancrazzi, A.5    Pieri, L.6
  • 163
    • 0035811366 scopus 로고    scopus 로고
    • Lnk adaptor: novel negative regulator of B cell lymphopoiesis
    • Rudd C.E. Lnk adaptor: novel negative regulator of B cell lymphopoiesis. Sci. STKE 2001, 2001:pe 1.
    • (2001) Sci. STKE , vol.2001 , pp. pe 1
    • Rudd, C.E.1
  • 164
    • 84901777448 scopus 로고    scopus 로고
    • CALR exon 9 mutations are somatically acquired events in familial cases of essential thrombocythemia or primary myelofibrosis
    • Rumi E., Harutyunyan A.S., Pietra D., Milosevic J.D., Casetti I.C., Bellini M., et al. CALR exon 9 mutations are somatically acquired events in familial cases of essential thrombocythemia or primary myelofibrosis. Blood 2014, 123:2416-2419.
    • (2014) Blood , vol.123 , pp. 2416-2419
    • Rumi, E.1    Harutyunyan, A.S.2    Pietra, D.3    Milosevic, J.D.4    Casetti, I.C.5    Bellini, M.6
  • 165
    • 0037033012 scopus 로고    scopus 로고
    • The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
    • Saharinen P., Silvennoinen O. The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J. Biol. Chem. 2002, 277:47954-47963.
    • (2002) J. Biol. Chem. , vol.277 , pp. 47954-47963
    • Saharinen, P.1    Silvennoinen, O.2
  • 166
    • 70149101696 scopus 로고    scopus 로고
    • Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms
    • Saint-Martin C., Leroy G., Delhommeau F., Panelatti G., Dupont S., James C., et al. Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms. Blood 2009, 114:1628-1632.
    • (2009) Blood , vol.114 , pp. 1628-1632
    • Saint-Martin, C.1    Leroy, G.2    Delhommeau, F.3    Panelatti, G.4    Dupont, S.5    James, C.6
  • 167
    • 68949124841 scopus 로고    scopus 로고
    • Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
    • Sanada M., Suzuki T., Shih L.Y., Otsu M., Kato M., Yamazaki S., et al. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature 2009, 460:904-908.
    • (2009) Nature , vol.460 , pp. 904-908
    • Sanada, M.1    Suzuki, T.2    Shih, L.Y.3    Otsu, M.4    Kato, M.5    Yamazaki, S.6
  • 168
    • 84919466830 scopus 로고    scopus 로고
    • The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm
    • Sangkhae V., Etheridge S.L., Kaushansky K., Hitchcock I.S. The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm. Blood 2014, 124:3956-3963.
    • (2014) Blood , vol.124 , pp. 3956-3963
    • Sangkhae, V.1    Etheridge, S.L.2    Kaushansky, K.3    Hitchcock, I.S.4
  • 170
    • 77950388949 scopus 로고    scopus 로고
    • Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms
    • Schaub F.X., Looser R., Li S., Hao-Shen H., Lehmann T., Tichelli A., et al. Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms. Blood 2010, 115:2003-2007.
    • (2010) Blood , vol.115 , pp. 2003-2007
    • Schaub, F.X.1    Looser, R.2    Li, S.3    Hao-Shen, H.4    Lehmann, T.5    Tichelli, A.6
  • 171
    • 58149231402 scopus 로고    scopus 로고
    • Characterization of 35 new cases with four different MPLW515 mutations and essential thrombocytosis or primary myelofibrosis
    • Schnittger S., Bacher U., Haferlach C., Beelen D., Bojko P., Burkle D., et al. Characterization of 35 new cases with four different MPLW515 mutations and essential thrombocytosis or primary myelofibrosis. Haematologica 2009, 94:141-144.
    • (2009) Haematologica , vol.94 , pp. 141-144
    • Schnittger, S.1    Bacher, U.2    Haferlach, C.3    Beelen, D.4    Bojko, P.5    Burkle, D.6
  • 172
    • 84870406696 scopus 로고    scopus 로고
    • Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myelodysplastic/myeloproliferative disorders: an analysis of 636 cases
    • Schnittger S., Bacher U., Alpermann T., Reiter A., Ulke M., Dicker F., et al. Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myelodysplastic/myeloproliferative disorders: an analysis of 636 cases. Haematologica 2012, 97:1890-1894.
    • (2012) Haematologica , vol.97 , pp. 1890-1894
    • Schnittger, S.1    Bacher, U.2    Alpermann, T.3    Reiter, A.4    Ulke, M.5    Dicker, F.6
  • 174
    • 84924745425 scopus 로고    scopus 로고
    • CALR and ASXL1 mutation analysis in 190 patients with essential thrombocythemia
    • Shen H., Chao H., Ding Z., Feng Y., Cen J., Pan J., et al. CALR and ASXL1 mutation analysis in 190 patients with essential thrombocythemia. Leukemia Lymphoma 2015, 56:820-822.
    • (2015) Leukemia Lymphoma , vol.56 , pp. 820-822
    • Shen, H.1    Chao, H.2    Ding, Z.3    Feng, Y.4    Cen, J.5    Pan, J.6
  • 175
    • 84867403602 scopus 로고    scopus 로고
    • TET2 is essential for survival and hematopoietic stem cell homeostasis
    • Shide K., Kameda T., Shimoda H., Yamaji T., Abe H., Kamiunten A., et al. TET2 is essential for survival and hematopoietic stem cell homeostasis. Leukemia 2012, 26:2216-2223.
    • (2012) Leukemia , vol.26 , pp. 2216-2223
    • Shide, K.1    Kameda, T.2    Shimoda, H.3    Yamaji, T.4    Abe, H.5    Kamiunten, A.6
  • 176
    • 4143053704 scopus 로고    scopus 로고
    • Internal tandem duplication of fms-like tyrosine kinase 3 is associated with poor outcome in patients with myelodysplastic syndrome
    • Shih L.Y., Lin T.L., Wang P.N., Wu J.H., Dunn P., Kuo M.C., et al. Internal tandem duplication of fms-like tyrosine kinase 3 is associated with poor outcome in patients with myelodysplastic syndrome. Cancer 2004, 101:989-998.
    • (2004) Cancer , vol.101 , pp. 989-998
    • Shih, L.Y.1    Lin, T.L.2    Wang, P.N.3    Wu, J.H.4    Dunn, P.5    Kuo, M.C.6
  • 177
    • 84969390733 scopus 로고    scopus 로고
    • JAK2, CALR, and MPL mutation spectrum in Japanese myeloproliferative neoplasms patients
    • Shirane S., Araki M., Morishita S., Edahiro Y., Takei H., Yoo Y., et al. JAK2, CALR, and MPL mutation spectrum in Japanese myeloproliferative neoplasms patients. Haematologica 2014.
    • (2014) Haematologica
    • Shirane, S.1    Araki, M.2    Morishita, S.3    Edahiro, Y.4    Takei, H.5    Yoo, Y.6
  • 178
    • 55949136562 scopus 로고    scopus 로고
    • Roles of the EZH2 histone methyltransferase in cancer epigenetics
    • Simon J.A., Lange C.A. Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat. Res. 2008, 647:21-29.
    • (2008) Mutat. Res. , vol.647 , pp. 21-29
    • Simon, J.A.1    Lange, C.A.2
  • 180
    • 84873411400 scopus 로고    scopus 로고
    • Polycythemia vera and essential thrombocythemia: new developments in biology with therapeutic implications
    • Soriano G., Heaney M. Polycythemia vera and essential thrombocythemia: new developments in biology with therapeutic implications. Curr. Opin. Hematol. 2013, 20:169-175.
    • (2013) Curr. Opin. Hematol. , vol.20 , pp. 169-175
    • Soriano, G.1    Heaney, M.2
  • 181
    • 33344455687 scopus 로고    scopus 로고
    • An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor
    • Staerk J., Lacout C., Sato T., Smith S.O., Vainchenker W., Constantinescu S.N. An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor. Blood 2006, 107:1864-1871.
    • (2006) Blood , vol.107 , pp. 1864-1871
    • Staerk, J.1    Lacout, C.2    Sato, T.3    Smith, S.O.4    Vainchenker, W.5    Constantinescu, S.N.6
  • 182
    • 21344440357 scopus 로고    scopus 로고
    • The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both atypical myeloproliferative disorders and myelodysplastic syndromes
    • Steensma D.P., Dewald G.W., Lasho T.L., Powell H.L., McClure R.F., Levine R.L., et al. The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both atypical myeloproliferative disorders and myelodysplastic syndromes. Blood 2005, 106:1207-1209.
    • (2005) Blood , vol.106 , pp. 1207-1209
    • Steensma, D.P.1    Dewald, G.W.2    Lasho, T.L.3    Powell, H.L.4    McClure, R.F.5    Levine, R.L.6
  • 183
    • 33744500207 scopus 로고    scopus 로고
    • JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained
    • Steensma D.P., McClure R.F., Karp J.E., Tefferi A., Lasho T.L., Powell H.L., et al. JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained. Leukemia 2006, 20:971-978.
    • (2006) Leukemia , vol.20 , pp. 971-978
    • Steensma, D.P.1    McClure, R.F.2    Karp, J.E.3    Tefferi, A.4    Lasho, T.L.5    Powell, H.L.6
  • 184
    • 33751220843 scopus 로고    scopus 로고
    • T(3;12)(q26;q14) in polycythemia vera is associated with upregulation of the HMGA2 gene
    • Storlazzi C.T., Albano F., Locunsolo C., Lonoce A., Funes S., Guastadisegni M.C., et al. t(3;12)(q26;q14) in polycythemia vera is associated with upregulation of the HMGA2 gene. Leukemia 2006, 20:2190-2192.
    • (2006) Leukemia , vol.20 , pp. 2190-2192
    • Storlazzi, C.T.1    Albano, F.2    Locunsolo, C.3    Lonoce, A.4    Funes, S.5    Guastadisegni, M.C.6
  • 185
    • 84969392617 scopus 로고    scopus 로고
    • Calreticulin gene mutations in myeloproliferative neoplasms without Janus kinase 2 mutations
    • Sun C., Zhang S., Li J. Calreticulin gene mutations in myeloproliferative neoplasms without Janus kinase 2 mutations. Leukemia Lymphoma 2014, 1-6.
    • (2014) Leukemia Lymphoma , pp. 1-6
    • Sun, C.1    Zhang, S.2    Li, J.3
  • 186
    • 33748196233 scopus 로고    scopus 로고
    • The Cbl family proteins: ring leaders in regulation of cell signaling
    • Swaminathan G., Tsygankov A.Y. The Cbl family proteins: ring leaders in regulation of cell signaling. J. Cell. Physiol. 2006, 209:21-43.
    • (2006) J. Cell. Physiol. , vol.209 , pp. 21-43
    • Swaminathan, G.1    Tsygankov, A.Y.2
  • 188
    • 33749325187 scopus 로고    scopus 로고
    • Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation
    • Szpurka H., Tiu R., Murugesan G., Aboudola S., Hsi E.D., Theil K.S., et al. Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation. Blood 2006, 108:2173-2181.
    • (2006) Blood , vol.108 , pp. 2173-2181
    • Szpurka, H.1    Tiu, R.2    Murugesan, G.3    Aboudola, S.4    Hsi, E.D.5    Theil, K.S.6
  • 189
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani M., Koh K.P., Shen Y., Pastor W.A., Bandukwala H., Brudno Y., et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 2009, 324:930-935.
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3    Pastor, W.A.4    Bandukwala, H.5    Brudno, Y.6
  • 190
    • 0037148516 scopus 로고    scopus 로고
    • Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk
    • Takaki S., Morita H., Tezuka Y., Takatsu K. Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk. J. Exp. Med. 2002, 195:151-160.
    • (2002) J. Exp. Med. , vol.195 , pp. 151-160
    • Takaki, S.1    Morita, H.2    Tezuka, Y.3    Takatsu, K.4
  • 191
    • 0032913316 scopus 로고    scopus 로고
    • Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L
    • Taksin A.L., Couedic J.P., Dusanter-Fourt I., Masse A., Giraudier S., Katz A., et al. Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L. Blood 1999, 93:125-139.
    • (1999) Blood , vol.93 , pp. 125-139
    • Taksin, A.L.1    Couedic, J.P.2    Dusanter-Fourt, I.3    Masse, A.4    Giraudier, S.5    Katz, A.6
  • 192
    • 84989775088 scopus 로고    scopus 로고
    • Myeloproliferative neoplasms-a contemporary review
    • Tefferi A., Pardanani A. Myeloproliferative neoplasms-a contemporary review. JAMA Oncol. 2015, 1:97-105.
    • (2015) JAMA Oncol. , vol.1 , pp. 97-105
    • Tefferi, A.1    Pardanani, A.2
  • 193
    • 34548042964 scopus 로고    scopus 로고
    • Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel
    • Tefferi A., Thiele J., Orazi A., Kvasnicka H.M., Barbui T., Hanson C.A., et al. Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. Blood 2007, 110:1092-1097.
    • (2007) Blood , vol.110 , pp. 1092-1097
    • Tefferi, A.1    Thiele, J.2    Orazi, A.3    Kvasnicka, H.M.4    Barbui, T.5    Hanson, C.A.6
  • 194
    • 69249104612 scopus 로고    scopus 로고
    • The 2008 World Health Organization classification system for myeloproliferative neoplasms: order out of chaos
    • Tefferi A., Thiele J., Vardiman J.W. The 2008 World Health Organization classification system for myeloproliferative neoplasms: order out of chaos. Cancer 2009, 115:3842-3847.
    • (2009) Cancer , vol.115 , pp. 3842-3847
    • Tefferi, A.1    Thiele, J.2    Vardiman, J.W.3
  • 195
    • 67349145955 scopus 로고    scopus 로고
    • Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates
    • Tefferi A., Levine R.L., Lim K.H., Abdel-Wahab O., Lasho T.L., Patel J., et al. Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates. Leukemia 2009, 23:900-904.
    • (2009) Leukemia , vol.23 , pp. 900-904
    • Tefferi, A.1    Levine, R.L.2    Lim, K.H.3    Abdel-Wahab, O.4    Lasho, T.L.5    Patel, J.6
  • 196
    • 67349124376 scopus 로고    scopus 로고
    • TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis
    • Tefferi A., Pardanani A., Lim K.H., Abdel-Wahab O., Lasho T.L., Patel J., et al. TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. Leukemia 2009, 23:905-911.
    • (2009) Leukemia , vol.23 , pp. 905-911
    • Tefferi, A.1    Pardanani, A.2    Lim, K.H.3    Abdel-Wahab, O.4    Lasho, T.L.5    Patel, J.6
  • 197
    • 67650924270 scopus 로고    scopus 로고
    • Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML
    • Tefferi A., Lim K.H., Abdel-Wahab O., Lasho T.L., Patel J., Patnaik M.M., et al. Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML. Leukemia 2009, 23:1343-1345.
    • (2009) Leukemia , vol.23 , pp. 1343-1345
    • Tefferi, A.1    Lim, K.H.2    Abdel-Wahab, O.3    Lasho, T.L.4    Patel, J.5    Patnaik, M.M.6
  • 198
    • 84904056081 scopus 로고    scopus 로고
    • CALR and ASXL1 mutations-based molecular prognostication in primary myelofibrosis: an international study of 570 patients
    • Tefferi A., Guglielmelli P., Lasho T.L., Rotunno G., Finke C., Mannarelli C., et al. CALR and ASXL1 mutations-based molecular prognostication in primary myelofibrosis: an international study of 570 patients. Leukemia 2014, 28:1494-1500.
    • (2014) Leukemia , vol.28 , pp. 1494-1500
    • Tefferi, A.1    Guglielmelli, P.2    Lasho, T.L.3    Rotunno, G.4    Finke, C.5    Mannarelli, C.6
  • 200
    • 84904046605 scopus 로고    scopus 로고
    • Type 1 vs type 2 calreticulin mutations in primary myelofibrosis: differences in phenotype and prognostic impact
    • Tefferi A., Lasho T.L., Finke C., Belachew A.A., Wassie E.A., Ketterling R.P., et al. Type 1 vs type 2 calreticulin mutations in primary myelofibrosis: differences in phenotype and prognostic impact. Leukemia 2014, 28:1568-1570.
    • (2014) Leukemia , vol.28 , pp. 1568-1570
    • Tefferi, A.1    Lasho, T.L.2    Finke, C.3    Belachew, A.A.4    Wassie, E.A.5    Ketterling, R.P.6
  • 201
    • 84904042955 scopus 로고    scopus 로고
    • CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons
    • Tefferi A., Lasho T.L., Finke C.M., Knudson R.A., Ketterling R., Hanson C.H., et al. CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons. Leukemia 2014, 28:1472-1477.
    • (2014) Leukemia , vol.28 , pp. 1472-1477
    • Tefferi, A.1    Lasho, T.L.2    Finke, C.M.3    Knudson, R.A.4    Ketterling, R.5    Hanson, C.H.6
  • 202
    • 84904067758 scopus 로고    scopus 로고
    • An overview on CALR and CSF3R mutations and a proposal for revision of WHO diagnostic criteria for myeloproliferative neoplasms
    • Tefferi A., Thiele J., Vannucchi A.M., Barbui T. An overview on CALR and CSF3R mutations and a proposal for revision of WHO diagnostic criteria for myeloproliferative neoplasms. Leukemia 2014, 28:1407-1413.
    • (2014) Leukemia , vol.28 , pp. 1407-1413
    • Tefferi, A.1    Thiele, J.2    Vannucchi, A.M.3    Barbui, T.4
  • 203
    • 84908065771 scopus 로고    scopus 로고
    • The prognostic advantage of calreticulin mutations in myelofibrosis might be confined to type 1 or type 1-like CALR variants
    • Tefferi A., Lasho T.L., Tischer A., Wassie E.A., Finke C.M., Belachew A.A., et al. The prognostic advantage of calreticulin mutations in myelofibrosis might be confined to type 1 or type 1-like CALR variants. Blood 2014, 124:2465-2466.
    • (2014) Blood , vol.124 , pp. 2465-2466
    • Tefferi, A.1    Lasho, T.L.2    Tischer, A.3    Wassie, E.A.4    Finke, C.M.5    Belachew, A.A.6
  • 204
    • 77954581139 scopus 로고    scopus 로고
    • Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1
    • Tefferi A. Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1. Leukemia 2010, 24:1128-1138.
    • (2010) Leukemia , vol.24 , pp. 1128-1138
    • Tefferi, A.1
  • 205
    • 79953711716 scopus 로고    scopus 로고
    • How I treat myelofibrosis
    • Tefferi A. How I treat myelofibrosis. Blood 2011, 117:3494-3504.
    • (2011) Blood , vol.117 , pp. 3494-3504
    • Tefferi, A.1
  • 206
    • 50549085051 scopus 로고    scopus 로고
    • Epigenetic alteration of SOCS family members is a possible pathogenetic mechanism in JAK2 wild type myeloproliferative diseases
    • Teofili L., Martini M., Cenci T., Guidi F., Torti L., Giona F., et al. Epigenetic alteration of SOCS family members is a possible pathogenetic mechanism in JAK2 wild type myeloproliferative diseases. Int. J. Cancer 2008, 123:1586-1592.
    • (2008) Int. J. Cancer , vol.123 , pp. 1586-1592
    • Teofili, L.1    Martini, M.2    Cenci, T.3    Guidi, F.4    Torti, L.5    Giona, F.6
  • 207
    • 73949105527 scopus 로고    scopus 로고
    • Hereditary thrombocytosis caused by MPLSer505Asn is associated with a high thrombotic risk, splenomegaly and progression to bone marrow fibrosis
    • Teofili L., Giona F., Torti L., Cenci T., Ricerca B.M., Rumi C., et al. Hereditary thrombocytosis caused by MPLSer505Asn is associated with a high thrombotic risk, splenomegaly and progression to bone marrow fibrosis. Haematologica 2010, 95:65-70.
    • (2010) Haematologica , vol.95 , pp. 65-70
    • Teofili, L.1    Giona, F.2    Torti, L.3    Cenci, T.4    Ricerca, B.M.5    Rumi, C.6
  • 209
    • 34347394712 scopus 로고    scopus 로고
    • Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation
    • Theocharides A., Boissinot M., Girodon F., Garand R., Teo S.S., Lippert E., et al. Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation. Blood 2007, 110:375-379.
    • (2007) Blood , vol.110 , pp. 375-379
    • Theocharides, A.1    Boissinot, M.2    Girodon, F.3    Garand, R.4    Teo, S.S.5    Lippert, E.6
  • 210
    • 4544277651 scopus 로고    scopus 로고
    • Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis
    • Tong W., Lodish H.F. Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis. J. Exp. Med. 2004, 200:569-580.
    • (2004) J. Exp. Med. , vol.200 , pp. 569-580
    • Tong, W.1    Lodish, H.F.2
  • 212
  • 213
    • 34547953018 scopus 로고    scopus 로고
    • Clinical profile of homozygous JAK2 617V > F mutation in patients with polycythemia vera or essential thrombocythemia
    • Vannucchi A.M., Antonioli E., Guglielmelli P., Rambaldi A., Barosi G., Marchioli R., et al. Clinical profile of homozygous JAK2 617V > F mutation in patients with polycythemia vera or essential thrombocythemia. Blood 2007, 110:840-846.
    • (2007) Blood , vol.110 , pp. 840-846
    • Vannucchi, A.M.1    Antonioli, E.2    Guglielmelli, P.3    Rambaldi, A.4    Barosi, G.5    Marchioli, R.6
  • 214
    • 50949127379 scopus 로고    scopus 로고
    • Characteristics and clinical correlates of MPL 515W > L/K mutation in essential thrombocythemia
    • Vannucchi A.M., Antonioli E., Guglielmelli P., Pancrazzi A., Guerini V., Barosi G., et al. Characteristics and clinical correlates of MPL 515W > L/K mutation in essential thrombocythemia. Blood 2008, 112:844-847.
    • (2008) Blood , vol.112 , pp. 844-847
    • Vannucchi, A.M.1    Antonioli, E.2    Guglielmelli, P.3    Pancrazzi, A.4    Guerini, V.5    Barosi, G.6
  • 217
    • 0037124306 scopus 로고    scopus 로고
    • Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice
    • Velazquez L., Cheng A.M., Fleming H.E., Furlonger C., Vesely S., Bernstein A., et al. Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J. Exp. Med. 2002, 195:1599-1611.
    • (2002) J. Exp. Med. , vol.195 , pp. 1599-1611
    • Velazquez, L.1    Cheng, A.M.2    Fleming, H.E.3    Furlonger, C.4    Vesely, S.5    Bernstein, A.6
  • 218
    • 33750304807 scopus 로고    scopus 로고
    • JAK2V617F mutational frequency in polycythemia vera: 100%, >90%, less?
    • Verstovsek S., Silver R.T., Cross N.C., Tefferi A. JAK2V617F mutational frequency in polycythemia vera: 100%, >90%, less?. Leukemia 2006, 20:2067.
    • (2006) Leukemia , vol.20 , pp. 2067
    • Verstovsek, S.1    Silver, R.T.2    Cross, N.C.3    Tefferi, A.4
  • 219
    • 33644533192 scopus 로고    scopus 로고
    • JAK2 V617F mutation in classic chronic myeloproliferative diseases: a report on a series of 349 patients
    • Vizmanos J.L., Ormazabal C., Larrayoz M.J., Cross N.C., Calasanz M.J. JAK2 V617F mutation in classic chronic myeloproliferative diseases: a report on a series of 349 patients. Leukemia 2006, 20:534-535.
    • (2006) Leukemia , vol.20 , pp. 534-535
    • Vizmanos, J.L.1    Ormazabal, C.2    Larrayoz, M.J.3    Cross, N.C.4    Calasanz, M.J.5
  • 220
    • 79960255863 scopus 로고    scopus 로고
    • Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
    • Walter M.J., Ding L., Shen D., Shao J., Grillot M., McLellan M., et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia 2011, 25:1153-1158.
    • (2011) Leukemia , vol.25 , pp. 1153-1158
    • Walter, M.J.1    Ding, L.2    Shen, D.3    Shao, J.4    Grillot, M.5    McLellan, M.6
  • 221
    • 33747610392 scopus 로고    scopus 로고
    • Refractory anemia with ringed sideroblasts associated with marked thrombocytosis harbors JAK2 mutation and shows overlapping myeloproliferative and myelodysplastic features
    • Wang S.A., Hasserjian R.P., Loew J.M., Sechman E.V., Jones D., Hao S., et al. Refractory anemia with ringed sideroblasts associated with marked thrombocytosis harbors JAK2 mutation and shows overlapping myeloproliferative and myelodysplastic features. Leukemia 2006, 20:1641-1644.
    • (2006) Leukemia , vol.20 , pp. 1641-1644
    • Wang, S.A.1    Hasserjian, R.P.2    Loew, J.M.3    Sechman, E.V.4    Jones, D.5    Hao, S.6
  • 223
    • 84901751270 scopus 로고    scopus 로고
    • Mutation analysis of JAK2V617F, FLT3-ITD, NPM1, and DNMT3A in Chinese patients with myeloproliferative neoplasms
    • Wang M., He N., Tian T., Liu L., Yu S., Ma D. Mutation analysis of JAK2V617F, FLT3-ITD, NPM1, and DNMT3A in Chinese patients with myeloproliferative neoplasms. BioMed Res. Int. 2014, 2014:485645.
    • (2014) BioMed Res. Int. , vol.2014 , pp. 485645
    • Wang, M.1    He, N.2    Tian, T.3    Liu, L.4    Yu, S.5    Ma, D.6
  • 224
    • 33744490974 scopus 로고    scopus 로고
    • Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
    • Wernig G., Mercher T., Okabe R., Levine R.L., Lee B.H., Gilliland D.G. Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood 2006, 107:4274-4281.
    • (2006) Blood , vol.107 , pp. 4274-4281
    • Wernig, G.1    Mercher, T.2    Okabe, R.3    Levine, R.L.4    Lee, B.H.5    Gilliland, D.G.6
  • 225
    • 35448963775 scopus 로고    scopus 로고
    • Phenotypic variations and new mutations in JAK2 V617F-negative polycythemia vera, erythrocytosis, and idiopathic myelofibrosis
    • Williams D.M., Kim A.H., Rogers O., Spivak J.L., Moliterno A.R. Phenotypic variations and new mutations in JAK2 V617F-negative polycythemia vera, erythrocytosis, and idiopathic myelofibrosis. Exp. Hematol. 2007, 35:1641-1646.
    • (2007) Exp. Hematol. , vol.35 , pp. 1641-1646
    • Williams, D.M.1    Kim, A.H.2    Rogers, O.3    Spivak, J.L.4    Moliterno, A.R.5
  • 226
    • 84883457828 scopus 로고    scopus 로고
    • FLT3 mutations in myeloproliferative neoplasms: the Beaumont experience
    • Williams L., Kelley H.H., Meng X., Prada A., Crisan D. FLT3 mutations in myeloproliferative neoplasms: the Beaumont experience. Diagn. Mol. Pathol. 2013, 22:156-160.
    • (2013) Diagn. Mol. Pathol. , vol.22 , pp. 156-160
    • Williams, L.1    Kelley, H.H.2    Meng, X.3    Prada, A.4    Crisan, D.5
  • 227
    • 84863688974 scopus 로고    scopus 로고
    • JAK2 V617F, MPL W515L and JAK2 exon 12 mutations in chinese patients with primary myelofibrosis
    • Xia J., Lu M.Z., Jiang Y.Q., Yang G.H., Zhuang Y., Sun H.L., et al. JAK2 V617F, MPL W515L and JAK2 exon 12 mutations in chinese patients with primary myelofibrosis. Chin. J. Cancer Res. 2012, 24:72-76.
    • (2012) Chin. J. Cancer Res. , vol.24 , pp. 72-76
    • Xia, J.1    Lu, M.Z.2    Jiang, Y.Q.3    Yang, G.H.4    Zhuang, Y.5    Sun, H.L.6
  • 229
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan X.J., Xu J., Gu Z.H., Pan C.M., Lu G., Shen Y., et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat. Genet. 2011, 43:309-315.
    • (2011) Nat. Genet. , vol.43 , pp. 309-315
    • Yan, X.J.1    Xu, J.2    Gu, Z.H.3    Pan, C.M.4    Lu, G.5    Shen, Y.6
  • 230
    • 34247570512 scopus 로고    scopus 로고
    • Oncogenic HMGA2: short or small?
    • Young A.R., Narita M. Oncogenic HMGA2: short or small?. Genes Dev. 2007, 21:1005-1009.
    • (2007) Genes Dev. , vol.21 , pp. 1005-1009
    • Young, A.R.1    Narita, M.2
  • 231
    • 84861082246 scopus 로고    scopus 로고
    • Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome
    • Zhang S.J., Rampal R., Manshouri T., Patel J., Mensah N., Kayserian A., et al. Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome. Blood 2012, 119:4480-4485.
    • (2012) Blood , vol.119 , pp. 4480-4485
    • Zhang, S.J.1    Rampal, R.2    Manshouri, T.3    Patel, J.4    Mensah, N.5    Kayserian, A.6
  • 232
    • 84888388716 scopus 로고    scopus 로고
    • Methylation profiling of SOCS1, SOCS2, SOCS3, CISH and SHP1 in Philadelphia-negative myeloproliferative neoplasm
    • Zhang M.Y., Fung T.K., Chen F.Y., Chim C.S. Methylation profiling of SOCS1, SOCS2, SOCS3, CISH and SHP1 in Philadelphia-negative myeloproliferative neoplasm. J. Cell. Mol. Med. 2013, 17:1282-1290.
    • (2013) J. Cell. Mol. Med. , vol.17 , pp. 1282-1290
    • Zhang, M.Y.1    Fung, T.K.2    Chen, F.Y.3    Chim, C.S.4


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